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ERBB3 and SOS1
Number of citations of the paper that reports this interaction (PubMedID
11173924
)
0
Data Source:
HPRD
(in vitro, in vivo)
ERBB3
SOS1
Description
erb-b2 receptor tyrosine kinase 3
SOS Ras/Rac guanine nucleotide exchange factor 1
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Plasma Membrane
Basal Plasma Membrane
Membrane
Basolateral Plasma Membrane
Apical Plasma Membrane
Lateral Plasma Membrane
ERBB3:ERBB2 Complex
Receptor Complex
Cytoplasm
Cytosol
Plasma Membrane
Postsynaptic Density
Neuronal Cell Body
Glutamatergic Synapse
GTPase Complex
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Transmembrane Signaling Receptor Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Growth Factor Binding
Protein Tyrosine Kinase Activator Activity
Ubiquitin Protein Ligase Binding
Signaling Receptor Activity
Neuregulin Receptor Activity
Neuregulin Binding
Identical Protein Binding
ErbB-3 Class Receptor Binding
Protein Heterodimerization Activity
Guanyl-nucleotide Exchange Factor Activity
GTPase Activator Activity
Epidermal Growth Factor Receptor Binding
Protein Binding
SH3 Domain Binding
Protein Kinase Binding
Protein Heterodimerization Activity
Molecular Condensate Scaffold Activity
Biological Process
Endocardial Cushion Development
Negative Regulation Of Cell Adhesion
Signal Transduction
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
Peripheral Nervous System Development
Heart Development
Negative Regulation Of Signal Transduction
Positive Regulation Of Gene Expression
Schwann Cell Differentiation
Schwann Cell Development
Cranial Nerve Development
Neuron Differentiation
ERBB2-ERBB3 Signaling Pathway
Wound Healing
Regulation Of Cell Population Proliferation
Myelination
Negative Regulation Of Apoptotic Process
Positive Regulation Of MAPK Cascade
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of Epithelial Cell Proliferation
Negative Regulation Of Secretion
Neuron Apoptotic Process
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Cardiac Muscle Tissue Development
Positive Regulation Of Calcineurin-NFAT Signaling Cascade
Motor Neuron Apoptotic Process
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Negative Regulation Of Motor Neuron Apoptotic Process
B Cell Homeostasis
Hair Follicle Development
Lymphocyte Homeostasis
Response To Ischemia
Heart Morphogenesis
Cardiac Atrium Morphogenesis
Pericardium Morphogenesis
Regulation Of Transcription By RNA Polymerase II
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Small GTPase-mediated Signal Transduction
Ras Protein Signal Transduction
Vitellogenesis
Axon Guidance
Insulin Receptor Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
Schwann Cell Development
Cytokine-mediated Signaling Pathway
Regulation Of T Cell Differentiation In Thymus
Multicellular Organism Growth
Fc-epsilon Receptor Signaling Pathway
T Cell Activation
Regulation Of Cell Population Proliferation
Regulation Of T Cell Proliferation
Myelination
Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Insulin-like Growth Factor Receptor Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Blood Vessel Morphogenesis
B Cell Receptor Signaling Pathway
Leukocyte Migration
Positive Regulation Of Small GTPase Mediated Signal Transduction
Roof Of Mouth Development
Eyelid Development In Camera-type Eye
Heart Trabecula Morphogenesis
Midbrain Morphogenesis
Regulation Of Pro-B Cell Differentiation
Pathways
SOS-mediated signalling
SOS-mediated signalling
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
SHC1 events in ERBB2 signaling
SHC1 events in ERBB4 signaling
Signaling by SCF-KIT
Regulation of KIT signaling
Signalling to RAS
Signalling to RAS
GRB2 events in EGFR signaling
SHC1 events in EGFR signaling
Downstream signal transduction
NRAGE signals death through JNK
GRB2 events in ERBB2 signaling
GRB2 events in ERBB2 signaling
Tie2 Signaling
EGFR Transactivation by Gastrin
DAP12 signaling
SHC-related events triggered by IGF1R
SHC-related events triggered by IGF1R
Role of LAT2/NTAL/LAB on calcium mobilization
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization
