KRT1 and CSTA

Number of citations of the paper that reports this interaction (PMID 8999895)
22

Data Source:
BioGRID (pull down)

		KRT1	CSTA
Gene Name		keratin 1, type II	cystatin A (stefin A)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Cytoskeleton Plasma Membrane Membrane Extracellular Matrix Keratin Filament Extracellular Vesicular Exosome Blood Microparticle	Cornified Envelope Extracellular Space Nucleus Nucleoplasm Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Receptor Activity Structural Molecule Activity Protein Binding Carbohydrate Binding	Protease Binding Cysteine-type Endopeptidase Inhibitor Activity Structural Molecule Activity Protein Binding, Bridging
	Biological Process	Complement Activation, Lectin Pathway Retina Homeostasis Response To Oxidative Stress Fibrinolysis Regulation Of Angiogenesis Negative Regulation Of Inflammatory Response Establishment Of Skin Barrier	Negative Regulation Of Peptidase Activity Negative Regulation Of Endopeptidase Activity Single Organismal Cell-cell Adhesion Peptide Cross-linking Keratinocyte Differentiation Negative Regulation Of Proteolysis
Pathways
Drugs
Diseases
GWAS			Calcium levels ( 20705733)
Protein-Protein Interactions		15 interactors: CALB2 CSTA DSP EVPL F12 FANCA FANCC IVL KNG1 KRT5 LOR MBL2 PI3 PRKCE YWHAQ	12 interactors: CTSB CTSH CTSL DSP EVPL IVL KRT1 LOR PI3 PTN UCHL5 ZDHHC17
Entrez ID		3848	1475
HPRD ID		00763	01697
Ensembl ID		ENSG00000167768	ENSG00000121552
Uniprot IDs		P04264	P01040 Q6IB90
PDB IDs			1CYU 1CYV 1DVC 1DVD 1GD3 1GD4 1N9J 1NB3 1NB5 3K9M 3KFQ 3KSE
Enriched GO Terms of Interacting Partners?		Peptide Cross-linking Keratinocyte Differentiation Epidermis Development Epidermal Cell Differentiation Skin Development Keratinization Epithelial Cell Differentiation Epithelium Development Blood Coagulation, Intrinsic Pathway Regulation Of Wound Healing Regulation Of Protein Processing Protein Activation Cascade Cytosolic Calcium Ion Homeostasis Tissue Development Positive Regulation Of Wound Healing Wound Healing Negative Regulation Of Endopeptidase Activity Negative Regulation Of Blood Coagulation Negative Regulation Of Peptidase Activity Negative Regulation Of Coagulation Positive Regulation Of Cellular Glucuronidation Response To Wounding Cellular Calcium Ion Homeostasis Negative Regulation Of Wound Healing Calcium Ion Homeostasis Positive Regulation Of Transport Anatomical Structure Development Acute Inflammatory Response Organ Development Negative Regulation Of Proteolysis Ventricular Compact Myocardium Morphogenesis Factor XII Activation TRAM-dependent Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Regulation Of Blood Coagulation Negative Regulation Of Hydrolase Activity Cellular Metal Ion Homeostasis Regulation Of Peptidase Activity Blood Coagulation Inflammatory Response Developmental Process Hemostasis Protein Metabolic Process Cellular Cation Homeostasis Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Protein Localization To Adherens Junction Positive Regulation Of Fibrinolysis Cellular Ion Homeostasis Response To Stress	Peptide Cross-linking Cellular Response To Thyroid Hormone Stimulus Response To Thyroid Hormone Skin Development Keratinocyte Differentiation Epidermal Cell Differentiation Organ Development Keratinization Epithelial Cell Differentiation Tissue Development Epithelium Development Epidermis Development Protein Metabolic Process System Development Multicellular Organismal Development Anatomical Structure Development Developmental Process Cellular Protein Metabolic Process Collagen Catabolic Process Regulation Of Immune Response Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Regulation Of Endopeptidase Activity Multicellular Organismal Metabolic Process Regulation Of Peptidase Activity Extracellular Matrix Disassembly Ventricular Compact Myocardium Morphogenesis Neuropeptide Catabolic Process Macrophage Apoptotic Process Toll-like Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Protein Localization To Adherens Junction Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Proteolysis Involved In Cellular Protein Catabolic Process Activation Of Innate Immune Response Cellular Protein Catabolic Process Cellular Protein Modification Process Cellular Response To Hormone Stimulus Bradykinin Catabolic Process Immune Response Regulation Of Immune System Process Protein Catabolic Process Positive Regulation Of Immune Response Tissue Homeostasis Positive Regulation Of Innate Immune Response Myeloid Cell Apoptotic Process Complement Activation, Lectin Pathway
Tagcloud ?		arose backcrosses bareskin bsk chr clustered corneal den denuded facility granulin grn hair intersubspecific junctional jup keratin kinds linkage mapped opacity plakoglobin portion rara recombination resembling rex rim3 spontaneously	abcc3 abcc5 amphiregulin areg ccna2 ctsd cycloheximide dissimilar dleu2 efna1 estrogens hydroxytamoxifen ici igfbp4 irs1 mini mmp15 mvln pcna permit regulations reinforced rtq secondly tacc1 tam tff1 ugt1a1 znf217
Tagcloud (Difference) ?		arose backcrosses bareskin bsk chr clustered corneal den denuded facility granulin grn hair intersubspecific junctional jup keratin kinds linkage mapped opacity plakoglobin portion rara recombination resembling rex rim3 spontaneously	abcc3 abcc5 amphiregulin areg ccna2 ctsd cycloheximide dissimilar dleu2 efna1 estrogens hydroxytamoxifen ici igfbp4 irs1 mini mmp15 mvln pcna permit regulations reinforced rtq secondly tacc1 tam tff1 ugt1a1 znf217
Tagcloud (Intersection) ?