NOS1AP and CKM

Number of citations of the paper that reports this interaction (PubMedID 25814554)
62

Data Source:
BioGRID (two hybrid)

		NOS1AP	CKM
Description		nitric oxide synthase 1 adaptor protein	creatine kinase, M-type
Image		No pdb structure
GO Annotations	Cellular Component	Podosome Nucleus Mitochondrion Cytosol Caveola Z Disc Filopodium T-tubule Nuclear Membrane Sarcoplasmic Reticulum Membrane Sarcolemma Cell Projection Perinuclear Region Of Cytoplasm Anchoring Junction Glutamatergic Synapse	Extracellular Space Cytoplasm Cytosol
	Molecular Function	Protein Binding Nitric-oxide Synthase Regulator Activity Signaling Adaptor Activity Nitric-oxide Synthase Binding	Nucleotide Binding Catalytic Activity Creatine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Transferase Activity, Transferring Phosphorus-containing Groups
	Biological Process	Regulation Of Heart Rate By Chemical Signal Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Cardiac Muscle Cell Action Potential Postsynaptic Actin Cytoskeleton Organization Positive Regulation Of Potassium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Positive Regulation Of Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential	Phosphocreatine Biosynthetic Process
Pathways			Creatine metabolism
Drugs			Creatine (Diaminomethyl-Methyl-Amino)-Acetic Acid D-arginine Phosphocreatine
Diseases
GWAS		Alanine aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Body mass index (change over time) ( 25133637) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 20062061 20062063 25055868) Electrocardiographic traits (multivariate) ( 32602732) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 30598549) Iris color (L* coordinate) ( 30895295) Lateral ventricle temporal horn volume ( 31530798) Long QT syndrome ( 32429735) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494 27863252) Mosquito bite size ( 28199695) Obesity-related traits ( 23251661) QT interval ( 19305408 19305409 19587794 30679814 16648850 29874175 29213071 20031603 22726844 23166209 24952745) Sum of carotid plaque area ( 32469969) Sum of stenosis ( 32469969) T wave morphology restitution during exercise ( 31607149) T wave morphology restitution during exercise (MTAG) ( 31607149) T wave morphology restitution during recovery from exercise ( 31607149) T wave morphology restitution during recovery from exercise (MTAG) ( 31607149) Word reading ( 23738518)	Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Creatine kinase levels in statin users ( 25214527) Intelligence (MTAG) ( 29326435)
Interacting Genes		18 interacting genes: AKNAD1 APP CKM FYN HSPD1 LRP1 LRP2 LRP8 NHP2 NOS1 PLAGL2 PNP RASD1 RYBP SYN1 SYN2 SYN3 TRAF4	12 interacting genes: CBLC CKB FHL2 HSPB2 LINC02487 MYOC MYOM2 NOS1AP TRIM54 TRIM55 TRIM63 YWHAQ
Entrez ID		9722	1158
HPRD ID		12023	00426
Ensembl ID		ENSG00000198929	ENSG00000104879
Uniprot IDs		O75052	B2R892 P06732
PDB IDs			1I0E 7BF2
Enriched GO Terms of Interacting Partners?		Apolipoprotein Binding Synaptic Vesicle Cycle Synaptic Vesicle Clustering Low-density Lipoprotein Particle Receptor Activity Clathrin-coated Pit Synaptic Signaling Cargo Receptor Activity Schaffer Collateral - CA1 Synapse Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Astrocyte Activation Involved In Immune Response Postsynaptic Density Cellular Response To Growth Factor Stimulus Growth Factor Receptor Binding Positive Regulation Of Lysosomal Protein Catabolic Process Neurotransmitter Secretion Chemical Synaptic Transmission Response To Growth Factor Trans-synaptic Signaling Cellular Response To Amyloid-beta Positive Regulation Of Protein Catabolic Process In The Vacuole Cell-cell Signaling Regulation Of Protein Catabolic Process Signaling Response To Amyloid-beta Cell Communication Receptor Complex High-density Lipoprotein Particle Binding Regulation Of Lysosomal Protein Catabolic Process Retinoid Metabolic Process Reelin-mediated Signaling Pathway Diterpenoid Metabolic Process Cell Body Regulation Of Dendritic Spine Maintenance Calcium-dependent Protein Binding Dendrite Extrinsic Component Of Synaptic Vesicle Membrane Vesicle-mediated Transport Modulation Of Chemical Synaptic Transmission Synapse Organization Terpenoid Metabolic Process Vesicle-mediated Transport In Synapse Protein-folding Chaperone Binding Heparan Sulfate Proteoglycan Binding Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Neuron Projection Morphogenesis Astrocyte Activation Layer Formation In Cerebral Cortex Isoprenoid Metabolic Process Neurotransmitter Transport	Z Disc Skeletal Muscle Adaptation Ubiquitin Protein Ligase Activity M Band Substantia Nigra Development Muscle System Process Skeletal Muscle Hypertrophy Neural Nucleus Development Receptor Tyrosine Kinase Binding Futile Creatine Cycle Atrial Cardiac Muscle Cell Development Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Microtubule
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