LRP1 and SNX17

Number of citations of the paper that reports this interaction (PMID 12169628)
26

Data Source:
HPRD (in vitro, in vivo)

		LRP1	SNX17
Gene Name		low density lipoprotein receptor-related protein 1	sorting nexin 17
Image
Gene Ontology Annotations	Cellular Component	Nucleolus Cytoplasm Lysosomal Membrane Endosome Plasma Membrane Integral Component Of Plasma Membrane Coated Pit Focal Adhesion Clathrin-coated Vesicle Dendrite Endocytic Vesicle Membrane Neuronal Cell Body Receptor Complex	Cytoplasm Endosome Early Endosome Golgi Apparatus Cytosol Endosome Membrane Membrane Cytoplasmic Membrane-bounded Vesicle Cytoplasmic Vesicle Membrane Intracellular Membrane-bounded Organelle Protein Complex
	Molecular Function	Protease Binding Receptor Activity Calcium Ion Binding Protein Binding Protein Complex Binding Apolipoprotein Binding Lipoprotein Transporter Activity Poly(A) RNA Binding Lipoprotein Particle Receptor Binding	Receptor Binding Protein Binding Protein C-terminus Binding Phosphatidylinositol Binding Low-density Lipoprotein Particle Receptor Binding
	Biological Process	Retinoid Metabolic Process Receptor-mediated Endocytosis Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Aging Phototransduction, Visible Light Cholesterol Metabolic Process Cell Proliferation Positive Regulation Of Cholesterol Efflux Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Lipid Transport Regulation Of Cholesterol Transport Regulation Of Phospholipase A2 Activity Regulation Of Actin Cytoskeleton Organization Aorta Morphogenesis Lipoprotein Metabolic Process Lipoprotein Transport Apoptotic Cell Clearance Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Protein Transport Beta-amyloid Clearance Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway	Cholesterol Catabolic Process Intracellular Protein Transport Receptor-mediated Endocytosis Signal Transduction Endosomal Transport Regulation Of Endocytosis
Pathways		Scavenging of heme from plasma Visual phototransduction Diseases associated with visual transduction Retinoid metabolism and transport
Drugs
Diseases
GWAS		Abdominal aortic aneurysm ( 22055160) HDL cholesterol ( 20686565) Migraine ( 22683712 21666692) Pulmonary function ( 21946350) Pulmonary function (interaction) ( 23284291) Triglycerides ( 20686565)
Protein-Protein Interactions		63 interactors: A2M ANAPC10 ANKS1B APBA2 APBB1 APOE APP BACE1 C3 C4BPA CACNA1A CALR CANX CAV1 CC2D1A CD82 CTGF CTSG DAB1 DAB2 DLG4 ELANE F8 F9 FURIN GIPC1 GTPBP1 GULP1 HNRNPDL HSP90B1 ITGB1BP1 KAT5 LIPC LPL LRPAP1 LTF MAPK8IP1 MAPK8IP2 MAPRE1 MDK MMP13 MMP14 MMP15 MMP16 MMP17 NOS1AP PDGFB PID1 PLAT PLAUR PRKACA RIC8B SCN3A SERPINA1 SERPINE1 SHC1 SKIL SNRNP70 SNX17 SRC SYNJ2BP THBS1 WNT3A	10 interactors: APP HRAS LDLR LRP1 LRP2 LRP8 RLIM SELP SKIL VLDLR
Entrez ID		4035	9784
HPRD ID		00138	05812
Ensembl ID		ENSG00000123384	ENSG00000115234
Uniprot IDs		Q07954 Q59FG2	B4DQ37 B4DTB8 Q15036
PDB IDs		1CR8 1D2L 1J8E 2FYJ 2FYL 2KNX 2KNY	3FOG 3LUI 4GXB
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Catalytic Activity Regulation Of Proteolysis Negative Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Signaling Positive Regulation Of Protein Modification Process Regulation Of Signal Transduction Response To Wounding Regulation Of Protein Phosphorylation Blood Coagulation Hemostasis Regulation Of Protein Kinase Activity Response To Stress Regulation Of Kinase Activity Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Endocytosis Negative Regulation Of Cellular Metabolic Process Response To Lipid Positive Regulation Of Protein Phosphorylation Regulation Of Cellular Component Organization Platelet Activation Regulation Of Phosphorylation Positive Regulation Of Transferase Activity Positive Regulation Of Protein Kinase Activity Regulation Of Body Fluid Levels Positive Regulation Of Kinase Activity Positive Regulation Of Signal Transduction Wound Healing Regulation Of Protein Processing Vesicle-mediated Transport Positive Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Negative Regulation Of Protein Processing Locomotion Extracellular Matrix Disassembly Regulation Of Protein Binding Regulation Of Vesicle-mediated Transport Regulation Of Blood Coagulation Anatomical Structure Morphogenesis Response To Stimulus Secretion By Cell	Endocytosis Response To Light Stimulus Vesicle-mediated Transport Response To Radiation Phototransduction, Visible Light Retinoid Metabolic Process Steroid Metabolic Process Diterpenoid Metabolic Process Detection Of Visible Light Phototransduction Detection Of Light Stimulus Cholesterol Metabolic Process Isoprenoid Metabolic Process Alcohol Metabolic Process Receptor-mediated Endocytosis Sterol Metabolic Process Detection Of Abiotic Stimulus Response To External Stimulus Response To Abiotic Stimulus Reelin-mediated Signaling Pathway Positive Regulation Of Cell Projection Organization Lipid Metabolic Process Nervous System Development Blood Coagulation Hemostasis Central Nervous System Development System Development Regulation Of Cell Projection Organization Regulation Of Transcription From RNA Polymerase II Promoter Organ Development Regulation Of Cellular Component Organization Regulation Of Neuron Differentiation Detection Of Stimulus Regulation Of Body Fluid Levels Behavior Wound Healing Multicellular Organismal Development Positive Regulation Of Neuron Projection Development Plasma Lipoprotein Particle Clearance Anatomical Structure Development Negative Regulation Of Gene Expression Transport Response To Wounding Regulation Of Neurogenesis Learning Or Memory Signal Transduction Regulation Of Protein Kinase Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Wound Healing Brain Development
Tagcloud ?		aacr an2 ang4043 angiopep bbb biologics bt confers conjugate conjugated conjugation crosses endows entity extending implanted indications intracarotid intracranially kin mab neuro penetrant penetrates penetration retains systemically ther transcytosis	1x10 a2ic aa2t abi analyzer bait bigdye ccdc32 gal gal4 heterotetramer lexa ligated monocyte ncbi nlm ogdh papd4 pbtm116 plasmin prey prism procathepsin ready reconstituting resultant rps2 terminator zbtb4
Tagcloud (Difference) ?		aacr an2 ang4043 angiopep bbb biologics bt confers conjugate conjugated conjugation crosses endows entity extending implanted indications intracarotid intracranially kin mab neuro penetrant penetrates penetration retains systemically ther transcytosis	1x10 a2ic aa2t abi analyzer bait bigdye ccdc32 gal gal4 heterotetramer lexa ligated monocyte ncbi nlm ogdh papd4 pbtm116 plasmin prey prism procathepsin ready reconstituting resultant rps2 terminator zbtb4
Tagcloud (Intersection) ?