CHRM3 and RAB5IF

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		CHRM3	RAB5IF
Description		cholinergic receptor muscarinic 3	RAB5 interacting factor
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Dendrite Synapse Postsynaptic Membrane	Mitochondrion Mitochondrial Inner Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Multi-pass Translocon Complex
	Molecular Function	Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity G Protein-coupled Receptor Activity Protein Binding G Protein-coupled Acetylcholine Receptor Activity Signaling Receptor Activity Acetylcholine Binding	Protein Binding
	Biological Process	Smooth Muscle Contraction Regulation Of Smooth Muscle Contraction Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Nervous System Development Calcium-mediated Signaling Positive Regulation Of Insulin Secretion Protein Modification Process Positive Regulation Of Smooth Muscle Contraction Saliva Secretion Acetylcholine Receptor Signaling Pathway Ligand-gated Ion Channel Signaling Pathway	Mitochondrial Respirasome Assembly Multi-pass Transmembrane Protein Insertion Into ER Membrane
Pathways		Muscarinic acetylcholine receptors Acetylcholine regulates insulin secretion G alpha (q) signalling events	Complex IV assembly
Drugs		Cevimeline Tramadol Succinylcholine Trospium Ziprasidone Disopyramide Amitriptyline Ipratropium Olanzapine Metixene Terfenadine Clozapine Doxylamine Trihexyphenidyl Oxyphencyclimine Procyclidine Loxapine Carbamoylcholine Hyoscyamine Cyproheptadine Meperidine Imipramine Methscopolamine bromide Chlorpromazine Darifenacin Haloperidol Tridihexethyl Anisotropine methylbromide Nortriptyline Amoxapine Cinnarizine Atropine Thiopental Nicardipine Paroxetine Homatropine methylbromide Trimipramine Scopolamine Benzquinamide Propiomazine Dicyclomine Tropicamide Brompheniramine Maprotiline Methantheline Glycopyrronium Bethanechol Tolterodine Oxybutynin Promethazine Pilocarpine Doxepin Desipramine Ketamine Quetiapine Mivacurium Diphenidol Aripiprazole Chlorprothixene Pancuronium Pipecuronium Methotrimeprazine Tiotropium Solifenacin Isopropamide Acetylcholine Arecoline Mepenzolate ALKS 27 Pizotifen Fesoterodine Methacholine Hexocyclium Aclidinium Umeclidinium Trimebutine Dosulepin Viloxazine Etoperidone Imidafenacin Butylscopolamine Homatropine Thonzylamine Revefenacin Propiverine Rociverine Diphemanil Aripiprazole lauroxil
Diseases
GWAS		Acute respiratory distress syndrome ( 34032881) Chronic obstructive pulmonary disease ( 30804561) Colorectal cancer ( 29228715) Depression in smokers ( 30219690) Electroencephalogram traits ( 25387704) Feeling worry ( 29500382) Femur bone mineral density x serum urate levels interaction ( 34046847) FEV1 ( 30804560) Generalized epilepsy ( 22949513) Gut microbiota beta diversity (weighted UniFrac distance) ( 33208821) Hallucinations in long-term cannabis use ( 31740666) Hypertension ( 17554300) Interleukin-6 (red blood cell fatty acid level interaction) ( 28820441) Lung function (FEV1/FVC) ( 28166213 30804560) Peak expiratory flow ( 30804560) Platelet count ( 21507922) Post bronchodilator FEV1 ( 26634245) Reflection (response to stress) ( 30886212) Sulfasalazine-induced agranulocytosis ( 28762467) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Interacting Genes		26 interacting genes: ARF1 ARF6 BSG CALM3 CCDC184 CD2BP2 COMMD7 CSNK1A1 GNAQ GNAS GPRASP1 GRK6 GZMB JAKMIP1 MAGED2 POM121C PPP1R9B RAB5IF RGS7 SEPTIN3 SET SGSM3 SNCA TAP1 TPM3 YIPF3	1 interacting genes: CHRM3
Entrez ID		1131	55969
HPRD ID		00329	12761
Ensembl ID		ENSG00000133019	ENSG00000101084
Uniprot IDs		P20309	Q9BUV8
PDB IDs		2CSA 8E9W 8E9Y 8E9Z 8EA0
Enriched GO Terms of Interacting Partners?		GTPase Activity Regulation Of Endocytosis Response To Prostaglandin E Regulation Of G Protein-coupled Receptor Signaling Pathway Cytoplasm Adenylate Cyclase Activator Activity Presynaptic Endocytosis Cellular Localization Establishment Of Protein Localization Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Vesicle-mediated Transport G Protein Activity Intracellular Protein Localization GTP Binding Positive Regulation Of Protein Localization To Cell Periphery Guanyl Nucleotide Binding Establishment Of Localization In Cell Vesicle-mediated Transport In Synapse Response To Ketone Cellular Response To Acidic PH Presynapse G-protein Beta/gamma-subunit Complex Binding GTPase Activator Activity Response To Alcohol Regulation Of Presynapse Assembly Regulation Of Presynapse Organization Response To Acidic PH Nucleotide Binding Regulation Of Cell Communication Protein Transport Regulation Of Signaling Mitotic Cleavage Furrow Ingression Membrane Cellular Response To Growth Factor Stimulus Regulation Of Signal Transduction Response To Growth Factor Erythrocyte Apoptotic Process Growth Cone G Protein-coupled Receptor Signaling Pathway Response To Amphetamine Postsynaptic Cytosol Regulation Of Synaptic Vesicle Recycling Cellular Response To PH Heterotrimeric G-protein Complex Positive Regulation Of Catalytic Activity Cell Migration Involved In Coronary Angiogenesis Metanephric Glomerular Mesangial Cell Proliferation Involved In Metanephros Development Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity	Acetylcholine Binding Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Saliva Secretion Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Activity G Protein-coupled Acetylcholine Receptor Signaling Pathway Synaptic Transmission, Cholinergic Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Positive Regulation Of Smooth Muscle Contraction Smooth Muscle Contraction Ligand-gated Ion Channel Signaling Pathway Postsynaptic Signal Transduction Positive Regulation Of Muscle Contraction G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Acetylcholine Receptor Signaling Pathway Regulation Of Smooth Muscle Contraction Basal Plasma Membrane Body Fluid Secretion Digestive System Process Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Insulin Secretion Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Secretion Positive Regulation Of Hormone Secretion Regulation Of Muscle Contraction Regulation Of Insulin Secretion Calcium-mediated Signaling Muscle Contraction Regulation Of Peptide Hormone Secretion Regulation Of Hormone Secretion Muscle System Process Regulation Of Protein Secretion Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Signaling Receptor Activity Postsynaptic Membrane Regulation Of Muscle System Process Basolateral Plasma Membrane Positive Regulation Of Protein Transport Regulation Of Body Fluid Levels Positive Regulation Of Secretion Positive Regulation Of Secretion By Cell Positive Regulation Of Establishment Of Protein Localization Chemical Synaptic Transmission Trans-synaptic Signaling Synaptic Signaling G Protein-coupled Receptor Activity
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