YES1 and CD36

Number of citations of the paper that reports this interaction (PMID 1715582)
83

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		YES1	CD36
Gene Name		YES proto-oncogene 1, Src family tyrosine kinase	CD36 molecule (thrombospondin receptor)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Golgi Apparatus Microtubule Organizing Center Cytosol Actin Filament Plasma Membrane Focal Adhesion Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Extracellular Vesicular Exosome	Extracellular Space Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Endocytic Vesicle Membrane Platelet Alpha Granule Membrane Membrane Raft Phagocytic Vesicle
	Molecular Function	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Epidermal Growth Factor Receptor Binding Protein Binding ATP Binding Enzyme Binding Ion Channel Binding	Low-density Lipoprotein Receptor Activity High-density Lipoprotein Particle Binding Lipid Binding Low-density Lipoprotein Particle Binding Transforming Growth Factor Beta Binding Thrombospondin Receptor Activity Lipoteichoic Acid Receptor Activity Lipoprotein Particle Binding
	Biological Process	Cellular Protein Modification Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Axon Guidance Blood Coagulation Glucose Transport Cell Differentiation T Cell Costimulation Cellular Response To Platelet-derived Growth Factor Stimulus Peptidyl-tyrosine Autophosphorylation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Cell Proliferation Regulation Of Vascular Permeability Innate Immune Response Ephrin Receptor Signaling Pathway Leukocyte Migration Cellular Response To Peptide Hormone Stimulus	Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cell-matrix Adhesion Toll-like Receptor Signaling Pathway Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Platelet Degranulation MyD88-dependent Toll-like Receptor Signaling Pathway Lipid Metabolic Process Receptor-mediated Endocytosis Phagocytosis, Recognition Cell Adhesion Cell Surface Receptor Signaling Pathway Nitric Oxide Mediated Signal Transduction Blood Coagulation Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Storage Plasma Membrane Long-chain Fatty Acid Transport Lipid Storage CGMP-mediated Signaling Platelet Activation Positive Regulation Of Blood Coagulation Cholesterol Transport Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Plasma Lipoprotein Particle Clearance Low-density Lipoprotein Particle Clearance Response To Stilbenoid Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Lipoprotein Transport Negative Regulation Of Transcription Factor Import Into Nucleus Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apoptotic Cell Clearance Positive Regulation Of MAPK Cascade Negative Regulation Of Growth Of Symbiont In Host Cellular Lipid Metabolic Process Small Molecule Metabolic Process Long-chain Fatty Acid Import Innate Immune Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Defense Response To Gram-positive Bacterium Low-density Lipoprotein Particle Mediated Signaling Positive Regulation Of Phagocytosis, Engulfment Positive Regulation Of Macrophage Cytokine Production Cellular Response To Bacterial Lipopeptide Cellular Response To Lipopolysaccharide Cellular Response To Lipoteichoic Acid Cellular Response To Hydroperoxide Regulation Of Removal Of Superoxide Radicals Positive Regulation Of Blood Microparticle Formation Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Axon guidance Costimulation by the CD28 family EPHB-mediated forward signaling Signaling by SCF-KIT EPHA-mediated growth cone collapse Regulation of KIT signaling EPH-ephrin mediated repulsion of cells Regulation of signaling by CBL EPH-Ephrin signaling Fcgamma receptor (FCGR) dependent phagocytosis FCGR activation Innate Immune System CTLA4 inhibitory signaling CD28 co-stimulation Cytokine Signaling in Immune system PECAM1 interactions Cell surface interactions at the vascular wall Signaling by ERBB2 Signaling by Interleukins Interleukin-3, 5 and GM-CSF signaling Adaptive Immune System	PPARA activates gene expression Metabolism of lipids and lipoproteins Platelet degranulation Toll Like Receptor TLR6:TLR2 Cascade Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade Response to elevated platelet cytosolic Ca2+ Transcriptional regulation of white adipocyte differentiation MyD88:Mal cascade initiated on plasma membrane Class I MHC mediated antigen processing & presentation Innate Immune System Fatty acid, triacylglycerol, and ketone body metabolism Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Platelet activation, signaling and aggregation Scavenging by Class B Receptors Antigen processing-Cross presentation Cross-presentation of particulate exogenous antigens (phagosomes) Adaptive Immune System
Drugs		Dasatinib
Diseases
