CHRM3 and CSNK1A1

Number of citations of the paper that reports this interaction (PMID 10777483)
18

Data Source:
HPRD (in vitro)

		CHRM3	CSNK1A1
Gene Name		cholinergic receptor, muscarinic 3	casein kinase 1, alpha 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Basolateral Plasma Membrane Cell Junction Dendrite Asymmetric Synapse Axon Terminus Postsynaptic Membrane	Condensed Chromosome Kinetochore Cytoplasm Centrosome Cytosol MRNA Cleavage And Polyadenylation Specificity Factor Complex Membrane Nuclear Speck Primary Cilium
	Molecular Function	Phosphatidylinositol Phospholipase C Activity Receptor Activity Protein Binding Drug Binding G-protein Coupled Acetylcholine Receptor Activity Acetylcholine Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding
	Biological Process	Regulation Of Vascular Smooth Muscle Contraction Energy Reserve Metabolic Process Cellular Protein Modification Process Smooth Muscle Contraction Signal Transduction G-protein Coupled Receptor Signaling Pathway G-protein Coupled Acetylcholine Receptor Signaling Pathway Nervous System Development Cell Proliferation Small Molecule Metabolic Process Positive Regulation Of Smooth Muscle Contraction Saliva Secretion Regulation Of Insulin Secretion	Protein Phosphorylation Phagocytosis Mitotic Nuclear Division Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Cell Shape Wnt Signaling Pathway Peptidyl-serine Phosphorylation Cell Division Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		G alpha (q) signalling events G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Acetylcholine regulates insulin secretion Integration of energy metabolism Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Muscarinic acetylcholine receptors Regulation of insulin secretion Amine ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Hedgehog 'off' state misspliced GSK3beta mutants stabilize beta-catenin APC truncation mutants have impaired AXIN binding T41 mutants of beta-catenin aren't phosphorylated TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex Signaling by Wnt APC truncation mutants are not K63 polyubiquitinated disassembly of the destruction complex and recruitment of AXIN to the membrane S37 mutants of beta-catenin aren't phosphorylated Degradation of beta-catenin by the destruction complex RNF mutants show enhanced WNT signaling and proliferation AXIN mutants destabilize the destruction complex, activating WNT signaling S33 mutants of beta-catenin aren't phosphorylated Hedgehog 'on' state XAV939 inhibits tankyrase, stabilizing AXIN Beta-catenin phosphorylation cascade truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated deletions in the AMER1 gene destabilize the destruction complex TCF dependent signaling in response to WNT AMER1 mutants destabilize the destruction complex deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by Hedgehog Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Degradation of GLI2 by the proteasome Activation of SMO
Drugs		Cevimeline Tramadol Succinylcholine Ziprasidone Disopyramide Amitriptyline Ipratropium bromide Olanzapine Metixene Terfenadine Clozapine Trihexyphenidyl Oxyphencyclimine Procyclidine Promazine Hyoscyamine Cyproheptadine Imipramine Methylscopolamine Darifenacin Tridihexethyl Anisotropine Methylbromide Nortriptyline Atropine Nicardipine Paroxetine Homatropine Methylbromide Diphemanil Methylsulfate Scopolamine Benzquinamide Propiomazine Cryptenamine Tropicamide Brompheniramine Maprotiline Tolterodine Oxybutynin Promethazine Pilocarpine Doxepin Desipramine Quetiapine Mivacurium Diphenidol Aripiprazole Chlorprothixene Pancuronium Pipecuronium Methotrimeprazine Tiotropium Solifenacin Isopropamide Mepenzolate Fesoterodine Methacholine Aclidinium
Diseases
GWAS		Epilepsy (generalized) ( 22949513) Hypertension ( 17554300) Platelet counts ( 21507922) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)	Esophageal cancer ( 21642993)
Protein-Protein Interactions		9 interactors: ARF1 ARF6 CSNK1A1 GNAQ GPRASP1 GRK6 GZMB PPP1R9B SET	43 interactors: ACTB ADAP1 AP3B1 AP3B2 APC AXIN1 BID CDC25A CHRM3 CREM CTNNB1 EIF2B5 ERF FADD GLI3 GNB2 HMGB1 HMGB2 HNRNPC HSPA4 KPNA2 KPNB1 LGALS3 MAPT MDM4 NFATC3 PARK2 PDE4D PHLPP1 PPP1CC PPP1R14A PPP2R5A PSEN2 RCC1 SLC18A2 SNCA SYT9 TGFBR1 TIAM1 TNFRSF1B TP53 YWHAQ YWHAZ
Entrez ID		1131	1452
HPRD ID		00329	02739
