LASP1 and PRKG1

Number of citations of the paper that reports this interaction (PMID 12571245)
20

Data Source:
HPRD (in vivo, in vitro)

		LASP1	PRKG1
Gene Name		LIM and SH3 protein 1	protein kinase, cGMP-dependent, type I
Image
Gene Ontology Annotations	Cellular Component	Focal Adhesion Cortical Actin Cytoskeleton Extracellular Vesicular Exosome	Cytoplasm Golgi Apparatus Cytosol Plasma Membrane
	Molecular Function	SH3/SH2 Adaptor Activity Protein Binding Zinc Ion Binding Ion Transmembrane Transporter Activity Actin Filament Binding	CGMP-dependent Protein Kinase Activity Calcium Channel Regulator Activity Protein Binding ATP Binding CGMP Binding
	Biological Process	Ion Transport Positive Regulation Of Signal Transduction Ion Transmembrane Transport	Neuron Migration Protein Phosphorylation Signal Transduction Blood Coagulation Dendrite Development CGMP-mediated Signaling Actin Cytoskeleton Organization Forebrain Development Regulation Of GTPase Activity Relaxation Of Vascular Smooth Muscle Negative Regulation Of Platelet Aggregation
Pathways			Ca2+ pathway Signaling by Wnt beta-catenin independent WNT signaling
Drugs
Diseases
GWAS			Asthma ( 21907864) Obesity-related traits ( 23251661)
Protein-Protein Interactions		33 interactors: ACD ACTA1 ACTB ACTC1 ARHGEF15 ATXN1 CDK7 DAZAP2 FHL3 FXR2 GOLGA2 KRTAP4-2 LZTS2 MDFI PLSCR1 POT1 PRKAR2B PRKG1 PRKG2 PSMA3 REL RHOXF2 SEPT3 SPRY2 TCF4 TERF1 THAP1 TINF2 TRIM27 TRIP13 ZBTB9 ZC2HC1A ZYX	34 interactors: ANXA7 CFTR CREB1 CRIP2 FAM124A FHOD1 GABRR1 GKAP1 GTF2I HDAC1 ITPR1 LASP1 LMO2 MRVI1 NPR1 PDE5A PLCB3 PPP1R12A PPP1R12B PPP1R17 PRKCA RAF1 RGS2 RYR1 SELL SEPT3 SF1 SPP1 TBXA2R TNNT1 TRIM39-RPP21 TRPC3 VASP ZNF646
Entrez ID		3927	5592
HPRD ID		04229	08910
Ensembl ID		ENSG00000002834	ENSG00000185532
Uniprot IDs		B4DGQ0 B4DIC4 Q14847	Q13976
PDB IDs		3I35	1ZXA 3NMD 3OCP 3OD0 3OGJ
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Telomere Assembly Organelle Organization Cell Cycle Negative Regulation Of DNA Replication Negative Regulation Of Cellular Metabolic Process Regulation Of Telomerase Activity Cellular Component Assembly Telomere Maintenance Negative Regulation Of Transferase Activity Regulation Of Catalytic Activity Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Telomere Maintenance Via Telomere Lengthening Regulation Of Nitrogen Compound Metabolic Process Regulation Of DNA Replication Protein Localization To Chromosome, Telomeric Region Telomere Capping Positive Regulation Of Cellular Metabolic Process Regulation Of DNA Biosynthetic Process Regulation Of Cellular Process Cell Cycle Process Skeletal Muscle Thin Filament Assembly Positive Regulation Of Telomerase Activity Mitotic Cell Cycle Regulation Of Protein Metabolic Process Skeletal Myofibril Assembly Negative Regulation Of Cellular Protein Metabolic Process Cytoskeleton Organization Positive Regulation Of Transferase Activity Telomere Maintenance Via Telomerase Negative Regulation Of Telomerase Activity Positive Regulation Of Telomere Maintenance Actin Cytoskeleton Organization Negative Regulation Of Protein Metabolic Process Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Metabolic Process Response To Stress Regulation Of Chromosome Organization Actin Filament-based Process Positive Regulation Of Organelle Organization Blood Coagulation Mitotic Cell Cycle Process Hemostasis Chromosome Organization	Regulation Of Body Fluid Levels Hemostasis Regulation Of Muscle Contraction Blood Coagulation Negative Regulation Of Muscle Contraction Regulation Of Cardiac Muscle Hypertrophy Wound Healing Response To Wounding Cellular Response To Stimulus Response To Stimulus Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Cellular Process Response To Organic Substance Cellular Cation Homeostasis Cellular Ion Homeostasis Cellular Calcium Ion Homeostasis Relaxation Of Muscle Calcium Ion Homeostasis Regulation Of Blood Vessel Size Regulation Of Tube Size Blood Circulation Signal Transduction Cellular Chemical Homeostasis Regulation Of Phospholipase Activity Platelet Activation Ion Homeostasis Neurotrophin TRK Receptor Signaling Pathway Vasodilation Neurotrophin Signaling Pathway Cellular Metal Ion Homeostasis Signaling Cell Communication Muscle System Process Cellular Homeostasis Metal Ion Homeostasis Relaxation Of Vascular Smooth Muscle Activation Of Phospholipase C Activity Positive Regulation Of Metabolic Process Regulation Of Smooth Muscle Contraction Relaxation Of Smooth Muscle Positive Regulation Of Phospholipase C Activity Regulation Of Ion Homeostasis Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Purine-containing Compound Cytosolic Calcium Ion Homeostasis Chemical Homeostasis Cellular Response To Fibroblast Growth Factor Stimulus Relaxation Of Cardiac Muscle
Tagcloud ?		already axis colonization correlates cytoskeletal deaths distant effectors epithelia hnscc inhibits integrated metastasis metastatic mir mirna multilayered neck nuak1 organs postextravasation prometastatic reactivation reconstitution remodeling sparc suppressing triggers underpins	1n9c acsl3 agpat3 bovinesnp50 bta1 c10 c12 c14 c18 chuk dgat1 echs1 ehhadh groundwork htr1b lipj lipk minpp1 mogat1 nfkb2 osbpl8 oxct1 plink scd1 sfa sorbs1 ufa underling unraveling
Tagcloud (Difference) ?		already axis colonization correlates cytoskeletal deaths distant effectors epithelia hnscc inhibits integrated metastasis metastatic mir mirna multilayered neck nuak1 organs postextravasation prometastatic reactivation reconstitution remodeling sparc suppressing triggers underpins	1n9c acsl3 agpat3 bovinesnp50 bta1 c10 c12 c14 c18 chuk dgat1 echs1 ehhadh groundwork htr1b lipj lipk minpp1 mogat1 nfkb2 osbpl8 oxct1 plink scd1 sfa sorbs1 ufa underling unraveling
Tagcloud (Intersection) ?