YES1 and GFAP

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		YES1	GFAP
Description		YES proto-oncogene 1, Src family tyrosine kinase	glial fibrillary acidic protein
Image
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Centrosome Cytosol Cytoskeleton Actin Filament Plasma Membrane Focal Adhesion Membrane Extracellular Exosome Anchoring Junction	Cytoplasm Lysosome Cytosol Cytoskeleton Intermediate Filament Membrane Cell Projection Cell Body Intermediate Filament Cytoskeleton Glial Cell Projection Astrocyte Projection Astrocyte End-foot Cytoplasmic Side Of Lysosomal Membrane
	Molecular Function	Nucleotide Binding Phosphotyrosine Residue Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Enzyme Binding Transmembrane Transporter Binding	Integrin Binding Structural Constituent Of Cytoskeleton Protein Binding Kinase Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Inflammatory Response To Antigenic Stimulus Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of D-glucose Transmembrane Transport Cell Differentiation T Cell Costimulation Cellular Response To Platelet-derived Growth Factor Stimulus Protein Modification Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Vascular Permeability Positive Regulation Of Transcription By RNA Polymerase II Ephrin Receptor Signaling Pathway Leukocyte Migration Cellular Response To Retinoic Acid Cellular Response To Transforming Growth Factor Beta Stimulus	Intracellular Protein Transport Gene Expression Positive Regulation Of Schwann Cell Proliferation Negative Regulation Of Neuron Projection Development Astrocyte Development Schwann Cell Proliferation Extracellular Matrix Organization Neuron Projection Regeneration Neuron Projection Development Regulation Of Protein-containing Complex Assembly Intermediate Filament-based Process Intermediate Filament Organization Regulation Of Neurotransmitter Uptake Bergmann Glial Cell Differentiation Positive Regulation Of Glial Cell Proliferation Long-term Synaptic Potentiation D-aspartate Import Across Plasma Membrane Regulation Of Chaperone-mediated Autophagy
Pathways		Signaling by ERBB2 Signaling by SCF-KIT Signaling by SCF-KIT Regulation of KIT signaling FCGR activation PECAM1 interactions EPH-Ephrin signaling Co-stimulation by CD28 Co-inhibition by CTLA4 EPHB-mediated forward signaling EPHB-mediated forward signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells RUNX2 regulates osteoblast differentiation Regulation of signaling by CBL Regulation of signaling by CBL FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Signaling by CSF1 (M-CSF) in myeloid cells	Nuclear signaling by ERBB4 Chaperone Mediated Autophagy
Drugs		Dasatinib Fostamatinib
Diseases			Alexander disease
GWAS		Diastolic blood pressure ( 29403010 30487518) Hypertension ( 30487518) Mean arterial pressure ( 29403010 30487518) PR interval in Tripanosoma cruzi seropositivity ( 24324551) Pulmonary function in asthmatics ( 23541324) Pursuit maintenance gain ( 29064472) Systolic blood pressure ( 29403010 30224653 30487518 30578418) Thyroid autoantibody positivity (anti-thyroglobulin (TgAb) and/or anti-thyroid peroxidase (TPOAb) levels) ( 31794020)	Asthma ( 31619474) Cognitive function ( 25644384) Craniofacial microsomia ( 26853712)
