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ARAF and PRPF6
Number of citations of the paper that reports this interaction (PMID
10848612
)
10
Data Source:
HPRD
(in vitro, two hybrid)
ARAF
PRPF6
Gene Name
A-Raf proto-oncogene, serine/threonine kinase
pre-mRNA processing factor 6
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cellular_component
Nucleus
Nucleoplasm
Spliceosomal Complex
U5 SnRNP
Membrane
Nuclear Speck
U4/U6 X U5 Tri-snRNP Complex
U4/U6 SnRNP
Catalytic Step 2 Spliceosome
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Receptor Signaling Protein Activity
Protein Binding
ATP Binding
Metal Ion Binding
Transcription Coactivator Activity
RNA Binding
Protein Binding
Ribonucleoprotein Complex Binding
Poly(A) RNA Binding
Androgen Receptor Binding
Biological Process
Cellular Protein Modification Process
Protein Phosphorylation
Regulation Of TOR Signaling
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Peptidyl-serine Phosphorylation
Intracellular Signal Transduction
Negative Regulation Of Apoptotic Process
Spliceosomal Tri-snRNP Complex Assembly
Spliceosomal Complex Assembly
RNA Splicing, Via Transesterification Reactions
MRNA Splicing, Via Spliceosome
RNA Localization
RNA Splicing
Gene Expression
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Minor Pathway
mRNA Splicing - Major Pathway
Drugs
Adenosine triphosphate
Diseases
GWAS
Prostate cancer (
23535732
)
Protein-Protein Interactions
38 interactors:
AGTRAP
ASS1
BAD
CHD6
COPS3
CPS1
CSNK2B
DIDO1
E2F6
EFEMP1
GNA12
HRAS
IRAK2
IRF7
KLHL12
KRAS
MAP2K1
MAP2K2
MLH1
MYO18A
NELFCD
NUDT14
PBK
PDGFRB
PIK3R1
PKM
PRPF6
RABGGTB
RGS12
RRAS
RRAS2
TEKT4P2
TESK1
TIMM44
TIRAP
WNK1
YWHAG
YWHAZ
13 interactors:
AR
ARAF
CD2BP2
EFTUD2
ESR1
NR3C1
RAF1
SMARCA2
SRRM2
TIMM44
TXNL4A
TXNL4B
YWHAB
Entrez ID
369
24148
HPRD ID
02405
10729
Ensembl ID
ENSG00000078061
ENSG00000101161
Uniprot IDs
B4DV85
P10398
Q96II5
O94906
PDB IDs
1WXM
Enriched GO Terms of Interacting Partners
?
Intracellular Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Cellular Response To Fibroblast Growth Factor Stimulus
Response To Fibroblast Growth Factor
Immune Response-regulating Signaling Pathway
Cellular Response To Stimulus
Regulation Of Phosphorylation
Fibroblast Growth Factor Receptor Signaling Pathway
Regulation Of Phosphorus Metabolic Process
Regulation Of Kinase Activity
Cellular Response To Peptide Hormone Stimulus
Innate Immune Response
Signal Transduction
Positive Regulation Of Signal Transduction
Regulation Of Cell Motility
Regulation Of Signal Transduction
Cellular Response To Peptide
Cellular Response To Organonitrogen Compound
Immune Response
Neurotrophin TRK Receptor Signaling Pathway
Ras Protein Signal Transduction
Neurotrophin Signaling Pathway
Regulation Of Locomotion
Fc-epsilon Receptor Signaling Pathway
Regulation Of Cellular Component Movement
Signaling
Response To Hormone
Regulation Of Signaling
Cell Communication
Toll-like Receptor 4 Signaling Pathway
Fc Receptor Signaling Pathway
Cellular Response To Hormone Stimulus
Regulation Of Cell Migration
Phosphorylation
Response To Stimulus
Regulation Of MAPK Cascade
Response To Oleic Acid
Intrinsic Apoptotic Signaling Pathway
Response To Peptide Hormone
Defense Response
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Regulation Of Immune Response
Response To Peptide
Positive Regulation Of Cell Motility
Toll-like Receptor Signaling Pathway
Apoptotic Signaling Pathway
Positive Regulation Of Cellular Component Movement
Positive Regulation Of MAP Kinase Activity
Cellular Response To Insulin Stimulus
MRNA Splicing, Via Spliceosome
RNA Splicing, Via Transesterification Reactions
RNA Splicing
Gene Expression
MRNA Processing
Intracellular Steroid Hormone Receptor Signaling Pathway
RNA Metabolic Process
MRNA Metabolic Process
Cellular Response To Hormone Stimulus
RNA Processing
Cellular Metabolic Process
Steroid Hormone Mediated Signaling Pathway
Hormone-mediated Signaling Pathway
Regulation Of Apoptotic Process
Regulation Of Cell Death
Response To Hormone
Transcription Initiation From RNA Polymerase II Promoter
Cellular Response To Steroid Hormone Stimulus
Ribonucleoprotein Complex Assembly
Nucleobase-containing Compound Metabolic Process
Intracellular Receptor Signaling Pathway
Positive Regulation Of Cellular Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
DNA-templated Transcription, Initiation
Cellular Nitrogen Compound Metabolic Process
Cellular Component Assembly
Mammary Gland Duct Morphogenesis
Spliceosomal Complex Assembly
Nitrogen Compound Metabolic Process
Organelle Organization
Death-inducing Signaling Complex Assembly
Negative Regulation Of Integrin Biosynthetic Process
Glucocorticoid Mediated Signaling Pathway
Activation Of MAPKK Activity
Negative Regulation Of Dephosphorylation
Prostate Gland Development
Ribonucleoprotein Complex Biogenesis
Regulation Of Phosphorus Metabolic Process
Positive Regulation Of Peptidyl-serine Phosphorylation
Metabolic Process
Mammary Gland Morphogenesis
Positive Regulation Of Phosphorylation
Positive Regulation Of Metabolic Process
Transcription From RNA Polymerase II Promoter
Cellular Response To Organic Cyclic Compound
Positive Regulation Of Cellular Biosynthetic Process
Aortic Smooth Muscle Cell Differentiation
Mammary Gland Epithelium Development
Cellular Response To Lipid
Tagcloud
?
al
augmentation
braf
craf1
die
differentiated
disruption
dramatically
drosophila
elegans
embryos
enlarged
establish
failed
finding
gestation
interacts
mek
membranes
mid
mutagenesis
programmed
ras
signalling
unlike
unpublished
vessels
w
Tagcloud (Difference)
?
al
augmentation
braf
craf1
die
differentiated
disruption
dramatically
drosophila
elegans
embryos
enlarged
establish
failed
finding
gestation
interacts
mek
membranes
mid
mutagenesis
programmed
ras
signalling
unlike
unpublished
vessels
w
Tagcloud (Intersection)
?