CHRM3 and PPP1R9B

Number of citations of the paper that reports this interaction (PMID 17464283)
18

Data Source:
HPRD (in vitro)

		CHRM3	PPP1R9B
Gene Name		cholinergic receptor, muscarinic 3	protein phosphatase 1, regulatory subunit 9B
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Basolateral Plasma Membrane Cell Junction Dendrite Asymmetric Synapse Axon Terminus Postsynaptic Membrane	Protein Phosphatase Type 1 Complex Nucleoplasm Cytoplasm Plasma Membrane Adherens Junction Lamellipodium Filopodium Cortical Actin Cytoskeleton Ruffle Membrane Dendritic Spine Synapse
	Molecular Function	Phosphatidylinositol Phospholipase C Activity Receptor Activity Protein Binding Drug Binding G-protein Coupled Acetylcholine Receptor Activity Acetylcholine Binding	Actin Binding Protein Phosphatase Inhibitor Activity Protein Binding Protein Phosphatase 1 Binding
	Biological Process	Regulation Of Vascular Smooth Muscle Contraction Energy Reserve Metabolic Process Cellular Protein Modification Process Smooth Muscle Contraction Signal Transduction G-protein Coupled Receptor Signaling Pathway G-protein Coupled Acetylcholine Receptor Signaling Pathway Nervous System Development Cell Proliferation Small Molecule Metabolic Process Positive Regulation Of Smooth Muscle Contraction Saliva Secretion Regulation Of Insulin Secretion	Regulation Of Cell Growth By Extracellular Stimulus Regulation Of Protein Phosphorylation Actin Filament Organization Cell Cycle Arrest Regulation Of Exit From Mitosis RNA Splicing Dendrite Development Cell Migration Calcium-mediated Signaling Negative Regulation Of Cell Growth Regulation Of Cell Proliferation Negative Regulation Of Catalytic Activity Filopodium Assembly Regulation Of Synaptic Transmission Cellular Response To Morphine Regulation Of Opioid Receptor Signaling Pathway
Pathways		G alpha (q) signalling events G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Acetylcholine regulates insulin secretion Integration of energy metabolism Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Muscarinic acetylcholine receptors Regulation of insulin secretion Amine ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs		Cevimeline Tramadol Succinylcholine Ziprasidone Disopyramide Amitriptyline Ipratropium bromide Olanzapine Metixene Terfenadine Clozapine Trihexyphenidyl Oxyphencyclimine Procyclidine Promazine Hyoscyamine Cyproheptadine Imipramine Methylscopolamine Darifenacin Tridihexethyl Anisotropine Methylbromide Nortriptyline Atropine Nicardipine Paroxetine Homatropine Methylbromide Diphemanil Methylsulfate Scopolamine Benzquinamide Propiomazine Cryptenamine Tropicamide Brompheniramine Maprotiline Tolterodine Oxybutynin Promethazine Pilocarpine Doxepin Desipramine Quetiapine Mivacurium Diphenidol Aripiprazole Chlorprothixene Pancuronium Pipecuronium Methotrimeprazine Tiotropium Solifenacin Isopropamide Mepenzolate Fesoterodine Methacholine Aclidinium
Diseases
GWAS		Epilepsy (generalized) ( 22949513) Hypertension ( 17554300) Platelet counts ( 21507922) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Protein-Protein Interactions		9 interactors: ARF1 ARF6 CSNK1A1 GNAQ GPRASP1 GRK6 GZMB PPP1R9B SET	23 interactors: ACTA1 ADRA1A ADRA1B ADRA2A ADRA2B ADRA2C CCKAR CCKBR CDKN2A CHRM3 DCX DRD2 MAPK1 PPP1CA PPP1CB PPP1CC PPP1R2 PPP1R9A PRKACA RGS2 RPS6KB1 TGOLN2 TIAM1
Entrez ID		1131	84687
HPRD ID		00329	04506
Ensembl ID			ENSG00000108819
Uniprot IDs		P20309	D3DTX6 Q96SB3
PDB IDs		2CSA
