UBB and NTRK2

Number of citations of the paper that reports this interaction (PMID 16701206)
51

Data Source:
HPRD (in vivo)

		UBB	NTRK2
Gene Name		ubiquitin B	neurotrophic tyrosine kinase, receptor, type 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Mitochondrion Cytosol Plasma Membrane Endosome Membrane Endocytic Vesicle Membrane Neuron Projection Neuronal Cell Body Extracellular Vesicular Exosome	Rough Endoplasmic Reticulum Cytosol Integral Component Of Plasma Membrane Cell Surface Endosome Membrane Growth Cone Terminal Bouton Dendritic Spine Perikaryon Receptor Complex Postsynaptic Membrane Presynaptic Active Zone Excitatory Synapse Neuronal Postsynaptic Density
	Molecular Function	Protein Binding	ATP Binding Protein Homodimerization Activity Neurotrophin Binding Ephrin Receptor Binding Brain-derived Neurotrophic Factor Binding Brain-derived Neurotrophic Factor-activated Receptor Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Activation Of MAPK Activity Protein Polyubiquitination Mitotic Cell Cycle Toll-like Receptor Signaling Pathway Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Carbohydrate Metabolic Process Glycogen Biosynthetic Process Glucose Metabolic Process DNA Repair Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Epidermal Growth Factor Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Notch Signaling Pathway Notch Receptor Processing I-kappaB Kinase/NF-kappaB Signaling JNK Cascade Circadian Rhythm Fibroblast Growth Factor Receptor Signaling Pathway Pathogenesis Gene Expression Viral Process Endosomal Transport Viral Life Cycle Virion Assembly Viral Protein Processing Cytokine-mediated Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Type I Interferon Production Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Ion Transmembrane Transport TRIF-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Small Molecule Metabolic Process Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Mitochondrion Transport Along Microtubule Neurotrophin TRK Receptor Signaling Pathway Neuron Projection Morphogenesis T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Mitochondrial Membrane Potential Transmembrane Transport Membrane Organization Regulation Of Proteasomal Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Cellular Response To Hypoxia Intracellular Transport Of Virus Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Apoptotic Signaling Pathway Regulation Of Neuron Death Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator	Vasculogenesis Neuron Migration Inflammatory Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Activation Of Adenylate Cyclase Activity Neuromuscular Junction Development Aging Learning Long-term Memory Circadian Rhythm Feeding Behavior Positive Regulation Of Cell Proliferation Response To Light Stimulus Positive Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development Response To Auditory Stimulus Glutamate Secretion Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Central Nervous System Neuron Development Cerebral Cortex Development Neuron Differentiation Brain-derived Neurotrophic Factor Receptor Signaling Pathway Regulation Of Rac GTPase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Calcium-mediated Signaling Using Intracellular Calcium Source Mechanoreceptor Differentiation Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Retinal Rod Cell Development Protein Autophosphorylation Regulation Of Neurotransmitter Secretion Neurotrophin TRK Receptor Signaling Pathway Oligodendrocyte Differentiation Peripheral Nervous System Neuron Development Positive Regulation Of Axonogenesis Regulation Of Dendrite Development Regulation Of Protein Kinase B Signaling Positive Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Potentiation Cellular Response To Tumor Necrosis Factor Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Anoikis
