YES1 and GP6

Number of citations of the paper that reports this interaction (PubMedID 1715582)
58

Data Source:
HPRD (in vivo)

		YES1	GP6
Description		YES proto-oncogene 1, Src family tyrosine kinase	glycoprotein VI platelet
Image
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Centrosome Cytosol Cytoskeleton Actin Filament Plasma Membrane Focal Adhesion Membrane Extracellular Exosome Anchoring Junction	Plasma Membrane Cell Surface Membrane Membrane Raft Extracellular Exosome Tetraspanin-enriched Microdomain
	Molecular Function	Nucleotide Binding Phosphotyrosine Residue Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Enzyme Binding Transmembrane Transporter Binding	Transmembrane Signaling Receptor Activity Protein Binding Collagen Binding Signaling Receptor Activity Collagen Receptor Activity Protein Tyrosine Kinase Binding
	Biological Process	Negative Regulation Of Inflammatory Response To Antigenic Stimulus Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of D-glucose Transmembrane Transport Cell Differentiation T Cell Costimulation Cellular Response To Platelet-derived Growth Factor Stimulus Protein Modification Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Vascular Permeability Positive Regulation Of Transcription By RNA Polymerase II Ephrin Receptor Signaling Pathway Leukocyte Migration Cellular Response To Retinoic Acid Cellular Response To Transforming Growth Factor Beta Stimulus	Immune Response-regulating Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Blood Coagulation Hemostasis Platelet Activation Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Collagen-activated Signaling Pathway Platelet Aggregation Positive Regulation Of Platelet Aggregation
Pathways		Signaling by ERBB2 Signaling by SCF-KIT Signaling by SCF-KIT Regulation of KIT signaling FCGR activation PECAM1 interactions EPH-Ephrin signaling Co-stimulation by CD28 Co-inhibition by CTLA4 EPHB-mediated forward signaling EPHB-mediated forward signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells RUNX2 regulates osteoblast differentiation Regulation of signaling by CBL Regulation of signaling by CBL FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Signaling by CSF1 (M-CSF) in myeloid cells	GPVI-mediated activation cascade Cell surface interactions at the vascular wall Platelet Adhesion to exposed collagen
Drugs		Dasatinib Fostamatinib
Diseases
GWAS		Diastolic blood pressure ( 29403010 30487518) Hypertension ( 30487518) Mean arterial pressure ( 29403010 30487518) PR interval in Tripanosoma cruzi seropositivity ( 24324551) Pulmonary function in asthmatics ( 23541324) Pursuit maintenance gain ( 29064472) Systolic blood pressure ( 29403010 30224653 30487518 30578418) Thyroid autoantibody positivity (anti-thyroglobulin (TgAb) and/or anti-thyroid peroxidase (TPOAb) levels) ( 31794020)	Blood protein levels ( 30072576) Breast cancer and/or colorectal cancer ( 29698419) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Inflammatory biomarkers (multivariate analysis) ( 33110245) Mean platelet volume ( 27863252 32888494) Mean spheric corpuscular volume ( 32888494) Platelet aggregation ( 29185836 20526338) Platelet count ( 32888494) Platelet distribution width ( 27863252 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Venous thromboembolism ( 31420334)
Interacting Genes		98 interacting genes: ADAM12 ADAM15 AMOTL2 AR BCAR1 BECN1 BICD2 C1orf94 CARD9 CBL CBLB CBLC CCDC33 CD2AP CD36 CD46 CDH1 CDKN1B CEP57L1 CEP83 CHMP1A CPSF6 CRKL CSF1R DDIT4L DENND2C DES DLG4 DOK1 DOK2 DRC4 DTX3 DVL2 EFS EGFR EPHB2 ERBB2 ERBB3 ERBB4 FASLG FGFR1 FLACC1 FLT1 FUNDC1 FXR1 FXR2 GAB1 GFAP GP6 IKZF3 ITGB4 JAK2 JAKMIP1 KDR KHDRBS1 KIT LASP1 LIN7C MET MST1R NEDD4 NHERF1 NIF3L1 NPHS1 OGT PAK2 PDCD6IP PDGFRB PECAM1 PICK1 PIK3R3 PTEN PTK2 PTPRE RASA1 RPL10 SH3GLB2 SKAP2 SOCS1 SOCS2 SOCS3 SOCS7 SPRR2A SSBP3 STAP2 THAP1 TNK2 TP53BP2 TRAF2 TRAF6 TRIM5 TRPV4 TSGA10IP TYRO3 ZBTB8A ZC2HC1A ZNF438 ZNF512B	7 interacting genes: CRP FCER1G FCGR2A FCGR3A FYN LYN YES1
Entrez ID		7525	51206
HPRD ID		01285	10406
Ensembl ID		ENSG00000176105	ENSG00000088053
Uniprot IDs		P07947	Q9HCN6
PDB IDs		2HDA	2GI7 5OU7 5OU8 5OU9 7NMU 7R58
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Receptor Complex Positive Regulation Of Signal Transduction Signal Transduction Positive Regulation Of Cell Communication Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Signaling Intracellular Signal Transduction Peptidyl-tyrosine Phosphorylation Regulation Of Signal Transduction Regulation Of Programmed Cell Death Regulation Of Protein Phosphorylation Regulation Of Intracellular Signal Transduction Identical Protein Binding Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Positive Regulation Of Protein Metabolic Process Regulation Of Cell Migration Regulation Of Apoptotic Process Plasma Membrane Regulation Of Protein Modification Process Regulation Of Phosphorus Metabolic Process Regulation Of Cell Motility Regulation Of Developmental Process Cell Migration Negative Regulation Of Programmed Cell Death Regulation Of Cellular Component Organization Regulation Of Locomotion Positive Regulation Of Phosphate Metabolic Process Response To Growth Factor Positive Regulation Of Protein Modification Process Protein Kinase Activity Cell Motility SH3 Domain Binding Regulation Of Protein Metabolic Process Regulation Of Protein Kinase Activity Protein Binding Positive Regulation Of MAP Kinase Activity Positive Regulation Of Cell Population Proliferation	Fc-gamma Receptor Signaling Pathway Fc Receptor Signaling Pathway Immune Effector Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Immune Response-regulating Signaling Pathway IgG Binding Adaptive Immune Response Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Immune System Process Regulation Of Immune Response Negative Regulation Of Inflammatory Response To Antigenic Stimulus Immunoglobulin Mediated Immune Response Fc-gamma Receptor III Complex Non-membrane Spanning Protein Tyrosine Kinase Activity B Cell Mediated Immunity T Cell Costimulation Immune Response Ephrin Receptor Signaling Pathway Leukocyte Migration Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Cell Activation Acute Inflammatory Response IgG Receptor Activity Regulation Of Immune System Process Antibody-dependent Cellular Cytotoxicity Regulation Of Multicellular Organismal Process Regulation Of Cytokine Production Positive Regulation Of Lymphocyte Activation Positive Regulation Of Multicellular Organismal Process Immune Response-activating Signaling Pathway Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulated Exocytosis Hypersensitivity Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Cell Activation Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Regulation Of Inflammatory Response Lymphocyte Mediated Immunity Activation Of Immune Response Positive Regulation Of Immune System Process Protein Tyrosine Kinase Activity Cell Surface Receptor Signaling Pathway Lymphocyte Activation Acute Inflammatory Response To Antigenic Stimulus Transmembrane Transporter Binding Leukocyte Mediated Immunity Regulation Of Lymphocyte Activation Negative Regulation Of Immune System Process Stimulatory C-type Lectin Receptor Signaling Pathway
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