ERBB3 and CALM1

Number of citations of the paper that reports this interaction (PubMedID 31980649)
68

Data Source:
BioGRID (two hybrid)

		ERBB3	CALM1
Description		erb-b2 receptor tyrosine kinase 3	calmodulin 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane ERBB3:ERBB2 Complex Receptor Complex	Spindle Pole Extracellular Region Nucleus Nucleoplasm Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Spindle Microtubule Plasma Membrane Cilium Voltage-gated Potassium Channel Complex Membrane Sarcomere Synaptic Vesicle Membrane Motile Cilium Vesicle Protein-containing Complex Calcium Channel Complex Cell Projection Myelin Sheath Calyx Of Held Sperm Midpiece Presynaptic Cytosol Catalytic Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Signaling Receptor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Growth Factor Binding Protein Tyrosine Kinase Activator Activity Ubiquitin Protein Ligase Binding Signaling Receptor Activity Neuregulin Receptor Activity Neuregulin Binding Identical Protein Binding ErbB-3 Class Receptor Binding Protein Heterodimerization Activity	Calcium Channel Regulator Activity Calcium Ion Binding Protein Binding Adenylate Cyclase Activator Activity Calcium Channel Inhibitor Activity Protein Kinase Binding Titin Binding Protein Serine/threonine Kinase Activator Activity Transmembrane Transporter Binding Metal Ion Binding Calcium-dependent Protein Binding Protein Phosphatase Activator Activity Transporter Inhibitor Activity
	Biological Process	Endocardial Cushion Development Negative Regulation Of Cell Adhesion Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Peripheral Nervous System Development Heart Development Negative Regulation Of Signal Transduction Positive Regulation Of Gene Expression Schwann Cell Differentiation Schwann Cell Development Cranial Nerve Development Neuron Differentiation ERBB2-ERBB3 Signaling Pathway Wound Healing Regulation Of Cell Population Proliferation Myelination Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Secretion Neuron Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cardiac Muscle Tissue Development Positive Regulation Of Calcineurin-NFAT Signaling Cascade Motor Neuron Apoptotic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Motor Neuron Apoptotic Process	G2/M Transition Of Mitotic Cell Cycle Regulation Of Heart Rate Detection Of Calcium Ion G Protein-coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Autophagosome Membrane Docking Substantia Nigra Development Regulation Of Cytokinesis Cellular Response To Interferon-beta Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Calcium-mediated Signaling Response To Calcium Ion Regulation Of Cardiac Muscle Contraction Long-term Synaptic Potentiation Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cellular Response To Type II Interferon Calcineurin-mediated Signaling Regulation Of Cardiac Muscle Cell Action Potential Organelle Localization By Membrane Tethering Presynaptic Endocytosis Negative Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Negative Regulation Of Calcium Ion Export Across Plasma Membrane Mitochondrion-endoplasmic Reticulum Membrane Tethering
