LRP1 and CC2D1A

Number of citations of the paper that reports this interaction (PMID 20205790)
0

Data Source:
BioGRID (two hybrid)

		LRP1	CC2D1A
Gene Name		low density lipoprotein receptor-related protein 1	coiled-coil and C2 domain containing 1A
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleolus Cytoplasm Lysosomal Membrane Endosome Plasma Membrane Integral Component Of Plasma Membrane Coated Pit Focal Adhesion Clathrin-coated Vesicle Dendrite Endocytic Vesicle Membrane Neuronal Cell Body Receptor Complex	Nucleus Cytoplasm Microtubule Organizing Center Membrane Extracellular Vesicular Exosome
	Molecular Function	Protease Binding Receptor Activity Calcium Ion Binding Protein Binding Protein Complex Binding Apolipoprotein Binding Lipoprotein Transporter Activity Poly(A) RNA Binding Lipoprotein Particle Receptor Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Signal Transducer Activity
	Biological Process	Retinoid Metabolic Process Receptor-mediated Endocytosis Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Aging Phototransduction, Visible Light Cholesterol Metabolic Process Cell Proliferation Positive Regulation Of Cholesterol Efflux Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Lipid Transport Regulation Of Cholesterol Transport Regulation Of Phospholipase A2 Activity Regulation Of Actin Cytoskeleton Organization Aorta Morphogenesis Lipoprotein Metabolic Process Lipoprotein Transport Apoptotic Cell Clearance Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Protein Transport Beta-amyloid Clearance Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Signal Transduction Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Pathways		Scavenging of heme from plasma Visual phototransduction Diseases associated with visual transduction Retinoid metabolism and transport
Drugs
Diseases
GWAS		Abdominal aortic aneurysm ( 22055160) HDL cholesterol ( 20686565) Migraine ( 22683712 21666692) Pulmonary function ( 21946350) Pulmonary function (interaction) ( 23284291) Triglycerides ( 20686565)
Protein-Protein Interactions		63 interactors: A2M ANAPC10 ANKS1B APBA2 APBB1 APOE APP BACE1 C3 C4BPA CACNA1A CALR CANX CAV1 CC2D1A CD82 CTGF CTSG DAB1 DAB2 DLG4 ELANE F8 F9 FURIN GIPC1 GTPBP1 GULP1 HNRNPDL HSP90B1 ITGB1BP1 KAT5 LIPC LPL LRPAP1 LTF MAPK8IP1 MAPK8IP2 MAPRE1 MDK MMP13 MMP14 MMP15 MMP16 MMP17 NOS1AP PDGFB PID1 PLAT PLAUR PRKACA RIC8B SCN3A SERPINA1 SERPINE1 SHC1 SKIL SNRNP70 SNX17 SRC SYNJ2BP THBS1 WNT3A	4 interactors: CDC37 CHMP4A CHMP4C LRP1
Entrez ID		4035	54862
HPRD ID		00138	08616
Ensembl ID		ENSG00000123384	ENSG00000132024
Uniprot IDs		Q07954 Q59FG2	Q6P1N0
PDB IDs		1CR8 1D2L 1J8E 2FYJ 2FYL 2KNX 2KNY
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Catalytic Activity Regulation Of Proteolysis Negative Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Signaling Positive Regulation Of Protein Modification Process Regulation Of Signal Transduction Response To Wounding Regulation Of Protein Phosphorylation Blood Coagulation Hemostasis Regulation Of Protein Kinase Activity Response To Stress Regulation Of Kinase Activity Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Endocytosis Negative Regulation Of Cellular Metabolic Process Response To Lipid Positive Regulation Of Protein Phosphorylation Regulation Of Cellular Component Organization Platelet Activation Regulation Of Phosphorylation Positive Regulation Of Transferase Activity Positive Regulation Of Protein Kinase Activity Regulation Of Body Fluid Levels Positive Regulation Of Kinase Activity Positive Regulation Of Signal Transduction Wound Healing Regulation Of Protein Processing Vesicle-mediated Transport Positive Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Negative Regulation Of Protein Processing Locomotion Extracellular Matrix Disassembly Regulation Of Protein Binding Regulation Of Vesicle-mediated Transport Regulation Of Blood Coagulation Anatomical Structure Morphogenesis Response To Stimulus Secretion By Cell	Cell Separation After Cytokinesis Mitotic Metaphase Plate Congression Metaphase Plate Congression Protein Transport Establishment Of Protein Localization Establishment Of Chromosome Localization Protein Localization Vacuolar Transport Mitotic Sister Chromatid Segregation Sister Chromatid Segregation Nucleus Organization Beta-amyloid Clearance Regulation Of Organelle Organization Viral Life Cycle Endosomal Transport Negative Regulation Of Neuron Death Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Negative Regulation Of Autophagic Vacuole Assembly Chromosome Segregation Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Neuron Death Abscission Intracellular Transport Mitotic Nuclear Division Viral Budding Via Host ESCRT Complex Establishment Of Organelle Localization Posttranslational Protein Targeting To Membrane Positive Regulation Of Viral Release From Host Cell Regulation Of Mitotic Spindle Assembly Viral Budding Negative Regulation Of Cytokinesis Regulation Of Spindle Assembly Organelle Localization Protein Targeting Cell Division Regulation Of Phospholipase A2 Activity Transport Regulation Of Cellular Component Organization Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Macroautophagy Establishment Of Localization In Cell Regulation Of Mitotic Spindle Organization Regulation Of Cytoskeleton Organization Regulation Of Autophagic Vacuole Assembly Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Cholesterol Efflux Regulation Of Vacuole Organization Viral Process Membrane Tubulation
Tagcloud ?		aacr an2 ang4043 angiopep bbb biologics bt confers conjugate conjugated conjugation crosses endows entity extending implanted indications intracarotid intracranially kin mab neuro penetrant penetrates penetration retains systemically ther transcytosis	aki colocalize cooperation defenses elicits endocytic endolysosomes endosomal freud ifn innate interacted knockdown lamp1 linking lysosomal modes modulates operational rab5 resided synergized tape tbk1 termed tlr3 tlr4 trif wave
Tagcloud (Difference) ?		aacr an2 ang4043 angiopep bbb biologics bt confers conjugate conjugated conjugation crosses endows entity extending implanted indications intracarotid intracranially kin mab neuro penetrant penetrates penetration retains systemically ther transcytosis	aki colocalize cooperation defenses elicits endocytic endolysosomes endosomal freud ifn innate interacted knockdown lamp1 linking lysosomal modes modulates operational rab5 resided synergized tape tbk1 termed tlr3 tlr4 trif wave
Tagcloud (Intersection) ?