Interacting Genes		98 interacting genes: ADAM12 ADAM15 AMOTL2 AR BCAR1 BECN1 BICD2 C1orf94 CARD9 CBL CBLB CBLC CCDC33 CD2AP CD36 CD46 CDH1 CDKN1B CEP57L1 CEP83 CHMP1A CPSF6 CRKL CSF1R DDIT4L DENND2C DES DLG4 DOK1 DOK2 DRC4 DTX3 DVL2 EFS EGFR EPHB2 ERBB2 ERBB3 ERBB4 FASLG FGFR1 FLACC1 FLT1 FUNDC1 FXR1 FXR2 GAB1 GFAP GP6 IKZF3 ITGB4 JAK2 JAKMIP1 KDR KHDRBS1 KIT LASP1 LIN7C MET MST1R NEDD4 NHERF1 NIF3L1 NPHS1 OGT PAK2 PDCD6IP PDGFRB PECAM1 PICK1 PIK3R3 PTEN PTK2 PTPRE RASA1 RPL10 SH3GLB2 SKAP2 SOCS1 SOCS2 SOCS3 SOCS7 SPRR2A SSBP3 STAP2 THAP1 TNK2 TP53BP2 TRAF2 TRAF6 TRIM5 TRPV4 TSGA10IP TYRO3 ZBTB8A ZC2HC1A ZNF438 ZNF512B	86 interacting genes: ABI2 AKT1 APP AURKB BIRC2 CAMK2A CARD10 CCDC57 CDC37 CDK1 CEP76 CFAP206 CRYAB CT55 CWF19L2 DSCAM ENKD1 EPM2AIP1 FAM50B FXR1 FXR2 GOLGA2 GRAP2 HGS HOMEZ IKBKG ITSN1 KIAA0408 KRT13 KRT15 KRT19 KRT27 KRT31 KRT39 LENG1 LGALS14 LMO2 MAPK9 MEN1 MOS MYBPHL MYO15B NEFL NEIL3 NEK6 NFKBID NTAQ1 NXF1 PDLIM1 PDLIM7 PDZK1 PIAS2 PIH1D2 POM121 PPP1R16B PPP1R18 PRKACA PRKCA PRKCG PSEN1 PSEN2 RIBC2 ROCK1 RORA S100A1 S100B SH3YL1 SMARCA2 SMARCB1 SRC STAT1 TBC1D21 TBC1D22B TFIP11 TLE5 TP53BP2 TRIM27 TSC1 TUBGCP4 UBASH3A UBE3A VIM YES1 ZC2HC1C ZNF655 ZNF774
Entrez ID		7525	2670
HPRD ID		01285	00675
Ensembl ID		ENSG00000176105	ENSG00000131095
Uniprot IDs		P07947	A0A1X7SBR3 P14136
PDB IDs		2HDA	6A9P
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Receptor Complex Positive Regulation Of Signal Transduction Signal Transduction Positive Regulation Of Cell Communication Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Signaling Intracellular Signal Transduction Peptidyl-tyrosine Phosphorylation Regulation Of Signal Transduction Regulation Of Programmed Cell Death Regulation Of Protein Phosphorylation Regulation Of Intracellular Signal Transduction Identical Protein Binding Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Positive Regulation Of Protein Metabolic Process Regulation Of Cell Migration Regulation Of Apoptotic Process Plasma Membrane Regulation Of Protein Modification Process Regulation Of Phosphorus Metabolic Process Regulation Of Cell Motility Regulation Of Developmental Process Cell Migration Negative Regulation Of Programmed Cell Death Regulation Of Cellular Component Organization Regulation Of Locomotion Positive Regulation Of Phosphate Metabolic Process Response To Growth Factor Positive Regulation Of Protein Modification Process Protein Kinase Activity Cell Motility SH3 Domain Binding Regulation Of Protein Metabolic Process Regulation Of Protein Kinase Activity Protein Binding Positive Regulation Of MAP Kinase Activity Positive Regulation Of Cell Population Proliferation	Cytoskeleton Organization Intermediate Filament Organization Cytoskeleton Supramolecular Fiber Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Protein Binding Protein Serine/threonine/tyrosine Kinase Activity Intracellular Signal Transduction Structural Constituent Of Skin Epidermis Cytoplasm Protein Kinase Activity Intermediate Filament Protein Serine Kinase Activity Regulation Of Cellular Component Organization Microtubule Cytoskeleton Organization Organelle Organization Response To Peptide Hormone Positive Regulation Of Signaling Regulation Of Generation Of Precursor Metabolites And Energy Protein Serine/threonine Kinase Activity Protein-containing Complex Keratin Filament Regulation Of Synaptic Plasticity Protein Phosphorylation Nucleus Kinase Activity Regulation Of Neuronal Synaptic Plasticity Structural Constituent Of Cytoskeleton Response To Hormone Regulation Of Protein Metabolic Process Positive Regulation Of Cell Communication Cytosol Regulation Of Sister Chromatid Segregation Regulation Of Cell Cycle Regulation Of Apoptotic Process Synaptic Membrane Mitotic Nuclear Membrane Disassembly Developmental Process Negative Regulation Of TORC1 Signaling Intracellular Signaling Cassette Regulation Of Proteolysis Phosphorylation Regulation Of Circadian Rhythm Regulation Of Signaling Positive Regulation Of Gene Expression Regulation Of Cell Communication Regulation Of Programmed Cell Death Positive Regulation Of Signal Transduction Structural Molecule Activity
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