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LRP1 and THBS1
Number of citations of the paper that reports this interaction (PubMedID
14991768
)
0
Data Source:
HPRD
(in vitro, in vivo)
LRP1
THBS1
Description
LDL receptor related protein 1
thrombospondin 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleolus
Cytoplasm
Lysosomal Membrane
Early Endosome
Golgi Apparatus
Microtubule Organizing Center
Cytosol
Cytoskeleton
Plasma Membrane
Clathrin-coated Pit
Focal Adhesion
Membrane
Basolateral Plasma Membrane
Endocytic Vesicle Membrane
Receptor Complex
Plasma Membrane Protein Complex
Extracellular Region
Fibrinogen Complex
Extracellular Space
Endoplasmic Reticulum
Endoplasmic Reticulum Lumen
External Side Of Plasma Membrane
Cell Surface
Sarcoplasmic Reticulum
Secretory Granule
Extracellular Matrix
Platelet Alpha Granule
Platelet Alpha Granule Lumen
Extracellular Exosome
Molecular Function
Amyloid-beta Binding
RNA Binding
Low-density Lipoprotein Particle Receptor Activity
Scavenger Receptor Activity
Calcium Ion Binding
Protein Binding
Alpha-2 Macroglobulin Receptor Activity
Apolipoprotein Receptor Activity
Clathrin Heavy Chain Binding
Apolipoprotein Binding
Signaling Receptor Activity
Cargo Receptor Activity
Heparan Sulfate Proteoglycan Binding
Protein-containing Complex Binding
Metal Ion Binding
Lipoprotein Particle Receptor Binding
Phosphatidylserine Binding
Fibronectin Binding
Protease Binding
Endopeptidase Inhibitor Activity
Integrin Binding
Extracellular Matrix Structural Constituent
Calcium Ion Binding
Protein Binding
Heparin Binding
Fibroblast Growth Factor Binding
Low-density Lipoprotein Particle Binding
Protein Homodimerization Activity
Laminin Binding
Proteoglycan Binding
Transforming Growth Factor Beta Binding
Extracellular Matrix Binding
Fibrinogen Binding
Collagen V Binding
Biological Process
Retinoid Metabolic Process
Astrocyte Activation Involved In Immune Response
Lipid Metabolic Process
Endocytosis
Receptor-mediated Endocytosis
Phagocytosis
Lysosomal Transport
Enzyme-linked Receptor Protein Signaling Pathway
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Gene Expression
Regulation Of Extracellular Matrix Disassembly
Positive Regulation Of Cholesterol Efflux
Negative Regulation Of Smooth Muscle Cell Migration
Regulation Of Endocytosis
Negative Regulation Of Wnt Signaling Pathway
Receptor Internalization
Positive Regulation Of Lipid Transport
Regulation Of Actin Cytoskeleton Organization
Aorta Morphogenesis
Lipoprotein Transport
Apoptotic Cell Clearance
Transcytosis
Positive Regulation Of Endocytosis
Positive Regulation Of Transport
Regulation Of Protein Metabolic Process
Negative Regulation Of SMAD Protein Signal Transduction
Amyloid-beta Clearance
Amyloid-beta Clearance By Transcytosis
Amyloid-beta Clearance By Cellular Catabolic Process
Transport Across Blood-brain Barrier
Positive Regulation Of Amyloid-beta Clearance
Regulation Of Extracellular Matrix Organization
Positive Regulation Of Reverse Cholesterol Transport
Positive Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Transcytosis
Cellular Response To Amyloid-beta
Positive Regulation Of Lysosomal Protein Catabolic Process
Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Angiogenesis
Response To Hypoxia
Negative Regulation Of Endothelial Cell Proliferation
Negative Regulation Of Cell-matrix Adhesion
Sprouting Angiogenesis
Chronic Inflammatory Response
Negative Regulation Of Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II
Negative Regulation Of Dendritic Cell Antigen Processing And Presentation
Positive Regulation Of Immune System Process
Apoptotic Process
Inflammatory Response
Immune Response
Response To Unfolded Protein
Cell Adhesion
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Response To Xenobiotic Stimulus
Response To Mechanical Stimulus
Response To Glucose
Positive Regulation Of Endothelial Cell Migration
Negative Regulation Of Endothelial Cell Migration
Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane
Negative Regulation Of Nitric Oxide Mediated Signal Transduction
Negative Regulation Of CGMP-mediated Signaling
Negative Regulation Of Plasminogen Activation
Positive Regulation Of Macrophage Chemotaxis
Positive Regulation Of Fibroblast Migration
Regulation Of Cell-substrate Adhesion
Cell Migration
Negative Regulation Of Angiogenesis
Positive Regulation Of Cell Migration
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Response To Magnesium Ion
Response To Progesterone
Negative Regulation Of Interleukin-10 Production
