NOS1AP and SYN3

Number of citations: 44 (PubMedID 11867766)
Data Source: HPRD (in vivo)

		NOS1AP	SYN3
Name		nitric oxide synthase 1 adaptor protein	synapsin III
Structure		No pdb structure
GO Annotations	Cellular Component	Podosome Nucleus Mitochondrion Cytosol Caveola Z Disc Filopodium T-tubule Nuclear Membrane Sarcoplasmic Reticulum Membrane Sarcolemma Cell Projection Perinuclear Region Of Cytoplasm Anchoring Junction Glutamatergic Synapse	Synaptic Vesicle Postsynaptic Density Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Synapse Extrinsic Component Of Synaptic Vesicle Membrane Glutamatergic Synapse
	Molecular Function	Protein Binding Nitric-oxide Synthase Regulator Activity Signaling Adaptor Activity Nitric-oxide Synthase Binding	Nucleotide Binding Protein Binding ATP Binding
	Biological Process	Regulation Of Heart Rate By Chemical Signal Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Cardiac Muscle Cell Action Potential Postsynaptic Actin Cytoskeleton Organization Positive Regulation Of Potassium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Positive Regulation Of Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential	Chemical Synaptic Transmission Neurotransmitter Secretion Regulation Of Synaptic Transmission, GABAergic Modulation Of Chemical Synaptic Transmission Synapse Organization Synaptic Vesicle Clustering Synaptic Vesicle Cycle
Pathways		None	Serotonin Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle
GWAS		Alanine aminotransferase levels in non-alcoholic fatty liver disease ( 31311600 ) Body mass index (change over time) ( 25133637 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Electrocardiographic traits ( 20062061 20062063 25055868 ) Electrocardiographic traits (multivariate) ( 32602732 ) Granulocyte percentage of myeloid white cells ( 27863252 ) Heel bone mineral density ( 30598549 ) Iris color (L* coordinate) ( 30895295 ) Lateral ventricle temporal horn volume ( 31530798 ) Long QT syndrome ( 32429735 ) Mean platelet volume ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Monocyte count ( 32888494 ) Monocyte percentage of white cells ( 32888494 27863252 ) Mosquito bite size ( 28199695 ) Obesity-related traits ( 23251661 ) QT interval ( 19305408 19305409 19587794 30679814 16648850 29874175 29213071 20031603 22726844 23166209 24952745 ) Sum of carotid plaque area ( 32469969 ) Sum of stenosis ( 32469969 ) T wave morphology restitution during exercise ( 31607149 ) T wave morphology restitution during exercise (MTAG) ( 31607149 ) T wave morphology restitution during recovery from exercise ( 31607149 ) T wave morphology restitution during recovery from exercise (MTAG) ( 31607149 ) Word reading ( 23738518 )	Advanced age-related macular degeneration ( 26691988 ) Age-related macular degeneration ( 20385819 ) Alzheimer's disease progression score ( 29860282 ) Benign prostatic hyperplasia ( 30988330 ) Chronic obstructive pulmonary disease ( 30804561 ) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398 ) Heel bone mineral density ( 30598549 ) Height ( 20881960 21998595 25282103 25429064 31562340 ) Interleukin-6 levels ( 22205395 ) Intracranial aneurysm ( 29531279 ) Intraocular pressure ( 29785010 31959993 30054594 29617998 ) Metabolite levels ( 23823483 ) Refractive error ( 32231278 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 ) Triglyceride levels ( 31170924 ) Trunk fat mass adjusted for trunk lean mass ( 32239398 )
Interacting Genes		18 interacting genes: AKNAD1 APP CKM FYN HSPD1 LRP1 LRP2 LRP8 NHP2 NOS1 PLAGL2 PNP RASD1 RYBP SYN1 SYN2 SYN3 TRAF4	8 interacting genes: C9orf72 MORF4L1 MORF4L2 NOS1AP PIAS2 SNCA SYN1 SYN2
Entrez ID		9722	8224
HPRD ID		12023	04083
Ensembl ID		ENSG00000198929	ENSG00000185666
Uniprot IDs		O75052	O14994 Q17R54 Q59EX7
PDB IDs		Not available	2P0A
GO Terms Enriched among Interactors		Apolipoprotein Binding Synaptic Vesicle Cycle Synaptic Vesicle Clustering Low-density Lipoprotein Particle Receptor Activity Clathrin-coated Pit Synaptic Signaling Cargo Receptor Activity Schaffer Collateral - CA1 Synapse Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Astrocyte Activation Involved In Immune Response Postsynaptic Density Cellular Response To Growth Factor Stimulus Growth Factor Receptor Binding Positive Regulation Of Lysosomal Protein Catabolic Process Neurotransmitter Secretion Chemical Synaptic Transmission Response To Growth Factor Trans-synaptic Signaling Cellular Response To Amyloid-beta Positive Regulation Of Protein Catabolic Process In The Vacuole Cell-cell Signaling Regulation Of Protein Catabolic Process Signaling Response To Amyloid-beta Cell Communication Receptor Complex High-density Lipoprotein Particle Binding Regulation Of Lysosomal Protein Catabolic Process Retinoid Metabolic Process Reelin-mediated Signaling Pathway Diterpenoid Metabolic Process Cell Body Regulation Of Dendritic Spine Maintenance Calcium-dependent Protein Binding Dendrite Extrinsic Component Of Synaptic Vesicle Membrane Vesicle-mediated Transport Modulation Of Chemical Synaptic Transmission Synapse Organization Terpenoid Metabolic Process Vesicle-mediated Transport In Synapse Protein-folding Chaperone Binding Heparan Sulfate Proteoglycan Binding Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Neuron Projection Morphogenesis Astrocyte Activation Layer Formation In Cerebral Cortex Isoprenoid Metabolic Process Neurotransmitter Transport	Neurotransmitter Secretion Synaptic Vesicle Cycle Vesicle-mediated Transport In Synapse Neurotransmitter Transport Synaptic Vesicle Clustering Vesicle Localization Regulation Of Synaptic Vesicle Cycle Synaptic Vesicle Membrane Synaptic Vesicle Signal Release Regulation Of Exocytosis NuA4 Histone Acetyltransferase Complex Negative Regulation Of Exocytosis Presynapse Synapse Organization Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Chemical Synaptic Transmission Response To Desipramine Negative Regulation Of Norepinephrine Uptake Trans-synaptic Signaling Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Synaptic Signaling Synapse Positive Regulation Of DNA Recombination Axon Secretion By Cell Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Neurotransmitter Secretion Regulated Exocytosis Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Organelle Localization Positive Regulation Of Hydrogen Peroxide Catabolic Process Cell Junction Organization Schaffer Collateral - CA1 Synapse Positive Regulation Of Double-strand Break Repair Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Positive Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Cation Transmembrane Transport Secretion Negative Regulation Of Chaperone-mediated Autophagy Vesicle-mediated Transport Nucleosome Positive Regulation Of Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Positive Regulation Of Membrane Repolarization During Cardiac Muscle Cell Action Potential Negative Regulation Of Dopamine Metabolic Process Growth Cone