KRT1 and -

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KRT1	-
Description		keratin 1	U2 small nuclear RNA auxiliary factor 1 like 5
Image			No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Membrane Keratin Filament Extracellular Exosome Blood Microparticle Ficolin-1-rich Granule Lumen
	Molecular Function	Protein Binding Carbohydrate Binding Structural Constituent Of Skin Epidermis Signaling Receptor Activity Protein Heterodimerization Activity
	Biological Process	Complement Activation, Lectin Pathway Response To Oxidative Stress Peptide Cross-linking Keratinization Fibrinolysis Intermediate Filament Organization Regulation Of Angiogenesis Negative Regulation Of Inflammatory Response Protein Heterotetramerization Establishment Of Skin Barrier
Pathways		Neutrophil degranulation Keratinization Formation of the cornified envelope Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
Drugs		Zinc Copper Zinc acetate
Diseases		Ichthyosis hystrix, Curth-Macklin type Epidermolytic palmoplantar keratoderma (EPPK) Striate palmoplantar keratoderma Epidermolytic hyperkeratosis (EHK); Bullous congenital ichthyosiform erythroderma (BCIE)
GWAS			HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535)
Interacting Genes		54 interacting genes: - AMOTL2 CALB2 CSTA DSP EVPL F12 FANCA FANCC FFAR2 GOLGA2 GOLGA6L9 HAUS1 HMG20A HOOK2 IVL KNG1 KRT13 KRT14 KRT15 KRT16 KRT19 KRT24 KRT25 KRT26 KRT27 KRT28 KRT31 KRT33B KRT34 KRT35 KRT36 KRT37 KRT38 KRT39 KRT40 KRT5 LINC00839 LORICRIN MBL2 NINL NUP62 OGT PI3 PRKCE RINT1 RNF26 SGTB TFIP11 TLCD4 TRIM54 U2AF1 UBE3A YWHAQ	16 interacting genes: AP1B1 AP2B1 CARNMT1 EFHC2 HMGB2 HNRNPK KRT1 KRT75 MEOX2 MLH1 SNRNP35 SRRM4 SRSF3 TRA2B U2AF2 ZNF417
Entrez ID		3848	102724594
HPRD ID		00763
Ensembl ID		ENSG00000167768	ENSG00000275895
Uniprot IDs		P04264
PDB IDs		4ZRY 6E2J 6UUI
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament Structural Molecule Activity Epithelial Cell Differentiation Cytoskeleton Organization Supramolecular Fiber Organization Morphogenesis Of An Epithelium Tissue Morphogenesis Cytoskeleton Organelle Organization Cornified Envelope Peptide Cross-linking Structural Constituent Of Cytoskeleton Anatomical Structure Morphogenesis Cell Differentiation Keratinocyte Differentiation Extracellular Exosome Cellular Developmental Process Epidermis Development Cytosol Epidermal Cell Differentiation Keratinization Hair Cycle Developmental Process Centrosome Cycle Intermediate Filament Cytoskeleton Hair Follicle Morphogenesis Microtubule Organizing Center Organization Protein Localization To Perinuclear Region Of Cytoplasm Tissue Development Cell Surface Pattern Recognition Receptor Signaling Pathway Fanconi Anaemia Nuclear Complex	Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Regulation Of RNA Splicing RNA Splicing MRNA Metabolic Process MRNA Processing MRNA Binding Regulation Of MRNA Metabolic Process Spliceosomal Complex MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Regulation Of Alternative MRNA Splicing, Via Spliceosome Clathrin Adaptor Complex RNA Processing Nucleic Acid Binding Pre-mRNA Binding RNA Metabolic Process Nucleic Acid Metabolic Process Negative Regulation Of MRNA Splicing, Via Spliceosome RNA Binding Negative Regulation Of RNA Splicing Membrane Coat Clathrin Binding Condensed Chromosome Positive Regulation Of RNA Splicing Somatic Cell DNA Recombination Late Recombination Nodule Meiotic Metaphase I Homologous Chromosome Alignment Carnosine N-methyltransferase Activity Nucleobase-containing Compound Metabolic Process Protein Domain Specific Binding Cornified Envelope Structural Constituent Of Skin Epidermis Double-strand Break Repair Via Nonhomologous End Joining Non-sequence-specific DNA Binding, Bending Keratinization Meiotic Spindle Midzone Assembly Meiotic Metaphase Chromosome Alignment Chiasma Protein-RNA Sequence-specific Adaptor Activity Poly-pyrimidine Tract Binding Carnosine Metabolic Process Intermediate Filament Organization Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Male Meiosis Chromosome Segregation MutLalpha Complex Keratin Filament Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization
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