YES1 and NPHS1

Number of citations of the paper that reports this interaction (PMID 12668668)
54

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		YES1	NPHS1
Gene Name		YES proto-oncogene 1, Src family tyrosine kinase	nephrosis 1, congenital, Finnish type (nephrin)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Golgi Apparatus Microtubule Organizing Center Cytosol Actin Filament Plasma Membrane Focal Adhesion Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Slit Diaphragm Cell Projection Protein Complex Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Epidermal Growth Factor Receptor Binding Protein Binding ATP Binding Enzyme Binding Ion Channel Binding	Protein Binding Myosin Binding Protein Domain Specific Binding Spectrin Binding Alpha-actinin Binding
	Biological Process	Cellular Protein Modification Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Axon Guidance Blood Coagulation Glucose Transport Cell Differentiation T Cell Costimulation Cellular Response To Platelet-derived Growth Factor Stimulus Peptidyl-tyrosine Autophosphorylation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Cell Proliferation Regulation Of Vascular Permeability Innate Immune Response Ephrin Receptor Signaling Pathway Leukocyte Migration Cellular Response To Peptide Hormone Stimulus	Cell Adhesion JNK Cascade Skeletal Muscle Tissue Development Myoblast Fusion Excretion Positive Regulation Of Actin Filament Polymerization Glomerular Basement Membrane Development Regulation Of Excretion Glomerular Visceral Epithelial Cell Development
Pathways		Axon guidance Costimulation by the CD28 family EPHB-mediated forward signaling Signaling by SCF-KIT EPHA-mediated growth cone collapse Regulation of KIT signaling EPH-ephrin mediated repulsion of cells Regulation of signaling by CBL EPH-Ephrin signaling Fcgamma receptor (FCGR) dependent phagocytosis FCGR activation Innate Immune System CTLA4 inhibitory signaling CD28 co-stimulation Cytokine Signaling in Immune system PECAM1 interactions Cell surface interactions at the vascular wall Signaling by ERBB2 Signaling by Interleukins Interleukin-3, 5 and GM-CSF signaling Adaptive Immune System
Drugs		Dasatinib
Diseases
GWAS		Pulmonary function in asthmatics ( 23541324)
Protein-Protein Interactions		49 interactors: ADAM12 ADAM15 C1orf94 CBL CD2AP CD36 CD46 CDH1 CDKN1B CSF1R DLG4 DOK1 EPHB2 FASLG FLT1 FUNDC1 FXR2 GP6 ITGB4 JAK2 KDR KHDRBS1 KIT MST1R NEDD4 NIF3L1 NPHS1 OGT PAK2 PDCD6IP PDGFRB PECAM1 PTK2 PTPRE RASA1 RPL10 SLC9A3R1 SOCS3 SPRR2A SSBP3 THAP1 TNK2 TP53BP2 TRAF2 TRAF6 TRPV4 TYRO3 ZBTB8A ZNF512B	11 interactors: CASK CD2AP FYN IQGAP1 KIRREL LYN NCK1 NCK2 NPHS2 SRC YES1
Entrez ID		7525	4868
HPRD ID		01285	04094
Ensembl ID		ENSG00000176105	ENSG00000161270
Uniprot IDs		P07947	O60500
PDB IDs		2HDA
Enriched GO Terms of Interacting Partners?		Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Signal Transduction Positive Regulation Of Protein Metabolic Process Signaling Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Signaling Cell Communication Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Surface Receptor Signaling Pathway Regulation Of Protein Metabolic Process Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Signal Transduction Cellular Response To Stimulus Positive Regulation Of Intracellular Signal Transduction Immune System Process Peptidyl-tyrosine Phosphorylation Regulation Of Cellular Protein Metabolic Process Protein Autophosphorylation Positive Regulation Of Protein Modification Process Regulation Of Protein Phosphorylation Regulation Of Cellular Component Organization Innate Immune Response Response To Stimulus Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Phosphorylation Regulation Of Cellular Process Locomotion Intracellular Signal Transduction Immune Response Regulation Of Phosphorylation Positive Regulation Of Cell Proliferation Positive Regulation Of Metabolic Process Cell Differentiation Positive Regulation Of Phosphorylation Regulation Of Catalytic Activity Regulation Of Protein Kinase Activity Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Regulation Of Immune System Process Regulation Of Kinase Activity Positive Regulation Of Cellular Metabolic Process Response To Stress Regulation Of Peptidyl-tyrosine Phosphorylation Cellular Response To Organic Substance System Development Regulation Of Cellular Component Movement Regulation Of Immune Response Positive Regulation Of Transferase Activity	Cellular Response To Platelet-derived Growth Factor Stimulus Response To Platelet-derived Growth Factor Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Ephrin Receptor Signaling Pathway Positive Regulation Of Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Adhesion Neuron Projection Morphogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Projection Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Axon Guidance Regulation Of Lymphocyte Activation Neuron Projection Development Cell Migration Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Cell Activation Signal Complex Assembly Cell Motility Enzyme Linked Receptor Protein Signaling Pathway T Cell Costimulation Neuron Development Axonogenesis Phagocytosis Axon Development Fc Receptor Signaling Pathway Cell Morphogenesis Involved In Neuron Differentiation Cell Morphogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Chemotaxis Neuron Differentiation Cell Development Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Cell Morphogenesis Involved In Differentiation Locomotion Immune Response-regulating Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Protein Complex Assembly Movement Of Cell Or Subcellular Component Regulation Of Cell Proliferation
Tagcloud ?		answered antiapoptotic coculture defensive deregulated dramatic heat hyperthermia indicative indispensable insult mechanistically meiotic mta1 naturally negligible nonreceptor pachytene paracrine ps scs sertoli spermatocytes standpoint su6656 testicular testis thereafter varicocele	1beta actin actinin actn4 blocks coactivator cytosol defective fails filtration focal fsgs glomerular glomerulosclerosis ikappabalpha k255e mechanistically p50 p65 podocytes potentiate proteinuria recruit reporter segmental specialized terminally tnfalpha translocate
Tagcloud (Difference) ?		answered antiapoptotic coculture defensive deregulated dramatic heat hyperthermia indicative indispensable insult meiotic mta1 naturally negligible nonreceptor pachytene paracrine ps scs sertoli spermatocytes standpoint su6656 testicular testis thereafter varicocele	1beta actin actinin actn4 blocks coactivator cytosol defective fails filtration focal fsgs glomerular glomerulosclerosis ikappabalpha k255e p50 p65 podocytes potentiate proteinuria recruit reporter segmental specialized terminally tnfalpha translocate
Tagcloud (Intersection) ?		mechanistically