LASP1 and KRTAP19-6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LASP1	KRTAP19-6
Description		LIM and SH3 protein 1	keratin associated protein 19-6
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Focal Adhesion Cell Cortex Cortical Actin Cytoskeleton Postsynapse	Cytosol Intermediate Filament
	Molecular Function	Actin Binding Protein Binding Monoatomic Ion Transmembrane Transporter Activity Cadherin Binding Metal Ion Binding Actin Filament Binding	Protein Binding
	Biological Process	Monoatomic Ion Transport Monoatomic Ion Transmembrane Transport
Pathways			Keratinization
Drugs
Diseases
GWAS		Cognitive decline rate in late mild cognitive impairment ( 26252872) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912)
Interacting Genes		121 interacting genes: ACD ACTA1 ACTB ACTC1 ACTMAP ANKS1A ARHGEF15 ARHGEF16 ARID5A ATXN1 BAG4 BAHD1 BHLHE40 C14orf119 CAMK2A CATSPER1 CDK7 CEBPA CERCAM CHERP COPS5 CRK CRYBA1 CRYBA2 CSTF2T CTNNA3 CYSRT1 DAZAP2 DMRT3 DNMT1 DOK6 DRC4 DTX2 EHMT2 EVX2 FAM168A FAM168B FBXO17 FHL3 FOXH1 FXR2 GCM2 GOLGA2 GUCD1 HGS HNRNPF HOXA1 INTS11 KRTAP10-8 KRTAP12-4 KRTAP19-3 KRTAP19-4 KRTAP19-6 KRTAP26-1 KRTAP3-2 KRTAP3-3 KRTAP4-2 KRTAP6-2 LENG8 LMO4 LZTS2 MDFI MED25 MGAT5B MKRN3 NOXA1 NUTF2 OTX1 OXER1 PITX1 PLSCR1 POLD1 POT1 POU1F1 PRKAR2B PRKG1 PRKG2 PRR20A PRR20B PRR20C PRR20D PRR20E PRR35 PSMA3 QRICH1 RBFOX1 RBPMS RBPMS2 REL RHOXF2 RNF38 SAXO4 SEPTIN3 SPAG8 SPRY2 STAT3 TCF4 TEKT3 TEKT4 TEKT5 TERF1 TFG THAP1 TINF2 TLX3 TNS2 TRIM27 TRIP13 UFSP1 UHRF1 VAC14 VEZF1 VGLL3 VPS37C WWOX YES1 YTHDF1 ZBTB9 ZC2HC1A ZC3H10 ZYX	69 interacting genes: ATOSB ATPAF2 BCAS2 C11orf16 CATSPER1 CCDC24 CCNK CERK CIMIP1 CREB5 CRY2 CSKMT CYSRT1 DMRTB1 DTX2 ENKD1 FANCL FNDC11 FOXH1 GPANK1 GUCD1 HOXA1 HSF4 INCA1 KIFC3 KPRP KRTAP12-4 KRTAP26-1 KRTAP6-3 KRTAP9-3 LASP1 LONRF1 MEIS2 MGAT5B MKRN3 MYOZ3 MYPOP NOC4L NTAQ1 OIP5 OTX1 PATZ1 PLAC8 PLEKHN1 PLSCR3 PLSCR4 POU4F2 PROP1 PSMB2 RBPMS2 RHOXF2 RUNX1T1 SAXO4 SLC25A18 SMN1 SMN2 SNRPB SNRPC SPAG8 SPMIP6 TEKT4 TEKT5 TENT5B TFAP2D TSPYL6 VENTX VGLL3 VPS37C ZNF414
Entrez ID		3927	337973
HPRD ID		04229	11210
Ensembl ID		ENSG00000002834	ENSG00000186925
Uniprot IDs		B4DIC4 Q14847	A4FU57 Q3LI70
PDB IDs		3I35
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Protein Binding Shelterin Complex Regulation Of Nucleobase-containing Compound Metabolic Process Intermediate Filament Nuclear Telomere Cap Complex Axonemal A Tubule Inner Sheath Positive Regulation Of Nucleobase-containing Compound Metabolic Process Telomere Capping Telomere Assembly Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Sperm Flagellum Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Flagellated Sperm Motility Sperm Motility Cilium-dependent Cell Motility Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Cilium Movement Involved In Cell Motility Telomeric DNA Binding Neuron Fate Specification Regulation Of Macromolecule Metabolic Process CGMP-dependent Protein Kinase Activity Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Cytoplasmic Stress Granule DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of DNA Biosynthetic Process Chromatin Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Nucleus DNA Binding Positive Regulation Of Metabolic Process Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Negative Regulation Of Telomere Maintenance Regulation Of Metabolic Process Cilium Movement Negative Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Via Telomerase Transcription Regulator Complex Mesenchyme Migration	Axonemal A Tubule Inner Sheath Protein Binding Sperm Flagellum Sperm Motility Flagellated Sperm Motility Cilium-dependent Cell Motility Cilium Movement Involved In Cell Motility Chromatin Spliceosomal SnRNP Assembly SMN-Sm Protein Complex Nucleus Cilium Movement Cajal Body Motile Cilium DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cilium SMN Complex Spliceosomal Complex Assembly
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