Pathways			CaMK IV-mediated phosphorylation of CREB CaMK IV-mediated phosphorylation of CREB Calmodulin induced events Cam-PDE 1 activation CaM pathway Platelet degranulation Translocation of SLC2A4 (GLUT4) to the plasma membrane Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation PKA activation DARPP-32 events Synthesis of IP3 and IP4 in the cytosol Calcineurin activates NFAT Calcineurin activates NFAT eNOS activation Transcriptional activation of mitochondrial biogenesis Inactivation, recovery and regulation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Stimuli-sensing channels FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization Ca2+ pathway Reduction of cytosolic Ca++ levels Sodium/Calcium exchangers Unblocking of NMDA receptors, glutamate binding and activation CREB1 phosphorylation through the activation of Adenylate Cyclase CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Ras activation upon Ca2+ influx through NMDA receptor Smooth Muscle Contraction Smooth Muscle Contraction Activation of Ca-permeable Kainate Receptor Uptake and function of anthrax toxins VEGFR2 mediated vascular permeability VEGFR2 mediated cell proliferation Phase 0 - rapid depolarisation Ion homeostasis CLEC7A (Dectin-1) induces NFAT activation CLEC7A (Dectin-1) induces NFAT activation RHO GTPases activate IQGAPs RHO GTPases activate PAKs RHO GTPases activate PAKs RAF activation RAF/MAP kinase cascade Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Glycogen breakdown (glycogenolysis) Glycogen breakdown (glycogenolysis) Protein methylation Extra-nuclear estrogen signaling Loss of phosphorylation of MECP2 at T308 Regulation of MECP2 expression and activity Ion transport by P-type ATPases Negative regulation of NMDA receptor-mediated neuronal transmission Activation of RAC1 downstream of NMDARs Activation of RAC1 downstream of NMDARs Activation of AMPK downstream of NMDARs Long-term potentiation Long-term potentiation RAS processing Signaling downstream of RAS mutants Signaling by RAF1 mutants FCGR3A-mediated IL10 synthesis FCGR3A-mediated IL10 synthesis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells CASP4 inflammasome assembly Microbial factors inhibit CASP4 activity CASP4 inflammasome assembly Microbial factors inhibit CASP4 activity CASP4 inflammasome assembly Microbial factors inhibit CASP4 activity
