ARAF and NUDT14

Number of citations: 0 (PubMedID 12620389)
Data Source: HPRD (two hybrid)

		ARAF	NUDT14
Name		A-Raf proto-oncogene, serine/threonine kinase	nudix hydrolase 14
Structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol	Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	Protein Binding UDP-sugar Diphosphatase Activity Hydrolase Activity Hydrolase Activity, Acting On Acid Anhydrides, In Phosphorus-containing Anhydrides Identical Protein Binding Metal Ion Binding ADP-ribose Diphosphatase Activity
	Biological Process	MAPK Cascade Signal Transduction Regulation Of TOR Signaling Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Peptidyl-serine Phosphorylation Protein Modification Process Negative Regulation Of Apoptotic Process	Nucleoside Phosphate Metabolic Process Protein N-linked Glycosylation Via Asparagine Ribose Phosphate Metabolic Process
Pathways		RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants SHOC2 M1731 mutant abolishes MRAS complex function Gain-of-function MRAS complexes activate RAF signaling	Synthesis of dolichyl-phosphate-glucose
Drugs		ATP	None
Diseases		Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)	None
GWAS		No GWAS studies recorded	Brain morphology (MOSTest) ( 32665545 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Immature fraction of reticulocytes ( 32888494 ) Neutrophil count ( 32888494 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) White blood cell count ( 32888494 )
Interacting Genes		57 interacting genes: AGTRAP AKT1 ASS1 BAD BECN1 CCND2 CDK4 CDK6 CDKN2B CHD6 COPS3 CPS1 CSNK2B DIDO1 E2F6 EFEMP1 EPHA2 FGFR4 GLIS2 GNA12 HRAS IRAK2 IRF7 KLHL12 LATS2 MAP2K1 MAP2K2 MAP2K3 MAP2K5 MLH1 MYC MYO18A NELFCD NF2 NRAS NUDT14 PBK PDGFRB PIK3CA PIK3R1 PKM PRPF6 RABGGTB RASSF1 RGS12 RRAS RRAS2 SFN STK11 TEKT4P2 TESK1 TIMM44 TIRAP TP53 TSC1 WNK1 YWHAG	11 interacting genes: ARAF LNX1 LNX2 NIF3L1 NTAQ1 RAF1 REL TEPSIN TERF1 TERF2IP ZCCHC10
Entrez ID		369	256281
HPRD ID		02405	14847
Ensembl ID		ENSG00000078061	ENSG00000183828
Uniprot IDs		A0A024R178 P10398 Q96II5	B3KXY7 O95848
PDB IDs		1WXM 2MSE 9AXM	3Q91 8OTV
GO Terms Enriched among Interactors		Intracellular Signal Transduction Signal Transduction Nucleotide Binding Intracellular Signaling Cassette ATP Binding Regulation Of Intracellular Signal Transduction Protein Kinase Activity Kinase Activity Protein Tyrosine Kinase Activity Protein Serine/threonine Kinase Activity Regulation Of Signal Transduction Protein Serine Kinase Activity Regulation Of Cell Population Proliferation Positive Regulation Of Cellular Component Organization MAP Kinase Kinase Activity Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Signal Transduction MAPK Cascade Cell Surface Receptor Signaling Pathway Intrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Metabolic Process Cellular Response To Stress Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Motility Regulation Of Protein Localization Regulation Of Catalytic Activity Regulation Of Cell Cycle Regulation Of Cell Adhesion Regulation Of Epithelial Cell Proliferation Regulation Of Locomotion Regulation Of Protein Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cellular Component Biogenesis Regulation Of Protein Localization To Membrane Apoptotic Signaling Pathway Cellular Response To Radiation Regulation Of Cellular Localization Negative Regulation Of Macroautophagy Regulation Of Multicellular Organismal Process Enzyme-linked Receptor Protein Signaling Pathway Protein Phosphorylation Positive Regulation Of Protein Localization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Phosphate-containing Compound Metabolic Process Regulation Of Primary Metabolic Process	Nuclear Telomere Cap Complex Shelterin Complex G-rich Strand Telomeric DNA Binding Telomere Capping MAP Kinase Kinase Kinase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Regulation Of Peptidyl-serine Phosphorylation Telomere Maintenance Via Telomere Lengthening Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Protein-N-terminal Glutamine Amidohydrolase Activity Coated Vesicle Membrane Death-inducing Signaling Complex Assembly Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of DNA Recombination At Telomere Protein-N-terminal Asparagine Amidohydrolase Activity PDZ Domain Binding DNA Biosynthetic Process Regulation Of Protein Phosphorylation Telomere Maintenance Positive Regulation Of Chromosome Organization Regulation Of Phosphorylation Regulation Of Telomere Maintenance NF-kappaB Complex Telomere Organization Adenylate Cyclase Activator Activity Identical Protein Binding Negative Regulation Of DNA Metabolic Process Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Establishment Of Protein Localization To Chromosome Telomerase Activity Ankyrin Repeat Binding Protection From Non-homologous End Joining At Telomere Zinc Ion Binding Regulation Of Phosphorus Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Telomere Localization Meiotic Telomere Clustering Telomeric D-loop Disassembly