ERBB3 and AGTR2

Number of citations of the paper that reports this interaction (PubMedID 10710290)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ERBB3	AGTR2
Description		erb-b2 receptor tyrosine kinase 3	angiotensin II receptor type 2
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane ERBB3:ERBB2 Complex Receptor Complex	Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Signaling Receptor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Growth Factor Binding Protein Tyrosine Kinase Activator Activity Ubiquitin Protein Ligase Binding Signaling Receptor Activity Neuregulin Receptor Activity Neuregulin Binding Identical Protein Binding ErbB-3 Class Receptor Binding Protein Heterodimerization Activity	G Protein-coupled Receptor Activity Angiotensin Type II Receptor Activity Protein Binding Receptor Antagonist Activity
	Biological Process	Endocardial Cushion Development Negative Regulation Of Cell Adhesion Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Peripheral Nervous System Development Heart Development Negative Regulation Of Signal Transduction Positive Regulation Of Gene Expression Schwann Cell Differentiation Schwann Cell Development Cranial Nerve Development Neuron Differentiation ERBB2-ERBB3 Signaling Pathway Wound Healing Regulation Of Cell Population Proliferation Myelination Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Secretion Neuron Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cardiac Muscle Tissue Development Positive Regulation Of Calcineurin-NFAT Signaling Cascade Motor Neuron Apoptotic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Motor Neuron Apoptotic Process	Blood Vessel Remodeling Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Angiotensin-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Brain Renin-angiotensin System Inflammatory Response Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Brain Development Regulation Of Blood Pressure Negative Regulation Of Heart Rate Negative Regulation Of Cell Growth Regulation Of Metanephros Size Exploration Behavior Nitric Oxide-cGMP-mediated Signaling Angiotensin-activated Signaling Pathway Vasodilation Regulation Of Apoptotic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of DNA-templated Transcription Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Neuron Apoptotic Process Positive Regulation Of Metanephric Glomerulus Development Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Blood Vessel Diameter Maintenance Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			Peptide ligand-binding receptors G alpha (i) signalling events
Drugs		Tucatinib	Tasosartan CYT006-AngQb Olodanrigan
Diseases		Type I diabetes mellitus Lethal congenital contractural syndrome (LCCS)	Non-syndromic X-linked mental retardation
GWAS		Age at first sexual intercourse ( 34211149) Allergic disease (asthma, hay fever or eczema) ( 29785011) Alopecia areata ( 25608926) Anorexia nervosa ( 28494655) Asthma ( 31959851 31619474 30929738) Asthma (adult onset) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Autoimmune thyroid disease ( 32581359) Body mass index ( 32700739) Brain morphology (MOSTest) ( 32665545) Cognitive function ( 25644384) Household income (MTAG) ( 31844048) Hypothyroidism ( 27182965) Obesity-related traits ( 23251661) Polycystic ovary syndrome ( 26416764) Refractive error ( 32231278) Smoking initiation ( 33082346 30617275) Type 1 diabetes ( 17554300 18198356 18978792 19430480 21829393 30572963 17554260) Vitiligo ( 22951725)	Cystic fibrosis severity ( 21602797) Gestational age at birth (maternal effect) ( 28877031) Lung disease severity in cystic fibrosis ( 26417704) Offspring birth weight ( 31043758) Preterm birth (maternal effect) ( 28877031) Type 2 diabetes ( 29358691 30130595)
