LRP1 and NTF4

Number of citations of the paper that reports this interaction (PubMedID 7537086)
0

Data Source:
BioGRID (pull down)

		LRP1	NTF4
Description		LDL receptor related protein 1	neurotrophin 4
Image
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Lysosomal Membrane Early Endosome Golgi Apparatus Microtubule Organizing Center Cytosol Cytoskeleton Plasma Membrane Clathrin-coated Pit Focal Adhesion Membrane Basolateral Plasma Membrane Endocytic Vesicle Membrane Receptor Complex Plasma Membrane Protein Complex	Extracellular Region Extracellular Space Synaptic Vesicle Axon Dendrite
	Molecular Function	Amyloid-beta Binding RNA Binding Low-density Lipoprotein Particle Receptor Activity Scavenger Receptor Activity Calcium Ion Binding Protein Binding Alpha-2 Macroglobulin Receptor Activity Apolipoprotein Receptor Activity Clathrin Heavy Chain Binding Apolipoprotein Binding Signaling Receptor Activity Cargo Receptor Activity Heparan Sulfate Proteoglycan Binding Protein-containing Complex Binding Metal Ion Binding Lipoprotein Particle Receptor Binding	Signaling Receptor Binding Nerve Growth Factor Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Retinoid Metabolic Process Astrocyte Activation Involved In Immune Response Lipid Metabolic Process Endocytosis Receptor-mediated Endocytosis Phagocytosis Lysosomal Transport Enzyme-linked Receptor Protein Signaling Pathway Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Gene Expression Regulation Of Extracellular Matrix Disassembly Positive Regulation Of Cholesterol Efflux Negative Regulation Of Smooth Muscle Cell Migration Regulation Of Endocytosis Negative Regulation Of Wnt Signaling Pathway Receptor Internalization Positive Regulation Of Lipid Transport Regulation Of Actin Cytoskeleton Organization Aorta Morphogenesis Lipoprotein Transport Apoptotic Cell Clearance Transcytosis Positive Regulation Of Endocytosis Positive Regulation Of Transport Regulation Of Protein Metabolic Process Negative Regulation Of SMAD Protein Signal Transduction Amyloid-beta Clearance Amyloid-beta Clearance By Transcytosis Amyloid-beta Clearance By Cellular Catabolic Process Transport Across Blood-brain Barrier Positive Regulation Of Amyloid-beta Clearance Regulation Of Extracellular Matrix Organization Positive Regulation Of Reverse Cholesterol Transport Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Transcytosis Cellular Response To Amyloid-beta Positive Regulation Of Lysosomal Protein Catabolic Process Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Long-term Memory Sensory Organ Boundary Specification Adult Locomotory Behavior Epidermis Development Nerve Development Ameloblast Differentiation Nerve Growth Factor Signaling Pathway Mechanoreceptor Differentiation Negative Regulation Of Programmed Cell Death Negative Regulation Of Neuron Apoptotic Process Neuron Projection Morphogenesis Modulation Of Chemical Synaptic Transmission Innervation Taste Bud Development
Pathways		Scavenging of heme from plasma Retinoid metabolism and transport	PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling NTF4 activates NTRK2 (TRKB) signaling Activated NTRK2 signals through RAS Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through PI3K Activated NTRK2 signals through FRS2 and FRS3 Activated NTRK2 signals through FRS2 and FRS3
Drugs		Antihemophilic factor, human recombinant Tenecteplase Coagulation Factor IX (Recombinant) Lanoteplase Von Willebrand factor human Coagulation Factor IX Human Lonoctocog alfa Moroctocog alfa
Diseases			Primary open angle glaucoma
GWAS		Abdominal aortic aneurysm ( 22055160 27899403) Adult asthma ( 30787307) Appendicular lean mass ( 33097823) Asthma ( 31959851 31619474 29273806 27182965) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Body mass index ( 28552196) Cervical artery dissection ( 25420145) Coronary artery disease ( 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) HDL cholesterol ( 20686565 24097068) HDL cholesterol levels ( 28334899) Headache ( 29397368) Height ( 31562340) Itch intensity from mosquito bite ( 28199695) Lung function (FEV1/FVC) ( 30804560) Medication use (anilides) ( 31015401) Medication use (antimigraine preparations) ( 31015401) Migraine ( 27322543 22683712 21666692 23793025 27182965) Migraine - clinic-based ( 23793025) Migraine without aura ( 23793025 27322543) Moyamoya disease ( 29273593) Peak expiratory flow ( 30804560) Pulmonary function ( 21946350) Pulmonary function (smoking interaction) ( 23284291) Pulse pressure ( 30578418) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Spontaneous coronary artery dissection ( 32374345 32887874) Triglyceride levels ( 28334899) Triglycerides ( 25961943 24097068 20686565)	Asparaginase-induced acute pancreatitis in acute lymphoblastic leukemia (onset time) ( 27114598)
