NDUFA13 and UBE3A

Number of citations of the paper that reports this interaction (PMID 21765936)
4

Data Source:
BioGRID (pull down)

		NDUFA13	UBE3A
Gene Name		NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13	ubiquitin protein ligase E3A
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Mitochondrial Respiratory Chain Complex I Integral Component Of Membrane Mitochondrial Membrane Extracellular Vesicular Exosome	Proteasome Complex Nucleus Cytoplasm Cytosol
	Molecular Function	NADH Dehydrogenase Activity Protein Binding ATP Binding NADH Dehydrogenase (ubiquinone) Activity	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Ligase Activity
	Biological Process	Positive Regulation Of Peptidase Activity Respiratory Electron Transport Chain Negative Regulation Of Cell Growth Cellular Response To Interferon-beta Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Metabolic Process Small Molecule Metabolic Process Protein Import Into Mitochondrial Inner Membrane Positive Regulation Of Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Cellular Response To Retinoic Acid Reactive Oxygen Species Metabolic Process Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Ovarian Follicle Development Proteolysis Ubiquitin-dependent Protein Catabolic Process Brain Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process Androgen Receptor Signaling Pathway Sperm Entry Regulation Of Circadian Rhythm Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Autoubiquitination Prostate Gland Growth Protein K48-linked Ubiquitination Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Pathways		Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. Respiratory electron transport The citric acid (TCA) cycle and respiratory electron transport	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs		NADH
Diseases
GWAS			Cardiac hypertrophy ( 21348951) Obesity-related traits ( 23251661)
Protein-Protein Interactions		5 interactors: EXOSC6 LIG4 STAT3 UBE3A XRN1	80 interactors: ADRM1 AFG3L1P AFTPH AHSP ANXA1 APP AR ARC ASAP3 ATG9A BARD1 BLK BPY2 BPY2B BPY2C BRCA1 C11orf49 CDKN1B CEBPZ DLG1 EAPP EID1 EIF4G1 HBA1 HPCAL4 HSPA4 JADE1 KLHL38 LCK MAGEA8 MCM7 MDM2 MEOX2 NDUFA13 NELFCD NOMO2 PARVA PDE1B PGR PML POLE4 PRDX1 PSAP PSMC3 PSMD4 RAD23A RAD23B RARA RMI1 RNF2 SACS SCAMP1 SCRIB SGK223 SHBG SMAD9 SOD1 SUMO3 TAT TBC1D14 TCF19 TP53 TRIM65 TSC2 TTC3 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2G1 UBE2G2 UBE2L3 UBE2L6 UBQLN2 UCHL5 YOD1 YWHAE YWHAZ
Entrez ID		51079	7337
HPRD ID		09452	03375
Ensembl ID			ENSG00000114062
Uniprot IDs		Q9P0J0	Q05086 Q9BUI6 Q9H2G0
PDB IDs			1C4Z 1D5F 1EQX 2KR1 4GIZ
Enriched GO Terms of Interacting Partners?		Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Isotype Switching Somatic Recombination Of Immunoglobulin Gene Segments Somatic Diversification Of Immunoglobulins Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response B Cell Activation Involved In Immune Response Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Immunoglobulin Production Somatic Stem Cell Maintenance Viral Process Sperm Entry DNA Ligation Involved In DNA Recombination RRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process Stem Cell Maintenance Leukocyte Activation Involved In Immune Response B Cell Activation MRNA Catabolic Process Cellular Macromolecule Catabolic Process Immunoglobulin Mediated Immune Response B Cell Mediated Immunity RNA Catabolic Process Central Nervous System Development Intracellular Receptor Signaling Pathway DNA Recombination Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Stem Cell Development Lagging Strand Elongation Pro-B Cell Differentiation Leukocyte Mediated Immunity Adaptive Immune Response Nuclear MRNA Surveillance RNA Metabolic Process Establishment Of Integrated Proviral Latency Stem Cell Differentiation DNA Deamination Negative Regulation Of Glycolytic Process RNA Surveillance Immunoglobulin V(D)J Recombination Radial Glial Cell Differentiation Establishment Of Viral Latency Histone MRNA Catabolic Process T Cell Receptor V(D)J Recombination DNA Ligation Involved In DNA Repair RRNA Catabolic Process Lymphoid Progenitor Cell Differentiation Lymphocyte Activation DNA Ligation Interleukin-6-mediated Signaling Pathway	Protein Polyubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Proteolysis Protein Catabolic Process Response To Stress Cellular Response To Organic Substance Regulation Of Mitotic Cell Cycle Phase Transition Protein Modification By Small Protein Conjugation Negative Regulation Of Mitotic Cell Cycle Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Regulation Of Protein Metabolic Process Response To Organic Substance Cellular Macromolecule Catabolic Process Positive Regulation Of Cellular Metabolic Process Protein Ubiquitination Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Protein Catabolic Process Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Mitotic Cell Cycle Checkpoint Cell Death Death Cell Cycle Checkpoint DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Apoptotic Process Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Regulation Of G1/S Transition Of Mitotic Cell Cycle Signal Transduction Involved In DNA Damage Checkpoint Regulation Of Cell Cycle G1/S Phase Transition Signal Transduction In Response To DNA Damage Signal Transduction Involved In Cell Cycle Checkpoint Regulation Of Cell Cycle Arrest Programmed Cell Death Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Catalytic Activity Proteasomal Protein Catabolic Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Protein K48-linked Ubiquitination Regulation Of Cell Cycle Catabolic Process Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint
Tagcloud ?			2h5 accompanies anova dynactin gadd45a gtf2h5 invites keuls macaques malfunctioning nbn1 ndd ndds newman ovx perimenopausal presenilin1 proteosome psen1 rad23a raphe scna serotonin speculation subserving symptomology ube2d3 ubea5 ubiquinase
Tagcloud (Difference) ?			2h5 accompanies anova dynactin gadd45a gtf2h5 invites keuls macaques malfunctioning nbn1 ndd ndds newman ovx perimenopausal presenilin1 proteosome psen1 rad23a raphe scna serotonin speculation subserving symptomology ube2d3 ubea5 ubiquinase
Tagcloud (Intersection) ?