CHRM3 and CD2BP2

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		CHRM3	CD2BP2
Description		cholinergic receptor muscarinic 3	CD2 cytoplasmic tail binding protein 2
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Dendrite Synapse Postsynaptic Membrane	Fibrillar Center Nucleus Nucleoplasm U5 SnRNP Cytoplasm Cytosol Nuclear Speck U4/U6 X U5 Tri-snRNP Complex
	Molecular Function	Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity G Protein-coupled Receptor Activity Protein Binding G Protein-coupled Acetylcholine Receptor Activity Signaling Receptor Activity Acetylcholine Binding	Protein Binding Ribonucleoprotein Complex Binding
	Biological Process	Smooth Muscle Contraction Regulation Of Smooth Muscle Contraction Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Nervous System Development Calcium-mediated Signaling Positive Regulation Of Insulin Secretion Protein Modification Process Positive Regulation Of Smooth Muscle Contraction Saliva Secretion Acetylcholine Receptor Signaling Pathway Ligand-gated Ion Channel Signaling Pathway	Spliceosomal Tri-snRNP Complex Assembly MRNA Processing RNA Splicing
Pathways		Muscarinic acetylcholine receptors Acetylcholine regulates insulin secretion G alpha (q) signalling events
Drugs		Cevimeline Tramadol Succinylcholine Trospium Ziprasidone Disopyramide Amitriptyline Ipratropium Olanzapine Metixene Terfenadine Clozapine Doxylamine Trihexyphenidyl Oxyphencyclimine Procyclidine Loxapine Carbamoylcholine Hyoscyamine Cyproheptadine Meperidine Imipramine Methscopolamine bromide Chlorpromazine Darifenacin Haloperidol Tridihexethyl Anisotropine methylbromide Nortriptyline Amoxapine Cinnarizine Atropine Thiopental Nicardipine Paroxetine Homatropine methylbromide Trimipramine Scopolamine Benzquinamide Propiomazine Dicyclomine Tropicamide Brompheniramine Maprotiline Methantheline Glycopyrronium Bethanechol Tolterodine Oxybutynin Promethazine Pilocarpine Doxepin Desipramine Ketamine Quetiapine Mivacurium Diphenidol Aripiprazole Chlorprothixene Pancuronium Pipecuronium Methotrimeprazine Tiotropium Solifenacin Isopropamide Acetylcholine Arecoline Mepenzolate ALKS 27 Pizotifen Fesoterodine Methacholine Hexocyclium Aclidinium Umeclidinium Trimebutine Dosulepin Viloxazine Etoperidone Imidafenacin Butylscopolamine Homatropine Thonzylamine Revefenacin Propiverine Rociverine Diphemanil Aripiprazole lauroxil
Diseases
GWAS		Acute respiratory distress syndrome ( 34032881) Chronic obstructive pulmonary disease ( 30804561) Colorectal cancer ( 29228715) Depression in smokers ( 30219690) Electroencephalogram traits ( 25387704) Feeling worry ( 29500382) Femur bone mineral density x serum urate levels interaction ( 34046847) FEV1 ( 30804560) Generalized epilepsy ( 22949513) Gut microbiota beta diversity (weighted UniFrac distance) ( 33208821) Hallucinations in long-term cannabis use ( 31740666) Hypertension ( 17554300) Interleukin-6 (red blood cell fatty acid level interaction) ( 28820441) Lung function (FEV1/FVC) ( 28166213 30804560) Peak expiratory flow ( 30804560) Platelet count ( 21507922) Post bronchodilator FEV1 ( 26634245) Reflection (response to stress) ( 30886212) Sulfasalazine-induced agranulocytosis ( 28762467) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)	Brain morphology (MOSTest) ( 32665545)
