KRT1 and DSP

Number of citations of the paper that reports this interaction (PubMedID 9261168)
0

Data Source:
HPRD (in vitro, two hybrid)

		KRT1	DSP
Description		keratin 1	desmoplakin
Image
GO Annotations	Cellular Component	Cornified Envelope Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Membrane Keratin Filament Extracellular Exosome Blood Microparticle Ficolin-1-rich Granule Lumen	Cornified Envelope Nucleus Cytoplasm Cytoskeleton Intermediate Filament Plasma Membrane Cell-cell Junction Adherens Junction Fascia Adherens Intercalated Disc Membrane Basolateral Plasma Membrane Desmosome Extracellular Exosome Anchoring Junction Ficolin-1-rich Granule Membrane
	Molecular Function	Protein Binding Carbohydrate Binding Structural Constituent Of Skin Epidermis Signaling Receptor Activity Protein Heterodimerization Activity	RNA Binding Protein Kinase C Binding Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Scaffold Protein Binding
	Biological Process	Complement Activation, Lectin Pathway Response To Oxidative Stress Peptide Cross-linking Keratinization Fibrinolysis Intermediate Filament Organization Regulation Of Angiogenesis Negative Regulation Of Inflammatory Response Protein Heterotetramerization Establishment Of Skin Barrier	Desmosome Organization Ventricular Compact Myocardium Morphogenesis Epidermis Development Peptide Cross-linking Keratinocyte Differentiation Adherens Junction Organization Wound Healing Skin Development Intermediate Filament Cytoskeleton Organization Intermediate Filament Organization Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Epithelial Cell-cell Adhesion Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential Protein Localization To Cell-cell Junction
Pathways		Neutrophil degranulation Keratinization Formation of the cornified envelope Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	Apoptotic cleavage of cell adhesion proteins Neutrophil degranulation Keratinization Formation of the cornified envelope RND3 GTPase cycle RND1 GTPase cycle
Drugs		Zinc Copper Zinc acetate	Zinc Artenimol Zinc acetate
Diseases		Ichthyosis hystrix, Curth-Macklin type Epidermolytic palmoplantar keratoderma (EPPK) Striate palmoplantar keratoderma Epidermolytic hyperkeratosis (EHK); Bullous congenital ichthyosiform erythroderma (BCIE)	Striate palmoplantar keratoderma Skin fragility-woolly hair syndrome Arrhythmogenic right ventricular cardiomyopathy (ARVC) Naxos disease and Carvajal syndrome Epidermolysis bullosa simplex, including: Epidermolysis bullosa simplex, Dowling-Meara type (EBS-DM); Epidermolysis bullosa simplex, Koebner type (EBS-K); Epidermolysis bullosa simplex, Weber-Cockayne type (EBS-WC); Epidermolysis bullosa simplex with mottled pigmentation (EBS-MP); Epidermolysis bullosa simplex with migratory circinate erythema; Epidermolysis bullosa simplex, recessive; Epidermolysis bullosa, lethal acantholytic
GWAS			Chronic obstructive pulmonary disease ( 28166215 30804561) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Idiopathic pulmonary fibrosis ( 29066090 31710517) Interstitial lung disease ( 23583980) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Numerical cognitive ability ( 31620175) PR interval ( 32439900) Response to fenofibrate (triglyceride levels) ( 27002377) Resting heart rate ( 27798624)
Interacting Genes		54 interacting genes: - AMOTL2 CALB2 CSTA DSP EVPL F12 FANCA FANCC FFAR2 GOLGA2 GOLGA6L9 HAUS1 HMG20A HOOK2 IVL KNG1 KRT13 KRT14 KRT15 KRT16 KRT19 KRT24 KRT25 KRT26 KRT27 KRT28 KRT31 KRT33B KRT34 KRT35 KRT36 KRT37 KRT38 KRT39 KRT40 KRT5 LINC00839 LORICRIN MBL2 NINL NUP62 OGT PI3 PRKCE RINT1 RNF26 SGTB TFIP11 TLCD4 TRIM54 U2AF1 UBE3A YWHAQ	36 interacting genes: ARID3A CASP10 CASP2 CASP4 CASP6 CASP7 CASP9 CDC42 CDH5 COL17A1 COPS6 DES DSC1 ENO3 EVPL H19 IVL JUP KRT1 KRT5 KRT6A MTDH PECAM1 PKP1 PKP2 PKP3 PKP4 PRKACA PRKCE PTEN RNF10 TTC3 UCHL5 USP7 VIM WEE2-AS1
Entrez ID		3848	1832
HPRD ID		00763	00513
Ensembl ID		ENSG00000167768	ENSG00000096696
Uniprot IDs		P04264	A0AAQ5BH43 B4DKX6 P15924
PDB IDs		4ZRY 6E2J 6UUI	1LM5 1LM7 3R6N 5DZZ
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament Structural Molecule Activity Epithelial Cell Differentiation Cytoskeleton Organization Supramolecular Fiber Organization Morphogenesis Of An Epithelium Tissue Morphogenesis Cytoskeleton Organelle Organization Cornified Envelope Peptide Cross-linking Structural Constituent Of Cytoskeleton Anatomical Structure Morphogenesis Cell Differentiation Keratinocyte Differentiation Extracellular Exosome Cellular Developmental Process Epidermis Development Cytosol Epidermal Cell Differentiation Keratinization Hair Cycle Developmental Process Centrosome Cycle Intermediate Filament Cytoskeleton Hair Follicle Morphogenesis Microtubule Organizing Center Organization Protein Localization To Perinuclear Region Of Cytoplasm Tissue Development Cell Surface Pattern Recognition Receptor Signaling Pathway Fanconi Anaemia Nuclear Complex	Cornified Envelope Desmosome Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Cysteine-type Endopeptidase Activity Cell-cell Junction Organization Desmosome Organization Cell Junction Assembly Intermediate Filament Organization Cysteine-type Peptidase Activity Cell-cell Junction Anchoring Junction Desmosome Assembly Cell Junction Organization Positive Regulation Of Neuron Apoptotic Process Cell-cell Junction Assembly Cytoplasm Peptidase Activity Keratinization Alpha-catenin Binding Adherens Junction Intermediate Filament Cytoskeleton Cadherin Binding Desmosome Maintenance Cytoskeleton Organization Cytosol Peptide Cross-linking Structural Constituent Of Skin Epidermis Supramolecular Fiber Organization Cell-cell Adhesion Cell Adhesion Epidermis Development Cellular Component Assembly Positive Regulation Of Signal Transduction Regulation Of Neuron Apoptotic Process Execution Phase Of Apoptosis Proteolysis Cellular Response To Staurosporine Protein Metabolic Process Protein Processing Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Protein Maturation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Periphery Response To Indole-3-methanol Cell Junction Structural Constituent Of Cytoskeleton Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?