Pathways		Loss of Function of TGFBR2 in Cancer NF-kB is activated and signals survival Signaling by FGFR in disease Hedgehog 'off' state Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Glucose metabolism Toll Like Receptor TLR1:TLR2 Cascade Signaling by NOTCH1 Signaling by NOTCH2 Toll Like Receptor 5 (TLR5) Cascade AXIN mutants destabilize the destruction complex, activating WNT signaling S33 mutants of beta-catenin aren't phosphorylated Stabilization of p53 Removal of licensing factors from origins Switching of origins to a post-replicative state Downregulation of ERBB2:ERBB3 signaling TGFBR2 MSI Frameshift Mutants in Cancer Signaling by NOTCH Endosomal Sorting Complex Required For Transport (ESCRT) Spry regulation of FGF signaling Signaling by NOTCH SCF(Skp2)-mediated degradation of p27/p21 deletions in the AMER1 gene destabilize the destruction complex Regulation of innate immune responses to cytosolic DNA Autodegradation of the E3 ubiquitin ligase COP1 Toll Like Receptor 3 (TLR3) Cascade Metabolism of carbohydrates CDK-mediated phosphorylation and removal of Cdc6 Cellular response to hypoxia Hedgehog ligand biogenesis p75NTR recruits signalling complexes Fanconi Anemia pathway Separation of Sister Chromatids HIV Infection APC truncation mutants have impaired AXIN binding Assembly of the pre-replicative complex Synthesis And Processing Of GAG, GAGPOL Polyproteins Activated TLR4 signalling S37 mutants of beta-catenin aren't phosphorylated p53-Dependent G1 DNA Damage Response regulation of FZD by ubiquitination Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 p53-Independent DNA Damage Response MyD88:Mal cascade initiated on plasma membrane Stimuli-sensing channels Membrane binding and targetting of GAG proteins p53-Independent G1/S DNA damage checkpoint G1/S DNA Damage Checkpoints Downregulation of ERBB4 signaling Vpu mediated degradation of CD4 Cell death signalling via NRAGE, NRIF and NADE ISG15 antiviral mechanism Interferon Signaling M/G1 Transition p75 NTR receptor-mediated signalling Signaling by FGFR Toll Like Receptor 10 (TLR10) Cascade Signaling by NOTCH1 in Cancer TCF dependent signaling in response to WNT SCF-beta-TrCP mediated degradation of Emi1 degradation of AXIN Degradation of GLI1 by the proteasome degradation of DVL Cell Cycle Checkpoints Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Regulation of Apoptosis Degradation of GLI2 by the proteasome Signaling by the B Cell Receptor (BCR) Vif-mediated degradation of APOBEC3G Signaling by NOTCH1 HD Domain Mutants in Cancer Constitutive Signaling by NOTCH1 HD Domain Mutants Downregulation of TGF-beta receptor signaling truncated APC mutants destabilize the destruction complex Cyclin E associated events during G1/S transition TGF-beta receptor signaling activates SMADs Regulation of PLK1 Activity at G2/M Transition FCERI mediated NF-kB activation Regulation of the Fanconi anemia pathway Generic Transcription Pathway G1/S Transition Toll Like Receptor 9 (TLR9) Cascade FBXW7 Mutants and NOTCH1 in Cancer IRAK1 recruits IKK complex Negative regulation of FGFR signaling truncations of AMER1 destabilize the destruction complex EGFR downregulation TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) IRAK2 mediated activation of TAK1 complex Processing-defective Hh variants abrogate ligand secretion Regulation of activated PAK-2p34 by proteasome mediated degradation Host Interactions of HIV factors phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex Signaling by ERBB4 Antiviral mechanism by IFN-stimulated genes Fc epsilon receptor (FCERI) signaling Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Interleukin-3, 5 and GM-CSF signaling TAK1 activates NFkB by phosphorylation and activation of IKKs complex M Phase APC truncation mutants are not K63 polyubiquitinated Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon HIV Life Cycle Budding and maturation of HIV virion Hedgehog 'on' state Programmed Cell Death Class I MHC mediated antigen processing & presentation IKK complex recruitment mediated by RIP1 MAP kinase activation in TLR cascade Regulation of DNA replication Cytokine Signaling in Immune system Signaling by Overexpressed Wild-Type EGFR in Cancer MyD88-independent cascade Cell Cycle, Mitotic Signaling by TGF-beta Receptor Complex in Cancer Oxidative Stress Induced Senescence Activation of NF-kappaB in B cells Asymmetric localization of PCP proteins deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation TRAF6 mediated induction of TAK1 complex Negative regulators of RIG-I/MDA5 signaling misspliced GSK3beta mutants stabilize beta-catenin Hh ligand biogenesis disease SMAD2/3 MH2 Domain Mutants in Cancer T41 mutants of beta-catenin aren't phosphorylated Cellular Senescence Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by EGFRvIII in Cancer Assembly Of The HIV Virion Downstream signaling events of B Cell Receptor (BCR) Degradation of beta-catenin by the destruction complex NOD1/2 Signaling Pathway Glycogen storage diseases MyD88 dependent cascade initiated on endosome Mitotic G1-G1/S phases activated TAK1 mediates p38 MAPK activation