Negative Regulation Of Interleukin-12 Production
Negative Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Transforming Growth Factor Beta1 Production
Response To Testosterone
Cellular Response To Heat
Response To Endoplasmic Reticulum Stress
Nitric Oxide-cGMP-mediated Signaling
Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Positive Regulation Of Phosphorylation
Positive Regulation Of Macrophage Activation
Negative Regulation Of Apoptotic Process
Positive Regulation Of MAPK Cascade
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Negative Regulation Of Blood Vessel Endothelial Cell Migration
Engulfment Of Apoptotic Cell
Positive Regulation Of Translation
Positive Regulation Of Angiogenesis
Behavioral Response To Pain
Blood Vessel Morphogenesis
Positive Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Chemotaxis
Response To Calcium Ion
Negative Regulation Of Focal Adhesion Assembly
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Negative Regulation Of Fibrinolysis
Cellular Response To Tumor Necrosis Factor
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Transforming Growth Factor Beta Production
Blood Coagulation, Fibrin Clot Formation
Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis
Negative Regulation Of Sprouting Angiogenesis
Positive Regulation Of Endothelial Cell Apoptotic Process
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Negative Regulation Of Endothelial Cell Chemotaxis
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Scavenging of heme from plasma
Retinoid metabolism and transport
Platelet degranulation
Signaling by PDGF
Integrin cell surface interactions
Syndecan interactions
Defective B3GALTL causes PpS
O-glycosylation of TSR domain-containing proteins
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs
Antihemophilic factor, human recombinant
Tenecteplase
Coagulation Factor IX (Recombinant)
Lanoteplase
Von Willebrand factor human
Coagulation Factor IX Human
Lonoctocog alfa
Moroctocog alfa
Diseases
GWAS
Abdominal aortic aneurysm (
22055160
27899403
)
Adult asthma (
30787307
)
Appendicular lean mass (
33097823
)
Asthma (
31959851
31619474
29273806
27182965
)
Asthma (adult onset) (
31036433
)
Asthma (childhood onset) (
31036433
)
Autism spectrum disorder or schizophrenia (
28540026
)
Bipolar disorder (
31043756
)
Body mass index (
28552196
)
Cervical artery dissection (
25420145
)
Coronary artery disease (
29212778
)
Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) (
28714975
)
HDL cholesterol (
20686565
24097068
)
HDL cholesterol levels (
28334899
)
Headache (
29397368
)
Height (
31562340
)
Itch intensity from mosquito bite (
28199695
)
Lung function (FEV1/FVC) (
30804560
)
Medication use (anilides) (
31015401
)
Medication use (antimigraine preparations) (
31015401
)
Migraine (
27322543
22683712
21666692
23793025
27182965
)
Migraine - clinic-based (
23793025
)
Migraine without aura (
23793025
27322543
)
Moyamoya disease (
29273593
)
Peak expiratory flow (
30804560
)
Pulmonary function (
21946350
)
Pulmonary function (smoking interaction) (
23284291
)
Pulse pressure (
30578418
)
Refractive error (
32231278
)
Schizophrenia (
25056061
29483656
)
Spontaneous coronary artery dissection (
32374345
32887874
)
Triglyceride levels (
28334899
)
Triglycerides (
25961943
24097068
20686565
)
Cortical volume (
32963231
)
Liver enzyme levels (alanine transaminase) (
33972514
)
Logical memory (immediate recall) in normal cognition (
29274321
)
Urate levels (
31578528
)
Interacting Genes
74 interacting genes:
A2M
ANAPC10
ANKS1B
APBA2
APBB1
APOE
APP
BACE1
BDNF
C3
C4BPA
CACNA1A
CALR
CANX
CAV1
CC2D1A
CCN2
CD82
CLU
CTSG
DAB1
DAB2
DLG4
EGFR
ELANE
F8
F9
FURIN
GIPC1
GTPBP1
GULP1
HNRNPDL
HSP90AA1
HSP90B1
ITGB1BP1
KAT5
LIPC
LPL
LRPAP1
LTF
MAPK8IP1
MAPK8IP2
MAPRE1
MDK
MMP13
MMP14
MMP15
MMP16
MMP17
MTDH
NGF
NOS1AP
NTF3
NTF4
PDGFB
PID1
PLAT
PLAUR
PRKACA
PTPN11
RBM11
RIC8B
RNF10
SCN3A
SERPINA1
SERPINE1
SHC1
SKIL
SNRNP70
SNX17
SRC
SYNJ2BP
THBS1
WNT3A
52 interacting genes:
APP
BGN
CALCR
CALR
CD36
CD47
CFH
COL11A1
COL18A1
COL1A1
COL2A1
COL3A1
COL4A1
COL5A1
COL6A1
COL7A1
CORO1A
CTSG
DCN
DHFR
DYRK1A
ELANE
F2
FBN2
FGA
FGF2
FN1
HRG
HSP90AA1
IGFBP5
ITGB3
JAG1
KNG1
LAMB3
LRP1
LRP2
LRP5
MMP2
MMP9
MTDH
PDGFB
PLG
PLSCR1
SCARB2
SPARC
TFPI
TGFB1
TGM2
TNFAIP6
TNFRSF11B
WEE2-AS1
WWP2
Entrez ID
4035
7057
HPRD ID
00138
01765
Ensembl ID
ENSG00000123384
ENSG00000137801
Uniprot IDs
Q07954
Q59FG2
P07996
PDB IDs
1CR8
1D2L
1J8E
2FYJ
2FYL
2KNX
2KNY
1LSL
1UX6
1Z78
1ZA4
2ERF
2ES3
2OUH
2OUJ
3R6B
5FOE
7YYK
Enriched GO Terms of Interacting Partners
?
