CHRM3 and GZMB

Number of citations of the paper that reports this interaction (PMID 11665980)
9

Data Source:
HPRD (in vivo, in vitro)

		CHRM3	GZMB
Gene Name		cholinergic receptor, muscarinic 3	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Basolateral Plasma Membrane Cell Junction Dendrite Asymmetric Synapse Axon Terminus Postsynaptic Membrane	Immunological Synapse Nucleus Cytoplasm Cytosol Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Phosphatidylinositol Phospholipase C Activity Receptor Activity Protein Binding Drug Binding G-protein Coupled Acetylcholine Receptor Activity Acetylcholine Binding	Serine-type Endopeptidase Activity Protein Binding Serine-type Peptidase Activity
	Biological Process	Regulation Of Vascular Smooth Muscle Contraction Energy Reserve Metabolic Process Cellular Protein Modification Process Smooth Muscle Contraction Signal Transduction G-protein Coupled Receptor Signaling Pathway G-protein Coupled Acetylcholine Receptor Signaling Pathway Nervous System Development Cell Proliferation Small Molecule Metabolic Process Positive Regulation Of Smooth Muscle Contraction Saliva Secretion Regulation Of Insulin Secretion	Proteolysis Apoptotic Process Immune Response Notch Signaling Pathway Granzyme-mediated Apoptotic Signaling Pathway Protein Processing Cytolysis Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Pathways		G alpha (q) signalling events G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Acetylcholine regulates insulin secretion Integration of energy metabolism Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Muscarinic acetylcholine receptors Regulation of insulin secretion Amine ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Signaling by NOTCH2 Signaling by NOTCH Activation, myristolyation of BID and translocation to mitochondria Programmed Cell Death NOTCH2 intracellular domain regulates transcription Intrinsic Pathway for Apoptosis
Drugs		Cevimeline Tramadol Succinylcholine Ziprasidone Disopyramide Amitriptyline Ipratropium bromide Olanzapine Metixene Terfenadine Clozapine Trihexyphenidyl Oxyphencyclimine Procyclidine Promazine Hyoscyamine Cyproheptadine Imipramine Methylscopolamine Darifenacin Tridihexethyl Anisotropine Methylbromide Nortriptyline Atropine Nicardipine Paroxetine Homatropine Methylbromide Diphemanil Methylsulfate Scopolamine Benzquinamide Propiomazine Cryptenamine Tropicamide Brompheniramine Maprotiline Tolterodine Oxybutynin Promethazine Pilocarpine Doxepin Desipramine Quetiapine Mivacurium Diphenidol Aripiprazole Chlorprothixene Pancuronium Pipecuronium Methotrimeprazine Tiotropium Solifenacin Isopropamide Mepenzolate Fesoterodine Methacholine Aclidinium	Alpha-D-Mannose
Diseases
GWAS		Epilepsy (generalized) ( 22949513) Hypertension ( 17554300) Platelet counts ( 21507922) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)	Vitiligo ( 20410501)
Protein-Protein Interactions		9 interactors: ARF1 ARF6 CSNK1A1 GNAQ GPRASP1 GRK6 GZMB PPP1R9B SET	26 interactors: BID CASP3 CASP7 CASP8 CASP9 CD2AP CHRM3 DFFA GRIA3 IGF2R LMNA LMNB1 PARP1 PRF1 PRKDC PTGES3 PTK2 RAB27A SERPINB9 SRGN TUBA1A UBE4A UBE4B XRCC4 XRCC5 XRCC6
Entrez ID		1131	3002
HPRD ID		00329	00476
Ensembl ID			ENSG00000100453
Uniprot IDs		P20309	P10144 Q67BC3
PDB IDs		2CSA	1FQ3 1IAU
Enriched GO Terms of Interacting Partners?		Regulation Of Organelle Organization Regulation Of Signaling Regulation Of Cellular Component Organization Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Signal Transduction Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Signal Transduction G-protein Coupled Receptor Catabolic Process Regulation Of Opioid Receptor Signaling Pathway Signaling Cell Cycle Cell Communication Cellular Response To Morphine Cellular Response To Isoquinoline Alkaloid Regulation Of Cell Growth By Extracellular Stimulus Regulation Of Establishment Of Protein Localization Granzyme-mediated Apoptotic Signaling Pathway Regulation Of Cellular Process Regulation Of Endocytosis Negative Regulation Of Catalytic Activity Cellular Response To Stimulus Regulation Of Protein Localization Myeloid Cell Apoptotic Process Phospholipase C-activating Dopamine Receptor Signaling Pathway Organelle Organization Intracellular Signal Transduction Neuron Remodeling Protein Localization To Endosome COPI-coated Vesicle Budding Regulation Of Exit From Mitosis COPI Coating Of Golgi Vesicle Wnt Signaling Pathway Regulation Of Melanocyte Differentiation Golgi Vesicle Budding Regulation Of Cellular Localization Regulation Of Synaptic Transmission Nucleosome Disassembly Maternal Behavior Long Term Synaptic Depression Establishment Of Epithelial Cell Polarity Filopodium Assembly Cellular Copper Ion Homeostasis Protein Localization To Cell Surface Metabolic Process Cell Projection Organization Cellular Response To Ammonium Ion Hepatocyte Apoptotic Process Receptor Catabolic Process Negative Regulation Of Receptor-mediated Endocytosis Regulation Of Actin Cytoskeleton Organization	Apoptotic Process Programmed Cell Death Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cell Death Death Execution Phase Of Apoptosis Cellular Response To Stimulus Response To Stimulus Apoptotic Signaling Pathway Protein Processing Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Apoptotic Process Telomere Maintenance Glial Cell Apoptotic Process Regulation Of Cell Death Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Intrinsic Apoptotic Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Establishment Of Integrated Proviral Latency Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Zymogen Activation Response To Abiotic Stimulus Establishment Of Viral Latency Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cell Death Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Signal Transduction Response To Radiation Response To Stress Positive Regulation Of Peptidase Activity Immune Response Immune System Development Double-strand Break Repair Positive Regulation Of Proteolysis Immune System Process Signaling Cellular Hyperosmotic Salinity Response Cell Communication Cellular Response To DNA Damage Stimulus Cellular Response To Stress Regulation Of Endopeptidase Activity Hemopoiesis Organ Development V(D)J Recombination Regulation Of Peptidase Activity
Tagcloud ?		additions adenocarcinomas animal aom attenuates azoxymethane bethanechol bethenechol chloride colonic drinking euthanized injections intestinal intraperitoneal m3r metalloproteinase mmp10 mmp13 mmp7 mucosa muscarinic name neoplasia nicotinic prominent strikingly thickness	adhered autonomous basement cleaved cleaves compromised constituents cremaster cytotoxic deficit destruction diapedesis ectromelia effector enabled expediting extend granzyme homing inflamed interplay intravital killer lamellipodia lymphocytes migrating null proteomic venules
Tagcloud (Difference) ?		additions adenocarcinomas animal aom attenuates azoxymethane bethanechol bethenechol chloride colonic drinking euthanized injections intestinal intraperitoneal m3r metalloproteinase mmp10 mmp13 mmp7 mucosa muscarinic name neoplasia nicotinic prominent strikingly thickness	adhered autonomous basement cleaved cleaves compromised constituents cremaster cytotoxic deficit destruction diapedesis ectromelia effector enabled expediting extend granzyme homing inflamed interplay intravital killer lamellipodia lymphocytes migrating null proteomic venules
Tagcloud (Intersection) ?