Regulation of mRNA stability by proteins that bind AU-rich elements misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TRIF-mediated TLR3/TLR4 signaling DNA Replication Pre-Initiation Senescence-Associated Secretory Phenotype (SASP) APC/C:Cdc20 mediated degradation of mitotic proteins TGFBR1 KD Mutants in Cancer S45 mutants of beta-catenin aren't phosphorylated Regulation of APC/C activators between G1/S and early anaphase Late Phase of HIV Life Cycle APC/C:Cdc20 mediated degradation of Cyclin B NOTCH2 Activation and Transmission of Signal to the Nucleus TCR signaling AMER1 mutants destabilize the destruction complex Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Interleukin-1 signaling APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint PCP/CE pathway Mitotic G2-G2/M phases Adaptive Immune System APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Regulation of Hypoxia-inducible Factor (HIF) by oxygen Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Ubiquitin-dependent degradation of Cyclin D G2/M Transition TGFBR1 LBD Mutants in Cancer Oncogene Induced Senescence Autodegradation of Cdh1 by Cdh1:APC/C Ion channel transport p75NTR signals via NF-kB Regulation of signaling by CBL XAV939 inhibits tankyrase, stabilizing AXIN Disease TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Signal Transduction Innate Immune System Synthesis of DNA Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer G1 Phase Signaling by Ligand-Responsive EGFR Variants in Cancer Loss of Function of TGFBR1 in Cancer Ubiquitin-dependent degradation of Cyclin D1 Activated NOTCH1 Transmits Signal to the Nucleus NOTCH1 Intracellular Domain Regulates Transcription Toll-Like Receptors Cascades Cyclin D associated events in G1 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Regulation of mitotic cell cycle Signaling by Hedgehog Association of licensing factors with the pre-replicative complex IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Ubiquitin Mediated Degradation of Phosphorylated Cdc25A TCF7L2 mutants don't bind CTBP p53-Dependent G1/S DNA damage checkpoint Signaling by Wnt AUF1 (hnRNP D0) destabilizes mRNA Downregulation of SMAD2/3:SMAD4 transcriptional activity APC/C:Cdc20 mediated degradation of Securin SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription CDK-mediated phosphorylation and removal of Cdc6 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer IRAK1 recruits IKK complex Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants RNF mutants show enhanced WNT signaling and proliferation Myoclonic epilepsy of Lafora Signaling by NOTCH1 in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer IRAK2 mediated activation of TAK1 complex Loss of Function of SMAD4 in Cancer AXIN missense mutants destabilize the destruction complex S Phase APC/C-mediated degradation of cell cycle proteins Toll Like Receptor 2 (TLR2) Cascade Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins Glycogen synthesis NRIF signals cell death from the nucleus Toll Like Receptor 4 (TLR4) Cascade Signaling by EGFR in Cancer Signaling by NOTCH1 PEST Domain Mutants in Cancer SCF(Skp2)-mediated degradation of p27/p21 Cyclin A:Cdk2-associated events at S phase entry Constitutive Signaling by NOTCH1 PEST Domain Mutants Mitotic Metaphase and Anaphase Downstream TCR signaling Antigen processing: Ubiquitination & Proteasome degradation Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Toll Like Receptor 7/8 (TLR7/8) Cascade Orc1 removal from chromatin Mitotic Anaphase deactivation of the beta-catenin transactivating complex Toll Like Receptor TLR6:TLR2 Cascade MyD88 cascade initiated on plasma membrane Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Signalling by NGF Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Cytosolic sensors of pathogen-associated DNA beta-catenin independent WNT signaling RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Orc1 removal from chromatin Signaling by TGF-beta Receptor Complex CDT1 association with the CDC6:ORC:origin complex Antigen processing-Cross presentation ER-Phagosome pathway SMAD4 MH2 Domain Mutants in Cancer	Signalling by NGF Activation of TRKA receptors NGF-independant TRKA activation NGF signalling via TRKA from the plasma membrane
Drugs
Diseases
GWAS			Waist-to-hip circumference ratio (interaction) ( 23192594)
