LASP1 and ZC3H10

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LASP1	ZC3H10
Description		LIM and SH3 protein 1	zinc finger CCCH-type containing 10
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Focal Adhesion Cell Cortex Cortical Actin Cytoskeleton Postsynapse	Nucleus
	Molecular Function	Actin Binding Protein Binding Monoatomic Ion Transmembrane Transporter Activity Cadherin Binding Metal Ion Binding Actin Filament Binding	RNA Binding Protein Binding Zinc Ion Binding MiRNA Binding Metal Ion Binding
	Biological Process	Monoatomic Ion Transport Monoatomic Ion Transmembrane Transport	Post-transcriptional Regulation Of Gene Expression Regulation Of RNA Splicing Negative Regulation Of MiRNA Processing
Pathways
Drugs
Diseases
GWAS		Cognitive decline rate in late mild cognitive impairment ( 26252872) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Anorexia nervosa ( 28494655) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011)
Interacting Genes		121 interacting genes: ACD ACTA1 ACTB ACTC1 ACTMAP ANKS1A ARHGEF15 ARHGEF16 ARID5A ATXN1 BAG4 BAHD1 BHLHE40 C14orf119 CAMK2A CATSPER1 CDK7 CEBPA CERCAM CHERP COPS5 CRK CRYBA1 CRYBA2 CSTF2T CTNNA3 CYSRT1 DAZAP2 DMRT3 DNMT1 DOK6 DRC4 DTX2 EHMT2 EVX2 FAM168A FAM168B FBXO17 FHL3 FOXH1 FXR2 GCM2 GOLGA2 GUCD1 HGS HNRNPF HOXA1 INTS11 KRTAP10-8 KRTAP12-4 KRTAP19-3 KRTAP19-4 KRTAP19-6 KRTAP26-1 KRTAP3-2 KRTAP3-3 KRTAP4-2 KRTAP6-2 LENG8 LMO4 LZTS2 MDFI MED25 MGAT5B MKRN3 NOXA1 NUTF2 OTX1 OXER1 PITX1 PLSCR1 POLD1 POT1 POU1F1 PRKAR2B PRKG1 PRKG2 PRR20A PRR20B PRR20C PRR20D PRR20E PRR35 PSMA3 QRICH1 RBFOX1 RBPMS RBPMS2 REL RHOXF2 RNF38 SAXO4 SEPTIN3 SPAG8 SPRY2 STAT3 TCF4 TEKT3 TEKT4 TEKT5 TERF1 TFG THAP1 TINF2 TLX3 TNS2 TRIM27 TRIP13 UFSP1 UHRF1 VAC14 VEZF1 VGLL3 VPS37C WWOX YES1 YTHDF1 ZBTB9 ZC2HC1A ZC3H10 ZYX	52 interacting genes: ACTMAP ALG13 AOC1 APPBP2 ARID5A ATXN1 BOLL C10orf55 CRX DAB1 DAZAP2 DMRTB1 ESRP1 FAM168B FOSB FOXH1 HIVEP1 INTS11 KLHDC7B KRTAP19-1 KRTAP6-1 KRTAP6-2 KRTAP8-1 LASP1 MIR143 MSX2 NCS1 NFYA OTX2 OXER1 PIAS2 PICALM PLA2G10 POU2F1 PRR20A PRR20B PRR20C PRR20D PRR20E QKI RBFOX2 RBM38 RBPMS RBPMS2 RNF4 SNRPA SPMIP9 STAM2 TENT5A TENT5B UBE2I ZNF34
Entrez ID		3927	84872
HPRD ID		04229	07860
Ensembl ID		ENSG00000002834	ENSG00000135482
Uniprot IDs		B4DIC4 Q14847	Q96K80
PDB IDs		3I35
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Protein Binding Shelterin Complex Regulation Of Nucleobase-containing Compound Metabolic Process Intermediate Filament Nuclear Telomere Cap Complex Axonemal A Tubule Inner Sheath Positive Regulation Of Nucleobase-containing Compound Metabolic Process Telomere Capping Telomere Assembly Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Sperm Flagellum Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Flagellated Sperm Motility Sperm Motility Cilium-dependent Cell Motility Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Cilium Movement Involved In Cell Motility Telomeric DNA Binding Neuron Fate Specification Regulation Of Macromolecule Metabolic Process CGMP-dependent Protein Kinase Activity Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Cytoplasmic Stress Granule DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of DNA Biosynthetic Process Chromatin Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Nucleus DNA Binding Positive Regulation Of Metabolic Process Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Negative Regulation Of Telomere Maintenance Regulation Of Metabolic Process Cilium Movement Negative Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Via Telomerase Transcription Regulator Complex Mesenchyme Migration	Regulation Of RNA Metabolic Process Regulation Of MRNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Stabilization Negative Regulation Of RNA Metabolic Process Negative Regulation Of MRNA Catabolic Process RNA Stabilization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Catabolic Process Regulation Of Gene Expression Negative Regulation Of MRNA Metabolic Process Regulation Of RNA Splicing Regulation Of Macromolecule Biosynthetic Process Regulation Of MRNA Stability Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process MRNA 3'-UTR Binding Regulation Of RNA Stability Regulation Of Primary Metabolic Process MRNA Binding Cytoplasmic Stress Granule Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process DNA Binding Negative Regulation Of Macromolecule Metabolic Process Nucleic Acid Binding Regulation Of MRNA Splicing, Via Spliceosome Poly(A) RNA Polymerase Activity Positive Regulation Of Biosynthetic Process Regulation Of MRNA Processing Positive Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Androgen Receptor Signaling Pathway Regulation Of Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Negative Regulation Of DNA-templated Transcription Intermediate Filament Regulation Of Metabolic Process Negative Regulation Of RNA Biosynthetic Process RNA Binding Transcription Factor Binding SUMO Transferase Activity 3'-UTR-mediated MRNA Stabilization
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