YES1 and SOCS2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		YES1	SOCS2
Description		YES proto-oncogene 1, Src family tyrosine kinase	suppressor of cytokine signaling 2
Image
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Centrosome Cytosol Cytoskeleton Actin Filament Plasma Membrane Focal Adhesion Membrane Extracellular Exosome Anchoring Junction	Cytoplasm Cytosol Cul5-RING Ubiquitin Ligase Complex
	Molecular Function	Nucleotide Binding Phosphotyrosine Residue Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Enzyme Binding Transmembrane Transporter Binding	Cytokine Receptor Binding Growth Hormone Receptor Binding Insulin-like Growth Factor Receptor Binding Protein Binding JAK Pathway Signal Transduction Adaptor Activity Phosphorylation-dependent Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Negative Regulation Of Inflammatory Response To Antigenic Stimulus Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of D-glucose Transmembrane Transport Cell Differentiation T Cell Costimulation Cellular Response To Platelet-derived Growth Factor Stimulus Protein Modification Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Vascular Permeability Positive Regulation Of Transcription By RNA Polymerase II Ephrin Receptor Signaling Pathway Leukocyte Migration Cellular Response To Retinoic Acid Cellular Response To Transforming Growth Factor Beta Stimulus	Regulation Of Cell Growth Cell Surface Receptor Signaling Pathway Via JAK-STAT Lactation Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Protein Ubiquitination Cytokine-mediated Signaling Pathway Response To Estradiol Cellular Response To Hormone Stimulus Intracellular Signal Transduction Erythropoietin-mediated Signaling Pathway Regulation Of Multicellular Organism Growth Negative Regulation Of Multicellular Organism Growth Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Neuron Differentiation Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Growth Hormone Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Growth Hormone Receptor Signaling Pathway Mammary Gland Alveolus Development
Pathways		Signaling by ERBB2 Signaling by SCF-KIT Signaling by SCF-KIT Regulation of KIT signaling FCGR activation PECAM1 interactions EPH-Ephrin signaling Co-stimulation by CD28 Co-inhibition by CTLA4 EPHB-mediated forward signaling EPHB-mediated forward signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells RUNX2 regulates osteoblast differentiation Regulation of signaling by CBL Regulation of signaling by CBL FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Signaling by CSF1 (M-CSF) in myeloid cells	Interleukin-7 signaling Neddylation Negative regulation of FLT3 Growth hormone receptor signaling
Drugs		Dasatinib Fostamatinib
Diseases
GWAS		Diastolic blood pressure ( 29403010 30487518) Hypertension ( 30487518) Mean arterial pressure ( 29403010 30487518) PR interval in Tripanosoma cruzi seropositivity ( 24324551) Pulmonary function in asthmatics ( 23541324) Pursuit maintenance gain ( 29064472) Systolic blood pressure ( 29403010 30224653 30487518 30578418) Thyroid autoantibody positivity (anti-thyroglobulin (TgAb) and/or anti-thyroid peroxidase (TPOAb) levels) ( 31794020)	Height ( 18391951 18391952 20881960 23563607 25282103 25429064 28552196 31562340) Hepatic lipid content in extreme obesity ( 25246029) Hip circumference adjusted for BMI ( 34021172) Joint damage in rheumatoid arthritis ( 31596875) Pubertal anthropometrics ( 23449627) Type 2 diabetes ( 30054458)
Interacting Genes		98 interacting genes: ADAM12 ADAM15 AMOTL2 AR BCAR1 BECN1 BICD2 C1orf94 CARD9 CBL CBLB CBLC CCDC33 CD2AP CD36 CD46 CDH1 CDKN1B CEP57L1 CEP83 CHMP1A CPSF6 CRKL CSF1R DDIT4L DENND2C DES DLG4 DOK1 DOK2 DRC4 DTX3 DVL2 EFS EGFR EPHB2 ERBB2 ERBB3 ERBB4 FASLG FGFR1 FLACC1 FLT1 FUNDC1 FXR1 FXR2 GAB1 GFAP GP6 IKZF3 ITGB4 JAK2 JAKMIP1 KDR KHDRBS1 KIT LASP1 LIN7C MET MST1R NEDD4 NHERF1 NIF3L1 NPHS1 OGT PAK2 PDCD6IP PDGFRB PECAM1 PICK1 PIK3R3 PTEN PTK2 PTPRE RASA1 RPL10 SH3GLB2 SKAP2 SOCS1 SOCS2 SOCS3 SOCS7 SPRR2A SSBP3 STAP2 THAP1 TNK2 TP53BP2 TRAF2 TRAF6 TRIM5 TRPV4 TSGA10IP TYRO3 ZBTB8A ZC2HC1A ZNF438 ZNF512B	21 interacting genes: ARFIP2 BMI1 EGFR EPOR ERBB3 ERBB4 GHR IGF1R INSR JAK1 JAK3 KIT MET PLA2G1B PRLR PTK2 RYBP SOCS3 STK16 TPD52 YES1
Entrez ID		7525	8835
HPRD ID		01285	05490
Ensembl ID		ENSG00000176105	ENSG00000120833
Uniprot IDs		P07947	O14508
PDB IDs		2HDA	2C9W 4JGH 5BO4 6I4X 6I5J 6I5N 7M6T 7ZLM 7ZLN 7ZLO 7ZLP 7ZLR 7ZLS
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Receptor Complex Positive Regulation Of Signal Transduction Signal Transduction Positive Regulation Of Cell Communication Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Signaling Intracellular Signal Transduction Peptidyl-tyrosine Phosphorylation Regulation Of Signal Transduction Regulation Of Programmed Cell Death Regulation Of Protein Phosphorylation Regulation Of Intracellular Signal Transduction Identical Protein Binding Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Positive Regulation Of Protein Metabolic Process Regulation Of Cell Migration Regulation Of Apoptotic Process Plasma Membrane Regulation Of Protein Modification Process Regulation Of Phosphorus Metabolic Process Regulation Of Cell Motility Regulation Of Developmental Process Cell Migration Negative Regulation Of Programmed Cell Death Regulation Of Cellular Component Organization Regulation Of Locomotion Positive Regulation Of Phosphate Metabolic Process Response To Growth Factor Positive Regulation Of Protein Modification Process Protein Kinase Activity Cell Motility SH3 Domain Binding Regulation Of Protein Metabolic Process Regulation Of Protein Kinase Activity Protein Binding Positive Regulation Of MAP Kinase Activity Positive Regulation Of Cell Population Proliferation	Protein Tyrosine Kinase Activity Protein Kinase Activity Receptor Complex Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Phosphorylation Phosphorylation Protein Phosphatase Binding Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Population Proliferation Cell Surface Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via STAT ATP Binding Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Programmed Cell Death Negative Regulation Of Programmed Cell Death Peptidyl-tyrosine Phosphorylation Protein Autophosphorylation Nucleotide Binding Transferase Activity Growth Hormone Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of MAPK Cascade Protein Modification Process Regulation Of Cell Population Proliferation Regulation Of Multicellular Organismal Process Positive Regulation Of Multicellular Organismal Process Phosphate-containing Compound Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Growth Hormone Receptor Signaling Pathway Via JAK-STAT Cell Differentiation Regulation Of MAPK Cascade Protein Tyrosine Kinase Activator Activity Cellular Developmental Process Epidermal Growth Factor Receptor Signaling Pathway Protein Metabolic Process Positive Regulation Of Metabolic Process Basal Plasma Membrane Regulation Of Signal Transduction Positive Regulation Of Phosphate Metabolic Process ERBB Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process
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