Protein-Protein Interactions		67 interactors: APP ATXN3 BIRC2 BRCA1 CALCOCO2 CDC25A CDC34 CDKN1B CDT1 CDX2 CHEK1 DAZAP2 DUSP1 ECT2 EGFR ELF4 EPS15 ERBB2 FANCD2 FSHR HDAC6 HGS HLA-A IKBKB IKBKG JUN LIG4 LYN MAPT MDM2 MYBL2 MYC NR3C1 NTRK1 NTRK2 PARK2 PCNA PIN1 POLI PSMD4 RABGEF1 RAD23A RAD23B RNF11 SENP8 SH3KBP1 SKP2 SMAD4 SMURF1 SNCA SNCAIP SQSTM1 STUB1 SYK TGFBR1 TP53 TRAF6 TRIM37 TRIM5 UBASH3A UBASH3B UBE2N UBE3A UBQLN1 USP1 WWOX XIAP	29 interactors: AP1B1 BDNF DOK5 DYNLL1 FRS2 FRS3 FYN GIPC1 KIDINS220 NCK1 NCK2 NGFR NMNAT1 NTF3 NTF4 PIK3R1 PLCG1 POLR2G PTPN1 PTPN11 RASGRF1 SH2B1 SH2B2 SHC1 SHC2 SHC3 SQSTM1 TRAF6 UBB
Entrez ID		7314	4915
HPRD ID		06771	02712
Ensembl ID		ENSG00000170315	ENSG00000148053
Uniprot IDs		P0CG47 Q5U5U6	Q16620 Q548C2 Q5VWE5
PDB IDs			1HCF 1WWB 4ASZ 4AT3 4AT4 4AT5
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Regulation Of Signaling Response To Stress Positive Regulation Of Cellular Metabolic Process Response To Organic Substance Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Response To Growth Factor Cellular Response To Stress Cellular Response To Stimulus Regulation Of Cell Death Cellular Response To Organic Substance Positive Regulation Of Protein Metabolic Process Regulation Of Apoptotic Process Cellular Response To Growth Factor Stimulus Enzyme Linked Receptor Protein Signaling Pathway Protein Polyubiquitination Positive Regulation Of Protein Modification Process Regulation Of Phosphorylation Cellular Protein Modification Process Response To Stimulus Regulation Of Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Protein Phosphorylation Negative Regulation Of Signal Transduction Response To Abiotic Stimulus Protein Ubiquitination Negative Regulation Of Cell Death Protein Modification By Small Protein Conjugation Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Apoptotic Process Modification-dependent Protein Catabolic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Signaling Cellular Response To DNA Damage Stimulus Regulation Of Phosphorus Metabolic Process Response To Radiation Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Catalytic Activity Cellular Protein Catabolic Process Positive Regulation Of Signal Transduction Regulation Of Cellular Process Programmed Cell Death Positive Regulation Of Cellular Biosynthetic Process Cell Death Regulation Of Cell Cycle Death Positive Regulation Of Programmed Cell Death	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Signal Transduction Signaling Cell Communication Regulation Of Phosphorylation Cellular Response To Stimulus Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Regulation Of Kinase Activity Regulation Of Protein Metabolic Process Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Protein Phosphorylation Nervous System Development Insulin Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Protein Kinase Activity Activation Of Protein Kinase Activity Fc Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Positive Regulation Of Intracellular Signal Transduction Response To Stimulus Cellular Response To Peptide Hormone Stimulus Neuron Projection Development Cellular Response To Peptide Cellular Response To Organonitrogen Compound Neuron Projection Morphogenesis Regulation Of Cellular Protein Metabolic Process Immune Response-regulating Signaling Pathway Cellular Response To Insulin Stimulus Positive Regulation Of Cellular Protein Metabolic Process Cell Projection Organization Fc-epsilon Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Activation Of MAPK Activity Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Protein Phosphorylation Response To Organic Substance
Tagcloud ?		almost amount attenuation consequently display downregulated downregulation effectively every hypothesized inducible inhibiting kd knockdown oncogenic overcome polyubiquitin reports sensitization sirna stabilization stress suppressor taken tnfalpha ubiquitin ubiquitination weakening xenograft	a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh dnm1 drd2 eas fagerstrom gabbr2 grin3a mstcc n549s nrxn1 nrxn2 nrxn3 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss
Tagcloud (Difference) ?		almost amount attenuation consequently display downregulated downregulation effectively every hypothesized inducible inhibiting kd knockdown oncogenic overcome polyubiquitin reports sensitization sirna stabilization stress suppressor taken tnfalpha ubiquitin ubiquitination weakening xenograft	a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh dnm1 drd2 eas fagerstrom gabbr2 grin3a mstcc n549s nrxn1 nrxn2 nrxn3 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss
Tagcloud (Intersection) ?