Ensembl ID			ENSG00000113712
Uniprot IDs		P20309	B4DER9 P48729 Q6PJ06 Q71TU5
PDB IDs		2CSA
Enriched GO Terms of Interacting Partners?		Regulation Of Organelle Organization Regulation Of Signaling Regulation Of Cellular Component Organization Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Signal Transduction Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Signal Transduction G-protein Coupled Receptor Catabolic Process Regulation Of Opioid Receptor Signaling Pathway Signaling Cell Cycle Cell Communication Cellular Response To Morphine Cellular Response To Isoquinoline Alkaloid Regulation Of Cell Growth By Extracellular Stimulus Regulation Of Establishment Of Protein Localization Granzyme-mediated Apoptotic Signaling Pathway Regulation Of Cellular Process Regulation Of Endocytosis Negative Regulation Of Catalytic Activity Cellular Response To Stimulus Regulation Of Protein Localization Myeloid Cell Apoptotic Process Phospholipase C-activating Dopamine Receptor Signaling Pathway Organelle Organization Intracellular Signal Transduction Neuron Remodeling Protein Localization To Endosome COPI-coated Vesicle Budding Regulation Of Exit From Mitosis COPI Coating Of Golgi Vesicle Wnt Signaling Pathway Regulation Of Melanocyte Differentiation Golgi Vesicle Budding Regulation Of Cellular Localization Regulation Of Synaptic Transmission Nucleosome Disassembly Maternal Behavior Long Term Synaptic Depression Establishment Of Epithelial Cell Polarity Filopodium Assembly Cellular Copper Ion Homeostasis Protein Localization To Cell Surface Metabolic Process Cell Projection Organization Cellular Response To Ammonium Ion Hepatocyte Apoptotic Process Receptor Catabolic Process Negative Regulation Of Receptor-mediated Endocytosis Regulation Of Actin Cytoskeleton Organization	Death Apoptotic Process Programmed Cell Death Cell Death Cellular Response To Stimulus Regulation Of Cellular Localization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Signaling Positive Regulation Of Cell Death Response To Organic Substance Response To Stimulus Cell Communication Regulation Of Apoptotic Process Response To Stress Regulation Of Cell Death Regulation Of Protein Localization Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Regulation Of Cellular Process Regulation Of Signaling Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Intracellular Transport Execution Phase Of Apoptosis Response To External Stimulus Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Cell Death Immune System Process Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Cell Activation Regulation Of Establishment Of Protein Localization Developmental Process Thymus Development Regulation Of Catalytic Activity Signal Transduction Cellular Response To Organic Substance Positive Regulation Of Metabolic Process Positive Regulation Of Mitochondrion Organization Regulation Of Protein Metabolic Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway T Cell Differentiation In Thymus Regulation Of Cellular Component Organization Regulation Of Protein Complex Assembly Regulation Of Cellular Protein Metabolic Process Leukocyte Activation Positive Regulation Of Protein Metabolic Process Movement Of Cell Or Subcellular Component
Tagcloud ?		additions adenocarcinomas animal aom attenuates azoxymethane bethanechol bethenechol chloride colonic drinking euthanized injections intestinal intraperitoneal m3r metalloproteinase mmp10 mmp13 mmp7 mucosa muscarinic name neoplasia nicotinic prominent strikingly thickness	aberrantly antagonistic beauty becomes canonical concert connectivity ctnnb1 decipher discover facts functioning gbm gli2 hedgehog imperative integrative interplay missed ranked recapitulate relying shh similarities smo solve sonic surmised wnt
Tagcloud (Difference) ?		additions adenocarcinomas animal aom attenuates azoxymethane bethanechol bethenechol chloride colonic drinking euthanized injections intestinal intraperitoneal m3r metalloproteinase mmp10 mmp13 mmp7 mucosa muscarinic name neoplasia nicotinic prominent strikingly thickness	aberrantly antagonistic beauty becomes canonical concert connectivity ctnnb1 decipher discover facts functioning gbm gli2 hedgehog imperative integrative interplay missed ranked recapitulate relying shh similarities smo solve sonic surmised wnt
Tagcloud (Intersection) ?