ARAF and TIRAP

Number of citations of the paper that reports this interaction (PubMedID 21903422)
55

Data Source:
BioGRID (pull down)

		ARAF	TIRAP
Description		A-Raf proto-oncogene, serine/threonine kinase	TIR domain containing adaptor protein
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol	Cytoplasm Cytosol Plasma Membrane Cell Surface Membrane Endocytic Vesicle Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Ruffle Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	Protein Kinase C Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Protein-macromolecule Adaptor Activity Signaling Adaptor Activity Toll-like Receptor 4 Binding Toll-like Receptor 2 Binding Identical Protein Binding Molecular Adaptor Activity
	Biological Process	MAPK Cascade Signal Transduction Regulation Of TOR Signaling Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Peptidyl-serine Phosphorylation Protein Modification Process Negative Regulation Of Apoptotic Process	Immune System Process MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Signal Transduction Cell Surface Receptor Signaling Pathway Myeloid Cell Differentiation Positive Regulation Of B Cell Proliferation Positive Regulation Of Protein-containing Complex Assembly Response To Lipopolysaccharide Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-15 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway TIRAP-dependent Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Regulation Of Innate Immune Response Positive Regulation Of JNK Cascade Defense Response To Gram-positive Bacterium Positive Regulation Of ERK1 And ERK2 Cascade 3'-UTR-mediated MRNA Stabilization Cellular Response To Bacterial Lipopeptide Cellular Response To Lipoteichoic Acid Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Pathways		RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants SHOC2 M1731 mutant abolishes MRAS complex function Gain-of-function MRAS complexes activate RAF signaling	ER-Phagosome pathway MyD88:MAL(TIRAP) cascade initiated on plasma membrane MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4)
Drugs		ATP
Diseases		Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS			Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Eosinophil percentage of granulocytes ( 27863252) Neutrophil percentage of granulocytes ( 27863252)
Interacting Genes		57 interacting genes: AGTRAP AKT1 ASS1 BAD BECN1 CCND2 CDK4 CDK6 CDKN2B CHD6 COPS3 CPS1 CSNK2B DIDO1 E2F6 EFEMP1 EPHA2 FGFR4 GLIS2 GNA12 HRAS IRAK2 IRF7 KLHL12 LATS2 MAP2K1 MAP2K2 MAP2K3 MAP2K5 MLH1 MYC MYO18A NELFCD NF2 NRAS NUDT14 PBK PDGFRB PIK3CA PIK3R1 PKM PRPF6 RABGGTB RASSF1 RGS12 RRAS RRAS2 SFN STK11 TEKT4P2 TESK1 TIMM44 TIRAP TP53 TSC1 WNK1 YWHAG	25 interacting genes: APP ARAF BTK CASP1 CCDC47 CD247 DNAJC3 EIF2AK2 IL1RL1 IRAK2 IRAK4 LRRK1 LTN1 MPP3 MYD88 PCNA PRKRA SAMHD1 SOCS1 TICAM1 TICAM2 TLR2 TLR4 TRAF6 TRAM1
Entrez ID		369	114609
HPRD ID		02405	05878
Ensembl ID		ENSG00000078061	ENSG00000150455
Uniprot IDs		A0A024R178 P10398 Q96II5	P58753
PDB IDs		1WXM 2MSE 9AXM	2NDH 2Y92 3UB2 3UB3 3UB4 4FZ5 4LQD 5T7Q 5UZB 8JZM
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Signal Transduction Nucleotide Binding Intracellular Signaling Cassette ATP Binding Regulation Of Intracellular Signal Transduction Protein Kinase Activity Kinase Activity Protein Tyrosine Kinase Activity Protein Serine/threonine Kinase Activity Regulation Of Signal Transduction Protein Serine Kinase Activity Regulation Of Cell Population Proliferation Positive Regulation Of Cellular Component Organization MAP Kinase Kinase Activity Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Signal Transduction MAPK Cascade Cell Surface Receptor Signaling Pathway Intrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Metabolic Process Cellular Response To Stress Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Motility Regulation Of Protein Localization Regulation Of Catalytic Activity Regulation Of Cell Cycle Regulation Of Cell Adhesion Regulation Of Epithelial Cell Proliferation Regulation Of Locomotion Regulation Of Protein Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cellular Component Biogenesis Regulation Of Protein Localization To Membrane Apoptotic Signaling Pathway Cellular Response To Radiation Regulation Of Cellular Localization Negative Regulation Of Macroautophagy Regulation Of Multicellular Organismal Process Enzyme-linked Receptor Protein Signaling Pathway Protein Phosphorylation Positive Regulation Of Protein Localization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Phosphate-containing Compound Metabolic Process Regulation Of Primary Metabolic Process	Toll-like Receptor Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Positive Regulation Of Chemokine Production Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Activation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Regulation Of Innate Immune Response Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Defense Response Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-activating Signaling Pathway Regulation Of Chemokine Production Defense Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Immune Response Positive Regulation Of Innate Immune Response Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Immune System Process Regulation Of Defense Response Innate Immune Response Positive Regulation Of Type I Interferon Production Positive Regulation Of Cytokine Production Response To Other Organism Positive Regulation Of Interleukin-6 Production Positive Regulation Of Intracellular Signal Transduction Immune Response Defense Response To Symbiont Defense Response To Virus Defense Response To Other Organism Interleukin-33-mediated Signaling Pathway Immune System Process Interleukin-1-mediated Signaling Pathway Regulation Of Cytokine Production Regulation Of Immune System Process Response To External Biotic Stimulus Response To Stress Regulation Of Type I Interferon Production Positive Regulation Of Immune Response TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Interleukin-6 Production Response To Virus MyD88-independent Toll-like Receptor Signaling Pathway
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