Interacting Genes		196 interacting genes: ABL1 ABL2 ACYP1 AGTR2 ALDOA ATP5ME BCAR3 BEND5 BLK BLNK BTK CALM1 CD82 CDC25C CDK5 CFL1 CHN2 CRK CRKL CSPG5 DAB1 DAPP1 DUSP14 DUSP18 DUSP19 DUSP21 DUSP29 DYRK1A EGF EGFR EGR1 ENOPH1 ERBB2 ERBB4 ERG28 EYA4 EZR FAM241B FER FES FGFR1 FGR FHL3 FKBP1A FLNA FLYWCH1 GABARAPL1 GABARAPL2 GRAP2 GRB2 GRB7 HCK HDAC6 HINT1 HSH2D HSPA1A HSPA8 IL6ST ILKAP INPPL1 IRF2BP2 ITK JAK2 JAK3 JUP LAMTOR2 LBHD1 LCK LCP2 LRRC7 LYN MAP1B MATK MTMR1 MTMR10 MTMR2 MTMR6 MTMR8 MTMR9 MUC1 MUC4 MYCBP MYCBP2 NCK1 NCK2 NDUFAB1 NEDD4 NRG1 NRG2 NSMCE1 ODF2L PA2G4 PDGFRA PFDN2 PFDN4 PHPT1 PIK3R1 PIK3R2 PIK3R3 PIN4 PLCG1 PLCG2 PPM1A PPM1B PPM1F PPM1K PPM1M PRDX5 PRKACA PRRG4 PSMA5 PTEN PTGES3 PTK2 PTK2B PTK6 PTPDC1 PTPN11 PTPN12 PTPN20 PTPN6 PTPN7 PTPRH PTPRR RALGAPA1 RASA1 RASA4 RGS4 RIN1 RNF41 RPN1 RTN4 RWDD2A S100A10 SAP18 SELENOK SF3B6 SH2B1 SH2B3 SH2D1A SH2D1B SH2D2A SH2D3A SH2D3C SH3BP2 SHB SHC1 SHC2 SHC3 SHC4 SHD SLA SLA2 SMIM20 SNAP91 SNCA SNRPB2 SOCS2 SOCS3 SOCS5 SOCS6 SORL1 SOS1 SRC SRPK2 STAP1 STYX SYK SYNM TBCA TCEA2 TEC TMA7 TMEM134 TMEM14A TMEM230 TNS1 TNS2 TNS3 TNS4 TPTE TRIR TVP23B TXK TXN TXNL4A VAV1 VAV2 VAV3 VTA1 WRNIP1 YES1 YWHAZ ZAP70 ZNF207 ZNF532	13 interacting genes: ACE ACE2 AGT AGTRAP ARRB2 ERBB3 ERBIN GNAI2 GNAI3 MTUS1 PIK3CB SNTA1 ZBTB16
Entrez ID		2065	186
HPRD ID		01820	02071
Ensembl ID		ENSG00000065361	ENSG00000180772
Uniprot IDs		P21860	P50052
PDB IDs		1M6B 2L9U 3KEX 3LMG 3P11 4LEO 4P59 4RIW 4RIX 4RIY 5CUS 5O4O 5O7P 6KBI 6OP9 7BHE 7BHF 7D85 7MN5 7MN6 7MN8	5UNF 5UNG 5UNH 5XJM 6JOD 7C6A 7JNI
Enriched GO Terms of Interacting Partners?		Phosphotyrosine Residue Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Phosphorylation Protein Tyrosine Kinase Activity ERBB Signaling Pathway Intracellular Signal Transduction Phosphoprotein Phosphatase Activity Regulation Of Signal Transduction Cytosol Regulation Of Signaling Regulation Of Cell Communication Epidermal Growth Factor Receptor Signaling Pathway Signal Transduction Phosphate-containing Compound Metabolic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Protein Tyrosine Phosphatase Activity Dephosphorylation Regulation Of Immune Response Cell Activation Leukocyte Activation Cytoplasm Antigen Receptor-mediated Signaling Pathway Protein Phosphorylation Protein Modification Process Immune Response-activating Signaling Pathway Regulation Of Cell Adhesion Protein Kinase Activity Positive Regulation Of Signal Transduction Phosphorylation Immune Response-regulating Signaling Pathway Protein Dephosphorylation Positive Regulation Of Intracellular Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Cell Migration Receptor Tyrosine Kinase Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Immune Response Lymphocyte Activation Fc Receptor Mediated Stimulatory Signaling Pathway B Cell Receptor Signaling Pathway Positive Regulation Of Immune System Process Regulation Of MAPK Cascade Regulation Of Immune System Process	Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Regulation Of Gap Junction Assembly Angiotensin-activated Signaling Pathway Type 2 Angiotensin Receptor Binding Peptidyl-dipeptidase Activity Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Regulation Of Renal Output By Angiotensin Regulation Of Systemic Arterial Blood Pressure Regulation Of MAPK Cascade Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Regulation Of Blood Pressure Regulation Of Blood Volume By Renin-angiotensin Positive Regulation Of Gap Junction Assembly G Protein-coupled Receptor Signaling Pathway Regulation Of Heart Contraction Regulation Of Vasoconstriction Positive Regulation Of Reactive Oxygen Species Metabolic Process Plasma Membrane G Protein-coupled Receptor Binding Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Signal Transduction Regulation Of Blood Circulation Angiotensin Maturation Regulation Of System Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Multicellular Organismal Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Transport Guanyl Nucleotide Binding Renal System Process Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Superoxide Anion Generation Regulation Of Superoxide Anion Generation G-protein Beta/gamma-subunit Complex Binding Regulation Of Reactive Oxygen Species Metabolic Process Metallocarboxypeptidase Activity Negative Regulation Of Intracellular Signal Transduction Regulation Of Biological Quality Regulation Of Cardiac Conduction Blood Vessel Diameter Maintenance Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Tube Size Regulation Of Superoxide Metabolic Process Negative Regulation Of Catalytic Activity Carboxypeptidase Activity Negative Regulation Of MAPK Cascade Kidney Development Regulation Of Intracellular Signal Transduction Sodium Channel Regulator Activity
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