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LRP1 and NGF
Number of citations of the paper that reports this interaction (PubMedID
7537086
)
0
Data Source:
BioGRID
(pull down)
LRP1
NGF
Description
LDL receptor related protein 1
nerve growth factor
Image
GO Annotations
Cellular Component
Nucleus
Nucleolus
Cytoplasm
Lysosomal Membrane
Early Endosome
Golgi Apparatus
Microtubule Organizing Center
Cytosol
Cytoskeleton
Plasma Membrane
Clathrin-coated Pit
Focal Adhesion
Membrane
Basolateral Plasma Membrane
Endocytic Vesicle Membrane
Receptor Complex
Plasma Membrane Protein Complex
Extracellular Region
Extracellular Space
Endosome
Golgi Lumen
Cytosol
Synaptic Vesicle
Axon
Dendrite
Endosome Lumen
Molecular Function
Amyloid-beta Binding
RNA Binding
Low-density Lipoprotein Particle Receptor Activity
Scavenger Receptor Activity
Calcium Ion Binding
Protein Binding
Alpha-2 Macroglobulin Receptor Activity
Apolipoprotein Receptor Activity
Clathrin Heavy Chain Binding
Apolipoprotein Binding
Signaling Receptor Activity
Cargo Receptor Activity
Heparan Sulfate Proteoglycan Binding
Protein-containing Complex Binding
Metal Ion Binding
Lipoprotein Particle Receptor Binding
Enzyme Inhibitor Activity
Signaling Receptor Binding
Nerve Growth Factor Receptor Binding
Protein Binding
Growth Factor Activity
Metalloendopeptidase Inhibitor Activity
Lipid Binding
Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process
Transmembrane Receptor Protein Tyrosine Kinase Activator Activity
Peptidase Inhibitor Activity
Death Receptor Agonist Activity
Biological Process
Retinoid Metabolic Process
Astrocyte Activation Involved In Immune Response
Lipid Metabolic Process
Endocytosis
Receptor-mediated Endocytosis
Phagocytosis
Lysosomal Transport
Enzyme-linked Receptor Protein Signaling Pathway
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Gene Expression
Regulation Of Extracellular Matrix Disassembly
Positive Regulation Of Cholesterol Efflux
Negative Regulation Of Smooth Muscle Cell Migration
Regulation Of Endocytosis
Negative Regulation Of Wnt Signaling Pathway
Receptor Internalization
Positive Regulation Of Lipid Transport
Regulation Of Actin Cytoskeleton Organization
Aorta Morphogenesis
Lipoprotein Transport
Apoptotic Cell Clearance
Transcytosis
Positive Regulation Of Endocytosis
Positive Regulation Of Transport
Regulation Of Protein Metabolic Process
Negative Regulation Of SMAD Protein Signal Transduction
Amyloid-beta Clearance
Amyloid-beta Clearance By Transcytosis
Amyloid-beta Clearance By Cellular Catabolic Process
Transport Across Blood-brain Barrier
Positive Regulation Of Amyloid-beta Clearance
Regulation Of Extracellular Matrix Organization
Positive Regulation Of Reverse Cholesterol Transport
Positive Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Transcytosis
Cellular Response To Amyloid-beta
Positive Regulation Of Lysosomal Protein Catabolic Process
Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Signal Transduction
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Peripheral Nervous System Development
Circadian Rhythm
Negative Regulation Of Cell Population Proliferation
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Positive Regulation Of Gene Expression
Positive Regulation Of Neuron Projection Development
Positive Regulation Of Neuron Maturation
Sensory Perception Of Pain
Nerve Development
Neuron Projection Development
Positive Regulation Of Protein Ubiquitination
Nerve Growth Factor Signaling Pathway
Negative Regulation Of Neuron Apoptotic Process
Regulation Of Neuron Differentiation
Positive Regulation Of Neuron Differentiation
Positive Regulation Of Axon Extension
Positive Regulation Of Ras Protein Signal Transduction
Regulation Of Neurotransmitter Secretion
Neurotrophin TRK Receptor Signaling Pathway
Positive Regulation Of Collateral Sprouting
Axon Extension
Neuron Projection Morphogenesis
Modulation Of Chemical Synaptic Transmission
Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Neuron Apoptotic Process
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of ERK1 And ERK2 Cascade
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
Scavenging of heme from plasma
Retinoid metabolism and transport
PLC-gamma1 signalling
Signalling to RAS
NGF processing
NGF processing
Frs2-mediated activation
Frs2-mediated activation
ARMS-mediated activation
ARMS-mediated activation
Retrograde neurotrophin signalling
Retrograde neurotrophin signalling
TRKA activation by NGF
TRKA activation by NGF
Signalling to p38 via RIT and RIN
NRAGE signals death through JNK
p75NTR negatively regulates cell cycle via SC1
Ceramide signalling
PI3K/AKT activation
PI3K/AKT activation
Signalling to STAT3
NFG and proNGF binds to p75NTR
NADE modulates death signalling
NRIF signals cell death from the nucleus
NRIF signals cell death from the nucleus
p75NTR recruits signalling complexes
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
Axonal growth stimulation
Drugs
Antihemophilic factor, human recombinant
Tenecteplase
Coagulation Factor IX (Recombinant)
Lanoteplase
Von Willebrand factor human
Coagulation Factor IX Human
Lonoctocog alfa
Moroctocog alfa
Clenbuterol
RI 624
Polaprezinc
Fasinumab
Oleandrin
Diseases
GWAS
Abdominal aortic aneurysm (
22055160
27899403
)
Adult asthma (
30787307
)
Appendicular lean mass (
33097823
)
Asthma (
31959851
31619474
29273806
27182965
)
Asthma (adult onset) (
31036433
)
Asthma (childhood onset) (
31036433
)
Autism spectrum disorder or schizophrenia (
28540026
)
Bipolar disorder (
31043756
)
Body mass index (
28552196
)
Cervical artery dissection (
25420145
)
Coronary artery disease (
29212778
)
Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) (
28714975
)
HDL cholesterol (
20686565
24097068
)
HDL cholesterol levels (
28334899
)
Headache (
29397368
)
Height (
31562340
)
Itch intensity from mosquito bite (
28199695
)
Lung function (FEV1/FVC) (
30804560
)
Medication use (anilides) (
31015401
)
Medication use (antimigraine preparations) (
31015401
)
Migraine (
27322543
22683712
21666692
23793025
27182965
)
Migraine - clinic-based (
23793025
)
Migraine without aura (
23793025
27322543
)
Moyamoya disease (
29273593
)
Peak expiratory flow (
30804560
)
Pulmonary function (
21946350
)
Pulmonary function (smoking interaction) (
23284291
)
Pulse pressure (
30578418
)
Refractive error (
32231278
)
Schizophrenia (
25056061
29483656
)
Spontaneous coronary artery dissection (
32374345
32887874
)
Triglyceride levels (
28334899
)
Triglycerides (
25961943
24097068
20686565
)
Coronary artery disease (
33020668
)
Diastolic blood pressure (
27841878
)
Dysmenorrheic pain (
27454463
)
Dysmenorrheic pain severity (
29855537
)
Menstruation quality of life impact (dysmenorrhea) (
29855537
)
Migraine (
27182965
27322543
)
Migraine without aura (
27322543
)
Obstetric antiphospholipid syndrome (
28424481
)
Pain medicine use during menstruation (
29855537
)
Pediatric non-alcoholic fatty liver disease activity score (
23535911
)
Red blood cell count (
32888494
)
Schizophrenia (
30285260
)
Systolic blood pressure (
27841878
)
Interacting Genes
74 interacting genes:
A2M
ANAPC10
ANKS1B
APBA2
APBB1
APOE
APP
BACE1
BDNF
C3
C4BPA
CACNA1A
CALR
CANX
CAV1
CC2D1A
CCN2
CD82
CLU
CTSG
DAB1
DAB2
DLG4
EGFR
ELANE
F8
F9
FURIN
GIPC1
GTPBP1
GULP1
HNRNPDL
HSP90AA1
HSP90B1
ITGB1BP1
KAT5
LIPC
LPL
LRPAP1
LTF
MAPK8IP1
MAPK8IP2
MAPRE1
MDK
MMP13
MMP14
MMP15
MMP16
MMP17
MTDH
NGF
NOS1AP
NTF3
NTF4
PDGFB
PID1
PLAT
PLAUR
PRKACA
PTPN11
RBM11
RIC8B
RNF10
SCN3A
SERPINA1
SERPINE1
SHC1
SKIL
SNRNP70
SNX17
SRC
SYNJ2BP
THBS1
WNT3A
11 interacting genes:
A2M
CRYAB
ITGA9
ITGB1
LRP1
MMP7
NGFR
NTRK1
PLG
SORCS3
SORT1
Entrez ID
4035
4803
HPRD ID
00138
08874
Ensembl ID
ENSG00000123384
ENSG00000134259
Uniprot IDs
Q07954
Q59FG2
A0A346FYQ1
P01138
PDB IDs
1CR8
1D2L
1J8E
2FYJ
2FYL
2KNX
2KNY
1SG1
1WWW
2IFG
4EDW
4EDX
4ZBN
5JZ7
6YW8
Enriched GO Terms of Interacting Partners
?