Interacting Genes		74 interacting genes: A2M ANAPC10 ANKS1B APBA2 APBB1 APOE APP BACE1 BDNF C3 C4BPA CACNA1A CALR CANX CAV1 CC2D1A CCN2 CD82 CLU CTSG DAB1 DAB2 DLG4 EGFR ELANE F8 F9 FURIN GIPC1 GTPBP1 GULP1 HNRNPDL HSP90AA1 HSP90B1 ITGB1BP1 KAT5 LIPC LPL LRPAP1 LTF MAPK8IP1 MAPK8IP2 MAPRE1 MDK MMP13 MMP14 MMP15 MMP16 MMP17 MTDH NGF NOS1AP NTF3 NTF4 PDGFB PID1 PLAT PLAUR PRKACA PTPN11 RBM11 RIC8B RNF10 SCN3A SERPINA1 SERPINE1 SHC1 SKIL SNRNP70 SNX17 SRC SYNJ2BP THBS1 WNT3A	8 interacting genes: ADAMTSL4 BDNF CLIC1 CRX GLRX3 LRP1 NGFR NTRK2
Entrez ID		4035	4909
HPRD ID		00138	01220
Ensembl ID		ENSG00000123384	ENSG00000225950
Uniprot IDs		Q07954 Q59FG2	P34130
PDB IDs		1CR8 1D2L 1J8E 2FYJ 2FYL 2KNX 2KNY	1B8M 1B98 1HCF
Enriched GO Terms of Interacting Partners?		Signaling Receptor Binding Extracellular Space Extracellular Region Low-density Lipoprotein Particle Receptor Binding Endoplasmic Reticulum Lumen Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Endocytosis Regulation Of Multicellular Organismal Process Extracellular Matrix Heparin Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Cellular Component Organization Regulation Of Signal Transduction Golgi Lumen Regulation Of Apoptotic Process Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Signal Transduction Regulation Of Programmed Cell Death Regulation Of Protein Processing Regulation Of Protein Metabolic Process Cell Projection Morphogenesis Positive Regulation Of Protein Metabolic Process Regulation Of Protein Maturation Cell Surface Platelet Alpha Granule Lumen Regulation Of MAPK Cascade Negative Regulation Of Multicellular Organismal Process Regulation Of Proteolysis Nerve Growth Factor Receptor Binding Regulation Of Vesicle-mediated Transport Neuron Projection Morphogenesis Signal Transduction Positive Regulation Of Endocytosis Positive Regulation Of Receptor-mediated Endocytosis Regulation Of Receptor-mediated Endocytosis Modulation Of Chemical Synaptic Transmission Negative Regulation Of Signaling Negative Regulation Of Cell Communication Amyloid-beta Binding Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Apoptotic Process Negative Regulation Of Signal Transduction Positive Regulation Of Multicellular Organismal Process Perinuclear Region Of Cytoplasm Negative Regulation Of Programmed Cell Death Regulation Of Transport Positive Regulation Of MAPK Cascade	Brain-derived Neurotrophic Factor Receptor Signaling Pathway Neurotrophin Binding Neurotrophin Signaling Pathway Nervous System Development Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Synapse Assembly Nerve Development Positive Regulation Of Transcytosis Alpha-2 Macroglobulin Receptor Activity Cellular Response To Amyloid-beta Response To Amyloid-beta Apolipoprotein Receptor Activity Brain-derived Neurotrophic Factor Receptor Activity Pigment Cell Development Positive Regulation Of Axonogenesis Retina Development In Camera-type Eye Positive Regulation Of Brain-derived Neurotrophic Factor Receptor Signaling Pathway System Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Reverse Cholesterol Transport Amyloid-beta Binding Regulation Of Transcytosis Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Dorsal Aorta Development Dendrite Positive Regulation Of Cell Junction Assembly Modulation Of Chemical Synaptic Transmission Lipoprotein Particle Receptor Binding Death Receptor Activity Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Brain-derived Neurotrophic Factor Binding Protease Binding Circadian Rhythm Regulation Of Axonogenesis Positive Regulation Of Developmental Process Astrocyte Activation Involved In Immune Response Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Neurotrophin Receptor Activity Trans-synaptic Signaling By BDNF Dendritic Spine Positive Regulation Of Neuron Projection Development Nerve Growth Factor Receptor Binding Positive Regulation Of Lysosomal Protein Catabolic Process Negative Regulation Of Hair Follicle Development Nerve Growth Factor Binding Regulation Of Synapse Assembly Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Anatomical Structure Morphogenesis Regulation Of Programmed Cell Death
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