EIF2AK1 and CDC37

Number of citations of the paper that reports this interaction (PMID 11036079)
16

Data Source:
HPRD (in vitro, in vivo)

		EIF2AK1	CDC37
Gene Name		eukaryotic translation initiation factor 2-alpha kinase 1	cell division cycle 37
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Cytoplasm Cytosol Ruffle Membrane Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Eukaryotic Translation Initiation Factor 2alpha Kinase Activity ATP Binding Heme Binding Protein Homodimerization Activity	Protein Binding Kinase Binding Heat Shock Protein Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Protein Kinase B Binding Unfolded Protein Binding Chaperone Binding Hsp90 Protein Binding
	Biological Process	Response To Stress Negative Regulation Of Cell Proliferation Response To External Stimulus Regulation Of EIF2 Alpha Phosphorylation By Heme Negative Regulation Of Translational Initiation By Iron Protoporphyrinogen IX Metabolic Process Protein Autophosphorylation Negative Regulation Of Hemoglobin Biosynthetic Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Folding Protein Targeting Protein Stabilization Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway
Pathways			Signaling by ERBB2 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by EGFRvIII in Cancer Constitutive Signaling by EGFRvIII
Drugs
Diseases
GWAS			Multiple sclerosis ( 21833088)
Protein-Protein Interactions		4 interactors: CDC37 EIF2S1 HSP90AA1 LIG4	72 interactors: A2M APOE APP AR BTBD10 C19orf44 CC2D1A CDC37L1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CHGA CHUK CKS1B CKS2 CRYM CSNK2A1 CSNK2A2 CYP2C9 DCTN1 DEAF1 ECSIT EIF2AK1 ELAVL3 EXOSC1 FBXL12 FBXW4 GCDH GCH1 HSP90AA1 IFIT3 IFIT5 IKBKB IKBKE IKBKG IMMT LONP1 LOXL4 LUC7L2 MAP3K14 MAP3K3 MGEA5 MTOR MZT2B NCOA5 NOS3 NR2C2 PPHLN1 PRAM1 PRDX2 PRMT1 PSME1 RAD23A RNF32 RPS15A SAFB SNX5 SPTBN4 SQSTM1 SRC STAMBPL1 STIP1 STK11 TBK1 UBE2I ZNF205 ZNF235 ZNF266 ZNF667
Entrez ID		27102	11140
HPRD ID		10684	05456
Ensembl ID		ENSG00000086232	ENSG00000105401
Uniprot IDs		B4DIP4 Q9BQI3	Q16543
PDB IDs			1US7 2K5B 2W0G
Enriched GO Terms of Interacting Partners?		DNA Ligation Involved In DNA Recombination Response To Unfolded Protein Protein Import Into Mitochondrial Outer Membrane Protein Folding Lagging Strand Elongation Pro-B Cell Differentiation Cellular Response To Stress Establishment Of Integrated Proviral Latency Immunoglobulin V(D)J Recombination Establishment Of Viral Latency T Cell Receptor V(D)J Recombination Regulation Of Translational Initiation In Response To Stress DNA Ligation Involved In DNA Repair Protein Targeting Lymphoid Progenitor Cell Differentiation Posttranscriptional Regulation Of Gene Expression Chaperone-mediated Protein Complex Assembly DNA Ligation Regulation Of Translation In Response To Stress Nucleotide-excision Repair, DNA Gap Filling Cellular Response To Lithium Ion Protein Refolding Regulation Of Interferon-gamma-mediated Signaling Pathway Single Strand Break Repair Regulation Of Response To Interferon-gamma Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Catalytic Activity Isotype Switching Nitric Oxide Metabolic Process V(D)J Recombination DNA Strand Elongation Involved In DNA Replication Response To Lithium Ion Regulation Of Cellular Response To Heat Reactive Nitrogen Species Metabolic Process DNA Strand Elongation Response To X-ray Regulation Of Protein Kinase Activity Somatic Recombination Of Immunoglobulin Gene Segments Regulation Of Kinase Activity Somatic Diversification Of Immunoglobulins Regulation Of Nitric-oxide Synthase Activity Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response Regulation Of Immune Response B Cell Activation Involved In Immune Response Intracellular Protein Transport Intracellular Protein Transmembrane Transport Response To Gamma Radiation	Regulation Of Cellular Protein Metabolic Process Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Protein Phosphorylation Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Protein Phosphorylation Response To Stress Cellular Metabolic Process Response To External Stimulus Phosphorylation Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cell Cycle Positive Regulation Of Cellular Biosynthetic Process Regulation Of Protein Kinase Activity I-kappaB Kinase/NF-kappaB Signaling Response To Stimulus Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Protein Metabolic Process Regulation Of Kinase Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Mitotic Cell Cycle Phase Transition Response To Virus Cell Cycle Phase Transition Catabolic Process Regulation Of Catalytic Activity Intracellular Receptor Signaling Pathway Cell Cycle Regulation Of Gene Expression Positive Regulation Of Protein Metabolic Process Protein Metabolic Process Innate Immune Response Positive Regulation Of Cellular Protein Metabolic Process G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Process Phosphate-containing Compound Metabolic Process Cellular Protein Modification Process Cell Cycle Process Regulation Of Signal Transduction Protein Catabolic Process Mitotic Cell Cycle TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Signaling Toll-like Receptor 3 Signaling Pathway Regulation Of Signaling Positive Regulation Of Signal Transduction Cellular Response To Stimulus
Tagcloud ?		activates affects arginine coordinately depletion eukaryotic gcn2 hri indirectly inducible innate kinases mediate nitric nos oxide pathological perk phosphorylate physiological pkr synthase uniquely upstream	base chick clusters conforms consensus copies emphasize exons finger flanking gctat ggg glycosaminoglycans homeodomain hsp90 introns kilobases mzf1 pair presumptive promotion reorganization repetitive s8 sizes sp1 stabilization striking tatgggga
Tagcloud (Difference) ?		activates affects arginine coordinately depletion eukaryotic gcn2 hri indirectly inducible innate kinases mediate nitric nos oxide pathological perk phosphorylate physiological pkr synthase uniquely upstream	base chick clusters conforms consensus copies emphasize exons finger flanking gctat ggg glycosaminoglycans homeodomain hsp90 introns kilobases mzf1 pair presumptive promotion reorganization repetitive s8 sizes sp1 stabilization striking tatgggga
Tagcloud (Intersection) ?