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LASP1 and ACD
Number of citations of the paper that reports this interaction (PubMedID
21044950
)
82
Data Source:
BioGRID
(two hybrid)
LASP1
ACD
Description
LIM and SH3 protein 1
ACD shelterin complex subunit and telomerase recruitment factor
Image
GO Annotations
Cellular Component
Cytoplasm
Cytoskeleton
Focal Adhesion
Cell Cortex
Cortical Actin Cytoskeleton
Postsynapse
Chromosome, Telomeric Region
Nuclear Telomere Cap Complex
Nucleus
Nucleoplasm
Chromosome
Telomerase Holoenzyme Complex
Nuclear Body
Shelterin Complex
Molecular Function
Actin Binding
Protein Binding
Monoatomic Ion Transmembrane Transporter Activity
Cadherin Binding
Metal Ion Binding
Actin Filament Binding
DNA Binding
Protein Binding
Telomerase Inhibitor Activity
Telomeric DNA Binding
Protein-containing Complex Binding
DNA Polymerase Binding
Biological Process
Monoatomic Ion Transport
Monoatomic Ion Transmembrane Transport
Telomere Maintenance
Skeletal System Development
Urogenital System Development
Intracellular Protein Transport
Telomere Maintenance Via Telomerase
Telomere Capping
Embryonic Limb Morphogenesis
Protection From Non-homologous End Joining At Telomere
Telomere Assembly
Positive Regulation Of Telomere Maintenance
Negative Regulation Of Telomere Maintenance Via Telomerase
Segmentation
Protein Localization To Chromosome, Telomeric Region
Establishment Of Protein Localization To Telomere
Regulation Of Establishment Of Protein Localization To Telomere
Pathways
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Telomere Extension By Telomerase
Polymerase switching on the C-strand of the telomere
Processive synthesis on the C-strand of the telomere
Telomere C-strand (Lagging Strand) Synthesis
Telomere C-strand synthesis initiation
Removal of the Flap Intermediate from the C-strand
DNA Damage/Telomere Stress Induced Senescence
Inhibition of DNA recombination at telomere
Drugs
Diseases
GWAS
Cognitive decline rate in late mild cognitive impairment (
26252872
)
Peginterferon alfa-2a treatment response in chronic hepatitis B infection (
30972912
)
Hemoglobin levels (
32327693
)
Refractive error (
32231278
)
Schizophrenia (
25056061
29483656
)
Interacting Genes
121 interacting genes:
ACD
ACTA1
ACTB
ACTC1
ACTMAP
ANKS1A
ARHGEF15
ARHGEF16
ARID5A
ATXN1
BAG4
BAHD1
BHLHE40
C14orf119
CAMK2A
CATSPER1
CDK7
CEBPA
CERCAM
CHERP
COPS5
CRK
CRYBA1
CRYBA2
CSTF2T
CTNNA3
CYSRT1
DAZAP2
DMRT3
DNMT1
DOK6
DRC4
DTX2
EHMT2
EVX2
FAM168A
FAM168B
FBXO17
FHL3
FOXH1
FXR2
GCM2
GOLGA2
GUCD1
HGS
HNRNPF
HOXA1
INTS11
KRTAP10-8
KRTAP12-4
KRTAP19-3
KRTAP19-4
KRTAP19-6
KRTAP26-1
KRTAP3-2
KRTAP3-3
KRTAP4-2
KRTAP6-2
LENG8
LMO4
LZTS2
MDFI
MED25
MGAT5B
MKRN3
NOXA1
NUTF2
OTX1
OXER1
PITX1
PLSCR1
POLD1
POT1
POU1F1
PRKAR2B
PRKG1
PRKG2
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
PRR35
PSMA3
QRICH1
RBFOX1
RBPMS
RBPMS2
REL
RHOXF2
RNF38
SAXO4
SEPTIN3
SPAG8
SPRY2
STAT3
TCF4
TEKT3
TEKT4
TEKT5
TERF1
TFG
THAP1
TINF2
TLX3
TNS2
TRIM27
TRIP13
UFSP1
UHRF1
VAC14
VEZF1
VGLL3
VPS37C
WWOX
YES1
YTHDF1
ZBTB9
ZC2HC1A
ZC3H10
ZYX
64 interacting genes:
ACTB
ADPRH
AFAP1L2
AIPL1
ANKMY2
ANXA8L1
APOBEC3F
BAG3
CKB
CTTN
DBN1
DBNL
DCX
DPYSL3
EIF3G
EIF4B
ENO2
ENSA
FAM131B
FBXW7
FKBP6
GAPDH
HSP90AB1
IPO5
IVL
LASP1
LDHA
LGALSL
LLGL1
LRRC25
NCDN
NTAQ1
NUDC
NUDCD2
PAGE2
PDLIM2
PEX5
PFKP
PGM2
POT1
RBKS
RECQL4
RGS3
RPSA
SBDS
STIP1
STUB1
SULT1C2
TAGLN
TBC1D10A
TBCD
TINF2
TOMM34
TRIM15
TRIM16
TRIM55
TRIM63
TUBB2A
