LRP1 and LTF

Number of citations of the paper that reports this interaction (PMID 1464627)
47

Data Source:
HPRD (in vivo)

		LRP1	LTF
Gene Name		low density lipoprotein receptor-related protein 1	lactotransferrin
Image
Gene Ontology Annotations	Cellular Component	Nucleolus Cytoplasm Lysosomal Membrane Endosome Plasma Membrane Integral Component Of Plasma Membrane Coated Pit Focal Adhesion Clathrin-coated Vesicle Dendrite Endocytic Vesicle Membrane Neuronal Cell Body Receptor Complex	Extracellular Region Extracellular Space Nucleus Secretory Granule Specific Granule Extracellular Vesicular Exosome Phagocytic Vesicle Lumen
	Molecular Function	Protease Binding Receptor Activity Calcium Ion Binding Protein Binding Protein Complex Binding Apolipoprotein Binding Lipoprotein Transporter Activity Poly(A) RNA Binding Lipoprotein Particle Receptor Binding	DNA Binding Serine-type Endopeptidase Activity Iron Ion Binding Protein Binding Ferric Iron Binding Heparin Binding Protein Serine/threonine Kinase Activator Activity
	Biological Process	Retinoid Metabolic Process Receptor-mediated Endocytosis Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Aging Phototransduction, Visible Light Cholesterol Metabolic Process Cell Proliferation Positive Regulation Of Cholesterol Efflux Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Lipid Transport Regulation Of Cholesterol Transport Regulation Of Phospholipase A2 Activity Regulation Of Actin Cytoskeleton Organization Aorta Morphogenesis Lipoprotein Metabolic Process Lipoprotein Transport Apoptotic Cell Clearance Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Protein Transport Beta-amyloid Clearance Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway	Ossification Regulation Of Cytokine Production Retina Homeostasis Innate Immune Response In Mucosa Transcription, DNA-templated Proteolysis Iron Ion Transport Humoral Immune Response Antibacterial Humoral Response Antifungal Humoral Response Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Regulation Of Tumor Necrosis Factor Production Iron Assimilation By Chelation And Transport Positive Regulation Of Osteoblast Proliferation Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Osteoblast Differentiation Positive Regulation Of NF-kappaB Transcription Factor Activity Interaction With Host Response To Host Immune Response Bone Morphogenesis Positive Regulation Of Protein Serine/threonine Kinase Activity Phagosome Maturation Positive Regulation Of Bone Mineralization Involved In Bone Maturation Negative Regulation Of Single-species Biofilm Formation In Or On Host Organism Positive Regulation Of Chondrocyte Proliferation Negative Regulation Of Tumor Necrosis Factor (ligand) Superfamily Member 11 Production Negative Regulation Of Osteoclast Development
Pathways		Scavenging of heme from plasma Visual phototransduction Diseases associated with visual transduction Retinoid metabolism and transport	Amyloids Phagosomal maturation (early endosomal stage) Latent infection of Homo sapiens with Mycobacterium tuberculosis Response of Mtb to phagocytosis Mtb iron assimilation by chelation
Drugs			3h-Indole-5,6-Diol Alpha-D-Mannose Nitrilotriacetic Acid Alpha-D-Fucose Nimesulide 2-(4-(2-HYDROXY-3-(ISOPROPYLAMINO)PROPOXY)PHENYL)ETHANAMIDE parecoxib
Diseases
GWAS		Abdominal aortic aneurysm ( 22055160) HDL cholesterol ( 20686565) Migraine ( 22683712 21666692) Pulmonary function ( 21946350) Pulmonary function (interaction) ( 23284291) Triglycerides ( 20686565)	AIDS progression ( 21502085)
Protein-Protein Interactions		63 interactors: A2M ANAPC10 ANKS1B APBA2 APBB1 APOE APP BACE1 C3 C4BPA CACNA1A CALR CANX CAV1 CC2D1A CD82 CTGF CTSG DAB1 DAB2 DLG4 ELANE F8 F9 FURIN GIPC1 GTPBP1 GULP1 HNRNPDL HSP90B1 ITGB1BP1 KAT5 LIPC LPL LRPAP1 LTF MAPK8IP1 MAPK8IP2 MAPRE1 MDK MMP13 MMP14 MMP15 MMP16 MMP17 NOS1AP PDGFB PID1 PLAT PLAUR PRKACA RIC8B SCN3A SERPINA1 SERPINE1 SHC1 SKIL SNRNP70 SNX17 SRC SYNJ2BP THBS1 WNT3A	9 interactors: CALM1 CD14 CEL CP ITLN1 LCN1 LRP1 LYZ MUC7
Entrez ID		4035	4057
HPRD ID		00138	01028
Ensembl ID		ENSG00000123384	ENSG00000012223
Uniprot IDs		Q07954 Q59FG2	E7ER44 P02788