Drugs		Tucatinib	Chlorpromazine Cinchocaine Nicardipine Fluphenazine Isoflurane Trifluoperazine Loperamide Perphenazine Phenoxybenzamine Felodipine Melatonin Promethazine Pimozide Nifedipine Bepridil Calcium Aprindine Deacetoxyvinzolidine tert-butanol Trimethyllysine Dequalinium N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide Prenylamine Flunarizine (3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-INDOL-2-YLMETHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-5-SULFONAMIDE Myristic acid Calcium citrate Calcium citrate Calcium citrate Calcium Phosphate Calcium Phosphate Calcium Phosphate Calcium levulinate Calcium phosphate dihydrate Calcium phosphate dihydrate Calcium phosphate dihydrate
Diseases		Type I diabetes mellitus Lethal congenital contractural syndrome (LCCS)
GWAS		Age at first sexual intercourse ( 34211149) Allergic disease (asthma, hay fever or eczema) ( 29785011) Alopecia areata ( 25608926) Anorexia nervosa ( 28494655) Asthma ( 31959851 31619474 30929738) Asthma (adult onset) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Autoimmune thyroid disease ( 32581359) Body mass index ( 32700739) Brain morphology (MOSTest) ( 32665545) Cognitive function ( 25644384) Household income (MTAG) ( 31844048) Hypothyroidism ( 27182965) Obesity-related traits ( 23251661) Polycystic ovary syndrome ( 26416764) Refractive error ( 32231278) Smoking initiation ( 33082346 30617275) Type 1 diabetes ( 17554300 18198356 18978792 19430480 21829393 30572963 17554260) Vitiligo ( 22951725)	Leukocyte telomere length ( 32109421) Response to platinum-based neoadjuvant chemotherapy in cervical cancer ( 28120872)
Interacting Genes		196 interacting genes: ABL1 ABL2 ACYP1 AGTR2 ALDOA ATP5ME BCAR3 BEND5 BLK BLNK BTK CALM1 CD82 CDC25C CDK5 CFL1 CHN2 CRK CRKL CSPG5 DAB1 DAPP1 DUSP14 DUSP18 DUSP19 DUSP21 DUSP29 DYRK1A EGF EGFR EGR1 ENOPH1 ERBB2 ERBB4 ERG28 EYA4 EZR FAM241B FER FES FGFR1 FGR FHL3 FKBP1A FLNA FLYWCH1 GABARAPL1 GABARAPL2 GRAP2 GRB2 GRB7 HCK HDAC6 HINT1 HSH2D HSPA1A HSPA8 IL6ST ILKAP INPPL1 IRF2BP2 ITK JAK2 JAK3 JUP LAMTOR2 LBHD1 LCK LCP2 LRRC7 LYN MAP1B MATK MTMR1 MTMR10 MTMR2 MTMR6 MTMR8 MTMR9 MUC1 MUC4 MYCBP MYCBP2 NCK1 NCK2 NDUFAB1 NEDD4 NRG1 NRG2 NSMCE1 ODF2L PA2G4 PDGFRA PFDN2 PFDN4 PHPT1 PIK3R1 PIK3R2 PIK3R3 PIN4 PLCG1 PLCG2 PPM1A PPM1B PPM1F PPM1K PPM1M PRDX5 PRKACA PRRG4 PSMA5 PTEN PTGES3 PTK2 PTK2B PTK6 PTPDC1 PTPN11 PTPN12 PTPN20 PTPN6 PTPN7 PTPRH PTPRR RALGAPA1 RASA1 RASA4 RGS4 RIN1 RNF41 RPN1 RTN4 RWDD2A S100A10 SAP18 SELENOK SF3B6 SH2B1 SH2B3 SH2D1A SH2D1B SH2D2A SH2D3A SH2D3C SH3BP2 SHB SHC1 SHC2 SHC3 SHC4 SHD SLA SLA2 SMIM20 SNAP91 SNCA SNRPB2 SOCS2 SOCS3 SOCS5 SOCS6 SORL1 SOS1 SRC SRPK2 STAP1 STYX SYK SYNM TBCA TCEA2 TEC TMA7 TMEM134 TMEM14A TMEM230 TNS1 TNS2 TNS3 TNS4 TPTE TRIR TVP23B TXK TXN TXNL4A VAV1 VAV2 VAV3 VTA1 WRNIP1 YES1 YWHAZ ZAP70 ZNF207 ZNF532	268 interacting genes: ACADM ACE2 ADCY8 ADCYAP1R1 ADD1 ADD2 AKAP5 AKAP6 AKAP9 AR ARHGEF7 ARLN ARMC1 ASCL2 ATP2B1 ATRX BRWD1 C11orf65 CABIN1 CALCR CALD1 CAMK1 CAMK2G CAMKK1 CAMKK2 CAMTA2 CASP8AP2 CCDC14 CCNA2 CCND1 CCND2 CCNE1 CCP110 CDC37L1 CDC5L CHEK2 CKMT1B CLINT1 CLIP1 CLTB CNGA2 CNN1 CRHR1 CSNK2A1 CSNK2A2 CSNK2B DAPK1 DCTN2 DCUN1D1 