CHRM3 and ARF6

Number of citations of the paper that reports this interaction (PMID 12799371)
8

Data Source:
BioGRID (affinity chromatography technology, pull down)
HPRD (in vivo, in vitro)

		CHRM3	ARF6
Gene Name		cholinergic receptor, muscarinic 3	ADP-ribosylation factor 6
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Basolateral Plasma Membrane Cell Junction Dendrite Asymmetric Synapse Axon Terminus Postsynaptic Membrane	Ruffle Endosome Early Endosome Golgi Apparatus Plasma Membrane Focal Adhesion Cell Cortex Membrane Endocytic Vesicle Midbody Filopodium Membrane Cleavage Furrow Recycling Endosome Membrane Extracellular Vesicular Exosome
	Molecular Function	Phosphatidylinositol Phospholipase C Activity Receptor Activity Protein Binding Drug Binding G-protein Coupled Acetylcholine Receptor Activity Acetylcholine Binding	GTPase Activity Protein Binding GTP Binding Thioesterase Binding
	Biological Process	Regulation Of Vascular Smooth Muscle Contraction Energy Reserve Metabolic Process Cellular Protein Modification Process Smooth Muscle Contraction Signal Transduction G-protein Coupled Receptor Signaling Pathway G-protein Coupled Acetylcholine Receptor Signaling Pathway Nervous System Development Cell Proliferation Small Molecule Metabolic Process Positive Regulation Of Smooth Muscle Contraction Saliva Secretion Regulation Of Insulin Secretion	Liver Development Movement Of Cell Or Subcellular Component Cell Cycle Cell Adhesion Small GTPase Mediated Signal Transduction Metabolic Process Protein Transport Vesicle-mediated Transport Positive Regulation Of Actin Filament Polymerization Cortical Actin Cytoskeleton Organization Ruffle Organization Myeloid Cell Apoptotic Process Protein Localization To Cell Surface Regulation Of Rac Protein Signal Transduction Protein Localization To Endosome Negative Regulation Of Receptor-mediated Endocytosis Cell Division Regulation Of Filopodium Assembly Regulation Of Dendritic Spine Development Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Establishment Of Epithelial Cell Polarity Hepatocyte Apoptotic Process
Pathways		G alpha (q) signalling events G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Acetylcholine regulates insulin secretion Integration of energy metabolism Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Muscarinic acetylcholine receptors Regulation of insulin secretion Amine ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs		Cevimeline Tramadol Succinylcholine Ziprasidone Disopyramide Amitriptyline Ipratropium bromide Olanzapine Metixene Terfenadine Clozapine Trihexyphenidyl Oxyphencyclimine Procyclidine Promazine Hyoscyamine Cyproheptadine Imipramine Methylscopolamine Darifenacin Tridihexethyl Anisotropine Methylbromide Nortriptyline Atropine Nicardipine Paroxetine Homatropine Methylbromide Diphemanil Methylsulfate Scopolamine Benzquinamide Propiomazine Cryptenamine Tropicamide Brompheniramine Maprotiline Tolterodine Oxybutynin Promethazine Pilocarpine Doxepin Desipramine Quetiapine Mivacurium Diphenidol Aripiprazole Chlorprothixene Pancuronium Pipecuronium Methotrimeprazine Tiotropium Solifenacin Isopropamide Mepenzolate Fesoterodine Methacholine Aclidinium
Diseases
GWAS		Epilepsy (generalized) ( 22949513) Hypertension ( 17554300) Platelet counts ( 21507922) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Protein-Protein Interactions		9 interactors: ARF1 ARF6 CSNK1A1 GNAQ GPRASP1 GRK6 GZMB PPP1R9B SET	28 interactors: AP1B1 AP3B1 AP3D1 AP3S2 APP ARFIP2 ARRB1 ARRB2 ASAP2 ASAP3 ATP6V0C CAPN1 CHRM3 CYTH1 CYTH2 EXOC5 EZR GGA1 IKBKG ITSN1 MPP5 PIP5K1A PIP5K1C PLD1 RAB11FIP3 RAB11FIP4 RAB11FIP5 ZNF709
Entrez ID		1131	382
HPRD ID		00329	02714
Ensembl ID
Uniprot IDs		P20309	P62330
PDB IDs		2CSA	1E0S 2A5D 2A5F 2A5G 2BAO 2BAU 2J5X 2W83 3LVQ 3LVR 3N5C 3PCR 4FME 4KAX