GRB2:SOS provides linkage to MAPK signaling for Integrins
NCAM signaling for neurite out-growth
G alpha (12/13) signalling events
Activation of RAC1
Constitutive Signaling by EGFRvIII
SHC-mediated cascade:FGFR1
FRS-mediated FGFR1 signaling
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
SHC-mediated cascade:FGFR3
FRS-mediated FGFR3 signaling
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
Signaling by FGFR2 in disease
Signaling by FGFR4 in disease
Signaling by FGFR1 in disease
Signaling by FGFR3 in disease
RAF/MAP kinase cascade
Signal attenuation
Insulin receptor signalling cascade
Insulin receptor signalling cascade
MET activates RAS signaling
RET signaling
Interleukin-15 signaling
RAC1 GTPase cycle
Activated NTRK2 signals through RAS
Erythropoietin activates RAS
Activated NTRK2 signals through FRS2 and FRS3
Activated NTRK2 signals through FRS2 and FRS3
Activated NTRK3 signals through RAS
Interleukin receptor SHC signaling
FLT3 Signaling
Constitutive Signaling by Overexpressed ERBB2
Signaling by ERBB2 KD Mutants
Signaling by ERBB2 ECD mutants
Signaling by ERBB2 TMD/JMD mutants
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
Signaling by PDGFRA extracellular domain mutants
Potential therapeutics for SARS
Signaling by CSF1 (M-CSF) in myeloid cells
Signaling by FLT3 fusion proteins
Signaling by FLT3 ITD and TKD mutants
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Signaling by LTK
Drugs
Tucatinib
Diseases
Type I diabetes mellitus
Lethal congenital contractural syndrome (LCCS)
Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS
Age at first sexual intercourse (
34211149
)
Allergic disease (asthma, hay fever or eczema) (
29785011
)
Alopecia areata (
25608926
)
Anorexia nervosa (
28494655
)
Asthma (
31959851
31619474
30929738
)
Asthma (adult onset) (
30929738
)
Asthma or allergic disease (pleiotropy) (
29785011
)
Autoimmune thyroid disease (
32581359
)
Body mass index (
32700739
)
Brain morphology (MOSTest) (
32665545
)
Cognitive function (
25644384
)
Household income (MTAG) (
31844048
)
Hypothyroidism (
27182965
)
Obesity-related traits (
23251661
)
Polycystic ovary syndrome (
26416764
)
Refractive error (
32231278
)
Smoking initiation (
33082346
30617275
)
Type 1 diabetes (
17554300
18198356
18978792
19430480
21829393
30572963
17554260
)
Vitiligo (
22951725
)
Aseptic loosening in total joint arthroplasty (
31791832
)
Corticobasal degeneration (
26077951
)
Sensorimotor dexterity (
31596458
)
Interacting Genes
196 interacting genes:
ABL1
ABL2
ACYP1
AGTR2
ALDOA
ATP5ME
BCAR3
BEND5
BLK
BLNK
BTK
CALM1
CD82
CDC25C
CDK5
CFL1
CHN2
CRK
CRKL
CSPG5
DAB1
DAPP1
DUSP14
DUSP18
DUSP19
DUSP21
DUSP29
DYRK1A
EGF
EGFR
EGR1
ENOPH1
ERBB2
ERBB4
ERG28
EYA4
EZR
FAM241B
FER
FES
FGFR1
FGR
FHL3
FKBP1A
FLNA
FLYWCH1
GABARAPL1
GABARAPL2
GRAP2
GRB2
GRB7
HCK
HDAC6
HINT1
HSH2D
HSPA1A
HSPA8
IL6ST
ILKAP
INPPL1
IRF2BP2
ITK
JAK2
JAK3
JUP
LAMTOR2
LBHD1
LCK
LCP2
LRRC7
LYN
MAP1B
MATK
MTMR1
MTMR10
MTMR2
MTMR6
MTMR8
MTMR9
MUC1
MUC4
MYCBP
MYCBP2
NCK1
NCK2
NDUFAB1
NEDD4
NRG1
NRG2
NSMCE1
ODF2L
PA2G4
PDGFRA
PFDN2
PFDN4
PHPT1
PIK3R1
PIK3R2
PIK3R3
PIN4
PLCG1
PLCG2
PPM1A
PPM1B
PPM1F
PPM1K
PPM1M
PRDX5
PRKACA
PRRG4
PSMA5
PTEN
PTGES3
PTK2
PTK2B
PTK6
PTPDC1
PTPN11
PTPN12
PTPN20
PTPN6
PTPN7
PTPRH
PTPRR
RALGAPA1
RASA1
RASA4
RGS4
RIN1
RNF41
RPN1
RTN4
RWDD2A
S100A10
SAP18
SELENOK
SF3B6
SH2B1
SH2B3
SH2D1A
SH2D1B
SH2D2A
SH2D3A
SH2D3C
SH3BP2
SHB
SHC1
SHC2
SHC3
SHC4
SHD
SLA
SLA2
SMIM20
SNAP91
SNCA
SNRPB2
SOCS2
SOCS3
SOCS5
SOCS6
SORL1
SOS1
SRC
SRPK2
STAP1
STYX
SYK
SYNM
TBCA
TCEA2
TEC
TMA7
TMEM134
TMEM14A
TMEM230
TNS1
TNS2
TNS3
TNS4
TPTE
TRIR
TVP23B
TXK
TXN
TXNL4A
VAV1
VAV2
VAV3
VTA1
WRNIP1
YES1
YWHAZ
ZAP70
ZNF207
ZNF532
56 interacting genes:
ABI1
ABI3
ANXA2
ATP6V1E1
BIN1
CAV1
CD19
CD2AP
COPS3
CRK
CRKL
CSF1R
EGFR
EPS8
EPS8L1
EPS8L2
ERBB2
ERBB3
ESR1
FGFR1
FRS2
FYN
GAB1
GRAP
GRB2
HCK
HDLBP
HRAS
ITSN1
ITSN2
LAT2
LCK
MAPK1
MAPK3
MUC1
NCK1
NCK2
PACSIN1
PACSIN3
PIK3R2
PLCG1
PTPN11
PTPN6
RANBP9
RIT2
RRAS
SH3BP5
SH3KBP1
SHC1
SIRPA
SNX18
SNX9
SPTAN1
TNIK
UBASH3A
ZAP70
Entrez ID
2065
6654
HPRD ID
01820
01681
Ensembl ID
ENSG00000065361
ENSG00000115904
Uniprot IDs
P21860
G5E9C8
