UBB and HGS

Number of citations of the paper that reports this interaction (PMID 16429130)
88

Data Source:
HPRD (in vitro)

		UBB	HGS
Gene Name		ubiquitin B	hepatocyte growth factor-regulated tyrosine kinase substrate
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Mitochondrion Cytosol Plasma Membrane Endosome Membrane Endocytic Vesicle Membrane Neuron Projection Neuronal Cell Body Extracellular Vesicular Exosome	Cytoplasm Endosome Early Endosome Cytosol Secretory Granule Early Endosome Membrane Multivesicular Body Membrane Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome
	Molecular Function	Protein Binding	Protein Binding Protein Domain Specific Binding Metal Ion Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Activation Of MAPK Activity Protein Polyubiquitination Mitotic Cell Cycle Toll-like Receptor Signaling Pathway Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Carbohydrate Metabolic Process Glycogen Biosynthetic Process Glucose Metabolic Process DNA Repair Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Epidermal Growth Factor Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Notch Signaling Pathway Notch Receptor Processing I-kappaB Kinase/NF-kappaB Signaling JNK Cascade Circadian Rhythm Fibroblast Growth Factor Receptor Signaling Pathway Pathogenesis Gene Expression Viral Process Endosomal Transport Viral Life Cycle Virion Assembly Viral Protein Processing Cytokine-mediated Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Type I Interferon Production Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Ion Transmembrane Transport TRIF-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Small Molecule Metabolic Process Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Mitochondrion Transport Along Microtubule Neurotrophin TRK Receptor Signaling Pathway Neuron Projection Morphogenesis T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Mitochondrial Membrane Potential Transmembrane Transport Membrane Organization Regulation Of Proteasomal Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Cellular Response To Hypoxia Intracellular Transport Of Virus Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Apoptotic Signaling Pathway Regulation Of Neuron Death Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator	Protein Targeting To Lysosome Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Cell Proliferation Endosome To Lysosome Transport Membrane Invagination Positive Regulation Of Gene Expression Endosomal Transport Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Catabolic Process Negative Regulation Of JAK-STAT Cascade Membrane Organization Protein Localization To Membrane Positive Regulation Of Exosomal Secretion
Pathways		Loss of Function of TGFBR2 in Cancer NF-kB is activated and signals survival Signaling by FGFR in disease Hedgehog 'off' state Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Glucose metabolism Toll Like Receptor TLR1:TLR2 Cascade Signaling by NOTCH1 Signaling by NOTCH2 Toll Like Receptor 5 (TLR5) Cascade AXIN mutants destabilize the destruction complex, activating WNT signaling S33 mutants of beta-catenin aren't phosphorylated Stabilization of p53 Removal of licensing factors from origins Switching of origins to a post-replicative state Downregulation of ERBB2:ERBB3 signaling TGFBR2 MSI Frameshift Mutants in Cancer Signaling by NOTCH Endosomal Sorting Complex Required For Transport (ESCRT) Spry regulation of FGF signaling Signaling by NOTCH SCF(Skp2)-mediated degradation of p27/p21 deletions in the AMER1 gene destabilize the destruction complex Regulation of innate immune responses to cytosolic DNA Autodegradation of the E3 ubiquitin ligase COP1 Toll Like Receptor 3 (TLR3) Cascade Metabolism of carbohydrates CDK-mediated phosphorylation and removal of Cdc6 Cellular response to hypoxia Hedgehog ligand biogenesis p75NTR recruits signalling complexes Fanconi Anemia pathway Separation of Sister Chromatids HIV Infection APC truncation mutants have impaired AXIN binding Assembly of the pre-replicative complex Synthesis And Processing Of GAG, GAGPOL Polyproteins Activated TLR4 signalling S37 mutants of beta-catenin aren't phosphorylated p53-Dependent G1 DNA Damage Response regulation of FZD by ubiquitination Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 p53-Independent DNA Damage Response MyD88:Mal cascade initiated on plasma membrane Stimuli-sensing channels Membrane binding and targetting