DDAH1 DDIT4L DDX21 DDX5 DLG3 DMXL1 DNAJC13 DOCK11 DOCK3 DRC9 DRD2 DST EDF1 EGFR EIF3C ERBB2 ERBB3 ESR1 ESR2 ESRRG EWSR1 FAS FBXO9 FER FKBP3 FKBP4 GAD1 GAD2 GAP43 GCLM GEM GJB1 GLP1R GLP2R GNAS GRB7 GRIN1 GRK1 GRK4 GRK5 GRM3 GRM4 GRM5 GRM7 GSC2 GTF2I H2AX HERC2 HMMR HSP90AA1 HSPA4 HTR2C HUWE1 IDH1 IMMT INSR IQCE IQCN IQGAP1 IQGAP2 IQSEC2 ITGA6 ITPKA ITPKB KCNB1 KCNH1 KCNN1 KCNN2 KCNN3 KCNN4 KCNQ2 KCNQ3 KCNQ5 KDM5C KIF1B KRAS LACTB LINC00839 LMO7 LTF LUC7L LY96 LYST MAPT MATR3 MBIP METAP2 MFHAS1 MIP MORF4L1 MYBPC1 MYCBP2 MYF5 MYF6 MYLK MYO10 MYO5A MYO7A MYO9B MYOD1 MYOG NBR1 NEB NEUROD1 NEXN NOL7 NOS3 NR3C1 NRGN NSMF NT5C2 OBSCN OPALIN OPRM1 OPTN PAM PCNT PCP4 PDCD7 PDE1A PHACTR4 PHKB PHKG1 PIK3C3 PLA2G6 PLCD1 POC5 POLR2B PPEF1 PPEF2 PPIL2 PRDX1 PSMD12 PSMD2 PTAFR PTEN PTH2R PTPRA PUM3 RAB3B RAD23B RALA RALB RANBP2 RDX REL RELA RGS10 RGS2 RGS4 RIT2 RPL13A RPL22 RPS14 RPS15A RPS4Y1 RPS8 RRAD RS1 RYR1 S100B SCAPER SCLT1 SCN1A SCN4A SCN5A SCTR SDCBP SEC61A1 SEC61B SET SF3B1 SLF2 SLTM SNCA SNRPB2 SNTA1 SNX6 SPATA17 SPP1 SQSTM1 SRP14 SRSF5 STAG1 STIM2 STK38 STRN STRN3 STRN4 STX8 SUMO2 SYK SYNE2 SYT1 TBC1D1 TCF3 TCF4 THOP1 TNNI2 TPT1 TRDN TRPC3 TRPV1 TRPV4 TRPV6 TSC2 TTN UBC UBR4 UCHL5 USP16 UTRN VAMP7 VIPR1 XRCC4 YBX1 YWHAE ZBTB24 ZNF280A
Entrez ID		2065	801
HPRD ID		01820	00241
Ensembl ID		ENSG00000065361	ENSG00000198668
Uniprot IDs		P21860	B4DJ51 P0DP23 P0DP24 P0DP25 Q96HY3
PDB IDs		1M6B 2L9U 3KEX 3LMG 3P11 4LEO 4P59 4RIW 4RIX 4RIY 5CUS 5O4O 5O7P 6KBI 6OP9 7BHE 7BHF 7D85 7MN5 7MN6 7MN8	1CDL 1CLL 1CTR 1IWQ 1J7O 1J7P 1K90 1K93 1L7Z 1LVC 1NKF 1PK0 1S26 1SK6 1SW8 1UP5 1WRZ 1XFU 1XFV 1XFW 1XFX 1XFY 1XFZ 1Y6W 1YR5 1YRT 1YRU 1ZOT 1ZUZ 2BE6 2F3Y 2F3Z 2HF5 2I08 2JZI 2K0E 2K0F 2K0J 2K61 2KNE 2KUG 2KUH 2L53 2L7L 2LGF 2LL6 2LL7 2LQC 2LQP 2LV6 2M0J 2M0K 2M55 2MG5 2N27 2N6A 2N77 2N8J 2R28 2V01 2V02 2VAY 2W73 2WEL 2X0G 2Y4V 3BYA 3DVE 3DVJ 3DVK 3DVM 3EVV 3EWT 3EWV 3G43 3HR4 3J41 3O77 3O78 3OXQ 3SUI 3UCT 3UCW 3UCY 4BW7 4BW8 4BYF 4DCK 4DJC 4GOW 4JPZ 4JQ0 4L79 4LZX 4M1L 4OVN 4Q57 4Q5U 4UMO 4UPU 4V0C 5COC 5DBR 5DOW 5DSU 5GGM 5I0I 5J03 5J8H 5JQA 5JTH 5K7L 5K8Q 5NIN 5OEO 5TP5 5TP6 5V02 5V03 5V7X 5VMS 5WBX 5WC5 5WSU 5WSV 6B8L 6B8M 6B8N 6B8P 6B8Q 6BUT 6C1D 6C1G 6C1H 6CNM 6CNN 6CNO 6DAD 6DAE 6DAF 6DAH 6E2F 6E2G 6EEB 6FEG 6FEH 6GDK 6GDL 6HCS 6HR1 6JI8 6JII 6JIU 6JIY 6JRS 6JV2 6K4K 6K4L 6K4R 6K67 6M2W 6M7H 6MUD 6MUE 6N5W 6O5G 6OS4 6PAW 6PBX 6PBY 6PLM 6S5T 6SZ5 6TV7 6U39 6U3A 6U3B 6U3D 6UZZ 6V00 6V01 6X32 6X33 6X35 6X36 6XXF 6XXX 6XY3 6XYR 6Y4O 6Y4P 6Y94 6Y95 6YA9 6YNS 6YNU 6ZBI 7AUG 7BF1 7BF2 7BYL 7BYM 7BYN 7CR3 7CR4 7CR7 7KL5 7L8V 7MIR 7MIS 7PPO 7PQE 7PSZ 7PU9 7SHQ 7SX3 7SX4 7T2Q 7TCI 7TCP 7TZC 7U9T 7UA3 7UA4 7VMB 7VNP 7VNQ 7VNR 7VUO 7VUR 7VUS 7VUT 7VUU 7VVD 7VVH 7WJI 7WR3 7WR4 7WR5 7WZS 7XN4 7XN5 7XN6 7XNI 7XNK 7XNL 7XNN 7ZRP 7ZRQ 8AHS 8B6Q 8BD2 8BFG 8DGH 8DGK 8DUJ 8DVE 8EOW 8EP0 8EP1 8FNY 8FO6 8GM4 8GM5 8IJK 8J00 8J01 8J02 8J03 8J04 8J05 8J07 8JFK 8K9Z 8KA0 8KA1 8ODZ 8OE0 8OE4 8PB1 8SIK 8SIM 8SIN 8UXL 8UXM 8W4U 8X43 8XJI 8XKH 8XLF 8XLH 8XO1 8XYA 8XYB 8Y40 9CUI 9CUK 9E17 9JQI 9K8W 9K8X