Enriched GO Terms of Interacting Partners?		Regulation Of Organelle Organization Regulation Of Signaling Regulation Of Cellular Component Organization Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Signal Transduction Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Signal Transduction G-protein Coupled Receptor Catabolic Process Regulation Of Opioid Receptor Signaling Pathway Signaling Cell Cycle Cell Communication Cellular Response To Morphine Cellular Response To Isoquinoline Alkaloid Regulation Of Cell Growth By Extracellular Stimulus Regulation Of Establishment Of Protein Localization Granzyme-mediated Apoptotic Signaling Pathway Regulation Of Cellular Process Regulation Of Endocytosis Negative Regulation Of Catalytic Activity Cellular Response To Stimulus Regulation Of Protein Localization Myeloid Cell Apoptotic Process Phospholipase C-activating Dopamine Receptor Signaling Pathway Organelle Organization Intracellular Signal Transduction Neuron Remodeling Protein Localization To Endosome COPI-coated Vesicle Budding Regulation Of Exit From Mitosis COPI Coating Of Golgi Vesicle Wnt Signaling Pathway Regulation Of Melanocyte Differentiation Golgi Vesicle Budding Regulation Of Cellular Localization Regulation Of Synaptic Transmission Nucleosome Disassembly Maternal Behavior Long Term Synaptic Depression Establishment Of Epithelial Cell Polarity Filopodium Assembly Cellular Copper Ion Homeostasis Protein Localization To Cell Surface Metabolic Process Cell Projection Organization Cellular Response To Ammonium Ion Hepatocyte Apoptotic Process Receptor Catabolic Process Negative Regulation Of Receptor-mediated Endocytosis Regulation Of Actin Cytoskeleton Organization	Vesicle-mediated Transport Cellular Localization Protein Localization Establishment Of Localization In Cell Establishment Of Protein Localization Transport Establishment Of Vesicle Localization Vesicle Localization Synaptic Vesicle Transport Protein Transport Movement Of Cell Or Subcellular Component Axon Cargo Transport Endocytosis Establishment Of Organelle Localization Receptor Metabolic Process Regulation Of GTPase Activity Anterograde Synaptic Vesicle Transport Regulation Of ARF Protein Signal Transduction Intracellular Transport Chemotaxis Anterograde Axon Cargo Transport Regulation Of Ras Protein Signal Transduction Organelle Localization Cellular Protein Localization Positive Regulation Of GTPase Activity Positive Regulation Of Hydrolase Activity Regulation Of Small GTPase Mediated Signal Transduction Microtubule-based Transport Receptor Internalization Cytoskeleton-dependent Intracellular Transport Response To External Stimulus Antigen Processing And Presentation, Exogenous Lipid Antigen Via MHC Class Ib Positive Regulation Of NK T Cell Differentiation Positive Regulation Of Catalytic Activity Regulation Of Body Fluid Levels Synaptic Transmission Actin Cytoskeleton Organization Locomotion Cell-cell Signaling Platelet Activation Cytoskeletal Anchoring At Plasma Membrane Regulation Of Signaling Actin Filament-based Process Regulation Of Intracellular Signal Transduction G-protein Coupled Receptor Internalization Blood Coagulation Hemostasis Regulation Of Signal Transduction Post-Golgi Vesicle-mediated Transport Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway
Tagcloud ?		additions adenocarcinomas animal aom attenuates azoxymethane bethanechol bethenechol chloride colonic drinking euthanized injections intestinal intraperitoneal m3r metalloproteinase mmp10 mmp13 mmp7 mucosa muscarinic name neoplasia nicotinic prominent strikingly thickness	accessible cellubrevin cho colocalized compartment cryoimmunogold endocytic endosomal gdp gtpase horseradish hrp invaginations localize localizes morphologically pericentriolar perinuclear perturbs q67l recycling resembled ribosylation shortly t27n tracer uniquely vesicles
Tagcloud (Difference) ?		additions adenocarcinomas animal aom attenuates azoxymethane bethanechol bethenechol chloride colonic drinking euthanized injections intestinal intraperitoneal m3r metalloproteinase mmp10 mmp13 mmp7 mucosa muscarinic name neoplasia nicotinic prominent strikingly thickness	accessible cellubrevin cho colocalized compartment cryoimmunogold endocytic endosomal gdp gtpase horseradish hrp invaginations localize localizes morphologically pericentriolar perinuclear perturbs q67l recycling resembled ribosylation shortly t27n tracer uniquely vesicles
Tagcloud (Intersection) ?