of GAG proteins p53-Independent G1/S DNA damage checkpoint G1/S DNA Damage Checkpoints Downregulation of ERBB4 signaling Vpu mediated degradation of CD4 Cell death signalling via NRAGE, NRIF and NADE ISG15 antiviral mechanism Interferon Signaling M/G1 Transition p75 NTR receptor-mediated signalling Signaling by FGFR Toll Like Receptor 10 (TLR10) Cascade Signaling by NOTCH1 in Cancer TCF dependent signaling in response to WNT SCF-beta-TrCP mediated degradation of Emi1 degradation of AXIN Degradation of GLI1 by the proteasome degradation of DVL Cell Cycle Checkpoints Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Regulation of Apoptosis Degradation of GLI2 by the proteasome Signaling by the B Cell Receptor (BCR) Vif-mediated degradation of APOBEC3G Signaling by NOTCH1 HD Domain Mutants in Cancer Constitutive Signaling by NOTCH1 HD Domain Mutants Downregulation of TGF-beta receptor signaling truncated APC mutants destabilize the destruction complex Cyclin E associated events during G1/S transition TGF-beta receptor signaling activates SMADs Regulation of PLK1 Activity at G2/M Transition FCERI mediated NF-kB activation Regulation of the Fanconi anemia pathway Generic Transcription Pathway G1/S Transition Toll Like Receptor 9 (TLR9) Cascade FBXW7 Mutants and NOTCH1 in Cancer IRAK1 recruits IKK complex Negative regulation of FGFR signaling truncations of AMER1 destabilize the destruction complex EGFR downregulation TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) IRAK2 mediated activation of TAK1 complex Processing-defective Hh variants abrogate ligand secretion Regulation of activated PAK-2p34 by proteasome mediated degradation Host Interactions of HIV factors phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex Signaling by ERBB4 Antiviral mechanism by IFN-stimulated genes Fc epsilon receptor (FCERI) signaling Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Interleukin-3, 5 and GM-CSF signaling TAK1 activates NFkB by phosphorylation and activation of IKKs complex M Phase APC truncation mutants are not K63 polyubiquitinated Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon HIV Life Cycle Budding and maturation of HIV virion Hedgehog 'on' state Programmed Cell Death Class I MHC mediated antigen processing & presentation IKK complex recruitment mediated by RIP1 MAP kinase activation in TLR cascade Regulation of DNA replication Cytokine Signaling in Immune system Signaling by Overexpressed Wild-Type EGFR in Cancer MyD88-independent cascade Cell Cycle, Mitotic Signaling by TGF-beta Receptor Complex in Cancer Oxidative Stress Induced Senescence Activation of NF-kappaB in B cells Asymmetric localization of PCP proteins deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation TRAF6 mediated induction of TAK1 complex Negative regulators of RIG-I/MDA5 signaling misspliced GSK3beta mutants stabilize beta-catenin Hh ligand biogenesis disease SMAD2/3 MH2 Domain Mutants in Cancer T41 mutants of beta-catenin aren't phosphorylated Cellular Senescence Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by EGFRvIII in Cancer Assembly Of The HIV Virion Downstream signaling events of B Cell Receptor (BCR) Degradation of beta-catenin by the destruction complex NOD1/2 Signaling Pathway Glycogen storage diseases MyD88 dependent cascade initiated on endosome Mitotic G1-G1/S phases activated TAK1 mediates p38 MAPK activation Regulation of mRNA stability by proteins that bind AU-rich elements misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TRIF-mediated TLR3/TLR4 signaling DNA Replication Pre-Initiation Senescence-Associated Secretory Phenotype (SASP) APC/C:Cdc20 mediated degradation of mitotic proteins TGFBR1 KD Mutants in Cancer S45 mutants of beta-catenin aren't phosphorylated Regulation of APC/C activators between G1/S and early anaphase Late Phase of HIV Life Cycle APC/C:Cdc20 mediated degradation of Cyclin B NOTCH2 Activation and Transmission of Signal to the Nucleus TCR signaling AMER1 mutants destabilize the destruction complex Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Interleukin-1 signaling APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint PCP/CE pathway Mitotic G2-G2/M phases Adaptive Immune System APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Regulation of Hypoxia-inducible Factor (HIF) by oxygen Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Ubiquitin-dependent degradation of Cyclin D G2/M Transition TGFBR1 LBD Mutants