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ARAF and RABGGTB
Number of citations of the paper that reports this interaction (PubMedID
12620389
)
0
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
ARAF
RABGGTB
Description
A-Raf proto-oncogene, serine/threonine kinase
Rab geranylgeranyltransferase subunit beta
Image
GO Annotations
Cellular Component
Cytoplasm
Mitochondrion
Cytosol
Cytoplasm
Cytosol
Plasma Membrane
Rab-protein Geranylgeranyltransferase Complex
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Kinase Activity
Protein Binding
ATP Binding
Zinc Ion Binding
Kinase Activity
Transferase Activity
Metal Ion Binding
Protein Serine Kinase Activity
Catalytic Activity
Prenyltransferase Activity
Protein Geranylgeranyltransferase Activity
Rab Geranylgeranyltransferase Activity
Protein Binding
Zinc Ion Binding
Protein Prenyltransferase Activity
Transferase Activity
Small GTPase Binding
Metal Ion Binding
Biological Process
MAPK Cascade
Signal Transduction
Regulation Of TOR Signaling
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Peptidyl-serine Phosphorylation
Protein Modification Process
Negative Regulation Of Apoptotic Process
Endoplasmic Reticulum To Golgi Vesicle-mediated Transport
Visual Perception
Protein Geranylgeranylation
Protein Modification Process
Pathways
RAF activation
MAP2K and MAPK activation
Negative regulation of MAPK pathway
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF1 fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
SHOC2 M1731 mutant abolishes MRAS complex function
Gain-of-function MRAS complexes activate RAF signaling
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
RAB geranylgeranylation
Drugs
ATP
N-Formylmethionine
Farnesyl diphosphate
Geranylgeranyl diphosphate
Diseases
Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS
Daytime sleep phenotypes (
27126917
)
Serum metabolite levels (
23093944
)
Interacting Genes
57 interacting genes:
AGTRAP
AKT1
ASS1
BAD
BECN1
CCND2
CDK4
CDK6
CDKN2B
CHD6
COPS3
CPS1
CSNK2B
DIDO1
E2F6
EFEMP1
EPHA2
FGFR4
GLIS2
GNA12
HRAS
IRAK2
IRF7
KLHL12
LATS2
MAP2K1
MAP2K2
MAP2K3
MAP2K5
MLH1
MYC
MYO18A
NELFCD
NF2
NRAS
NUDT14
PBK
PDGFRB
PIK3CA
PIK3R1
PKM
PRPF6
RABGGTB
RASSF1
RGS12
RRAS
RRAS2
SFN
STK11
TEKT4P2
TESK1
TIMM44
TIRAP
TP53
TSC1
WNK1
YWHAG
19 interacting genes:
ALAS2
ARAF
B4GALT7
CHML
IGFBP6
NPSR1
PTP4A2
RAB11A
RAB1A
RAB27A
RAB37
RAB3A
RAB5A
RAB6A
RAB7A
SH3GLB1
TAFA1
TMEM25
WDR4
Entrez ID
369
5876
HPRD ID
02405
01532
Ensembl ID
ENSG00000078061
ENSG00000137955
Uniprot IDs
A0A024R178
P10398
Q96II5
A8KAJ2
P53611
Q6IB63
PDB IDs
1WXM
2MSE
9AXM
6J6X
6J74
6J7F
6J7X
6O60
Enriched GO Terms of Interacting Partners
?
Intracellular Signal Transduction
Signal Transduction
Nucleotide Binding
Intracellular Signaling Cassette
ATP Binding
Regulation Of Intracellular Signal Transduction
Protein Kinase Activity
Kinase Activity
Protein Tyrosine Kinase Activity
Protein Serine/threonine Kinase Activity
Regulation Of Signal Transduction
Protein Serine Kinase Activity
Regulation Of Cell Population Proliferation
Positive Regulation Of Cellular Component Organization
MAP Kinase Kinase Activity
Insulin-like Growth Factor Receptor Signaling Pathway
Regulation Of Cell Communication
Regulation Of Signaling
Positive Regulation Of Signal Transduction
MAPK Cascade
Cell Surface Receptor Signaling Pathway
Intrinsic Apoptotic Signaling Pathway
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Regulation Of Metabolic Process
Cellular Response To Stress
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Cell Motility
Regulation Of Protein Localization
Regulation Of Catalytic Activity
Regulation Of Cell Cycle
Regulation Of Cell Adhesion
Regulation Of Epithelial Cell Proliferation
Regulation Of Locomotion
Regulation Of Protein Metabolic Process
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Cellular Component Biogenesis
Regulation Of Protein Localization To Membrane
Apoptotic Signaling Pathway
Cellular Response To Radiation
Regulation Of Cellular Localization
Negative Regulation Of Macroautophagy
Regulation Of Multicellular Organismal Process
Enzyme-linked Receptor Protein Signaling Pathway
Protein Phosphorylation
Positive Regulation Of Protein Localization
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Phosphate-containing Compound Metabolic Process
Regulation Of Primary Metabolic Process
G Protein Activity
GTPase Activity
Myosin V Binding
GTP Binding
Endosome
Establishment Of Vesicle Localization
Vesicle Localization
Establishment Of Organelle Localization
Synaptic Vesicle Recycling
Protein Transport
Establishment Of Melanosome Localization
Melanosome Localization
Melanosome Transport
Pigment Granule Transport
Regulation Of Exocytosis
Positive Regulation Of Exocytosis
Pigment Granule Localization
Establishment Of Protein Localization
Nucleotide Binding
Exosomal Secretion
Intracellular Protein Localization
Organelle Localization
Synaptic Vesicle Membrane
Vesicle-mediated Transport
Intracellular Protein Transport
Regulation Of Vesicle-mediated Transport
Amyloid-beta Clearance By Transcytosis
Cytoplasmic Vesicle
Hydrolase Activity
Presynaptic Endosome
Regulation Of Neuronal Synaptic Plasticity
Regulation Of Secretion
Plasma Membrane To Endosome Transport
Golgi Apparatus
GDP Binding
Endosome To Plasma Membrane Protein Transport
Phagocytic Vesicle
Neurotransmitter Receptor Transport
Regulation Of Plasma Membrane Organization
Vesicle-mediated Transport In Synapse
Establishment Of Localization In Cell
Secretory Granule Membrane
Endosomal Transport
Melanosome
Transcytosis
Melanosome Membrane
Positive Regulation Of Secretion By Cell
Early Endosome To Late Endosome Transport
Regulation Of Secretion By Cell
Regulation Of Regulated Secretory Pathway
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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