YES1 and MST1R

Number of citations of the paper that reports this interaction (PMID 8918464)
24

Data Source:
HPRD (in vitro, in vivo)

		YES1	MST1R
Gene Name		YES proto-oncogene 1, Src family tyrosine kinase	macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Golgi Apparatus Microtubule Organizing Center Cytosol Actin Filament Plasma Membrane Focal Adhesion Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Extracellular Vesicular Exosome	Stress Fiber Integral Component Of Plasma Membrane Cell Surface
	Molecular Function	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Epidermal Growth Factor Receptor Binding Protein Binding ATP Binding Enzyme Binding Ion Channel Binding	Macrophage Colony-stimulating Factor Receptor Activity Protein Binding ATP Binding Enzyme Binding
	Biological Process	Cellular Protein Modification Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Axon Guidance Blood Coagulation Glucose Transport Cell Differentiation T Cell Costimulation Cellular Response To Platelet-derived Growth Factor Stimulus Peptidyl-tyrosine Autophosphorylation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Cell Proliferation Regulation Of Vascular Permeability Innate Immune Response Ephrin Receptor Signaling Pathway Leukocyte Migration Cellular Response To Peptide Hormone Stimulus	Movement Of Cell Or Subcellular Component Defense Response Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organismal Development Single Fertilization Positive Regulation Of Cell Proliferation Response To Virus Peptidyl-tyrosine Phosphorylation Macrophage Colony-stimulating Factor Signaling Pathway Positive Regulation Of MAP Kinase Activity Innate Immune Response Positive Regulation Of Protein Kinase B Signaling
Pathways		Axon guidance Costimulation by the CD28 family EPHB-mediated forward signaling Signaling by SCF-KIT EPHA-mediated growth cone collapse Regulation of KIT signaling EPH-ephrin mediated repulsion of cells Regulation of signaling by CBL EPH-Ephrin signaling Fcgamma receptor (FCGR) dependent phagocytosis FCGR activation Innate Immune System CTLA4 inhibitory signaling CD28 co-stimulation Cytokine Signaling in Immune system PECAM1 interactions Cell surface interactions at the vascular wall Signaling by ERBB2 Signaling by Interleukins Interleukin-3, 5 and GM-CSF signaling Adaptive Immune System
Drugs		Dasatinib
Diseases
GWAS		Pulmonary function in asthmatics ( 23541324)	Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		49 interactors: ADAM12 ADAM15 C1orf94 CBL CD2AP CD36 CD46 CDH1 CDKN1B CSF1R DLG4 DOK1 EPHB2 FASLG FLT1 FUNDC1 FXR2 GP6 ITGB4 JAK2 KDR KHDRBS1 KIT MST1R NEDD4 NIF3L1 NPHS1 OGT PAK2 PDCD6IP PDGFRB PECAM1 PTK2 PTPRE RASA1 RPL10 SLC9A3R1 SOCS3 SPRR2A SSBP3 THAP1 TNK2 TP53BP2 TRAF2 TRAF6 TRPV4 TYRO3 ZBTB8A ZNF512B	21 interactors: AKT1 EPOR GAB1 GRB2 HYAL2 JAK2 MST1 PIK3R1 PLCG1 PPP1CA RELA SFN SHC1 SRC STUB1 YES1 YWHAB YWHAE YWHAH YWHAQ YWHAZ
Entrez ID		7525	4486
HPRD ID		01285	02545
Ensembl ID		ENSG00000176105	ENSG00000164078
Uniprot IDs		P07947	B4E058 Q04912
PDB IDs		2HDA	3PLS 4FWW
Enriched GO Terms of Interacting Partners?		Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Signal Transduction Positive Regulation Of Protein Metabolic Process Signaling Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Signaling Cell Communication Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Surface Receptor Signaling Pathway Regulation Of Protein Metabolic Process Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Signal Transduction Cellular Response To Stimulus Positive Regulation Of Intracellular Signal Transduction Immune System Process Peptidyl-tyrosine Phosphorylation Regulation Of Cellular Protein Metabolic Process Protein Autophosphorylation Positive Regulation Of Protein Modification Process Regulation Of Protein Phosphorylation Regulation Of Cellular Component Organization Innate Immune Response Response To Stimulus Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Phosphorylation Regulation Of Cellular Process Locomotion Intracellular Signal Transduction Immune Response Regulation Of Phosphorylation Positive Regulation Of Cell Proliferation Positive Regulation Of Metabolic Process Cell Differentiation Positive Regulation Of Phosphorylation Regulation Of Catalytic Activity Regulation Of Protein Kinase Activity Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Regulation Of Immune System Process Regulation Of Kinase Activity Positive Regulation Of Cellular Metabolic Process Response To Stress Regulation Of Peptidyl-tyrosine Phosphorylation Cellular Response To Organic Substance System Development Regulation Of Cellular Component Movement Regulation Of Immune Response Positive Regulation Of Transferase Activity	Positive Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Positive Regulation Of Apoptotic Signaling Pathway Response To Growth Factor Positive Regulation Of Intracellular Transport Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Intracellular Transport Regulation Of Signal Transduction Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Signaling Fc Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Intrinsic Apoptotic Signaling Pathway Intracellular Signal Transduction Cellular Response To Fibroblast Growth Factor Stimulus Cellular Response To Organic Substance Response To Fibroblast Growth Factor Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Mitochondrion Organization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Peptide Positive Regulation Of Transport Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Body Fluid Levels System Development Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Apoptotic Process ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Mitochondrion Organization Signal Transduction Response To Peptide Hormone Regulation Of Cell Death Immune Response-regulating Signaling Pathway Regulation Of Establishment Of Protein Localization Cellular Response To Organonitrogen Compound Cellular Response To Stimulus Response To Peptide Response To Organic Substance Signaling Apoptotic Signaling Pathway Defense Response Multicellular Organismal Development Cell Communication
Tagcloud ?		answered antiapoptotic coculture defensive deregulated dramatic heat hyperthermia indicative indispensable insult mechanistically meiotic mta1 naturally negligible nonreceptor pachytene paracrine ps scs sertoli spermatocytes standpoint su6656 testicular testis thereafter varicocele	allow ann arbor better chl classical coexpression event expressions hodgkin hrs hybridization impact intensive interquartile lymphoma met multivariate noncovalent prognostic reed require ron step sternberg subgroup survival thirty twenty
Tagcloud (Difference) ?		answered antiapoptotic coculture defensive deregulated dramatic heat hyperthermia indicative indispensable insult mechanistically meiotic mta1 naturally negligible nonreceptor pachytene paracrine ps scs sertoli spermatocytes standpoint su6656 testicular testis thereafter varicocele	allow ann arbor better chl classical coexpression event expressions hodgkin hrs hybridization impact intensive interquartile lymphoma met multivariate noncovalent prognostic reed require ron step sternberg subgroup survival thirty twenty
Tagcloud (Intersection) ?