LRP1 and HSP90B1

Number of citations of the paper that reports this interaction (PMID 11861214)
15

Data Source:
HPRD (in vivo)

		LRP1	HSP90B1
Gene Name		low density lipoprotein receptor-related protein 1	heat shock protein 90kDa beta (Grp94), member 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleolus Cytoplasm Lysosomal Membrane Endosome Plasma Membrane Integral Component Of Plasma Membrane Coated Pit Focal Adhesion Clathrin-coated Vesicle Dendrite Endocytic Vesicle Membrane Neuronal Cell Body Receptor Complex	Extracellular Region Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Focal Adhesion Membrane Midbody Extracellular Matrix Melanosome Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Endocytic Vesicle Lumen
	Molecular Function	Protease Binding Receptor Activity Calcium Ion Binding Protein Binding Protein Complex Binding Apolipoprotein Binding Lipoprotein Transporter Activity Poly(A) RNA Binding Lipoprotein Particle Receptor Binding	RNA Binding Calcium Ion Binding Protein Binding ATP Binding Protein Phosphatase Binding Virion Binding Low-density Lipoprotein Particle Receptor Binding Unfolded Protein Binding
	Biological Process	Retinoid Metabolic Process Receptor-mediated Endocytosis Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Aging Phototransduction, Visible Light Cholesterol Metabolic Process Cell Proliferation Positive Regulation Of Cholesterol Efflux Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Lipid Transport Regulation Of Cholesterol Transport Regulation Of Phospholipase A2 Activity Regulation Of Actin Cytoskeleton Organization Aorta Morphogenesis Lipoprotein Metabolic Process Lipoprotein Transport Apoptotic Cell Clearance Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Protein Transport Beta-amyloid Clearance Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway	Response To Hypoxia Toll-like Receptor Signaling Pathway Protein Folding Receptor-mediated Endocytosis Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Protein Transport ER-associated Ubiquitin-dependent Protein Catabolic Process Endoplasmic Reticulum Unfolded Protein Response Actin Rod Assembly Negative Regulation Of Apoptotic Process Regulation Of Phosphoprotein Phosphatase Activity Cellular Protein Metabolic Process Innate Immune Response Sequestering Of Calcium Ion Cellular Response To ATP
Pathways		Scavenging of heme from plasma Visual phototransduction Diseases associated with visual transduction Retinoid metabolism and transport	Toll-Like Receptors Cascades Trafficking and processing of endosomal TLR Scavenging by Class A Receptors ATF6-alpha activates chaperones ATF6-alpha activates chaperone genes Unfolded Protein Response (UPR) Innate Immune System
Drugs			Rifabutin 2-Chlorodideoxyadenosine 1-Methoxy-2-(2-Methoxyethoxy)Ethane Adenosine-5\'-Diphosphate N-Ethyl-5\'-Carboxamido Adenosine Radicicol METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATE 2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATE
Diseases
GWAS		Abdominal aortic aneurysm ( 22055160) HDL cholesterol ( 20686565) Migraine ( 22683712 21666692) Pulmonary function ( 21946350) Pulmonary function (interaction) ( 23284291) Triglycerides ( 20686565)	Coronary heart disease ( 21626137)
Protein-Protein Interactions		63 interactors: A2M ANAPC10 ANKS1B APBA2 APBB1 APOE APP BACE1 C3 C4BPA CACNA1A CALR CANX CAV1 CC2D1A CD82 CTGF CTSG DAB1 DAB2 DLG4 ELANE F8 F9 FURIN GIPC1 GTPBP1 GULP1 HNRNPDL HSP90B1 ITGB1BP1 KAT5 LIPC LPL LRPAP1 LTF MAPK8IP1 MAPK8IP2 MAPRE1 MDK MMP13 MMP14 MMP15 MMP16 MMP17 NOS1AP PDGFB PID1 PLAT PLAUR PRKACA RIC8B SCN3A SERPINA1 SERPINE1 SHC1 SKIL SNRNP70 SNX17 SRC SYNJ2BP THBS1 WNT3A	21 interactors: APOB ASGR1 BIRC2 CCT2 CSNK2A1 CSNK2A2 EGFR ERBB2 FANCC HSPA9 LRP1 MAPK6 MDM2 MTTP NKX3-1 POLR2E TG TLR1 TLR2 TLR4 TXNDC11
Entrez ID		4035	7184
HPRD ID		00138	01860
Ensembl ID		ENSG00000123384	ENSG00000166598
Uniprot IDs		Q07954 Q59FG2	B4DHT9 P14625
PDB IDs		1CR8 1D2L 1J8E 2FYJ 2FYL 2KNX 2KNY
