EIF2AK1

Gene Name		eukaryotic translation initiation factor 2-alpha kinase 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm
	Molecular Function	Eukaryotic Translation Initiation Factor 2alpha Kinase Activity ATP Binding Heme Binding Protein Homodimerization Activity
	Biological Process	Response To Stress Negative Regulation Of Cell Proliferation Response To External Stimulus Regulation Of EIF2 Alpha Phosphorylation By Heme Negative Regulation Of Translational Initiation By Iron Protoporphyrinogen IX Metabolic Process Protein Autophosphorylation Negative Regulation Of Hemoglobin Biosynthetic Process
Pathways
Drugs
Diseases
GWAS
Protein-protein Interactions		4 interactors: CDC37 EIF2S1 HSP90AA1 LIG4
Entrez ID		27102
HPRD ID		10684
Ensembl ID		ENSG00000086232
Uniprot IDs		B4DIP4 Q9BQI3
PDB IDs
Enriched GO Terms of Interacting Partners?		DNA Ligation Involved In DNA Recombination Response To Unfolded Protein Protein Import Into Mitochondrial Outer Membrane Protein Folding Lagging Strand Elongation Pro-B Cell Differentiation Cellular Response To Stress Establishment Of Integrated Proviral Latency Immunoglobulin V(D)J Recombination Establishment Of Viral Latency T Cell Receptor V(D)J Recombination Regulation Of Translational Initiation In Response To Stress DNA Ligation Involved In DNA Repair Protein Targeting Lymphoid Progenitor Cell Differentiation Posttranscriptional Regulation Of Gene Expression Chaperone-mediated Protein Complex Assembly DNA Ligation Regulation Of Translation In Response To Stress Nucleotide-excision Repair, DNA Gap Filling Cellular Response To Lithium Ion Protein Refolding Regulation Of Interferon-gamma-mediated Signaling Pathway Single Strand Break Repair Regulation Of Response To Interferon-gamma Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Catalytic Activity Isotype Switching Nitric Oxide Metabolic Process V(D)J Recombination DNA Strand Elongation Involved In DNA Replication Response To Lithium Ion Regulation Of Cellular Response To Heat Reactive Nitrogen Species Metabolic Process DNA Strand Elongation Response To X-ray Regulation Of Protein Kinase Activity Somatic Recombination Of Immunoglobulin Gene Segments Regulation Of Kinase Activity Somatic Diversification Of Immunoglobulins Regulation Of Nitric-oxide Synthase Activity Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response Regulation Of Immune Response B Cell Activation Involved In Immune Response Intracellular Protein Transport Intracellular Protein Transmembrane Transport Response To Gamma Radiation
Tagcloud ?		activates affects arginine coordinately depletion eukaryotic gcn2 hri indirectly inducible innate kinases mediate nitric nos oxide pathological perk phosphorylate physiological pkr synthase uniquely upstream