YES1 and TYRO3

Number of citations of the paper that reports this interaction (PubMedID 7537495)
0

Data Source:
HPRD (in vivo)

		YES1	TYRO3
Description		YES proto-oncogene 1, Src family tyrosine kinase	TYRO3 protein tyrosine kinase
Image
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Centrosome Cytosol Cytoskeleton Actin Filament Plasma Membrane Focal Adhesion Membrane Extracellular Exosome Anchoring Junction	Nucleus Nuclear Envelope Endoplasmic Reticulum Membrane Plasma Membrane Cell Surface Membrane Receptor Complex
	Molecular Function	Nucleotide Binding Phosphotyrosine Residue Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Enzyme Binding Transmembrane Transporter Binding	Nucleotide Binding Virus Receptor Activity Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Phosphatidylinositol 3-kinase Binding
	Biological Process	Negative Regulation Of Inflammatory Response To Antigenic Stimulus Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of D-glucose Transmembrane Transport Cell Differentiation T Cell Costimulation Cellular Response To Platelet-derived Growth Factor Stimulus Protein Modification Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Vascular Permeability Positive Regulation Of Transcription By RNA Polymerase II Ephrin Receptor Signaling Pathway Leukocyte Migration Cellular Response To Retinoic Acid Cellular Response To Transforming Growth Factor Beta Stimulus	Neuron Migration Natural Killer Cell Differentiation Phagocytosis Cell Adhesion Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Neuropeptide Signaling Pathway Spermatogenesis Nervous System Development Cell Migration Forebrain Cell Migration Platelet Activation Secretion By Cell Negative Regulation Of Toll-like Receptor Signaling Pathway Substrate Adhesion-dependent Cell Spreading Ovulation Cycle Apoptotic Cell Clearance Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Innate Immune Response Lymphocyte Activation Symbiont Entry Into Host Cell Negative Regulation Of Inflammatory Response Negative Regulation Of Lymphocyte Activation Neuron Apoptotic Process Establishment Of Localization In Cell Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Vagina Development Neuron Cellular Homeostasis Platelet Aggregation Positive Regulation Of Viral Life Cycle
Pathways		Signaling by ERBB2 Signaling by SCF-KIT Signaling by SCF-KIT Regulation of KIT signaling FCGR activation PECAM1 interactions EPH-Ephrin signaling Co-stimulation by CD28 Co-inhibition by CTLA4 EPHB-mediated forward signaling EPHB-mediated forward signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells RUNX2 regulates osteoblast differentiation Regulation of signaling by CBL Regulation of signaling by CBL FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Signaling by CSF1 (M-CSF) in myeloid cells
Drugs		Dasatinib Fostamatinib	Fostamatinib
Diseases
GWAS		Diastolic blood pressure ( 29403010 30487518) Hypertension ( 30487518) Mean arterial pressure ( 29403010 30487518) PR interval in Tripanosoma cruzi seropositivity ( 24324551) Pulmonary function in asthmatics ( 23541324) Pursuit maintenance gain ( 29064472) Systolic blood pressure ( 29403010 30224653 30487518 30578418) Thyroid autoantibody positivity (anti-thyroglobulin (TgAb) and/or anti-thyroid peroxidase (TPOAb) levels) ( 31794020)	Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 30072576) HDL cholesterol levels ( 32203549) Metabolic syndrome ( 31589552) Microalbuminuria ( 31511532) Red blood cell count ( 32888494) Systemic lupus erythematosus ( 24871463) Urinary albumin-to-creatinine ratio ( 31511532 31630189)