in Cancer Oncogene Induced Senescence Autodegradation of Cdh1 by Cdh1:APC/C Ion channel transport p75NTR signals via NF-kB Regulation of signaling by CBL XAV939 inhibits tankyrase, stabilizing AXIN Disease TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Signal Transduction Innate Immune System Synthesis of DNA Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer G1 Phase Signaling by Ligand-Responsive EGFR Variants in Cancer Loss of Function of TGFBR1 in Cancer Ubiquitin-dependent degradation of Cyclin D1 Activated NOTCH1 Transmits Signal to the Nucleus NOTCH1 Intracellular Domain Regulates Transcription Toll-Like Receptors Cascades Cyclin D associated events in G1 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Regulation of mitotic cell cycle Signaling by Hedgehog Association of licensing factors with the pre-replicative complex IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Ubiquitin Mediated Degradation of Phosphorylated Cdc25A TCF7L2 mutants don't bind CTBP p53-Dependent G1/S DNA damage checkpoint Signaling by Wnt AUF1 (hnRNP D0) destabilizes mRNA Downregulation of SMAD2/3:SMAD4 transcriptional activity APC/C:Cdc20 mediated degradation of Securin SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription CDK-mediated phosphorylation and removal of Cdc6 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer IRAK1 recruits IKK complex Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants RNF mutants show enhanced WNT signaling and proliferation Myoclonic epilepsy of Lafora Signaling by NOTCH1 in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer IRAK2 mediated activation of TAK1 complex Loss of Function of SMAD4 in Cancer AXIN missense mutants destabilize the destruction complex S Phase APC/C-mediated degradation of cell cycle proteins Toll Like Receptor 2 (TLR2) Cascade Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins Glycogen synthesis NRIF signals cell death from the nucleus Toll Like Receptor 4 (TLR4) Cascade Signaling by EGFR in Cancer Signaling by NOTCH1 PEST Domain Mutants in Cancer SCF(Skp2)-mediated degradation of p27/p21 Cyclin A:Cdk2-associated events at S phase entry Constitutive Signaling by NOTCH1 PEST Domain Mutants Mitotic Metaphase and Anaphase Downstream TCR signaling Antigen processing: Ubiquitination & Proteasome degradation Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Toll Like Receptor 7/8 (TLR7/8) Cascade Orc1 removal from chromatin Mitotic Anaphase deactivation of the beta-catenin transactivating complex Toll Like Receptor TLR6:TLR2 Cascade MyD88 cascade initiated on plasma membrane Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Signalling by NGF Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Cytosolic sensors of pathogen-associated DNA beta-catenin independent WNT signaling RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Orc1 removal from chromatin Signaling by TGF-beta Receptor Complex CDT1 association with the CDC6:ORC:origin complex Antigen processing-Cross presentation ER-Phagosome pathway SMAD4 MH2 Domain Mutants in Cancer	Signaling by EGFR EGFR downregulation Endosomal Sorting Complex Required For Transport (ESCRT) Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer
Drugs
Diseases
GWAS			Eye color traits ( 20463881)
Protein-Protein Interactions		67 interactors: APP ATXN3 BIRC2 BRCA1 CALCOCO2 CDC25A CDC34 CDKN1B CDT1 CDX2 CHEK1 DAZAP2 DUSP1 ECT2 EGFR ELF4 EPS15 ERBB2 FANCD2 FSHR HDAC6 HGS HLA-A IKBKB IKBKG JUN LIG4 LYN MAPT MDM2 MYBL2 MYC NR3C1 NTRK1 NTRK2 PARK2 PCNA PIN1 POLI PSMD4 RABGEF1 RAD23A RAD23B RNF11 SENP8 SH3KBP1 SKP2 SMAD4 SMURF1 SNCA SNCAIP SQSTM1 STUB1 SYK TGFBR1 TP53 TRAF6 TRIM37 TRIM5 UBASH3A UBASH3B UBE2N UBE3A UBQLN1 USP1 WWOX XIAP	138 interactors: ABI2 ACLY AHCYL1 APC APLP2 APP ARFIP2 ARL6IP1 ATP1A1 ATP2A2 ATXN1L BCAS2 BEGAIN BRINP3 BSG CASK CBS CCDC103 CCDC114 CCDC33 CEP55 CEP57L1 CLTC CRMP1 CSTF2 CSTF2T CTTNBP2NL DAZAP2 DCTN2 DECR1 DGCR6 DLG4 EGFR EHMT2 EPS15 ESRRG EXOC7 EXOC8 GFAP GFI1B GGA2 GKAP1 HAP1 HNRNPDL HSPA8 IL2RB IL4R ILKAP ING5 INTS4 JAKMIP2 KRT15 KRT18 KRT19 KRT31 KRT38 KRT40 KRT6A LDOC1 LINC00265 LITAF LURAP1 LYST MAGEB4 MAP3K10 MAP3K7 MAPK1IP1L MARK4 MAT2A MED7 MEST MET MIF4GD MKNK1 MRFAP1L1 MTHFD1L NDC80 NEDD4 NEDD4L NF2 NMI NPAS2 NUP54 OSBPL5 P4HA3 PAK1 PEF1 PELP1 PFKM PIK3R1 PITX1 PLD3 POGZ PPP1R16A PPP1R7 PTCD3 RHOBTB3 RPS3A RSU1 SCAMP3 SCRN1 SF3B3 SMAD2 SMAD3 SMAD5 SNAP25 SNX1 SNX5 SNX7 STAM STAM2 STXBP1 SUMO1 SUN2 TADA2A TIMMDC1 TJP2 TMCC2 TOM1L1 TRAK1 TRAP1 TSG101 TUBB TUBB2A UBA1 UBA52 UBB UBC UBE2I UBE4B UBQLN1 UBQLN4 USHBP1 VMP1 VPS37A VPS37C VPS37D ZNF302
