ARAF and KLHL12

Number of citations of the paper that reports this interaction (PubMedID 16189514)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ARAF	KLHL12
Description		A-Raf proto-oncogene, serine/threonine kinase	kelch like family member 12
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol	Cytoplasm Cytosol COPII Vesicle Coat COPII-coated ER To Golgi Transport Vesicle Cytoplasmic Vesicle Cul3-RING Ubiquitin Ligase Complex Centriolar Satellite
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	Protein Binding Identical Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	MAPK Cascade Signal Transduction Regulation Of TOR Signaling Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Peptidyl-serine Phosphorylation Protein Modification Process Negative Regulation Of Apoptotic Process	Protein Monoubiquitination Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Anatomical Structure Morphogenesis Tissue Development Neural Crest Formation Neural Crest Cell Development Wnt Signaling Pathway Vesicle-mediated Transport Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process COPII Vesicle Coating
Pathways		RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants SHOC2 M1731 mutant abolishes MRAS complex function Gain-of-function MRAS complexes activate RAF signaling	Degradation of DVL
Drugs		ATP
Diseases		Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS
Interacting Genes		57 interacting genes: AGTRAP AKT1 ASS1 BAD BECN1 CCND2 CDK4 CDK6 CDKN2B CHD6 COPS3 CPS1 CSNK2B DIDO1 E2F6 EFEMP1 EPHA2 FGFR4 GLIS2 GNA12 HRAS IRAK2 IRF7 KLHL12 LATS2 MAP2K1 MAP2K2 MAP2K3 MAP2K5 MLH1 MYC MYO18A NELFCD NF2 NRAS NUDT14 PBK PDGFRB PIK3CA PIK3R1 PKM PRPF6 RABGGTB RASSF1 RGS12 RRAS RRAS2 SFN STK11 TEKT4P2 TESK1 TIMM44 TIRAP TP53 TSC1 WNK1 YWHAG	58 interacting genes: ARAF ATXN1 BAG6 BCL6 C1QTNF2 CARD10 CCBE1 COL8A1 CPSF6 CRTC3 CUL3 DGCR6 DRD4 DVL3 FAM90A1 FBXL17 FGD2 FLNA GLYCTK INMT KEAP1 KLHL2 KLHL24 KLHL3 LNPK LNX1 MAPRE1 MED25 MED28 MPP1 MRPL10 MTNR1A MYO15B NDC80 NTAQ1 PDCD6 PDGFRB PEA15 PLEKHA4 PNKP PRR13 RGL3 RIN1 RIT1 RNF4 RPP25L SDCBP SNX20 SYNE4 TAOK2 TBC1D10C TCEANC TTBK2 UBE2I VEGFB VTA1 ZBP1 ZBTB4
Entrez ID		369	59349
HPRD ID		02405	13925
Ensembl ID		ENSG00000078061	ENSG00000117153
Uniprot IDs		A0A024R178 P10398 Q96II5	Q53G59 Q9H7R2
PDB IDs		1WXM 2MSE 9AXM	2VPJ 6TTK 6V7O 8OIO 8RBH
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Signal Transduction Nucleotide Binding Intracellular Signaling Cassette ATP Binding Regulation Of Intracellular Signal Transduction Protein Kinase Activity Kinase Activity Protein Tyrosine Kinase Activity Protein Serine/threonine Kinase Activity Regulation Of Signal Transduction Protein Serine Kinase Activity Regulation Of Cell Population Proliferation Positive Regulation Of Cellular Component Organization MAP Kinase Kinase Activity Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Signal Transduction MAPK Cascade Cell Surface Receptor Signaling Pathway Intrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Metabolic Process Cellular Response To Stress Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Motility Regulation Of Protein Localization Regulation Of Catalytic Activity Regulation Of Cell Cycle Regulation Of Cell Adhesion Regulation Of Epithelial Cell Proliferation Regulation Of Locomotion Regulation Of Protein Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cellular Component Biogenesis Regulation Of Protein Localization To Membrane Apoptotic Signaling Pathway Cellular Response To Radiation Regulation Of Cellular Localization Negative Regulation Of Macroautophagy Regulation Of Multicellular Organismal Process Enzyme-linked Receptor Protein Signaling Pathway Protein Phosphorylation Positive Regulation Of Protein Localization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Phosphate-containing Compound Metabolic Process Regulation Of Primary Metabolic Process	Cul3-RING Ubiquitin Ligase Complex Protein Binding Regulation Of Signal Transduction Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Ubiquitin-like Ligase-substrate Adaptor Activity Identical Protein Binding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Modification Process POZ Domain Binding Proteolysis Involved In Protein Catabolic Process Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Regulation Of Organelle Organization Regulation Of Cell Communication Regulation Of Signaling Actin Cytoskeleton Organization Positive Regulation Of Signal Transduction Proteasomal Protein Catabolic Process Positive Regulation Of Organelle Organization Cytoskeleton Organization Actin Filament-based Process Paraspeckles Protein K48-linked Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Cell Motility Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Motility Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cellular Component Assembly Regulation Of Locomotion Positive Regulation Of Locomotion
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