Interacting Genes		98 interacting genes: ADAM12 ADAM15 AMOTL2 AR BCAR1 BECN1 BICD2 C1orf94 CARD9 CBL CBLB CBLC CCDC33 CD2AP CD36 CD46 CDH1 CDKN1B CEP57L1 CEP83 CHMP1A CPSF6 CRKL CSF1R DDIT4L DENND2C DES DLG4 DOK1 DOK2 DRC4 DTX3 DVL2 EFS EGFR EPHB2 ERBB2 ERBB3 ERBB4 FASLG FGFR1 FLACC1 FLT1 FUNDC1 FXR1 FXR2 GAB1 GFAP GP6 IKZF3 ITGB4 JAK2 JAKMIP1 KDR KHDRBS1 KIT LASP1 LIN7C MET MST1R NEDD4 NHERF1 NIF3L1 NPHS1 OGT PAK2 PDCD6IP PDGFRB PECAM1 PICK1 PIK3R3 PTEN PTK2 PTPRE RASA1 RPL10 SH3GLB2 SKAP2 SOCS1 SOCS2 SOCS3 SOCS7 SPRR2A SSBP3 STAP2 THAP1 TNK2 TP53BP2 TRAF2 TRAF6 TRIM5 TRPV4 TSGA10IP TYRO3 ZBTB8A ZC2HC1A ZNF438 ZNF512B	27 interacting genes: A2M APOE AXL CTDSP1 CTDSP2 ERBB2 FYN GAS6 IKBKG KLK4 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-2 KRTAP5-9 KRTAP9-2 LNX1 MDFI MGAT5B PIK3R1 PROS1 SRC TNIP1 VWC2L YES1
Entrez ID		7525	7301
HPRD ID		01285	02641
Ensembl ID		ENSG00000176105	ENSG00000092445
Uniprot IDs		P07947	H0YNK6 Q06418
PDB IDs		2HDA	1RHF
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Receptor Complex Positive Regulation Of Signal Transduction Signal Transduction Positive Regulation Of Cell Communication Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Signaling Intracellular Signal Transduction Peptidyl-tyrosine Phosphorylation Regulation Of Signal Transduction Regulation Of Programmed Cell Death Regulation Of Protein Phosphorylation Regulation Of Intracellular Signal Transduction Identical Protein Binding Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Positive Regulation Of Protein Metabolic Process Regulation Of Cell Migration Regulation Of Apoptotic Process Plasma Membrane Regulation Of Protein Modification Process Regulation Of Phosphorus Metabolic Process Regulation Of Cell Motility Regulation Of Developmental Process Cell Migration Negative Regulation Of Programmed Cell Death Regulation Of Cellular Component Organization Regulation Of Locomotion Positive Regulation Of Phosphate Metabolic Process Response To Growth Factor Positive Regulation Of Protein Modification Process Protein Kinase Activity Cell Motility SH3 Domain Binding Regulation Of Protein Metabolic Process Regulation Of Protein Kinase Activity Protein Binding Positive Regulation Of MAP Kinase Activity Positive Regulation Of Cell Population Proliferation	Intermediate Filament Keratin Filament Signaling Receptor Binding Protein Tyrosine Kinase Activity Identical Protein Binding Cellular Response To Platelet-derived Growth Factor Stimulus Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Response To Platelet-derived Growth Factor Negative Regulation Of Immune System Process Regulation Of Immune System Process Negative Regulation Of Inflammatory Response To Antigenic Stimulus Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Dendritic Spine Maintenance Vascular Endothelial Growth Factor Receptor Signaling Pathway ErbB-3 Class Receptor Binding Fc-gamma Receptor Signaling Pathway Leukocyte Migration Cellular Response To Oxygen-containing Compound Regulation Of Cell Activation Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Intracellular Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Substrate Adhesion-dependent Cell Spreading T Cell Costimulation Non-membrane Spanning Protein Tyrosine Kinase Activity RNA Polymerase II CTD Heptapeptide Repeat Phosphatase Activity Regulation Of Innate Immune Response Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Defense Response Cellular Response To Growth Factor Stimulus Peptidyl-tyrosine Phosphorylation Ephrin Receptor Signaling Pathway Regulation Of ERK1 And ERK2 Cascade Regulation Of Immune Response Negative Regulation Of Dendritic Cell Apoptotic Process Fc Receptor Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell-substrate Adhesion Positive Regulation Of Natural Killer Cell Differentiation Cellular Response To Interferon-alpha Regulation Of Intracellular Signal Transduction Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Immune System Process Regulation Of Lymphocyte Activation Response To Growth Factor Cellular Response To Transforming Growth Factor Beta Stimulus Phospholipase Activator Activity Platelet Alpha Granule Lumen Positive Regulation Of Lymphocyte Activation
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