LRP1 and SCN3A

Number of citations of the paper that reports this interaction (PMID 10827173)
91

Data Source:
HPRD (in vitro, two hybrid)

		LRP1	SCN3A
Gene Name		low density lipoprotein receptor-related protein 1	sodium channel, voltage gated, type III alpha subunit
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleolus Cytoplasm Lysosomal Membrane Endosome Plasma Membrane Integral Component Of Plasma Membrane Coated Pit Focal Adhesion Clathrin-coated Vesicle Dendrite Endocytic Vesicle Membrane Neuronal Cell Body Receptor Complex	Voltage-gated Sodium Channel Complex Cytoplasm Plasma Membrane
	Molecular Function	Protease Binding Receptor Activity Calcium Ion Binding Protein Binding Protein Complex Binding Apolipoprotein Binding Lipoprotein Transporter Activity Poly(A) RNA Binding Lipoprotein Particle Receptor Binding	Voltage-gated Sodium Channel Activity
	Biological Process	Retinoid Metabolic Process Receptor-mediated Endocytosis Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Aging Phototransduction, Visible Light Cholesterol Metabolic Process Cell Proliferation Positive Regulation Of Cholesterol Efflux Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Lipid Transport Regulation Of Cholesterol Transport Regulation Of Phospholipase A2 Activity Regulation Of Actin Cytoskeleton Organization Aorta Morphogenesis Lipoprotein Metabolic Process Lipoprotein Transport Apoptotic Cell Clearance Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Protein Transport Beta-amyloid Clearance Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway	Sodium Ion Transport Neuronal Action Potential Regulation Of Ion Transmembrane Transport Sodium Ion Transmembrane Transport Membrane Depolarization During Action Potential
Pathways		Scavenging of heme from plasma Visual phototransduction Diseases associated with visual transduction Retinoid metabolism and transport	Interaction between L1 and Ankyrins Axon guidance L1CAM interactions
Drugs
Diseases
GWAS		Abdominal aortic aneurysm ( 22055160) HDL cholesterol ( 20686565) Migraine ( 22683712 21666692) Pulmonary function ( 21946350) Pulmonary function (interaction) ( 23284291) Triglycerides ( 20686565)
Protein-Protein Interactions		63 interactors: A2M ANAPC10 ANKS1B APBA2 APBB1 APOE APP BACE1 C3 C4BPA CACNA1A CALR CANX CAV1 CC2D1A CD82 CTGF CTSG DAB1 DAB2 DLG4 ELANE F8 F9 FURIN GIPC1 GTPBP1 GULP1 HNRNPDL HSP90B1 ITGB1BP1 KAT5 LIPC LPL LRPAP1 LTF MAPK8IP1 MAPK8IP2 MAPRE1 MDK MMP13 MMP14 MMP15 MMP16 MMP17 NOS1AP PDGFB PID1 PLAT PLAUR PRKACA RIC8B SCN3A SERPINA1 SERPINE1 SHC1 SKIL SNRNP70 SNX17 SRC SYNJ2BP THBS1 WNT3A	4 interactors: LRP1 LRP2 LRP8 PRKCG
Entrez ID		4035	6328
HPRD ID		00138	01671
Ensembl ID		ENSG00000123384	ENSG00000153253
Uniprot IDs		Q07954 Q59FG2	Q9C007 Q9NY46
PDB IDs		1CR8 1D2L 1J8E 2FYJ 2FYL 2KNX 2KNY
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Catalytic Activity Regulation Of Proteolysis Negative Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Signaling Positive Regulation Of Protein Modification Process Regulation Of Signal Transduction Response To Wounding Regulation Of Protein Phosphorylation Blood Coagulation Hemostasis Regulation Of Protein Kinase Activity Response To Stress Regulation Of Kinase Activity Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Endocytosis Negative Regulation Of Cellular Metabolic Process Response To Lipid Positive Regulation Of Protein Phosphorylation Regulation Of Cellular Component Organization Platelet Activation Regulation Of Phosphorylation Positive Regulation Of Transferase Activity Positive Regulation Of Protein Kinase Activity Regulation Of Body Fluid Levels Positive Regulation Of Kinase Activity Positive Regulation Of Signal Transduction Wound Healing Regulation Of Protein Processing Vesicle-mediated Transport Positive Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Negative Regulation Of Protein Processing Locomotion Extracellular Matrix Disassembly Regulation Of Protein Binding Regulation Of Vesicle-mediated Transport Regulation Of Blood Coagulation Anatomical Structure Morphogenesis Response To Stimulus Secretion By Cell	Phototransduction, Visible Light Retinoid Metabolic Process Diterpenoid Metabolic Process Detection Of Visible Light Phototransduction Detection Of Light Stimulus Isoprenoid Metabolic Process Detection Of Abiotic Stimulus Response To Light Stimulus Receptor-mediated Endocytosis Response To Radiation Detection Of Stimulus Regulation Of Phospholipase Activity Endocytosis Positive Regulation Of Mismatch Repair Ammon Gyrus Development Beta-amyloid Clearance Cellular Lipid Metabolic Process Negative Regulation Of Neuron Apoptotic Process Regulation Of Mismatch Repair Response To Abiotic Stimulus Negative Regulation Of Neuron Death Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Neuron Apoptotic Process Lipid Metabolic Process Steroid Metabolic Process Regulation Of Neuron Death Vesicle-mediated Transport System Development Reelin-mediated Signaling Pathway Alcohol Metabolic Process Multicellular Organismal Development Response To External Stimulus Blood Coagulation Anatomical Structure Development Hemostasis Regulation Of Phospholipase A2 Activity Forebrain Development Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Chemosensory Behavior Vitamin D Metabolic Process Signal Transduction Positive Regulation Of Dendritic Spine Morphogenesis Cellular Response To Cholesterol Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Smooth Muscle Cell Migration Developmental Process Protein Metabolic Process Cellular Response To Sterol Positive Regulation Of Cholesterol Efflux
Tagcloud ?		aacr an2 ang4043 angiopep bbb biologics bt confers conjugate conjugated conjugation crosses endows entity extending implanted indications intracarotid intracranially kin mab neuro penetrant penetrates penetration retains systemically ther transcytosis	arrhythmias bjip black buthotus caught contractility desert hottentotta inotropic judean nav1 proarrhythmic prolong provoke provoked repolarization rodent safely scorpion scorpions sedated slices sodium tetrodotoxin thalamic transients venom venoms ventricular
Tagcloud (Difference) ?		aacr an2 ang4043 angiopep bbb biologics bt confers conjugate conjugated conjugation crosses endows entity extending implanted indications intracarotid intracranially kin mab neuro penetrant penetrates penetration retains systemically ther transcytosis	arrhythmias bjip black buthotus caught contractility desert hottentotta inotropic judean nav1 proarrhythmic prolong provoke provoked repolarization rodent safely scorpion scorpions sedated slices sodium tetrodotoxin thalamic transients venom venoms ventricular
Tagcloud (Intersection) ?