NOS1AP and SYN2

Number of citations of the paper that reports this interaction (PMID 11867766)
19

Data Source:
HPRD (in vivo)

		NOS1AP	SYN2
Gene Name		nitric oxide synthase 1 (neuronal) adaptor protein	synapsin II
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrion Cytosol Caveola Z Disc T-tubule Nuclear Membrane Sarcoplasmic Reticulum Membrane Sarcolemma Perinuclear Region Of Cytoplasm Inward Rectifier Potassium Channel Complex L-type Voltage-gated Calcium Channel Complex	Cell Junction Synaptic Vesicle Membrane Synapse
	Molecular Function	Nitric-oxide Synthase Binding	Catalytic Activity ATP Binding
	Biological Process	Regulation Of Heart Rate By Chemical Signal Positive Regulation Of Gene Expression Positive Regulation Of Nitric Oxide Mediated Signal Transduction Regulation Of Apoptotic Process Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Cardiac Muscle Cell Action Potential Positive Regulation Of Potassium Ion Transmembrane Transport Regulation Of High Voltage-gated Calcium Channel Activity Positive Regulation Of Delayed Rectifier Potassium Channel Activity Regulation Of Generation Of L-type Calcium Current Positive Regulation Of Peptidyl-cysteine S-nitrosylation	Synaptic Transmission Neurotransmitter Secretion Metabolic Process
Pathways
Drugs
Diseases
GWAS		Electrocardiographic traits ( 20062061 20062063) Obesity-related traits ( 23251661) QT interval ( 23166209 20031603 16648850 22726844 19305408 19305409 19587794) Word reading ( 23738518)	Fasting insulin-related traits (interaction with BMI) ( 22581228) Platelet counts ( 22139419) Type 2 diabetes ( 18372903)
Protein-Protein Interactions		11 interactors: APP FAM133A LRP1 LRP2 LRP8 NOS1 RASD1 SYN1 SYN2 SYN3 TRAF4	6 interactors: NOS1AP PRKACA SYN1 SYN3 YWHAE YWHAZ
Entrez ID		9722	6854
HPRD ID		12023	02857
Ensembl ID		ENSG00000198929
Uniprot IDs		O75052	Q86VA8
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Neurotransmitter Levels Signaling Cell Communication Phototransduction, Visible Light Retinoid Metabolic Process Regulation Of Synaptic Transmission Diterpenoid Metabolic Process Detection Of Visible Light Phototransduction Response To Light Stimulus Neurotransmitter Secretion Detection Of Light Stimulus Isoprenoid Metabolic Process Nitric Oxide Mediated Signal Transduction Response To Radiation Neurotransmitter Transport Secretion By Cell Response To Abiotic Stimulus Detection Of Abiotic Stimulus Regulation Of Signaling Secretion Endocytosis Steroid Metabolic Process Regulation Of Protein Tyrosine Kinase Activity Alcohol Metabolic Process Receptor-mediated Endocytosis Positive Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Ammon Gyrus Development Beta-amyloid Clearance Regulation Of Cellular Amino Acid Metabolic Process Blood Coagulation Hemostasis Forebrain Development Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Synaptic Growth At Neuromuscular Junction Regulation Of Cellular Ketone Metabolic Process Cholesterol Metabolic Process Transport Positive Regulation Of Protein Metabolic Process Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Positive Regulation Of Adrenergic Receptor Signaling Pathway Negative Regulation Of Adrenergic Receptor Signaling Pathway Collateral Sprouting In Absence Of Injury Negative Regulation Of Serotonin Uptake Sterol Metabolic Process Lipid Metabolic Process Detection Of Stimulus Regulation Of Body Fluid Levels Second-messenger-mediated Signaling	Regulation Of Heart Rate Regulation Of Heart Rate By Chemical Signal Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Signaling Regulation Of Heart Contraction Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Membrane Repolarization Positive Regulation Of Transport Positive Regulation Of Intracellular Transport Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cell-cell Signaling Regulation Of Potassium Ion Transmembrane Transport Regulation Of Synaptic Transmission Regulation Of Cellular Localization Cardiac Conduction Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Potassium Ion Transport Regulation Of Ion Transmembrane Transport Positive Regulation Of Signal Transduction Regulation Of Intracellular Transport Regulation Of Cation Channel Activity Secretion By Cell Regulation Of Apoptotic Process Regulation Of Mitochondrion Organization Regulation Of Cell Death Positive Regulation Of Nitric Oxide Mediated Signal Transduction Positive Regulation Of Dense Core Granule Biogenesis Neurotransmitter Secretion Regulation Of Ion Transport Secretion G2/M Transition Of Mitotic Cell Cycle Regulation Of Establishment Of Protein Localization Positive Regulation Of Peptidyl-cysteine S-nitrosylation Regulation Of Heart Rate By Hormone Histone H3-T6 Phosphorylation Negative Regulation Of Peptidyl-serine Dephosphorylation Regulation Of Neurotransmitter Levels Establishment Of Localization In Cell Regulation Of Protein Localization Neurotransmitter Transport Membrane Organization Regulation Of Generation Of L-type Calcium Current Golgi Reassembly
Tagcloud ?		accomplices counterbalance dao daoa dictate dpysl2 dtnbp1 famine grin1 grin2b grm3 grm4 hypomyelination il1b il1rn impa2 metabotropic ncam1 nd4 ndufv2 nurture oligodendrocyte pdlim5 pik3c3 pip5k2a reconcile rgs4 ywhah	agouti camk2g cd47 chances clstn2 consonant enpp1 epha5a gad2 gria3 grin2b kif minipumps myo5a negr1 neuroplasticity ntrk2 ntrk3 ppp3r1 prdx1 predecessors serotonine slc2a4 sv2b synaptogenesis synj2 therapeutical venlafaxine vlx
Tagcloud (Difference) ?		accomplices counterbalance dao daoa dictate dpysl2 dtnbp1 famine grin1 grm3 grm4 hypomyelination il1b il1rn impa2 metabotropic ncam1 nd4 ndufv2 nurture oligodendrocyte pdlim5 pik3c3 pip5k2a reconcile rgs4 ywhah	agouti camk2g cd47 chances clstn2 consonant enpp1 epha5a gad2 gria3 kif minipumps myo5a negr1 neuroplasticity ntrk2 ntrk3 ppp3r1 prdx1 predecessors serotonine slc2a4 sv2b synaptogenesis synj2 therapeutical venlafaxine vlx
Tagcloud (Intersection) ?		grin2b