LRP1 and DAB2

Number of citations of the paper that reports this interaction (PubMedID 11247302)
0

Data Source:
BioGRID (pull down)

		LRP1	DAB2
Description		LDL receptor related protein 1	DAB adaptor protein 2
Image
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Lysosomal Membrane Early Endosome Golgi Apparatus Microtubule Organizing Center Cytosol Cytoskeleton Plasma Membrane Clathrin-coated Pit Focal Adhesion Membrane Basolateral Plasma Membrane Endocytic Vesicle Membrane Receptor Complex Plasma Membrane Protein Complex	Fibrillar Center Cytoplasm Lysosomal Membrane Cytosol Plasma Membrane Clathrin-coated Pit Focal Adhesion Membrane Clathrin-coated Vesicle Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm
	Molecular Function	Amyloid-beta Binding RNA Binding Low-density Lipoprotein Particle Receptor Activity Scavenger Receptor Activity Calcium Ion Binding Protein Binding Alpha-2 Macroglobulin Receptor Activity Apolipoprotein Receptor Activity Clathrin Heavy Chain Binding Apolipoprotein Binding Signaling Receptor Activity Cargo Receptor Activity Heparan Sulfate Proteoglycan Binding Protein-containing Complex Binding Metal Ion Binding Lipoprotein Particle Receptor Binding	Protein Binding Clathrin Adaptor Activity Cargo Receptor Activity SMAD Binding Low-density Lipoprotein Particle Receptor Binding
	Biological Process	Retinoid Metabolic Process Astrocyte Activation Involved In Immune Response Lipid Metabolic Process Endocytosis Receptor-mediated Endocytosis Phagocytosis Lysosomal Transport Enzyme-linked Receptor Protein Signaling Pathway Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Gene Expression Regulation Of Extracellular Matrix Disassembly Positive Regulation Of Cholesterol Efflux Negative Regulation Of Smooth Muscle Cell Migration Regulation Of Endocytosis Negative Regulation Of Wnt Signaling Pathway Receptor Internalization Positive Regulation Of Lipid Transport Regulation Of Actin Cytoskeleton Organization Aorta Morphogenesis Lipoprotein Transport Apoptotic Cell Clearance Transcytosis Positive Regulation Of Endocytosis Positive Regulation Of Transport Regulation Of Protein Metabolic Process Negative Regulation Of SMAD Protein Signal Transduction Amyloid-beta Clearance Amyloid-beta Clearance By Transcytosis Amyloid-beta Clearance By Cellular Catabolic Process Transport Across Blood-brain Barrier Positive Regulation Of Amyloid-beta Clearance Regulation Of Extracellular Matrix Organization Positive Regulation Of Reverse Cholesterol Transport Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Transcytosis Cellular Response To Amyloid-beta Positive Regulation Of Lysosomal Protein Catabolic Process Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Endocytosis Receptor-mediated Endocytosis Apoptotic Process Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Neuron Projection Development Protein Transport Wnt Signaling Pathway Cell Differentiation Negative Regulation Of Cell Growth Positive Regulation Of Cell Migration Positive Regulation Of Aldosterone Biosynthetic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Leading Edge Cell Differentiation Negative Regulation Of Apoptotic Process Positive Regulation Of Endocytosis Positive Regulation Of Transcription By RNA Polymerase II Clathrin Coat Assembly Response To Steroid Hormone Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Response To Salt Negative Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Clathrin-dependent Endocytosis Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Aldosterone Secretion
Pathways		Scavenging of heme from plasma Retinoid metabolism and transport	Gap junction degradation Formation of annular gap junctions Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs		Antihemophilic factor, human recombinant Tenecteplase Coagulation Factor IX (Recombinant) Lanoteplase Von Willebrand factor human Coagulation Factor IX Human Lonoctocog alfa Moroctocog alfa
Diseases
GWAS		Abdominal aortic aneurysm ( 22055160 27899403) Adult asthma ( 30787307) Appendicular lean mass ( 33097823) Asthma ( 31959851 31619474 29273806 27182965) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Body mass index ( 28552196) Cervical artery dissection ( 25420145) Coronary artery disease ( 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) HDL cholesterol ( 20686565 24097068) HDL cholesterol levels ( 28334899) Headache ( 29397368) Height ( 31562340) Itch intensity from mosquito bite ( 28199695) Lung function (FEV1/FVC) ( 30804560) Medication use (anilides) ( 31015401) Medication use (antimigraine preparations) ( 31015401) Migraine ( 27322543 22683712 21666692 23793025 27182965) Migraine - clinic-based ( 23793025) Migraine without aura ( 23793025 27322543) Moyamoya disease ( 29273593) Peak expiratory flow ( 30804560) Pulmonary function ( 21946350) Pulmonary function (smoking interaction) ( 23284291) Pulse pressure ( 30578418) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Spontaneous coronary artery dissection ( 32374345 32887874) Triglyceride levels ( 28334899) Triglycerides ( 25961943 24097068 