Signaling Receptor Binding
Extracellular Space
Extracellular Region
Low-density Lipoprotein Particle Receptor Binding
Endoplasmic Reticulum Lumen
Regulation Of Cell Communication
Regulation Of Signaling
Positive Regulation Of Signal Transduction
Regulation Of Endocytosis
Regulation Of Multicellular Organismal Process
Extracellular Matrix
Heparin Binding
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Cellular Component Organization
Regulation Of Signal Transduction
Golgi Lumen
Regulation Of Apoptotic Process
Regulation Of Cellular Component Organization
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Programmed Cell Death
Regulation Of Protein Processing
Regulation Of Protein Metabolic Process
Cell Projection Morphogenesis
Positive Regulation Of Protein Metabolic Process
Regulation Of Protein Maturation
Cell Surface
Platelet Alpha Granule Lumen
Regulation Of MAPK Cascade
Negative Regulation Of Multicellular Organismal Process
Regulation Of Proteolysis
Nerve Growth Factor Receptor Binding
Regulation Of Vesicle-mediated Transport
Neuron Projection Morphogenesis
Signal Transduction
Positive Regulation Of Endocytosis
Positive Regulation Of Receptor-mediated Endocytosis
Regulation Of Receptor-mediated Endocytosis
Modulation Of Chemical Synaptic Transmission
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Amyloid-beta Binding
Regulation Of ERK1 And ERK2 Cascade
Negative Regulation Of Apoptotic Process
Negative Regulation Of Signal Transduction
Positive Regulation Of Multicellular Organismal Process
Perinuclear Region Of Cytoplasm
Negative Regulation Of Programmed Cell Death
Regulation Of Transport
Positive Regulation Of MAPK Cascade
Extracellular Matrix
Extracellular Region
Extracellular Space
Endoplasmic Reticulum Lumen
Platelet-derived Growth Factor Binding
Extracellular Matrix Organization
Extracellular Structure Organization
Extracellular Matrix Structural Constituent
Extracellular Matrix Structural Constituent Conferring Tensile Strength
Regulation Of Cell Migration
Regulation Of Multicellular Organismal Process
Regulation Of Cell Motility
Regulation Of Locomotion
Platelet Alpha Granule Lumen
Regulation Of Cell Communication
Regulation Of Signaling
Negative Regulation Of Multicellular Organismal Process
Collagen Trimer
Regulation Of Signal Transduction
Positive Regulation Of Cell Migration
Basement Membrane
Positive Regulation Of Cell Motility
Endodermal Cell Differentiation
Regulation Of Cell Adhesion
Positive Regulation Of Locomotion
Fibrillar Collagen Trimer
Regulation Of Blood Coagulation
Negative Regulation Of Wound Healing
Heparin Binding
Regulation Of Hemostasis
Cell Surface
Negative Regulation Of Blood Coagulation
Negative Regulation Of Hemostasis
Anatomical Structure Formation Involved In Morphogenesis
Negative Regulation Of Coagulation
Tissue Remodeling
Positive Regulation Of Smooth Muscle Cell Proliferation
Regulation Of Wound Healing
Animal Organ Morphogenesis
Response To Wounding
Anatomical Structure Morphogenesis
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Blood Coagulation
Cell Surface Receptor Signaling Pathway
Coagulation
Regulation Of Cell-substrate Adhesion
Platelet Activation
Biological Process Involved In Interaction With Symbiont
Positive Regulation Of Multicellular Organismal Process
Hemostasis
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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