Enriched GO Terms of Interacting Partners?		Phosphotyrosine Residue Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Phosphorylation Protein Tyrosine Kinase Activity ERBB Signaling Pathway Intracellular Signal Transduction Phosphoprotein Phosphatase Activity Regulation Of Signal Transduction Cytosol Regulation Of Signaling Regulation Of Cell Communication Epidermal Growth Factor Receptor Signaling Pathway Signal Transduction Phosphate-containing Compound Metabolic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Protein Tyrosine Phosphatase Activity Dephosphorylation Regulation Of Immune Response Cell Activation Leukocyte Activation Cytoplasm Antigen Receptor-mediated Signaling Pathway Protein Phosphorylation Protein Modification Process Immune Response-activating Signaling Pathway Regulation Of Cell Adhesion Protein Kinase Activity Positive Regulation Of Signal Transduction Phosphorylation Immune Response-regulating Signaling Pathway Protein Dephosphorylation Positive Regulation Of Intracellular Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Cell Migration Receptor Tyrosine Kinase Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Immune Response Lymphocyte Activation Fc Receptor Mediated Stimulatory Signaling Pathway B Cell Receptor Signaling Pathway Positive Regulation Of Immune System Process Regulation Of MAPK Cascade Regulation Of Immune System Process	Calmodulin Binding Cytosol Plasma Membrane Cytoplasm Regulation Of Signaling Regulation Of Cell Communication Intracellular Signal Transduction Signal Transduction Neuron Projection Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Intracellular Signaling Cassette Regulation Of Synaptic Plasticity Regulation Of Biological Quality Response To Calcium Ion Chemical Synaptic Transmission Biological_process Actin Binding Synaptic Signaling Regulation Of Signal Transduction Metal Ion Transport Trans-synaptic Signaling Positive Regulation Of Cell Communication Axon Cellular Response To Calcium Ion Regulation Of Membrane Potential Regulation Of Transport Positive Regulation Of Signaling Monoatomic Ion Channel Activity Synapse Small Conductance Calcium-activated Potassium Channel Activity Response To Metal Ion Regulation Of System Process Regulation Of Metal Ion Transport Cell Cortex Neuronal Cell Body Calcium Ion Homeostasis Cellular Response To Oxygen-containing Compound Calcium Ion Transport Estrogen Response Element Binding Regulation Of Intracellular Signal Transduction Identical Protein Binding Kinase Activity Response To Hormone Regulation Of Calcium Ion Transport Cellular Response To Metal Ion Cell Communication Muscle System Process Calcium/calmodulin-dependent Protein Kinase Activity Signaling Focal Adhesion
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?