CHRM3 and BSG

Number of citations: 90 (PubMedID 28298427)
Data Source: BioGRID (two hybrid)

		CHRM3	BSG
Name		cholinergic receptor muscarinic 3	basigin (Ok blood group)
Structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Dendrite Synapse Postsynaptic Membrane	Golgi Membrane Photoreceptor Outer Segment Photoreceptor Inner Segment Acrosomal Membrane Mitochondrion Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Focal Adhesion Membrane Basolateral Plasma Membrane Axon Sarcolemma Melanosome Cell Projection Extracellular Exosome
	Molecular Function	Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity G Protein-coupled Receptor Activity Protein Binding G Protein-coupled Acetylcholine Receptor Activity Signaling Receptor Activity Acetylcholine Binding	Virus Receptor Activity Protein Binding D-mannose Binding Carbohydrate Binding Signaling Receptor Activity Cadherin Binding Cell-cell Adhesion Mediator Activity
	Biological Process	Smooth Muscle Contraction Regulation Of Smooth Muscle Contraction Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Nervous System Development Calcium-mediated Signaling Positive Regulation Of Insulin Secretion Protein Modification Process Positive Regulation Of Smooth Muscle Contraction Saliva Secretion Acetylcholine Receptor Signaling Pathway Ligand-gated Ion Channel Signaling Pathway	Angiogenesis Neural Retina Development Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell Surface Receptor Signaling Pathway Axon Guidance Embryo Implantation Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Endothelial Cell Migration Neutrophil Chemotaxis Positive Regulation Of Interleukin-6 Production Odontogenesis Of Dentin-containing Tooth Response To Peptide Hormone Photoreceptor Cell Maintenance Positive Regulation Of Viral Entry Into Host Cell Response To Mercury Ion Decidualization Symbiont Entry Into Host Cell Response To CAMP Endothelial Tube Morphogenesis Dendrite Self-avoidance Protein Localization To Plasma Membrane Positive Regulation Of Matrix Metallopeptidase Secretion Neuron Projection Extension
Pathways		Muscarinic acetylcholine receptors Acetylcholine regulates insulin secretion G alpha (q) signalling events	Degradation of the extracellular matrix Basigin interactions Integrin cell surface interactions Proton-coupled monocarboxylate transport Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) Aspirin ADME
Drugs		Cevimeline Tramadol Succinylcholine Trospium Ziprasidone Disopyramide Amitriptyline Ipratropium Olanzapine Metixene Terfenadine Clozapine Doxylamine Trihexyphenidyl Oxyphencyclimine Procyclidine Loxapine Carbamoylcholine Hyoscyamine Cyproheptadine Meperidine Imipramine Methscopolamine bromide Chlorpromazine Darifenacin Haloperidol Tridihexethyl Anisotropine methylbromide Nortriptyline Amoxapine Cinnarizine Atropine Thiopental Nicardipine Paroxetine Homatropine methylbromide Trimipramine Scopolamine Benzquinamide Propiomazine Dicyclomine Tropicamide Brompheniramine Maprotiline Methantheline Glycopyrronium Bethanechol Tolterodine Oxybutynin Promethazine Pilocarpine Doxepin Desipramine Ketamine Quetiapine Mivacurium Diphenidol Aripiprazole Chlorprothixene Pancuronium Pipecuronium Methotrimeprazine Tiotropium Solifenacin Isopropamide Acetylcholine Arecoline Mepenzolate ALKS 27 Pizotifen Fesoterodine Methacholine Hexocyclium Aclidinium Umeclidinium Trimebutine Dosulepin Viloxazine Etoperidone Imidafenacin Butylscopolamine Homatropine Thonzylamine Revefenacin Propiverine Rociverine Diphemanil Aripiprazole lauroxil	None
GWAS		Acute respiratory distress syndrome ( 34032881 ) Chronic obstructive pulmonary disease ( 30804561 ) Colorectal cancer ( 29228715 ) Depression in smokers ( 30219690 ) Electroencephalogram traits ( 25387704 ) Feeling worry ( 29500382 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) FEV1 ( 30804560 ) Generalized epilepsy ( 22949513 ) Gut microbiota beta diversity (weighted UniFrac distance) ( 33208821 ) Hallucinations in long-term cannabis use ( 31740666 ) Hypertension ( 17554300 ) Interleukin-6 (red blood cell fatty acid level interaction) ( 28820441 ) Lung function (FEV1/FVC) ( 28166213 30804560 ) Peak expiratory flow ( 30804560 ) Platelet count ( 21507922 ) Post bronchodilator FEV1 ( 26634245 ) Reflection (response to stress) ( 30886212 ) Sulfasalazine-induced agranulocytosis ( 28762467 ) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010 )	Alzheimer's disease (late onset) ( 28714976 )
