KRT1 and DSP

Number of citations of the paper that reports this interaction (PMID 9261168)
30

Data Source:
HPRD (two hybrid, in vitro)

		KRT1	DSP
Gene Name		keratin 1, type II	desmoplakin
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Cytoskeleton Plasma Membrane Membrane Extracellular Matrix Keratin Filament Extracellular Vesicular Exosome Blood Microparticle	Cornified Envelope Nucleus Mitochondrion Intermediate Filament Plasma Membrane Fascia Adherens Intercalated Disc Basolateral Plasma Membrane Desmosome Extracellular Vesicular Exosome
	Molecular Function	Receptor Activity Structural Molecule Activity Protein Binding Carbohydrate Binding	Protein Kinase C Binding Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Protein Binding, Bridging Poly(A) RNA Binding Cell Adhesion Molecule Binding Scaffold Protein Binding
	Biological Process	Complement Activation, Lectin Pathway Retina Homeostasis Response To Oxidative Stress Fibrinolysis Regulation Of Angiogenesis Negative Regulation Of Inflammatory Response Establishment Of Skin Barrier	Desmosome Organization Ventricular Compact Myocardium Morphogenesis Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Epidermis Development Single Organismal Cell-cell Adhesion Peptide Cross-linking Keratinocyte Differentiation Adherens Junction Organization Wound Healing Intermediate Filament Organization Protein Localization To Adherens Junction Ventricular Cardiac Muscle Cell Action Potential Bundle Of His Cell To Purkinje Myocyte Communication Regulation Of Heart Rate By Cardiac Conduction
Pathways			Apoptotic cleavage of cell adhesion proteins Apoptotic cleavage of cellular proteins Programmed Cell Death Apoptotic execution phase
Drugs
Diseases
GWAS			Interstitial lung disease ( 23583980)
Protein-Protein Interactions		15 interactors: CALB2 CSTA DSP EVPL F12 FANCA FANCC IVL KNG1 KRT5 LOR MBL2 PI3 PRKCE YWHAQ	28 interactors: ARID3A CASP10 CASP2 CASP4 CASP6 CASP7 CASP9 CDH5 COL17A1 CSTA DES DSC1 EVPL IVL JUP KRT1 KRT5 KRT6A PECAM1 PKP1 PKP2 PKP3 PKP4 PRKACA PRKCE PSEN1 UCHL5 VIM
Entrez ID		3848	1832
HPRD ID		00763	00513
Ensembl ID		ENSG00000167768	ENSG00000096696
Uniprot IDs		P04264	D7RX09 P15924
PDB IDs			1LM5 1LM7 3R6N
Enriched GO Terms of Interacting Partners?		Peptide Cross-linking Keratinocyte Differentiation Epidermis Development Epidermal Cell Differentiation Skin Development Keratinization Epithelial Cell Differentiation Epithelium Development Blood Coagulation, Intrinsic Pathway Regulation Of Wound Healing Regulation Of Protein Processing Protein Activation Cascade Cytosolic Calcium Ion Homeostasis Tissue Development Positive Regulation Of Wound Healing Wound Healing Negative Regulation Of Endopeptidase Activity Negative Regulation Of Blood Coagulation Negative Regulation Of Peptidase Activity Negative Regulation Of Coagulation Positive Regulation Of Cellular Glucuronidation Response To Wounding Cellular Calcium Ion Homeostasis Negative Regulation Of Wound Healing Calcium Ion Homeostasis Positive Regulation Of Transport Anatomical Structure Development Acute Inflammatory Response Organ Development Negative Regulation Of Proteolysis Ventricular Compact Myocardium Morphogenesis Factor XII Activation TRAM-dependent Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Regulation Of Blood Coagulation Negative Regulation Of Hydrolase Activity Cellular Metal Ion Homeostasis Regulation Of Peptidase Activity Blood Coagulation Inflammatory Response Developmental Process Hemostasis Protein Metabolic Process Cellular Cation Homeostasis Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Protein Localization To Adherens Junction Positive Regulation Of Fibrinolysis Cellular Ion Homeostasis Response To Stress	Desmosome Assembly Cell Junction Assembly Desmosome Organization Cell Adhesion Execution Phase Of Apoptosis Apoptotic Process Programmed Cell Death Cell Death Death Epithelium Development Tissue Development Developmental Process Anatomical Structure Development Cell-cell Junction Organization Skin Development Cell-cell Junction Assembly Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Intermediate Filament Organization Single Organismal Cell-cell Adhesion Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Proteolysis Organ Development Epidermis Development Multicellular Organismal Development System Development Intermediate Filament Cytoskeleton Organization Intermediate Filament Bundle Assembly Intermediate Filament-based Process Cardiac Conduction Peptide Cross-linking Cellular Component Assembly Bundle Of His Cell To Purkinje Myocyte Communication Regulation Of Heart Contraction Apoptotic Signaling Pathway Regulation Of Tight Junction Assembly Intrinsic Apoptotic Signaling Pathway Regulation Of Endopeptidase Activity Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Regulation Of Peptidase Activity Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Hemidesmosome Assembly Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Cell Cycle Process Signaling Neurotrophin Signaling Pathway Cell Communication By Electrical Coupling
Tagcloud ?		arose backcrosses bareskin bsk chr clustered corneal den denuded facility granulin grn hair intersubspecific junctional jup keratin kinds linkage mapped opacity plakoglobin portion rara recombination resembling rex rim3 spontaneously	aspirated cam5 cleaner dsus gcdfp ham56 hmb45 ipx k903 l26 mac387 mcea mcead14 nonneoplastic opd papanicolaou pcea plap processor scant scraped semiquantitatively slides thinprep tlp tlus tpp uchl unstained
Tagcloud (Difference) ?		arose backcrosses bareskin bsk chr clustered corneal den denuded facility granulin grn hair intersubspecific junctional jup keratin kinds linkage mapped opacity plakoglobin portion rara recombination resembling rex rim3 spontaneously	aspirated cam5 cleaner dsus gcdfp ham56 hmb45 ipx k903 l26 mac387 mcea mcead14 nonneoplastic opd papanicolaou pcea plap processor scant scraped semiquantitatively slides thinprep tlp tlus tpp uchl unstained
Tagcloud (Intersection) ?