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ARAF and NUDT14
Number of citations of the paper that reports this interaction (PubMedID
12620389
)
0
Data Source:
HPRD
(two hybrid)
ARAF
NUDT14
Description
A-Raf proto-oncogene, serine/threonine kinase
nudix hydrolase 14
Image
GO Annotations
Cellular Component
Cytoplasm
Mitochondrion
Cytosol
Cytoplasm
Cytosol
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Kinase Activity
Protein Binding
ATP Binding
Zinc Ion Binding
Kinase Activity
Transferase Activity
Metal Ion Binding
Protein Serine Kinase Activity
Protein Binding
UDP-sugar Diphosphatase Activity
Hydrolase Activity
Hydrolase Activity, Acting On Acid Anhydrides, In Phosphorus-containing Anhydrides
Identical Protein Binding
Metal Ion Binding
ADP-ribose Diphosphatase Activity
Biological Process
MAPK Cascade
Signal Transduction
Regulation Of TOR Signaling
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Peptidyl-serine Phosphorylation
Protein Modification Process
Negative Regulation Of Apoptotic Process
Nucleoside Phosphate Metabolic Process
Protein N-linked Glycosylation Via Asparagine
Ribose Phosphate Metabolic Process
Pathways
RAF activation
MAP2K and MAPK activation
Negative regulation of MAPK pathway
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF1 fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
SHOC2 M1731 mutant abolishes MRAS complex function
Gain-of-function MRAS complexes activate RAF signaling
Synthesis of dolichyl-phosphate-glucose
Drugs
ATP
Diseases
Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS
Brain morphology (MOSTest) (
32665545
)
High light scatter reticulocyte count (
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
)
Immature fraction of reticulocytes (
32888494
)
Neutrophil count (
32888494
)
Reticulocyte count (
32888494
)
Reticulocyte fraction of red cells (
32888494
)
White blood cell count (
32888494
)
Interacting Genes
57 interacting genes:
AGTRAP
AKT1
ASS1
BAD
BECN1
CCND2
CDK4
CDK6
CDKN2B
CHD6
COPS3
CPS1
CSNK2B
DIDO1
E2F6
EFEMP1
EPHA2
FGFR4
GLIS2
GNA12
HRAS
IRAK2
IRF7
KLHL12
LATS2
MAP2K1
MAP2K2
MAP2K3
MAP2K5
MLH1
MYC
MYO18A
NELFCD
NF2
NRAS
NUDT14
PBK
PDGFRB
PIK3CA
PIK3R1
PKM
PRPF6
RABGGTB
RASSF1
RGS12
RRAS
RRAS2
SFN
STK11
TEKT4P2
TESK1
TIMM44
TIRAP
TP53
TSC1
WNK1
YWHAG
11 interacting genes:
ARAF
LNX1
LNX2
NIF3L1
NTAQ1
RAF1
REL
TEPSIN
TERF1
TERF2IP
ZCCHC10
Entrez ID
369
256281
HPRD ID
02405
14847
Ensembl ID
ENSG00000078061
ENSG00000183828
Uniprot IDs
A0A024R178
P10398
Q96II5
B3KXY7
O95848
PDB IDs
1WXM
2MSE
9AXM
3Q91
8OTV
Enriched GO Terms of Interacting Partners
?
Intracellular Signal Transduction
Signal Transduction
Nucleotide Binding
Intracellular Signaling Cassette
ATP Binding
Regulation Of Intracellular Signal Transduction
Protein Kinase Activity
Kinase Activity
Protein Tyrosine Kinase Activity
Protein Serine/threonine Kinase Activity
Regulation Of Signal Transduction
Protein Serine Kinase Activity
Regulation Of Cell Population Proliferation
Positive Regulation Of Cellular Component Organization
MAP Kinase Kinase Activity
Insulin-like Growth Factor Receptor Signaling Pathway
Regulation Of Cell Communication
Regulation Of Signaling
Positive Regulation Of Signal Transduction
MAPK Cascade
Cell Surface Receptor Signaling Pathway
Intrinsic Apoptotic Signaling Pathway
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Regulation Of Metabolic Process
Cellular Response To Stress
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Cell Motility
Regulation Of Protein Localization
Regulation Of Catalytic Activity
Regulation Of Cell Cycle
Regulation Of Cell Adhesion
Regulation Of Epithelial Cell Proliferation
Regulation Of Locomotion
Regulation Of Protein Metabolic Process
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Cellular Component Biogenesis
Regulation Of Protein Localization To Membrane
Apoptotic Signaling Pathway
Cellular Response To Radiation
Regulation Of Cellular Localization
Negative Regulation Of Macroautophagy
Regulation Of Multicellular Organismal Process
Enzyme-linked Receptor Protein Signaling Pathway
Protein Phosphorylation
Positive Regulation Of Protein Localization
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Phosphate-containing Compound Metabolic Process
Regulation Of Primary Metabolic Process
Nuclear Telomere Cap Complex
Shelterin Complex
G-rich Strand Telomeric DNA Binding
Telomere Capping
MAP Kinase Kinase Kinase Activity
Positive Regulation Of Peptidyl-serine Phosphorylation
Telomere Maintenance Via Telomerase
RNA-templated DNA Biosynthetic Process
Regulation Of Peptidyl-serine Phosphorylation
Telomere Maintenance Via Telomere Lengthening
Telomeric DNA Binding
Negative Regulation Of Telomere Maintenance
Negative Regulation Of Establishment Of Protein Localization To Telomere
Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere
Negative Regulation Of Establishment Of RNA Localization To Telomere
Positive Regulation Of Shelterin Complex Assembly
Protein-N-terminal Glutamine Amidohydrolase Activity
Coated Vesicle Membrane
Death-inducing Signaling Complex Assembly
Positive Regulation Of Telomere Maintenance
Negative Regulation Of Chromosome Organization
Negative Regulation Of Telomeric D-loop Disassembly
Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication
Negative Regulation Of DNA Recombination At Telomere
Protein-N-terminal Asparagine Amidohydrolase Activity
PDZ Domain Binding
DNA Biosynthetic Process
Regulation Of Protein Phosphorylation
Telomere Maintenance
Positive Regulation Of Chromosome Organization
Regulation Of Phosphorylation
Regulation Of Telomere Maintenance
NF-kappaB Complex
Telomere Organization
Adenylate Cyclase Activator Activity
Identical Protein Binding
Negative Regulation Of DNA Metabolic Process
Regulation Of Establishment Of Protein Localization To Telomere
Regulation Of Establishment Of Protein Localization To Chromosome
Telomerase Activity
Ankyrin Repeat Binding
Protection From Non-homologous End Joining At Telomere
Zinc Ion Binding
Regulation Of Phosphorus Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
ERBB2-ERBB3 Signaling Pathway
ERBB3 Signaling Pathway
Telomere Localization
Meiotic Telomere Clustering
Telomeric D-loop Disassembly
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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