KRT1 and CSTA

Number of citations of the paper that reports this interaction (PubMedID 8999895)
0

Data Source:
BioGRID (pull down)

		KRT1	CSTA
Description		keratin 1	cystatin A
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GO Annotations	Cellular Component	Cornified Envelope Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Membrane Keratin Filament Extracellular Exosome Blood Microparticle Ficolin-1-rich Granule Lumen	Cornified Envelope Extracellular Space Nucleoplasm Cytoplasm Cytosol Peptidase Inhibitor Complex
	Molecular Function	Protein Binding Carbohydrate Binding Structural Constituent Of Skin Epidermis Signaling Receptor Activity Protein Heterodimerization Activity	Protease Binding Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity
	Biological Process	Complement Activation, Lectin Pathway Response To Oxidative Stress Peptide Cross-linking Keratinization Fibrinolysis Intermediate Filament Organization Regulation Of Angiogenesis Negative Regulation Of Inflammatory Response Protein Heterotetramerization Establishment Of Skin Barrier	Cell Adhesion Peptide Cross-linking Keratinocyte Differentiation Negative Regulation Of Proteolysis Cell-cell Adhesion
Pathways		Neutrophil degranulation Keratinization Formation of the cornified envelope Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	Formation of the cornified envelope
Drugs		Zinc Copper Zinc acetate
Diseases		Ichthyosis hystrix, Curth-Macklin type Epidermolytic palmoplantar keratoderma (EPPK) Striate palmoplantar keratoderma Epidermolytic hyperkeratosis (EHK); Bullous congenital ichthyosiform erythroderma (BCIE)
GWAS			Apolipoprotein B levels ( 32203549) Calcium levels ( 20705733 25972035 29403010)
Interacting Genes		54 interacting genes: - AMOTL2 CALB2 CSTA DSP EVPL F12 FANCA FANCC FFAR2 GOLGA2 GOLGA6L9 HAUS1 HMG20A HOOK2 IVL KNG1 KRT13 KRT14 KRT15 KRT16 KRT19 KRT24 KRT25 KRT26 KRT27 KRT28 KRT31 KRT33B KRT34 KRT35 KRT36 KRT37 KRT38 KRT39 KRT40 KRT5 LINC00839 LORICRIN MBL2 NINL NUP62 OGT PI3 PRKCE RINT1 RNF26 SGTB TFIP11 TLCD4 TRIM54 U2AF1 UBE3A YWHAQ	12 interacting genes: CTSB CTSH CTSL EVPL IVL KRT1 LORICRIN PI3 PTN SLC26A4-AS1 UCHL5 ZDHHC17
Entrez ID		3848	1475
HPRD ID		00763	01697
Ensembl ID		ENSG00000167768	ENSG00000121552
Uniprot IDs		P04264	P01040
PDB IDs		4ZRY 6E2J 6UUI	1CYU 1CYV 1DVC 1DVD 1GD3 1GD4 1N9J 1NB3 1NB5 3K9M 3KFQ 3KSE 8GT0 8GT7
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament Structural Molecule Activity Epithelial Cell Differentiation Cytoskeleton Organization Supramolecular Fiber Organization Morphogenesis Of An Epithelium Tissue Morphogenesis Cytoskeleton Organelle Organization Cornified Envelope Peptide Cross-linking Structural Constituent Of Cytoskeleton Anatomical Structure Morphogenesis Cell Differentiation Keratinocyte Differentiation Extracellular Exosome Cellular Developmental Process Epidermis Development Cytosol Epidermal Cell Differentiation Keratinization Hair Cycle Developmental Process Centrosome Cycle Intermediate Filament Cytoskeleton Hair Follicle Morphogenesis Microtubule Organizing Center Organization Protein Localization To Perinuclear Region Of Cytoplasm Tissue Development Cell Surface Pattern Recognition Receptor Signaling Pathway Fanconi Anaemia Nuclear Complex	Peptide Cross-linking Cornified Envelope Cellular Response To Thyroid Hormone Stimulus Keratinization Response To Thyroid Hormone Cysteine-type Peptidase Activity Protein Metabolic Process Endolysosome Lumen Structural Constituent Of Skin Epidermis Cysteine-type Endopeptidase Activity Keratinocyte Differentiation Proteoglycan Binding Epidermal Cell Differentiation Protein Modification Process Symbiont Entry Into Host Cell Ficolin-1-rich Granule Lumen Decidualization Epithelial Cell Differentiation Biological Process Involved In Interaction With Host Extracellular Matrix Peptidase Activity Extracellular Exosome Collagen Catabolic Process Macromolecule Metabolic Process Extracellular Space Zymogen Activation Endopeptidase Inhibitor Activity Developmental Process HLA-A Specific Activating MHC Class I Receptor Activity Serpin Family Protein Binding Fusion Of Virus Membrane With Host Endosome Membrane Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Perforant Pathway To Dendrate Granule Cell Synapse Collagen Binding Collagen Metabolic Process Immune Response Adaptive Immune Response Immune System Process Proteolysis Involved In Protein Catabolic Process Kininogen Binding Enkephalin Processing Copulation Dendrite Regeneration Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Tissue Development Positive Regulation Of Lymphotoxin A Production Endopeptidase Activity Cellular Response To Hormone Stimulus Response To Odorant
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