GWAS		Pulmonary function in asthmatics ( 23541324)	HDL cholesterol ( 23726366) Left ventricular mass ( 19454037) Mean platelet volume ( 22423221) Response to fenofibrate ( 22890011)
Protein-Protein Interactions		49 interactors: ADAM12 ADAM15 C1orf94 CBL CD2AP CD36 CD46 CDH1 CDKN1B CSF1R DLG4 DOK1 EPHB2 FASLG FLT1 FUNDC1 FXR2 GP6 ITGB4 JAK2 KDR KHDRBS1 KIT MST1R NEDD4 NIF3L1 NPHS1 OGT PAK2 PDCD6IP PDGFRB PECAM1 PTK2 PTPRE RASA1 RPL10 SLC9A3R1 SOCS3 SPRR2A SSBP3 THAP1 TNK2 TP53BP2 TRAF2 TRAF6 TRPV4 TYRO3 ZBTB8A ZNF512B	18 interactors: APP CD9 CHRD COL1A1 COL1A2 FYN HSD11B1 ITGA2B ITGA6 ITGB1 ITGB3 LDLR LYN MATK SRC THBS1 VLDLR YES1
Entrez ID		7525	948
HPRD ID		01285	01430
Ensembl ID		ENSG00000176105	ENSG00000135218
Uniprot IDs		P07947	A4D1B1 P16671
PDB IDs		2HDA
Enriched GO Terms of Interacting Partners?		Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Signal Transduction Positive Regulation Of Protein Metabolic Process Signaling Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Signaling Cell Communication Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Surface Receptor Signaling Pathway Regulation Of Protein Metabolic Process Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Signal Transduction Cellular Response To Stimulus Positive Regulation Of Intracellular Signal Transduction Immune System Process Peptidyl-tyrosine Phosphorylation Regulation Of Cellular Protein Metabolic Process Protein Autophosphorylation Positive Regulation Of Protein Modification Process Regulation Of Protein Phosphorylation Regulation Of Cellular Component Organization Innate Immune Response Response To Stimulus Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Phosphorylation Regulation Of Cellular Process Locomotion Intracellular Signal Transduction Immune Response Regulation Of Phosphorylation Positive Regulation Of Cell Proliferation Positive Regulation Of Metabolic Process Cell Differentiation Positive Regulation Of Phosphorylation Regulation Of Catalytic Activity Regulation Of Protein Kinase Activity Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Regulation Of Immune System Process Regulation Of Kinase Activity Positive Regulation Of Cellular Metabolic Process Response To Stress Regulation Of Peptidyl-tyrosine Phosphorylation Cellular Response To Organic Substance System Development Regulation Of Cellular Component Movement Regulation Of Immune Response Positive Regulation Of Transferase Activity	Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Platelet Activation Response To Wounding Leukocyte Migration Movement Of Cell Or Subcellular Component Locomotion Cell Activation Anatomical Structure Morphogenesis Vesicle-mediated Transport Cell Migration Cell Motility Endocytosis Platelet Degranulation Anatomical Structure Development Peptidyl-tyrosine Autophosphorylation System Development Positive Regulation Of Cell Adhesion Extracellular Matrix Organization Extracellular Structure Organization Axon Guidance Regulation Of Cell Adhesion Developmental Process Response To External Stimulus Multicellular Organismal Development Axonogenesis Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Cell Differentiation Positive Regulation Of Cellular Component Movement Response To Stress Immune System Process Axon Development Positive Regulation Of Locomotion Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Cell Migration Chemotaxis Regulation Of Cell Motility Neuron Projection Morphogenesis Organ Development Regulation Of Locomotion Cell Surface Receptor Signaling Pathway Regulation Of Cellular Component Movement Cell Morphogenesis Involved In Differentiation Integrin-mediated Signaling Pathway Regulation Of Cell Proliferation Response To Abiotic Stimulus Cell Projection Organization
Tagcloud ?		answered antiapoptotic coculture defensive deregulated dramatic heat hyperthermia indicative indispensable insult mechanistically meiotic mta1 naturally negligible nonreceptor pachytene paracrine ps scs sertoli spermatocytes standpoint su6656 testicular testis thereafter varicocele	benzidine bfu cd41 cd71 cfu csf cytokines e2 epo erythroid erythropoiesis erythropoietin events express gata glycophorin gm interestingly late leukemia line lineage pas progenitor reagent stages strictly transforming understand
Tagcloud (Difference) ?		answered antiapoptotic coculture defensive deregulated dramatic heat hyperthermia indicative indispensable insult mechanistically meiotic mta1 naturally negligible nonreceptor pachytene paracrine ps scs sertoli spermatocytes standpoint su6656 testicular testis thereafter varicocele	benzidine bfu cd41 cd71 cfu csf cytokines e2 epo erythroid erythropoiesis erythropoietin events express gata glycophorin gm interestingly late leukemia line lineage pas progenitor reagent stages strictly transforming understand
Tagcloud (Intersection) ?