Entrez ID		7314	9146
HPRD ID		06771	05085
Ensembl ID		ENSG00000170315	ENSG00000185359
Uniprot IDs		P0CG47 Q5U5U6	O14964
PDB IDs			2D3G 3F1I 3OBQ 3ZYQ 4AVX
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Regulation Of Signaling Response To Stress Positive Regulation Of Cellular Metabolic Process Response To Organic Substance Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Response To Growth Factor Cellular Response To Stress Cellular Response To Stimulus Regulation Of Cell Death Cellular Response To Organic Substance Positive Regulation Of Protein Metabolic Process Regulation Of Apoptotic Process Cellular Response To Growth Factor Stimulus Enzyme Linked Receptor Protein Signaling Pathway Protein Polyubiquitination Positive Regulation Of Protein Modification Process Regulation Of Phosphorylation Cellular Protein Modification Process Response To Stimulus Regulation Of Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Protein Phosphorylation Negative Regulation Of Signal Transduction Response To Abiotic Stimulus Protein Ubiquitination Negative Regulation Of Cell Death Protein Modification By Small Protein Conjugation Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Apoptotic Process Modification-dependent Protein Catabolic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Signaling Cellular Response To DNA Damage Stimulus Regulation Of Phosphorus Metabolic Process Response To Radiation Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Catalytic Activity Cellular Protein Catabolic Process Positive Regulation Of Signal Transduction Regulation Of Cellular Process Programmed Cell Death Positive Regulation Of Cellular Biosynthetic Process Cell Death Regulation Of Cell Cycle Death Positive Regulation Of Programmed Cell Death	Establishment Of Localization In Cell Cellular Localization Viral Protein Processing Protein Localization Intracellular Transport Membrane Organization Endosomal Transport Establishment Of Protein Localization Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Protein Transport Regulation Of ERBB Signaling Pathway Virion Assembly Intracellular Transport Of Virus Viral Process Cellular Protein Localization Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Vesicle-mediated Transport Viral Life Cycle Cell Cycle Process Organelle Organization Negative Regulation Of Cellular Response To Growth Factor Stimulus Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Mitotic Cell Cycle Mitotic Cell Cycle Process Transport Post-Golgi Vesicle-mediated Transport Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Metabolic Process Gene Expression Cell Cycle Vesicle Organization Secretion By Cell Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway ERBB Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Intracellular Protein Transport Transcription Initiation From RNA Polymerase II Promoter Cellular Process Cellular Response To Transforming Growth Factor Beta Stimulus Posttranscriptional Regulation Of Gene Expression Secretion Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Response To Transforming Growth Factor Beta Regulation Of Protein Catabolic Process JNK Cascade Response To Organic Substance
Tagcloud ?		almost amount attenuation consequently display downregulated downregulation effectively every hypothesized inducible inhibiting kd knockdown oncogenic overcome polyubiquitin reports sensitization sirna stabilization stress suppressor taken tnfalpha ubiquitin ubiquitination weakening xenograft	adjustments associates confounders continued cubic cv geriatric gnri handgrip hemodialysis hospitalization hospitalizations malnutrition mhd mis nutritional observational outpatients qol scales sf sf36 spline sua tertile trends upcoming uric y
Tagcloud (Difference) ?		almost amount attenuation consequently display downregulated downregulation effectively every hypothesized inducible inhibiting kd knockdown oncogenic overcome polyubiquitin reports sensitization sirna stabilization stress suppressor taken tnfalpha ubiquitin ubiquitination weakening xenograft	adjustments associates confounders continued cubic cv geriatric gnri handgrip hemodialysis hospitalization hospitalizations malnutrition mhd mis nutritional observational outpatients qol scales sf sf36 spline sua tertile trends upcoming uric y
Tagcloud (Intersection) ?