20686565)	Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever or eczema) ( 29083406) Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Aspartate aminotransferase levels ( 33547301 29403010) Birth weight ( 31043758) Chronic kidney disease ( 20383146 31152163) Creatinine levels ( 31015462) Diverticular disease ( 30177863) Estimated glomerular filtration rate ( 31451708 31152163 30604766 31015462) Estimated glomerular filtration rate in diabetes ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) HDL cholesterol levels ( 32203549) Health literacy ( 31250787) Heel bone mineral density ( 30598549 28869591) Height ( 31562340) Non-albumin protein levels ( 29403010) Pancreatic cancer ( 22158540) Premature menopause in childhood cancer survivors ( 29432556) Self-reported allergy ( 23817569) Systemic lupus erythematosus ( 19838195) Urate levels ( 23263486) Waist-hip ratio ( 28552196)
Interacting Genes		74 interacting genes: A2M ANAPC10 ANKS1B APBA2 APBB1 APOE APP BACE1 BDNF C3 C4BPA CACNA1A CALR CANX CAV1 CC2D1A CCN2 CD82 CLU CTSG DAB1 DAB2 DLG4 EGFR ELANE F8 F9 FURIN GIPC1 GTPBP1 GULP1 HNRNPDL HSP90AA1 HSP90B1 ITGB1BP1 KAT5 LIPC LPL LRPAP1 LTF MAPK8IP1 MAPK8IP2 MAPRE1 MDK MMP13 MMP14 MMP15 MMP16 MMP17 MTDH NGF NOS1AP NTF3 NTF4 PDGFB PID1 PLAT PLAUR PRKACA PTPN11 RBM11 RIC8B RNF10 SCN3A SERPINA1 SERPINE1 SHC1 SKIL SNRNP70 SNX17 SRC SYNJ2BP THBS1 WNT3A	40 interacting genes: AP2M1 APLP1 APLP2 APP ATXN1L AXIN1 CDC16 CDK1 CSK DAB2IP DIP2A DVL1 DVL3 FCHO1 FCHO2 FGR GRB2 INPP5D ITGB3 ITGB5 ITSN1 LDLR LRP1 LRP2 LRP8 MIB1 MYO6 NECAP1 PIN1 PRKCB PRKCD PRKCG SGIP1 SMAD2 SMAD3 SMURF2 SRC SUMO2 TGFBR1 TGFBR2
Entrez ID		4035	1601
HPRD ID		00138	03139
Ensembl ID		ENSG00000123384	ENSG00000153071
Uniprot IDs		Q07954 Q59FG2	B2RAW0 P98082
PDB IDs		1CR8 1D2L 1J8E 2FYJ 2FYL 2KNX 2KNY	2LSW 6O5O 6OVF
Enriched GO Terms of Interacting Partners?		Signaling Receptor Binding Extracellular Space Extracellular Region Low-density Lipoprotein Particle Receptor Binding Endoplasmic Reticulum Lumen Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Endocytosis Regulation Of Multicellular Organismal Process Extracellular Matrix Heparin Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Cellular Component Organization Regulation Of Signal Transduction Golgi Lumen Regulation Of Apoptotic Process Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Signal Transduction Regulation Of Programmed Cell Death Regulation Of Protein Processing Regulation Of Protein Metabolic Process Cell Projection Morphogenesis Positive Regulation Of Protein Metabolic Process Regulation Of Protein Maturation Cell Surface Platelet Alpha Granule Lumen Regulation Of MAPK Cascade Negative Regulation Of Multicellular Organismal Process Regulation Of Proteolysis Nerve Growth Factor Receptor Binding Regulation Of Vesicle-mediated Transport Neuron Projection Morphogenesis Signal Transduction Positive Regulation Of Endocytosis Positive Regulation Of Receptor-mediated Endocytosis Regulation Of Receptor-mediated Endocytosis Modulation Of Chemical Synaptic Transmission Negative Regulation Of Signaling Negative Regulation Of Cell Communication Amyloid-beta Binding Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Apoptotic Process Negative Regulation Of Signal Transduction Positive Regulation Of Multicellular Organismal Process Perinuclear Region Of Cytoplasm Negative Regulation Of Programmed Cell Death Regulation Of Transport Positive Regulation Of MAPK Cascade	Clathrin-coated Pit Endocytosis Import Into Cell Plasma Membrane Cell Surface Receptor Signaling Pathway Anatomical Structure Morphogenesis Receptor Complex Signal Transduction Regulation Of Endocytosis Regulation Of Vesicle-mediated Transport Receptor-mediated Endocytosis Vesicle-mediated Transport Regulation Of Cellular Component Organization Intracellular Signal Transduction Regulation Of Protein Catabolic Process Regulation Of Signaling Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cellular Component Organization Positive Regulation Of Developmental Process Response To Growth Factor Regulation Of Cell Communication Clathrin-dependent Endocytosis Regulation Of Multicellular Organismal Process Regulation Of Developmental Process Cellular Response To Growth Factor Stimulus Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Tube Morphogenesis Positive Regulation Of Protein Catabolic Process Regulation Of Transport Low-density Lipoprotein Particle Receptor Activity Membrane I-SMAD Binding Cellular Response To Oxygen-containing Compound Presynaptic Endocytosis Regulation Of Cellular Response To Growth Factor Stimulus Vesicle-mediated Transport In Synapse Regulation Of Protein Localization Immune Response-activating Cell Surface Receptor Signaling Pathway SMAD Binding Cytosol Positive Regulation Of Lysosomal Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Neuron Projection Morphogenesis Enzyme-linked Receptor Protein Signaling Pathway Anatomical Structure Formation Involved In Morphogenesis Cell Projection Morphogenesis
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