KRT1 and SGTB

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KRT1	SGTB
Description		keratin 1	small glutamine rich tetratricopeptide repeat co-chaperone beta
Image			No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Membrane Keratin Filament Extracellular Exosome Blood Microparticle Ficolin-1-rich Granule Lumen	Membrane TRC Complex
	Molecular Function	Protein Binding Carbohydrate Binding Structural Constituent Of Skin Epidermis Signaling Receptor Activity Protein Heterodimerization Activity	Protein Binding Hsp70 Protein Binding Identical Protein Binding Protein-folding Chaperone Binding Molecular Adaptor Activity
	Biological Process	Complement Activation, Lectin Pathway Response To Oxidative Stress Peptide Cross-linking Keratinization Fibrinolysis Intermediate Filament Organization Regulation Of Angiogenesis Negative Regulation Of Inflammatory Response Protein Heterotetramerization Establishment Of Skin Barrier	Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Protein Homooligomerization Protein Heterooligomerization
Pathways		Neutrophil degranulation Keratinization Formation of the cornified envelope Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
Drugs		Zinc Copper Zinc acetate
Diseases		Ichthyosis hystrix, Curth-Macklin type Epidermolytic palmoplantar keratoderma (EPPK) Striate palmoplantar keratoderma Epidermolytic hyperkeratosis (EHK); Bullous congenital ichthyosiform erythroderma (BCIE)
GWAS			Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Intralaminar thalamic nuclei volume ( 34006833) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		54 interacting genes: - AMOTL2 CALB2 CSTA DSP EVPL F12 FANCA FANCC FFAR2 GOLGA2 GOLGA6L9 HAUS1 HMG20A HOOK2 IVL KNG1 KRT13 KRT14 KRT15 KRT16 KRT19 KRT24 KRT25 KRT26 KRT27 KRT28 KRT31 KRT33B KRT34 KRT35 KRT36 KRT37 KRT38 KRT39 KRT40 KRT5 LINC00839 LORICRIN MBL2 NINL NUP62 OGT PI3 PRKCE RINT1 RNF26 SGTB TFIP11 TLCD4 TRIM54 U2AF1 UBE3A YWHAQ	116 interacting genes: ABCG4 ADAT2 ADIPOQ AGR2 AGR3 ASPH BTC C1QA C1QL4 C1QTNF5 C1QTNF6 C5orf46 CALR CCL3L3 CD200R1 CD3D CD68 CD79B CD99L2 CDH15 CDSN CMPK1 COL10A1 COL1A2 COLQ COMP CREB3L3 CSH1 CSH2 CTAG1A CTAG1B CYB5R1 DEFA6 DEXI DMKN ECM1 EFEMP2 EMCN ERP29 ETNK1 EVA1A FBN1 FGF21 FZD7 GALNT11 GGH GIP GPX7 GYPA HSP90B1 HSPA13 IL6R IL6ST ITPRIP ITPRIPL1 KCNE5 KRT1 LAMP3 LAT LCN2 LHB LMO2 MYDGF NAXD NME3 OSMR PAGE3 PDIA6 PGRMC1 PODXL PPIB PPIC PRAP1 PRB1 PRB3 PRB4 PRR4 PSORS1C2 RAI2 RCN1 RNASE10 RNF144A RNF144B RNF170 SDC4 SDF2L1 SELENOM SERPINE1 SERPINF1 SERPINI2 SGCA SGTA SHISA5 SIL1 SLPI SOD3 SPINK4 SPP1 SRGN SYT11 SYT4 TFF1 TMEM108 TMEM123 TMPO TMUB1 TNFRSF19 TNFSF13 TXNDC12 UBL4A UPK3A VEGFC VWC2 WFDC12 ZG16 ZG16B
Entrez ID		3848	54557
HPRD ID		00763	18049
Ensembl ID		ENSG00000167768	ENSG00000197860
Uniprot IDs		P04264	Q96EQ0
PDB IDs		4ZRY 6E2J 6UUI
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament Structural Molecule Activity Epithelial Cell Differentiation Cytoskeleton Organization Supramolecular Fiber Organization Morphogenesis Of An Epithelium Tissue Morphogenesis Cytoskeleton Organelle Organization Cornified Envelope Peptide Cross-linking Structural Constituent Of Cytoskeleton Anatomical Structure Morphogenesis Cell Differentiation Keratinocyte Differentiation Extracellular Exosome Cellular Developmental Process Epidermis Development Cytosol Epidermal Cell Differentiation Keratinization Hair Cycle Developmental Process Centrosome Cycle Intermediate Filament Cytoskeleton Hair Follicle Morphogenesis Microtubule Organizing Center Organization Protein Localization To Perinuclear Region Of Cytoplasm Tissue Development Cell Surface Pattern Recognition Receptor Signaling Pathway Fanconi Anaemia Nuclear Complex	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Protein Binding Collagen Trimer Endoplasmic Reticulum Chaperone Complex Endoplasmic Reticulum Extracellular Matrix Protein Folding Smooth Endoplasmic Reticulum Extracellular Matrix Structural Constituent Serine-type Endopeptidase Inhibitor Activity Sarcoplasmic Reticulum Lumen Extracellular Exosome Interleukin-6 Binding Interleukin-6 Receptor Activity Oncostatin-M Receptor Complex Melanosome Response To Bacterium Hormone Activity Interleukin-6 Receptor Complex Ciliary Neurotrophic Factor Receptor Complex Oncostatin-M Receptor Activity Positive Regulation Of Transport Memory Response To Endoplasmic Reticulum Stress Defense Response To Bacterium Ciliary Neurotrophic Factor Receptor Activity Interleukin-11 Receptor Activity Interleukin-11 Binding Oncostatin-M-mediated Signaling Pathway Regulation Of Smooth Muscle Cell-matrix Adhesion Regulation Of Immune System Process Sequestering Of Calcium Ion Biomineral Tissue Development Basement Membrane Ciliary Neurotrophic Factor-mediated Signaling Pathway ERAD Pathway Growth Factor Activity Golgi Lumen Positive Regulation Of Acute Inflammatory Response Ciliary Neurotrophic Factor Receptor Binding Response To Stress Regulation Of Cell-substrate Adhesion
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