Interacting Genes		26 interacting genes: ARF1 ARF6 BSG CALM3 CCDC184 CD2BP2 COMMD7 CSNK1A1 GNAQ GNAS GPRASP1 GRK6 GZMB JAKMIP1 MAGED2 POM121C PPP1R9B RAB5IF RGS7 SEPTIN3 SET SGSM3 SNCA TAP1 TPM3 YIPF3	22 interacting genes: ACAD11 AKNA AP2M1 CD2 CHRM3 CPSF7 CSNK2A1 LRRK1 NAT10 OGT PRPF6 PSMF1 PTBP3 SF3B4 SFPQ SMU1 SNRPB SNRPN TRAPPC6A TXNL4A WBP11 ZNHIT2
Entrez ID		1131	10421
HPRD ID		00329	05127
Ensembl ID		ENSG00000133019	ENSG00000169217
Uniprot IDs		P20309	A0A024QZC1 O95400
PDB IDs		2CSA 8E9W 8E9Y 8E9Z 8EA0	1GYF 1L2Z 1SYX 4BWS 8Q7Q 8Q7V 8Q7W 8Q7X 8Q91 8RC0
Enriched GO Terms of Interacting Partners?		GTPase Activity Regulation Of Endocytosis Response To Prostaglandin E Regulation Of G Protein-coupled Receptor Signaling Pathway Cytoplasm Adenylate Cyclase Activator Activity Presynaptic Endocytosis Cellular Localization Establishment Of Protein Localization Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Vesicle-mediated Transport G Protein Activity Intracellular Protein Localization GTP Binding Positive Regulation Of Protein Localization To Cell Periphery Guanyl Nucleotide Binding Establishment Of Localization In Cell Vesicle-mediated Transport In Synapse Response To Ketone Cellular Response To Acidic PH Presynapse G-protein Beta/gamma-subunit Complex Binding GTPase Activator Activity Response To Alcohol Regulation Of Presynapse Assembly Regulation Of Presynapse Organization Response To Acidic PH Nucleotide Binding Regulation Of Cell Communication Protein Transport Regulation Of Signaling Mitotic Cleavage Furrow Ingression Membrane Cellular Response To Growth Factor Stimulus Regulation Of Signal Transduction Response To Growth Factor Erythrocyte Apoptotic Process Growth Cone G Protein-coupled Receptor Signaling Pathway Response To Amphetamine Postsynaptic Cytosol Regulation Of Synaptic Vesicle Recycling Cellular Response To PH Heterotrimeric G-protein Complex Positive Regulation Of Catalytic Activity Cell Migration Involved In Coronary Angiogenesis Metanephric Glomerular Mesangial Cell Proliferation Involved In Metanephros Development Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity	MRNA Metabolic Process MRNA Processing RNA Splicing RNA Processing MRNA Splicing, Via Spliceosome U2-type Precatalytic Spliceosome RNA Splicing, Via Transesterification Reactions U5 SnRNP RNA Metabolic Process U4/U6 X U5 Tri-snRNP Complex Spliceosomal Complex Assembly Nucleic Acid Metabolic Process Spliceosomal Complex SnRNP Binding U2 SnRNP Nucleobase-containing Compound Metabolic Process Nucleoplasm RNA Binding Negative Regulation Of Proteasomal Protein Catabolic Process U4 SnRNP Protein-containing Complex Assembly Macromolecule Metabolic Process Protein-RNA Complex Assembly Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Small Nuclear Ribonucleoprotein Complex Catalytic Step 2 Spliceosome U2-type Prespliceosome Protein-containing Complex Organization U1 SnRNP Precatalytic Spliceosome Sin3-type Complex Telomerase Holoenzyme Complex U2-type Prespliceosome Assembly U12-type Spliceosomal Complex Negative Regulation Of Protein Catabolic Process U2-type Spliceosomal Complex Negative Regulation Of Proteolysis Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly TRNA Acetylation MRNA N-acetyltransferase Activity TRNA Cytidine N4-acetyltransferase Activity TRNA Wobble Cytosine Modification RRNA Acetylation Involved In Maturation Of SSU-rRNA 18S RRNA Cytidine N-acetyltransferase Activity Neuroblast Delamination Spliceosomal SnRNP Assembly Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Translational Initiation Cellular Component Assembly
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