Signaling Receptor Binding
Extracellular Space
Extracellular Region
Low-density Lipoprotein Particle Receptor Binding
Endoplasmic Reticulum Lumen
Regulation Of Cell Communication
Regulation Of Signaling
Positive Regulation Of Signal Transduction
Regulation Of Endocytosis
Regulation Of Multicellular Organismal Process
Extracellular Matrix
Heparin Binding
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Cellular Component Organization
Regulation Of Signal Transduction
Golgi Lumen
Regulation Of Apoptotic Process
Regulation Of Cellular Component Organization
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Programmed Cell Death
Regulation Of Protein Processing
Regulation Of Protein Metabolic Process
Cell Projection Morphogenesis
Positive Regulation Of Protein Metabolic Process
Regulation Of Protein Maturation
Cell Surface
Platelet Alpha Granule Lumen
Regulation Of MAPK Cascade
Negative Regulation Of Multicellular Organismal Process
Regulation Of Proteolysis
Nerve Growth Factor Receptor Binding
Regulation Of Vesicle-mediated Transport
Neuron Projection Morphogenesis
Signal Transduction
Positive Regulation Of Endocytosis
Positive Regulation Of Receptor-mediated Endocytosis
Regulation Of Receptor-mediated Endocytosis
Modulation Of Chemical Synaptic Transmission
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Amyloid-beta Binding
Regulation Of ERK1 And ERK2 Cascade
Negative Regulation Of Apoptotic Process
Negative Regulation Of Signal Transduction
Positive Regulation Of Multicellular Organismal Process
Perinuclear Region Of Cytoplasm
Negative Regulation Of Programmed Cell Death
Regulation Of Transport
Positive Regulation Of MAPK Cascade
Nerve Growth Factor Binding
Cell Surface
Integrin Alpha9-beta1 Complex
Nerve Growth Factor Receptor Activity
Neurotrophin Binding
Integrin Binding Involved In Cell-matrix Adhesion
Cellular Response To Amyloid-beta
Synaptic Membrane
Cerebellar Climbing Fiber To Purkinje Cell Synapse
Modulation Of Chemical Synaptic Transmission
Response To Amyloid-beta
Signaling Receptor Activity
Amyloid-beta Binding
Negative Regulation Of Vasoconstriction
Enzyme-linked Receptor Protein Signaling Pathway
Nerve Growth Factor Signaling Pathway
Protease Binding
Neurotrophin TRK Receptor Signaling Pathway
Apolipoprotein Binding
Detection Of Temperature Stimulus
Dendritic Spine
Response To Temperature Stimulus
System Process
Integrin Complex
Neurotrophin Signaling Pathway
Plasma Membrane
Myoblast Differentiation
Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Regulation Of Cell Migration
Receptor Complex
Regulation Of Cell Motility
Regulation Of Locomotion
Extracellular Matrix Disassembly
Nerve Development
Extracellular Matrix Organization
Extracellular Structure Organization
Vascular Process In Circulatory System
Myoblast Fate Specification
Learning Or Memory
Coreceptor Activity
Integrin Alpha7-beta1 Complex
Positive Regulation Of Transcytosis
Alpha-2 Macroglobulin Receptor Activity
Apolipoprotein Receptor Activity
Antibacterial Peptide Secretion
Neurotrophin P75 Receptor Binding
Neurotensin Receptor Activity, Non-G Protein-coupled
Cell Surface Receptor Signaling Pathway
Endosome Membrane
Platelet Alpha Granule Lumen
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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