PLAG1 and PIAS2

Number of citations of the paper that reports this interaction (PMID 15208321)
6

Data Source:
BioGRID (pull down)

		PLAG1	PIAS2
Gene Name		pleiomorphic adenoma gene 1	protein inhibitor of activated STAT, 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus PML Body Nuclear Speck
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Metal Ion Binding	DNA Binding Transcription Coactivator Activity Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Binding Androgen Receptor Binding SUMO Ligase Activity
	Biological Process	Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Gland Morphogenesis Multicellular Organism Growth Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Glial Cell Proliferation Prostate Gland Growth	Transcription, DNA-templated Protein Sumoylation Androgen Receptor Signaling Pathway Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Androgen Receptor Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Height ( 19396169 19343178 19893584 18391951 20189936)
Protein-Protein Interactions		5 interactors: KPNA2 PIAS1 PIAS2 PIAS4 SMAD3	68 interactors: ACY3 ADA AKT1 AR C1QA CCHCR1 CCNDBP1 CHMP4B CLDN2 CTBP1 DDX39B ELK1 ESR1 ESR2 FLI1 GFAP GFI1 GLUL GOLGA2 GRM8 GTF2I GTF2IRD1 HDAC3 HUWE1 ITGB5 JUN MAPK8 MAPKAPK2 MBD1 MITF MSX2 MX2 MYCN NAV2 NR3C1 PARK7 PAXIP1 PGR PHC1 PIAS1 PIAS4 PLAG1 PLAGL1 PML PRKAB2 RUFY1 SIAH1 SIAH2 SMAD3 SMAD4 SNIP1 SREBF2 STAT4 SUMO1 SUMO1P1 SUMO2 SUMO3 TICAM2 TP53 TRIM23 TRIM27 TRIM55 TRIM63 TSR2 UBE2I ZBED1 ZBTB8A ZNF451
Entrez ID		5324	9063
HPRD ID		04321	06944
Ensembl ID		ENSG00000181690	ENSG00000078043
Uniprot IDs		Q6DJT9	O75928
PDB IDs			2ASQ 4FO9
Enriched GO Terms of Interacting Partners?		Protein Sumoylation Positive Regulation Of Protein Sumoylation Regulation Of Protein Sumoylation Peptidyl-lysine Modification Androgen Receptor Signaling Pathway Intracellular Steroid Hormone Receptor Signaling Pathway Protein Modification By Small Protein Conjugation Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transforming Growth Factor Beta3 Production Regulation Of Osteoblast Differentiation Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Keratinocyte Apoptotic Process Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process RNA Biosynthetic Process Signal Transduction Evasion Or Tolerance Of Host Defenses By Virus Peptidyl-amino Acid Modification Positive Regulation Of Cellular Metabolic Process Regulation Of Ossification Positive Regulation Of Apoptotic Signaling Pathway Intracellular Receptor Signaling Pathway Nitrogen Compound Metabolic Process Signaling Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Positive Regulation Of Extracellular Matrix Assembly Regulation Of Signal Transduction Cell Communication Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Extracellular Matrix Assembly Positive Regulation Of Smooth Muscle Cell Differentiation Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Primary MiRNA Processing Positive Regulation Of Protein Metabolic Process Regulation Of Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of Proteolysis RNA Metabolic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage SMAD Protein Complex Assembly Negative Regulation Of Osteoblast Proliferation Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated	Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Transcription, DNA-templated Response To Organic Substance RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated RNA Metabolic Process Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Protein Sumoylation Negative Regulation Of Nucleic Acid-templated Transcription Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of Cell Death Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Gland Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Protein Modification By Small Protein Conjugation Cellular Response To Lipid Macromolecule Biosynthetic Process Cellular Response To Stimulus Regulation Of Cellular Process Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Cellular Metabolic Process Cellular Response To Organic Cyclic Compound Regulation Of Cell Proliferation Regulation Of Signaling Signaling
Tagcloud ?		batch calling classify cooperative driver exome fer filtering fusions h3f3a indels leukemias lmo1 mllt10 nkx2 normalization normalizations obtaining perturbations pipelines ptk2b seq skipping snv snvs ssbp2 stat5b tlx1 tpm3	293t acts alphaclass androgen ar chaperone clone27 coimmunoprecipitation colocalization coregulator cytoplasm e3 factorkappab hek hela libraries ligase modulates prefoldintype sumoylation termed transcript transducer trapped twohybrid ubiquitously uxt yeast
Tagcloud (Difference) ?		batch calling classify cooperative driver exome fer filtering fusions h3f3a indels leukemias lmo1 mllt10 nkx2 normalization normalizations obtaining perturbations pipelines ptk2b seq skipping snv snvs ssbp2 stat5b tlx1 tpm3	293t acts alphaclass androgen ar chaperone clone27 coimmunoprecipitation colocalization coregulator cytoplasm e3 factorkappab hek hela libraries ligase modulates prefoldintype sumoylation termed transcript transducer trapped twohybrid ubiquitously uxt yeast
Tagcloud (Intersection) ?