TUBB4B
USP7
XRCC6
YWHAE
ZFP36L1
ZNF790
Entrez ID
3927
65057
HPRD ID
04229
12417
Ensembl ID
ENSG00000002834
ENSG00000102977
Uniprot IDs
B4DIC4
Q14847
A0A8Q3WM11
Q96AP0
PDB IDs
3I35
2I46
5H65
5I2X
5I2Y
5UN7
5XYF
7QXA
7QXB
7QXS
7S1T
7TRE
8SOJ
8SOK
Enriched GO Terms of Interacting Partners
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Identical Protein Binding
Protein Binding
Shelterin Complex
Regulation Of Nucleobase-containing Compound Metabolic Process
Intermediate Filament
Nuclear Telomere Cap Complex
Axonemal A Tubule Inner Sheath
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Telomere Capping
Telomere Assembly
Regulation Of RNA Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Sperm Flagellum
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Primary Metabolic Process
Positive Regulation Of Biosynthetic Process
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Telomere Maintenance Via Telomerase
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Positive Regulation Of RNA Metabolic Process
Flagellated Sperm Motility
Sperm Motility
Cilium-dependent Cell Motility
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Cilium Movement Involved In Cell Motility
Telomeric DNA Binding
Neuron Fate Specification
Regulation Of Macromolecule Metabolic Process
CGMP-dependent Protein Kinase Activity
Negative Regulation Of Telomere Maintenance Via Telomere Lengthening
Cytoplasmic Stress Granule
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Negative Regulation Of DNA Biosynthetic Process
Chromatin
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Gene Expression
Nucleus
DNA Binding
Positive Regulation Of Metabolic Process
Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation
Negative Regulation Of Telomere Maintenance
Regulation Of Metabolic Process
Cilium Movement
Negative Regulation Of Chromosome Organization
Regulation Of Telomere Maintenance Via Telomerase
Transcription Regulator Complex
Mesenchyme Migration
Cytoplasm
Cytosol
Cadherin Binding
Carbohydrate Catabolic Process
Nuclear Telomere Cap Complex
Protein Folding Chaperone Complex
Substantia Nigra Development
ADP Catabolic Process
Purine Ribonucleoside Diphosphate Catabolic Process
Glycolytic Process
Telomere Maintenance
Cellular Response To Heat
ADP Metabolic Process
Nicotinamide Nucleotide Metabolic Process
Nucleoside Diphosphate Catabolic Process
Monosaccharide Metabolic Process
Ribonucleoside Diphosphate Catabolic Process
Unfolded Protein Binding
Telomeric D-loop Binding
Telomere Assembly
Organelle Organization
Neural Nucleus Development
Pyruvate Metabolic Process
Glucose Metabolic Process
Telomere Organization
Protein Folding
Cortical Cytoskeleton
Glucose Catabolic Process
Telomeric DNA Binding
Protein Binding
Shelterin Complex
Ribonucleoside Diphosphate Metabolic Process
Purine Ribonucleotide Catabolic Process
Structural Constituent Of Postsynaptic Actin Cytoskeleton
Cytoskeleton Organization
Cytoskeleton
Microtubule Cytoskeleton Organization
Nucleoside Diphosphate Metabolic Process
Protein Stabilization
Chaperone-mediated Autophagy
Microtubule
Response To Heat
Purine Nucleotide Catabolic Process
Nitric-oxide Synthase Regulator Activity
TPR Domain Binding
Hexose Metabolic Process
Microtubule Cytoskeleton
Intercellular Bridge
Telomeric D-loop Disassembly
Hsp90 Protein Binding
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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