PDB IDs		1CR8 1D2L 1J8E 2FYJ 2FYL 2KNX 2KNY	1B0L 1BKA 1CB6 1DSN 1EH3 1FCK 1H43 1H44 1H45 1HSE 1L5T 1LCF 1LCT 1LFG 1LFH 1LFI 1LGB 1N76 1SQY 1U62 1VFD 1VFE 1XV4 1XV7 1Z6V 1Z6W 2BJJ 2DP4 2GMC 2GMD 2HD4 2PMS
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Catalytic Activity Regulation Of Proteolysis Negative Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Signaling Positive Regulation Of Protein Modification Process Regulation Of Signal Transduction Response To Wounding Regulation Of Protein Phosphorylation Blood Coagulation Hemostasis Regulation Of Protein Kinase Activity Response To Stress Regulation Of Kinase Activity Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Endocytosis Negative Regulation Of Cellular Metabolic Process Response To Lipid Positive Regulation Of Protein Phosphorylation Regulation Of Cellular Component Organization Platelet Activation Regulation Of Phosphorylation Positive Regulation Of Transferase Activity Positive Regulation Of Protein Kinase Activity Regulation Of Body Fluid Levels Positive Regulation Of Kinase Activity Positive Regulation Of Signal Transduction Wound Healing Regulation Of Protein Processing Vesicle-mediated Transport Positive Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Negative Regulation Of Protein Processing Locomotion Extracellular Matrix Disassembly Regulation Of Protein Binding Regulation Of Vesicle-mediated Transport Regulation Of Blood Coagulation Anatomical Structure Morphogenesis Response To Stimulus Secretion By Cell	Positive Regulation Of Transport Retina Homeostasis Alcohol Metabolic Process Response To External Stimulus Phototransduction, Visible Light Beta-amyloid Clearance Protein Esterification Intestinal Lipid Catabolic Process Regulation Of Phospholipase Activity Detection Of Visible Light Phototransduction Detection Of Light Stimulus Cholesterol Metabolic Process Sterol Metabolic Process Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Multicellular Organismal Lipid Catabolic Process Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Regulation Of High Voltage-gated Calcium Channel Activity Detection Of Abiotic Stimulus Response To Other Organism Tissue Homeostasis Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Response To Biotic Stimulus Pancreatic Juice Secretion Response To Nematode Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Intestinal Cholesterol Absorption Multicellular Organismal Homeostasis Transport Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Steroid Metabolic Process Phagocytosis Detection Of Calcium Ion Regulation Of Phospholipase A2 Activity Cholesterol Catabolic Process Lipid Digestion Regulation Of Cell Communication By Electrical Coupling Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Phosphoprotein Phosphatase Activity Lipid Transport Cellular Response To Lipoteichoic Acid Positive Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Autophosphorylation Response To Metal Ion Lipid Localization Negative Regulation Of Smooth Muscle Cell Migration Response To Magnesium Ion Positive Regulation Of Nitric-oxide Synthase Activity Response To Abiotic Stimulus
Tagcloud ?		aacr an2 ang4043 angiopep bbb biologics bt confers conjugate conjugated conjugation crosses endows entity extending implanted indications intracarotid intracranially kin mab neuro penetrant penetrates penetration retains systemically ther transcytosis	ag alox15 basel caries childhood dentition ecc eec enam environmental experience fifty genotypes genotyping gg habits imbalance infectious karger klk4 protective rs1264848 rs198968 rs3790506 rs4547741 rs7217186 tt tuft1 unrelated
Tagcloud (Difference) ?		aacr an2 ang4043 angiopep bbb biologics bt confers conjugate conjugated conjugation crosses endows entity extending implanted indications intracarotid intracranially kin mab neuro penetrant penetrates penetration retains systemically ther transcytosis	ag alox15 basel caries childhood dentition ecc eec enam environmental experience fifty genotypes genotyping gg habits imbalance infectious karger klk4 protective rs1264848 rs198968 rs3790506 rs4547741 rs7217186 tt tuft1 unrelated
Tagcloud (Intersection) ?