Enriched GO Terms of Interacting Partners?		Regulation Of Organelle Organization Regulation Of Signaling Regulation Of Cellular Component Organization Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Signal Transduction Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Signal Transduction G-protein Coupled Receptor Catabolic Process Regulation Of Opioid Receptor Signaling Pathway Signaling Cell Cycle Cell Communication Cellular Response To Morphine Cellular Response To Isoquinoline Alkaloid Regulation Of Cell Growth By Extracellular Stimulus Regulation Of Establishment Of Protein Localization Granzyme-mediated Apoptotic Signaling Pathway Regulation Of Cellular Process Regulation Of Endocytosis Negative Regulation Of Catalytic Activity Cellular Response To Stimulus Regulation Of Protein Localization Myeloid Cell Apoptotic Process Phospholipase C-activating Dopamine Receptor Signaling Pathway Organelle Organization Intracellular Signal Transduction Neuron Remodeling Protein Localization To Endosome COPI-coated Vesicle Budding Regulation Of Exit From Mitosis COPI Coating Of Golgi Vesicle Wnt Signaling Pathway Regulation Of Melanocyte Differentiation Golgi Vesicle Budding Regulation Of Cellular Localization Regulation Of Synaptic Transmission Nucleosome Disassembly Maternal Behavior Long Term Synaptic Depression Establishment Of Epithelial Cell Polarity Filopodium Assembly Cellular Copper Ion Homeostasis Protein Localization To Cell Surface Metabolic Process Cell Projection Organization Cellular Response To Ammonium Ion Hepatocyte Apoptotic Process Receptor Catabolic Process Negative Regulation Of Receptor-mediated Endocytosis Regulation Of Actin Cytoskeleton Organization	Energy Reserve Metabolic Process Adrenergic Receptor Signaling Pathway Regulation Of Signaling Regulation Of Muscle Contraction Regulation Of Smooth Muscle Contraction Regulation Of Vasoconstriction Regulation Of Signal Transduction Energy Derivation By Oxidation Of Organic Compounds Signal Transduction Cell Surface Receptor Signaling Pathway Activation Of MAPK Activity By Adrenergic Receptor Signaling Pathway Signaling Cellular Response To Stimulus Regulation Of Phosphorus Metabolic Process Cell Communication Negative Regulation Of Signaling Regulation Of MAPK Cascade Generation Of Precursor Metabolites And Energy Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Epidermal Growth Factor-activated Receptor Transactivation By G-protein Coupled Receptor Signaling Pathway Regulation Of Hormone Secretion Triglyceride Catabolic Process Positive Regulation Of MAPK Cascade Regulation Of Phosphorylation Receptor Transactivation Acylglycerol Catabolic Process Developmental Process Negative Regulation Of Epinephrine Secretion Response To External Stimulus Regulation Of Kinase Activity Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Glycogen Catabolic Process G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Norepinephrine Secretion Response To Organic Substance Response To Stimulus Positive Regulation Of Signal Transduction Muscle System Process Regulation Of Intracellular Signal Transduction Activation Of Protein Kinase Activity Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Regulation Of Cellular Localization Regulation Of Protein Kinase Activity Regulation Of MAP Kinase Activity System Development Anatomical Structure Development Regulation Of Norepinephrine Secretion Negative Regulation Of Signal Transduction Response To Abiotic Stimulus
Tagcloud ?		additions adenocarcinomas animal aom attenuates azoxymethane bethanechol bethenechol chloride colonic drinking euthanized injections intestinal intraperitoneal m3r metalloproteinase mmp10 mmp13 mmp7 mucosa muscarinic name neoplasia nicotinic prominent strikingly thickness	accn1 ago arises cgg description disturbed eef1a2 fmr1 fmrp fragile gabrd hes1 inherited intelligence interactive lending lymphoblastoid lymphoblasts males microarrays morphogenesis neurodevelopment overrepresentation retardation syndrome transcriptome trinucleotide unc13b untranslated
Tagcloud (Difference) ?		additions adenocarcinomas animal aom attenuates azoxymethane bethanechol bethenechol chloride colonic drinking euthanized injections intestinal intraperitoneal m3r metalloproteinase mmp10 mmp13 mmp7 mucosa muscarinic name neoplasia nicotinic prominent strikingly thickness	accn1 ago arises cgg description disturbed eef1a2 fmr1 fmrp fragile gabrd hes1 inherited intelligence interactive lending lymphoblastoid lymphoblasts males microarrays morphogenesis neurodevelopment overrepresentation retardation syndrome transcriptome trinucleotide unc13b untranslated
Tagcloud (Intersection) ?