KLRC3 and RHOU

Number of citations of the paper that reports this interaction (PubMedID 26598620)
63

Data Source:
BioGRID (pull down)

		KLRC3	RHOU
Description		killer cell lectin like receptor C3	ras homolog family member U
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Receptor Complex	Golgi Membrane Podosome Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Endosome Membrane Membrane Cell Projection Anchoring Junction
	Molecular Function	Transmembrane Signaling Receptor Activity Carbohydrate Binding	Nucleotide Binding GTPase Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Metal Ion Binding
	Biological Process	Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Defense Response Regulation Of Natural Killer Cell Activation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity	G1/S Transition Of Mitotic Cell Cycle Endocytosis Cytoskeleton Organization Actin Filament Organization Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Cell Shape Rac Protein Signal Transduction Establishment Of Cell Polarity Actin Cytoskeleton Organization Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Focal Adhesion Disassembly Positive Regulation Of Protein Targeting To Mitochondrion
Pathways			Interleukin-4 and Interleukin-13 signaling RHOU GTPase cycle RHOU GTPase cycle
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Composite immunoglobulin trait (IgA/IgG) ( 28628107) Mean corpuscular volume ( 27863252)	Aging ( 22773346) Basal cell carcinoma ( 18849993 24403052 25855136 27539887 33549134) Chronic lymphocytic leukemia ( 28165464) Dental caries ( 23259602) Endometriosis ( 20844546) Leukoderma in response to rhododendrol ( 32558222) Mercury levels ( 26025379) Non-melanoma skin cancer ( 29739929) Response to antidepressants in depression ( 27622933) Type 2 diabetes ( 23300278)
Interacting Genes		3 interacting genes: KLRD1 RHOU TYROBP	126 interacting genes: ACAD8 ADM2 ALG13 ANGPT4 ANXA4 ANXA6 AP1S1 ARHGEF25 AS3MT ATP5MG ATP6AP1 BDNF BMAL1 BNIPL BRF1 BRINP3 C14orf119 CDKL4 CFAP100 CHRNA4 CLEC7A CPNE3 CTCF CUL5 DACT2 DMRT2 DNM2 DOK4 DSCR8 EIF4B ELP5 EMC2 ERF ERO1A FAM110B FCHO2 FKBP15 GALNTL5 GLI3 GPRIN2 GRB2 H2BC14 HCAR1 HINT3 HSD17B13 ID2 IFFO1 IL17F INSM2 JAM3 KAAG1 KIAA1191 KLRC3 LANCL2 LARS2 LAYN LMO7 LYL1 ME3 MOS MRAS MRPL15 NCK1 NCR1 NPM3 NR1H2 NRBF2 NXPH4 OXCT2 P4HTM PAK1 PAK4 PCDHGA4 PDLIM3 PGK1 PIP5K1A PLCG1 PLEK PLOD3 POT1 PRB1 PRPF18 PSMA4 PXN QTRT1 RAB40A RAD51D RALBP1 RASSF1 RBIS RPL23AP5 RPS15A RPS17P16 S100A4 SEC14L4 SEMA3G SEPTIN6 SIVA1 SKIC2 SLC26A1 SNU13 SOX4 SSC4D STX16 SYK TCN2 TEKT2 TMEM106A TMEM169 TMEM255B TRIM59 USP37 UTP3 VWA5A WNT6 XPA ZFAND2B ZFP64 ZKSCAN7 ZNF117 ZNF177 ZNF20 ZNF569 ZNF625 ZNF747 ZNF84
Entrez ID		3823	58480
HPRD ID		04203	06965
Ensembl ID		ENSG00000205810	ENSG00000116574
Uniprot IDs		Q07444	Q7L0Q8
PDB IDs			2Q3H
Enriched GO Terms of Interacting Partners?		Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Natural Killer Cell Mediated Immunity Regulation Of Natural Killer Cell Activation Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Regulation Of Leukocyte Mediated Cytotoxicity Lymphocyte Mediated Immunity HLA-E Specific Inhibitory MHC Class Ib Receptor Activity MHC Class Ib Protein Binding, Via Antigen Binding Groove Leukocyte Mediated Immunity Stimulatory Killer Cell Immunoglobulin-like Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Activation Of Innate Immune Response Positive Regulation Of Osteoclast Development Positive Regulation Of Microglial Cell Mediated Cytotoxicity Protein-macromolecule Adaptor Activity Positive Regulation Of Receptor Localization To Synapse Positive Regulation Of Macrophage Fusion Microglial Cell Activation Involved In Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Immune Effector Process Negative Regulation Of Transforming Growth Factor Beta1 Production Immune Response-regulating Cell Surface Receptor Signaling Pathway MHC Class I Protein Complex Binding Positive Regulation Of Innate Immune Response T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Positive Regulation Of Focal Adhesion Disassembly Protein Antigen Binding Regulation Of Osteoclast Development Tetraspanin-enriched Microdomain Negative Regulation Of T Cell Mediated Cytotoxicity Immune Response-activating Signaling Pathway Neutrophil Activation Involved In Immune Response Negative Regulation Of Long-term Synaptic Potentiation Actin Cytoskeleton Organization Negative Regulation Of Transforming Growth Factor Beta Production Immune Effector Process Immune Response-regulating Signaling Pathway Actin Filament-based Process Activation Of Immune Response Regulation Of Innate Immune Response Negative Regulation Of B Cell Proliferation Endocytosis Positive Regulation Of Defense Response Positive Regulation Of Protein Localization To Cell Surface Macrophage Activation Involved In Immune Response Positive Regulation Of Superoxide Anion Generation Plasma Membrane	Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin
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