Novel Interactors		1 novel interactors: PDGFRB	None recorded
Interacting Genes		26 interacting genes: ARF1 ARF6 BSG CALM3 CCDC184 CD2BP2 COMMD7 CSNK1A1 GNAQ GNAS GPRASP1 GRK6 GZMB JAKMIP1 MAGED2 POM121C PPP1R9B RAB5IF RGS7 SEPTIN3 SET SGSM3 SNCA TAP1 TPM3 YIPF3	21 interacting genes: ADRB2 AQP6 CACNA1C CAV1 CCR4 CHRM3 CRBN F2RL1 HGS MMP1 OGT PDLIM7 PPIA PPIL2 PPP2R1B SLC16A1 SLC16A13 SLC16A3 SLC2A4 TMEM14B UBC
Entrez ID		1131	682
HPRD ID		00329	00176
Ensembl ID		ENSG00000133019	ENSG00000172270
Uniprot IDs		P20309	P35613 Q54A51
PDB IDs		2CSA 8E9W 8E9Y 8E9Z 8EA0	3B5H 3I84 3I85 3QQN 3QR2 4U0Q 5X0T 5XF0 6LYY 6LZ0 7CKO 7CKR 7DA5 7DAA 7DCE 7XY8 8XEJ
GO Terms Enriched among Interactors		GTPase Activity Regulation Of Endocytosis Response To Prostaglandin E Regulation Of G Protein-coupled Receptor Signaling Pathway Cytoplasm Adenylate Cyclase Activator Activity Presynaptic Endocytosis Cellular Localization Establishment Of Protein Localization Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Vesicle-mediated Transport G Protein Activity Intracellular Protein Localization GTP Binding Positive Regulation Of Protein Localization To Cell Periphery Guanyl Nucleotide Binding Establishment Of Localization In Cell Vesicle-mediated Transport In Synapse Response To Ketone Cellular Response To Acidic PH Presynapse G-protein Beta/gamma-subunit Complex Binding GTPase Activator Activity Response To Alcohol Regulation Of Presynapse Assembly Regulation Of Presynapse Organization Response To Acidic PH Nucleotide Binding Regulation Of Cell Communication Protein Transport Regulation Of Signaling Mitotic Cleavage Furrow Ingression Membrane Cellular Response To Growth Factor Stimulus Regulation Of Signal Transduction Response To Growth Factor Erythrocyte Apoptotic Process Growth Cone G Protein-coupled Receptor Signaling Pathway Response To Amphetamine Postsynaptic Cytosol Regulation Of Synaptic Vesicle Recycling Cellular Response To PH Heterotrimeric G-protein Complex Positive Regulation Of Catalytic Activity Cell Migration Involved In Coronary Angiogenesis Metanephric Glomerular Mesangial Cell Proliferation Involved In Metanephros Development Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity	Monocarboxylic Acid Transmembrane Transporter Activity Lactate:proton Symporter Activity Vascular Process In Circulatory System Plasma Membrane Lactate Transport Pyruvate Transmembrane Transport Pyruvate Transport Lactate Transmembrane Transporter Activity Regulation Of Muscle Contraction Regulation Of Transport Regulation Of Smooth Muscle Contraction Circulatory System Process Receptor-mediated Endocytosis Positive Regulation Of Cytosolic Calcium Ion Concentration Transmembrane Transporter Activity Lactate Transport Pyruvate Catabolic Process Lactate Transmembrane Transport Regulation Of Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of Protein Ubiquitination Positive Regulation Of Cell Communication Positive Regulation Of Signaling Membrane Negative Regulation Of Post-translational Protein Modification Basolateral Plasma Membrane Regulation Of Muscle System Process System Process Symporter Activity Positive Regulation Of Cold-induced Thermogenesis Regulation Of Protein Secretion Positive Regulation Of Cellular Component Biogenesis Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Signal Transduction Positive Regulation Of Secretion By Cell Regulation Of System Process Regulation Of Cardiac Muscle Cell Action Potential Negative Regulation Of Receptor Signaling Pathway Via STAT Positive Regulation Of Secretion Regulation Of Secretion By Cell Monocarboxylic Acid Transport Brown Fat Cell Differentiation Import Into Cell Blood Vessel Diameter Maintenance Regulation Of Cell Communication Positive Regulation Of Protein-containing Complex Disassembly G Protein-coupled Receptor Activity Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Apical Plasma Membrane Ligand-gated Ion Channel Signaling Pathway Regulation Of Cold-induced Thermogenesis Regulation Of Tube Size