Q07889
PDB IDs
1M6B
2L9U
3KEX
3LMG
3P11
4LEO
4P59
4RIW
4RIX
4RIY
5CUS
5O4O
5O7P
6KBI
6OP9
7BHE
7BHF
7D85
7MN5
7MN6
7MN8
1AWE
1BKD
1DBH
1NVU
1NVV
1NVW
1NVX
1Q9C
1XD2
1XD4
1XDV
2II0
3KSY
4NYI
4NYJ
4NYM
4URU
4URV
4URW
4URX
4URY
4URZ
4US0
4US1
4US2
5OVD
5OVE
5OVF
5OVG
5OVH
5OVI
5WFO
5WFP
5WFQ
5WFR
6BVI
6BVJ
6BVK
6BVL
6BVM
6CUO
6CUP
6CUR
6D55
6D56
6D59
6D5E
6D5G
6D5H
6D5J
6D5L
6D5M
6D5V
6D5W
6EPL
6EPM
6EPN
6EPO
6EPP
6F08
6SCM
6SFR
6V94
6V9F
6V9J
6V9L
6V9M
6V9N
6V9O
6Y44
7AVI
7AVL
7AVS
7AVT
7AVU
7AVV
7KFZ
7UKR
7UKS
8BE2
8BE4
8BE5
8BE6
8BE7
8BE8
8BE9
8BEA
8XJJ
Enriched GO Terms of Interacting Partners
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Phosphotyrosine Residue Binding
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Non-membrane Spanning Protein Tyrosine Kinase Activity
Enzyme-linked Receptor Protein Signaling Pathway
Peptidyl-tyrosine Phosphorylation
Protein Tyrosine Kinase Activity
ERBB Signaling Pathway
Intracellular Signal Transduction
Phosphoprotein Phosphatase Activity
Regulation Of Signal Transduction
Cytosol
Regulation Of Signaling
Regulation Of Cell Communication
Epidermal Growth Factor Receptor Signaling Pathway
Signal Transduction
Phosphate-containing Compound Metabolic Process
Immune Response-activating Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Regulation Of Intracellular Signal Transduction
Fc Receptor Signaling Pathway
Protein Tyrosine Phosphatase Activity
Dephosphorylation
Regulation Of Immune Response
Cell Activation
Leukocyte Activation
Cytoplasm
Antigen Receptor-mediated Signaling Pathway
Protein Phosphorylation
Protein Modification Process
Immune Response-activating Signaling Pathway
Regulation Of Cell Adhesion
Protein Kinase Activity
Positive Regulation Of Signal Transduction
Phosphorylation
Immune Response-regulating Signaling Pathway
Protein Dephosphorylation
Positive Regulation Of Intracellular Signal Transduction
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Cell Migration
Receptor Tyrosine Kinase Binding
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Immune Response
Lymphocyte Activation
Fc Receptor Mediated Stimulatory Signaling Pathway
B Cell Receptor Signaling Pathway
Positive Regulation Of Immune System Process
Regulation Of MAPK Cascade
Regulation Of Immune System Process
Phosphotyrosine Residue Binding
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Intracellular Signal Transduction
Regulation Of MAPK Cascade
Enzyme-linked Receptor Protein Signaling Pathway
Intracellular Signal Transduction
Regulation Of Signal Transduction
Plasma Membrane
Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Signaling
Intracellular Signaling Cassette
Peptidyl-tyrosine Phosphorylation
ERBB Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
Regulation Of Cell Communication
Regulation Of Cellular Component Organization
Antigen Receptor-mediated Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Signaling Pathway
Signal Transduction
Positive Regulation Of MAPK Cascade
Cell Migration
Positive Regulation Of Intracellular Signal Transduction
Immune Response-activating Signaling Pathway
Positive Regulation Of Cellular Component Organization
T Cell Receptor Signaling Pathway
Positive Regulation Of Immune System Process
Immune Response-regulating Signaling Pathway
Activation Of Immune Response
Regulation Of Immune System Process
Regulation Of Developmental Process
Cell Motility
Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Signaling
Regulation Of Immune Response
Regulation Of Actin Filament-based Process
Response To Growth Factor
Cytosol
Receptor Tyrosine Kinase Binding
Schwann Cell Development
Cytoplasm
Regulation Of Cell Adhesion
Positive Regulation Of Cell Adhesion
Positive Regulation Of Cell Communication
Regulation Of Actin Cytoskeleton Organization
Regulation Of Cytoskeleton Organization
Endocytosis
Regulation Of Anatomical Structure Morphogenesis
Cell Development
MAPK Cascade
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Tagcloud (Difference)
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Tagcloud (Intersection)
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