YES1 and LIN7C

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		YES1	LIN7C
Description		YES proto-oncogene 1, Src family tyrosine kinase	lin-7 cell polarity scaffold C
Image
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Centrosome Cytosol Cytoskeleton Actin Filament Plasma Membrane Focal Adhesion Membrane Extracellular Exosome Anchoring Junction	Cytoplasm Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Basolateral Plasma Membrane Synapse Postsynaptic Membrane Anchoring Junction MPP7-DLG1-LIN7 Complex Presynapse Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Phosphotyrosine Residue Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Enzyme Binding Transmembrane Transporter Binding	Protein Binding Cytoskeletal Protein Binding Protein Domain Specific Binding PDZ Domain Binding Protein-macromolecule Adaptor Activity L27 Domain Binding
	Biological Process	Negative Regulation Of Inflammatory Response To Antigenic Stimulus Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of D-glucose Transmembrane Transport Cell Differentiation T Cell Costimulation Cellular Response To Platelet-derived Growth Factor Stimulus Protein Modification Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Vascular Permeability Positive Regulation Of Transcription By RNA Polymerase II Ephrin Receptor Signaling Pathway Leukocyte Migration Cellular Response To Retinoic Acid Cellular Response To Transforming Growth Factor Beta Stimulus	Morphogenesis Of An Epithelial Sheet Exocytosis Neurotransmitter Secretion Regulation Of Synaptic Assembly At Neuromuscular Junction Protein Transport Synaptic Vesicle Transport
Pathways		Signaling by ERBB2 Signaling by SCF-KIT Signaling by SCF-KIT Regulation of KIT signaling FCGR activation PECAM1 interactions EPH-Ephrin signaling Co-stimulation by CD28 Co-inhibition by CTLA4 EPHB-mediated forward signaling EPHB-mediated forward signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells RUNX2 regulates osteoblast differentiation Regulation of signaling by CBL Regulation of signaling by CBL FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Signaling by CSF1 (M-CSF) in myeloid cells	Dopamine Neurotransmitter Release Cycle Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors
Drugs		Dasatinib Fostamatinib
Diseases
GWAS		Diastolic blood pressure ( 29403010 30487518) Hypertension ( 30487518) Mean arterial pressure ( 29403010 30487518) PR interval in Tripanosoma cruzi seropositivity ( 24324551) Pulmonary function in asthmatics ( 23541324) Pursuit maintenance gain ( 29064472) Systolic blood pressure ( 29403010 30224653 30487518 30578418) Thyroid autoantibody positivity (anti-thyroglobulin (TgAb) and/or anti-thyroid peroxidase (TPOAb) levels) ( 31794020)	Bone mineral density (paediatric, skull) ( 24945404) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Feeling miserable ( 29500382) Feeling nervous ( 29500382) Hip circumference ( 25673412) Lumbar spine bone mineral density ( 22504420) Menarche (age at onset) ( 27182965) Morning person ( 30696823) Survival in pancreatic cancer ( 28470677)
Interacting Genes		98 interacting genes: ADAM12 ADAM15 AMOTL2 AR BCAR1 BECN1 BICD2 C1orf94 CARD9 CBL CBLB CBLC CCDC33 CD2AP CD36 CD46 CDH1 CDKN1B CEP57L1 CEP83 CHMP1A CPSF6 CRKL CSF1R DDIT4L DENND2C DES DLG4 DOK1 DOK2 DRC4 DTX3 DVL2 EFS EGFR EPHB2 ERBB2 ERBB3 ERBB4 FASLG FGFR1 FLACC1 FLT1 FUNDC1 FXR1 FXR2 GAB1 GFAP GP6 IKZF3 ITGB4 JAK2 JAKMIP1 KDR KHDRBS1 KIT LASP1 LIN7C MET MST1R NEDD4 NHERF1 NIF3L1 NPHS1 OGT PAK2 PDCD6IP PDGFRB PECAM1 PICK1 PIK3R3 PTEN PTK2 PTPRE RASA1 RPL10 SH3GLB2 SKAP2 SOCS1 SOCS2 SOCS3 SOCS7 SPRR2A SSBP3 STAP2 THAP1 TNK2 TP53BP2 TRAF2 TRAF6 TRIM5 TRPV4 TSGA10IP TYRO3 ZBTB8A ZC2HC1A ZNF438 ZNF512B	9 interacting genes: ABCA1 BAIAP2 DNAJC5 HTR2C KCNJ12 MPP2 MPP7 SNCA YES1
Entrez ID		7525	55327
HPRD ID		01285	17279
Ensembl ID		ENSG00000176105	ENSG00000148943
Uniprot IDs		P07947	Q9NUP9
PDB IDs		2HDA	3LRA
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Receptor Complex Positive Regulation Of Signal Transduction Signal Transduction Positive Regulation Of Cell Communication Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Signaling Intracellular Signal Transduction Peptidyl-tyrosine Phosphorylation Regulation Of Signal Transduction Regulation Of Programmed Cell Death Regulation Of Protein Phosphorylation Regulation Of Intracellular Signal Transduction Identical Protein Binding Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Positive Regulation Of Protein Metabolic Process Regulation Of Cell Migration Regulation Of Apoptotic Process Plasma Membrane Regulation Of Protein Modification Process Regulation Of Phosphorus Metabolic Process Regulation Of Cell Motility Regulation Of Developmental Process Cell Migration Negative Regulation Of Programmed Cell Death Regulation Of Cellular Component Organization Regulation Of Locomotion Positive Regulation Of Phosphate Metabolic Process Response To Growth Factor Positive Regulation Of Protein Modification Process Protein Kinase Activity Cell Motility SH3 Domain Binding Regulation Of Protein Metabolic Process Regulation Of Protein Kinase Activity Protein Binding Positive Regulation Of MAP Kinase Activity Positive Regulation Of Cell Population Proliferation	Positive Regulation Of Protein-containing Complex Assembly Plasma Membrane Regulation Of Transport Regulation Of Protein-containing Complex Assembly Signal Release Positive Regulation Of Cellular Component Biogenesis Regulation Of Synaptic Plasticity Synaptic Vesicle Exocytosis Cellular Response To Retinoic Acid Cellular Component Assembly Sphingolipid Floppase Activity Membrane Protein Complex Oligomerization Long-term Synaptic Potentiation Excitatory Postsynaptic Potential Dendritic Shaft Response To Desipramine Presynapse Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Response To Growth Factor Cellular Response To Growth Factor Stimulus Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Dendritic Spine Cytoplasm Neuron Projection Branch Point Regulation Of Biological Quality Response To Vitamin B3 Secretion By Cell Positive Regulation Of High-density Lipoprotein Particle Assembly Apolipoprotein A-I Receptor Activity 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding Protein Tetramerization Vesicle-mediated Transport In Synapse Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Protein Localization To Cell Junction Response To Retinoic Acid Regulation Of Multicellular Organismal Process Regulation Of High-density Lipoprotein Particle Assembly Gq/11-coupled Serotonin Receptor Activity Positive Regulation Of Phosphatidylinositol Biosynthetic Process Regulation Of Postsynaptic Membrane Potential Regulation Of Membrane Potential Negative Regulation Of Serotonin Uptake Neuron Apoptotic Process Transporter Regulator Activity Regulated Exocytosis Negative Regulation Of Chaperone-mediated Autophagy
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