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Catalytic Activity Regulation Of Proteolysis Negative Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Signaling Positive Regulation Of Protein Modification Process Regulation Of Signal Transduction Response To Wounding Regulation Of Protein Phosphorylation Blood Coagulation Hemostasis Regulation Of Protein Kinase Activity Response To Stress Regulation Of Kinase Activity Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Endocytosis Negative Regulation Of Cellular Metabolic Process Response To Lipid Positive Regulation Of Protein Phosphorylation Regulation Of Cellular Component Organization Platelet Activation Regulation Of Phosphorylation Positive Regulation Of Transferase Activity Positive Regulation Of Protein Kinase Activity Regulation Of Body Fluid Levels Positive Regulation Of Kinase Activity Positive Regulation Of Signal Transduction Wound Healing Regulation Of Protein Processing Vesicle-mediated Transport Positive Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Negative Regulation Of Protein Processing Locomotion Extracellular Matrix Disassembly Regulation Of Protein Binding Regulation Of Vesicle-mediated Transport Regulation Of Blood Coagulation Anatomical Structure Morphogenesis Response To Stimulus Secretion By Cell	Cellular Response To Stimulus Response To External Stimulus Immune Response-regulating Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Detection Of Molecule Of Bacterial Origin Response To Stimulus Innate Immune Response Regulation Of Tumor Necrosis Factor Biosynthetic Process Positive Regulation Of Protein Metabolic Process Protein Metabolic Process Lipoprotein Transport Cellular Response To Triacyl Bacterial Lipopeptide Detection Of Triacyl Bacterial Lipopeptide Negative Regulation Of Mitotic Cell Cycle Cellular Response To Lipid Detection Of Biotic Stimulus Macrophage Activation Response To Abiotic Stimulus Toll-like Receptor Signaling Pathway Positive Regulation Of Nucleocytoplasmic Transport Immune System Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Immune Response Cell Communication Response To Stress Positive Regulation Of Nitric Oxide Biosynthetic Process Activation Of Innate Immune Response Cellular Metabolic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Immune Response Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Protein Transport Defense Response Cellular Protein Metabolic Process Positive Regulation Of Intracellular Protein Transport Regulation Of Protein Transport Detection Of Bacterial Lipoprotein Signal Transduction Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Innate Immune Response Regulation Of Establishment Of Protein Localization Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Cell Proliferation Regulation Of Mitotic Cell Cycle Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Interleukin-6 Production Positive Regulation Of Cytokine Biosynthetic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Tagcloud ?		aacr an2 ang4043 angiopep bbb biologics bt confers conjugate conjugated conjugation crosses endows entity extending implanted indications intracarotid intracranially kin mab neuro penetrant penetrates penetration retains systemically ther transcytosis	adaptive attenuates attractive carcinogen ceramides chaperone compensatory controversial cre dena diethyl expansion gp96 grp94 hccs hepatocyte hepatocytes hyperplasia maintains nitrosoamine oncogenesis paralog perturbs pharmacologically predisposes probed recombinase steatotic vital
Tagcloud (Difference) ?		aacr an2 ang4043 angiopep bbb biologics bt confers conjugate conjugated conjugation crosses endows entity extending implanted indications intracarotid intracranially kin mab neuro penetrant penetrates penetration retains systemically ther transcytosis	adaptive attenuates attractive carcinogen ceramides chaperone compensatory controversial cre dena diethyl expansion gp96 grp94 hccs hepatocyte hepatocytes hyperplasia maintains nitrosoamine oncogenesis paralog perturbs pharmacologically predisposes probed recombinase steatotic vital
Tagcloud (Intersection) ?